Zn2+ mediates high affinity binding of heparin to the αc domain of fibrinogen

Journal of Biological Chemistry

Volumn 288, Issue 41, 2013, Pages 29394-29402

  Fredenburgh, James C ^a,b   Leslie, Beverly A ^a,b   Stafford, Alan R ^a,b   Lim, Teresa ^a,b   Chan, Howard H ^a,b   Weitz, Jeffrey I ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT ACTIVITIES; DEGRADATION PRODUCTS; HEPARIN BINDING; HEPARIN-BINDING SITE; HIGH AFFINITY BINDING; NON-SPECIFIC BINDING; PEPTIDE ANALOGS; PLASMA PROTEIN;

DEGRADATION; MONOCLONAL ANTIBODIES; ZINC;

POLYSACCHARIDES;

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; CATION; FIBRIN; FIBRINOGEN; FIBRINOGEN DEGRADATION PRODUCT; FRAGMENT X; HEPARIN; MONOCLONAL ANTIBODY; PEPTIDE DERIVATIVE; PLASMA PROTEIN; PLASMIN; THROMBIN; UNCLASSIFIED DRUG; ZINC ION; PEPTIDE; PROTEIN BINDING; ZINC;

ALPHA C DOMAIN; ALPHA CHAIN; ANTICOAGULATION; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CHROMATOGRAPHY; CONTROLLED STUDY; FLUORESCENCE; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; SURFACE PLASMON RESONANCE; AMINO ACID SEQUENCE; BINDING COMPETITION; CHEMISTRY; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; SPECTROFLUOROMETRY; COAGULATION FACTORS;

AMINO ACID SEQUENCE; ANTITHROMBINS; BINDING SITES; BINDING, COMPETITIVE; FACTOR XA; FIBRIN; FIBRINOGEN; HEPARIN; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; SURFACE PLASMON RESONANCE; ZINC;

COAGULATION FACTORS; FIBRIN; FIBRINOGEN; HEPARIN; ZINC;

EID: 84885593825     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.469916     Document Type: Article

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