Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists

European Journal of Medicinal Chemistry

Volumn 51, Issue , 2012, Pages 184-192

  Wijtmans, Maikel ^a   Maussang, David ^a   Sirci, Francesco ^a   Scholten, Danny J ^a   Canals, Meritxell ^a   Mujić Delić, Azra ^a   Chong, Milagros ^a   Chatalic, Kristell L S ^a   Custers, Hans ^a   Janssen, Elwin ^a   De Graaf, Chris ^a   Smit, Martine J ^a   De Esch, Iwan J P ^a   Leurs, Rob ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

arrestin2; 3D fingerprint; Agonist; CXCR7; Internalization; Ligand

Indexed keywords

AMIDE; BETA ARRESTIN; BETA ARRESTIN 2; CHEMOKINE RECEPTOR AGONIST; CHEMOKINE RECEPTOR CXCR7; CHEMOKINE RECEPTOR CXCR7 AGONIST; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; STROMAL CELL DERIVED FACTOR 1; STYRENE DERIVATIVE; UNCLASSIFIED DRUG; VUF 11070; VUF 11207; VUF 11403;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INTERNALIZATION; MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION;

AMIDES; CHEMISTRY TECHNIQUES, SYNTHETIC; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, CXCR; STYRENE;

EID: 84860292943     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.02.041     Document Type: Article

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