By increasing the affinity of heparin for fibrin, Zn2+ promotes the formation of a ternary heparin-thrombin-fibrin complex that protects thrombin from inhibition by antithrombin

Biochemistry

Volumn 51, Issue 40, 2012, Pages 7964-7973

  Chan, Howard H ^a   Leslie, Beverly A ^a   Stafford, Alan R ^a   Roberts, Robin S ^a   Al Aswad, Nadine N ^b   Fredenburgh, James C ^a   Weitz, Jeffrey I ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; COMPLEX FORMATIONS; FIBRIN CLOTS; HEPARIN TREATMENT; HIGH AFFINITY; PHYSIOLOGICAL CONCENTRATIONS;

POLYSACCHARIDES; ZINC;

ENZYMES;

ANTITHROMBIN; FIBRIN; HEPARIN; THROMBIN; ZINC;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; DISSOCIATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; FIBRIN CLOT; HUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; THROMBOCYTE ACTIVATION;

ANTITHROMBINS; BLOOD COAGULATION; FIBRIN; HEPARIN; HUMANS; MODELS, MOLECULAR; PLASMA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STABILITY; THROMBIN; TIME FACTORS; ZINC;

EID: 84867457102     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301046b     Document Type: Article

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