메뉴 건너뛰기




Volumn , Issue , 2012, Pages 337-367

Pharmacokinetics and Pharmacodynamics of Therapeutic Peptides and Proteins

Author keywords

Exposure response correlations; Immunogenicity; Model based drug development; Peptide and protein therapeutics; Pharmacodynamics; Pharmacokinetics

Indexed keywords


EID: 84885541722     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527632909.ch14     Document Type: Chapter
Times cited : (5)

References (114)
  • 1
    • 84885546982 scopus 로고    scopus 로고
    • Biosimilars and Follow-On Biologies Report: The Global Outlook 2009-2024.
    • (accessed 8 February 2012)
    • Visiongain (2009) Biosimilars and Follow-On Biologies Report: The Global Outlook 2009-2024. http://www.visiongain.eom (accessed 8 February 2012)
    • (2009)
    • Visiongain1
  • 2
    • 84885549353 scopus 로고    scopus 로고
    • Follow-on Biologies: Intellectual Property and Innovation Issues.
    • A Congressional Researeh Serviee Report for Congress.
    • Sehaeht, W. and Thomas, J. (2007) Follow-on Biologies: Intellectual Property and Innovation Issues. A Congressional Researeh Serviee Report for Congress.
    • (2007)
    • Sehaeht, W.1    Thomas, J.2
  • 3
    • 84885491238 scopus 로고    scopus 로고
    • Biologies in perspeetiee: Expanded elinieal options amid greater eost serutiny
    • AARP Publie Poliey Institute.
    • Rueker, N.L. (2007) Biologies in perspeetiee: Expanded elinieal options amid greater eost serutiny, AARP Publie Poliey Institute.
    • (2007)
    • Rueker, N.L.1
  • 4
    • 46949105562 scopus 로고    scopus 로고
    • (Re)defining biopharmaeeutieal.
    • Rader, R.A. (2008) (Re)defining biopharmaeeutieal. Nat. Biotechnol., 26, 743-751.
    • (2008) Nat. Biotechnol. , vol.26 , pp. 743-751
    • Rader, R.A.1
  • 5
    • 0020315441 scopus 로고
    • Kineties of pharmaeologie response.
    • Holford, N.H. and Sheiner, L.B. (1982) Kineties of pharmaeologie response. Pharmacol. Ther., 16, 143-166.
    • (1982) Pharmacol. Ther. , vol.16 , pp. 143-166
    • Holford, N.H.1    Sheiner, L.B.2
  • 6
    • 0032974197 scopus 로고    scopus 로고
    • Modeling of pharmaeokinetie/pharmaeodynamie (PK/PD) relationships: eoneepts and perspeetives.
    • Derendorf, H. and Meibohm, B. (1999) Modeling of pharmaeokinetie/pharmaeodynamie (PK/PD) relationships: eoneepts and perspeetives. Pharm. Res., 16, 176-185.
    • (1999) Pharm. Res. , vol.16 , pp. 176-185
    • Derendorf, H.1    Meibohm, B.2
  • 7
    • 0030819215 scopus 로고    scopus 로고
    • Basie eoneepts of pharmaeokinetie/pharmaeodynamie (PK/PD) modelling.
    • Meibohm, B. and Derendorf, H. (1997) Basie eoneepts of pharmaeokinetie/pharmaeodynamie (PK/PD) modelling. Int. J. Clin. Pharmacol. Ther., 35,401-413.
    • (1997) Int. J. Clin. Pharmacol. Ther. , vol.35 , pp. 401-413
    • Meibohm, B.1    Derendorf, H.2
  • 8
    • 84889822280 scopus 로고    scopus 로고
    • Pharmaeokineties of peptides and proteins
    • in Pharmacokinetics and Pharmacodynamics of Biotech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim
    • Tang, L. and Meibohm, B. (2006) Pharmaeokineties of peptides and proteins, in Pharmacokinetics and Pharmacodynamics of Biotech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim, pp. 17-44.
    • (2006) , pp. 17-44
    • Tang, L.1    Meibohm, B.2
  • 9
    • 33846600867 scopus 로고    scopus 로고
    • Paving the eritieal path: how ean elinieal pharmaeology help aehieve the vision?
    • Lesko, L.J. (2007) Paving the eritieal path: how ean elinieal pharmaeology help aehieve the vision? Clin. Pharmacol. Ther., 81,170-177.
    • (2007) Clin. Pharmacol. Ther. , vol.81 , pp. 170-177
    • Lesko, L.J.1
  • 10
    • 0036144662 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic studies in drug product development.
    • Meibohm, B. and Derendorf, H. (2002) Pharmacokinetic/pharmacodynamic studies in drug product development. J. Pharm. Sci., 91, 18-31.
    • (2002) J. Pharm. Sci. , vol.91 , pp. 18-31
    • Meibohm, B.1    Derendorf, H.2
  • 12
    • 4344634877 scopus 로고    scopus 로고
    • Pharmacokinetic aspects of biotechnology products.
    • Tang, L., Persky, A.M., Hochhaus, G., and Meibohm, B. (2004) Pharmacokinetic aspects of biotechnology products. J. Pharm. Sci., 93, 2184-2204.
    • (2004) J. Pharm. Sci. , vol.93 , pp. 2184-2204
    • Tang, L.1    Persky, A.M.2    Hochhaus, G.3    Meibohm, B.4
  • 13
    • 0035409904 scopus 로고    scopus 로고
    • IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer.
    • Herbst, R.S., Kim, E.S., and Harari, P.M. (2001) IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer. Expert Opin. Biol. Ther., 1, 719-732.
    • (2001) Expert Opin. Biol. Ther. , vol.1 , pp. 719-732
    • Herbst, R.S.1    Kim, E.S.2    Harari, P.M.3
  • 14
    • 0031791711 scopus 로고    scopus 로고
    • Novel approaches for oral delivery of macromolecules.
    • Fasano, A. (1998) Novel approaches for oral delivery of macromolecules. J. Pharm. Sci., 87, 1351-1356.
    • (1998) J. Pharm. Sci. , vol.87 , pp. 1351-1356
    • Fasano, A.1
  • 16
    • 18944386159 scopus 로고    scopus 로고
    • A study of the pharmacokinetics and safety of recombinant activated factor VII in healthy Caucasian and Japanese subjects.
    • Fridberg, M.J., Hedner, U., Roberts, H.R., and Erhardtsen, E. (2005) A study of the pharmacokinetics and safety of recombinant activated factor VII in healthy Caucasian and Japanese subjects. Blood Coagul. Fibrinolysis, 16, 259-266.
    • (2005) Blood Coagul. Fibrinolysis , vol.16 , pp. 259-266
    • Fridberg, M.J.1    Hedner, U.2    Roberts, H.R.3    Erhardtsen, E.4
  • 17
    • 0035366382 scopus 로고    scopus 로고
    • Clinical evaluation of once-weekly dosing of epoetin alfa in chemotherapy patients: improvements in hemoglobin and quality of life are similar to three-times-weekly dosing.
    • Gabrilove, J.L., Cleeland, C.S., Livingston, R.B., Sarokhan, B., Winer, E., and Einhorn, L.H. (2001) Clinical evaluation of once-weekly dosing of epoetin alfa in chemotherapy patients: improvements in hemoglobin and quality of life are similar to three-times-weekly dosing. J. Clin. Oncol., 19, 2875-2882.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2875-2882
    • Gabrilove, J.L.1    Cleeland, C.S.2    Livingston, R.B.3    Sarokhan, B.4    Winer, E.5    Einhorn, L.H.6
  • 19
    • 0022668268 scopus 로고
    • Pharmacokinetics of gonadotropin-releasing hormone and its analogs.
    • Handelsman, D.J. and Swerdloff, R.S. (1986) Pharmacokinetics of gonadotropin-releasing hormone and its analogs. Endocr. Rev., 7, 95-105.
    • (1986) Endocr. Rev. , vol.7 , pp. 95-105
    • Handelsman, D.J.1    Swerdloff, R.S.2
  • 20
    • 0036073843 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of depot leuprorelin.
    • Periti, P., Mazzei, T., and Mini, E. (2002) Clinical pharmacokinetics of depot leuprorelin. Clin. Pharmacokinet., 41, 485-504.
    • (2002) Clin. Pharmacokinet. , vol.41 , pp. 485-504
    • Periti, P.1    Mazzei, T.2    Mini, E.3
  • 21
    • 2842572177 scopus 로고
    • Peptide, peptoid, and protein pharmacokinetics/pharmacodynamics
    • in Petides, Peptoids, and Proteins (eds P. Garzone, W. Colburn, and M. Mokotoff), Harvey Whitney Books, Cincinnati, OH
    • Colburn, W. (1991) Peptide, peptoid, and protein pharmacokinetics/pharmacodynamics, in Petides, Peptoids, and Proteins (eds P. Garzone, W. Colburn, and M. Mokotoff), Harvey Whitney Books, Cincinnati, OH, pp. 94-115.
    • (1991) , pp. 94-115
    • Colburn, W.1
  • 22
    • 0034020054 scopus 로고    scopus 로고
    • Lymphatic transport of proteins after subcutaneous administration.
    • Porter, C.J. and Charman, S.A. (2000) Lymphatic transport of proteins after subcutaneous administration. J. Pharm. Sci., 89, 297-310.
    • (2000) J. Pharm. Sci. , vol.89 , pp. 297-310
    • Porter, C.J.1    Charman, S.A.2
  • 23
    • 0025287316 scopus 로고
    • Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration.
    • Supersaxo, A., Hein, W.R., and Steffen, H. (1990) Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration. Pharm. Res., 7, 167-169.
    • (1990) Pharm. Res. , vol.7 , pp. 167-169
    • Supersaxo, A.1    Hein, W.R.2    Steffen, H.3
  • 24
    • 0023804898 scopus 로고
    • Recombinant human interferon alpha-2a: delivery to lymphoid tissue by selected modes of application.
    • Supersaxo, A., Hein, W., Gallati, H., and Steffen, H. (1988) Recombinant human interferon alpha-2a: delivery to lymphoid tissue by selected modes of application. Pharm. Res., 5, 472-476.
    • (1988) Pharm. Res. , vol.5 , pp. 472-476
    • Supersaxo, A.1    Hein, W.2    Gallati, H.3    Steffen, H.4
  • 25
    • 8944248248 scopus 로고
    • Points to consider in correlating bioassays and immunoassays in the quantitation of peptides and proteins
    • in Petides, Peptoids, and Proteins (eds P. Garzone, W. Colburn, and M. Mokotoff), Harvey Whitney Books, Cincinnati, OH
    • Chen, A., Baker, D., and Ferraiolo, B. (1991) Points to consider in correlating bioassays and immunoassays in the quantitation of peptides and proteins, in Petides, Peptoids, and Proteins (eds P. Garzone, W. Colburn, and M. Mokotoff), Harvey Whitney Books, Cincinnati, OH, pp. 54-71.
    • (1991) , pp. 54-71
    • Chen, A.1    Baker, D.2    Ferraiolo, B.3
  • 26
    • 0027492969 scopus 로고
    • Renal, metabolic, and hemodynamic side-effects of interleukin-2 and/or interferon alpha: evidence of a risk/benefit advantage of subcutaneous therapy.
    • Schomburg, A., Kirchner, H., and Atzpodien, J. (1993) Renal, metabolic, and hemodynamic side-effects of interleukin-2 and/or interferon alpha: evidence of a risk/benefit advantage of subcutaneous therapy. J. Cancer Res. Clin. Oncol., 119, 745-755.
    • (1993) J. Cancer Res. Clin. Oncol. , vol.119 , pp. 745-755
    • Schomburg, A.1    Kirchner, H.2    Atzpodien, J.3
  • 27
    • 6044257275 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of inhaled insulin.
    • Patton, J.S., Bukar, J.G., and Eldon, M.A. (2004) Clinical pharmacokinetics and pharmacodynamics of inhaled insulin. Clin. Pharmacokinet., 43, 781-801.
    • (2004) Clin. Pharmacokinet. , vol.43 , pp. 781-801
    • Patton, J.S.1    Bukar, J.G.2    Eldon, M.A.3
  • 28
    • 21544464003 scopus 로고    scopus 로고
    • Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial.
    • Skyler, J.S., Weinstock, R.S., Raskin, P., Yale, J.F., Barrett, E., Gerich, J.E., and Gerstein, H.C. (2005) Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial. Diabetes Care, 28, 1630-1635.
    • (2005) Diabetes Care , vol.28 , pp. 1630-1635
    • Skyler, J.S.1    Weinstock, R.S.2    Raskin, P.3    Yale, J.F.4    Barrett, E.5    Gerich, J.E.6    Gerstein, H.C.7
  • 29
    • 4644372272 scopus 로고    scopus 로고
    • Effieaey and safety of inhaled insulin (exubera) eompared with subeutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, eomparative trial.
    • Hollander, P.A., Blonde, L., Rowe, R., Mehta, A.E., Milburn, J.L., Hershon, K.S., Chiasson, J.L., and Levin, S.R. (2004) Effieaey and safety of inhaled insulin (exubera) eompared with subeutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, eomparative trial. Diabetes Care, 27, 2356-2362.
    • (2004) Diabetes Care , vol.27 , pp. 2356-2362
    • Hollander, P.A.1    Blonde, L.2    Rowe, R.3    Mehta, A.E.4    Milburn, J.L.5    Hershon, K.S.6    Chiasson, J.L.7    Levin, S.R.8
  • 30
    • 10744228212 scopus 로고    scopus 로고
    • Dose-response relationships of inhaled insulin delivered via the Aerodose insulin inhaler and subeutaneously injeeted insulin in patients with type 2 diabetes.
    • Kim, D., Mudaliar, S., Chinnapongse, S., Chu, N., Boies, S.M., Davis, T., Perera, A.D., Fishman, R.S., Shapiro, D.A., and Henry, R. (2003) Dose-response relationships of inhaled insulin delivered via the Aerodose insulin inhaler and subeutaneously injeeted insulin in patients with type 2 diabetes. Diabetes Care, 26, 2842-2847.
    • (2003) Diabetes Care , vol.26 , pp. 2842-2847
    • Kim, D.1    Mudaliar, S.2    Chinnapongse, S.3    Chu, N.4    Boies, S.M.5    Davis, T.6    Perera, A.D.7    Fishman, R.S.8    Shapiro, D.A.9    Henry, R.10
  • 32
    • 0034826771 scopus 로고    scopus 로고
    • Treating diabetes with aerosolized insulin.
    • Laube, B.L. (2001) Treating diabetes with aerosolized insulin. Chest, 120, 99S-106S.
    • (2001) Chest , vol.120
    • Laube, B.L.1
  • 33
    • 0039600350 scopus 로고    scopus 로고
    • Pharmaceutical Biotechnology: A Programmed Text
    • Teehnomie Pub. Co., Laneaster, PA.
    • Zito, S.W. (1997) Pharmaceutical Biotechnology: A Programmed Text, Teehnomie Pub. Co., Laneaster, PA.
    • (1997)
    • Zito, S.W.1
  • 34
    • 0037062327 scopus 로고    scopus 로고
    • Intranasal delivery eould be used to administer drugs direetly to the brain.
    • Lawrenee, D. (2002) Intranasal delivery eould be used to administer drugs direetly to the brain. Lancet, 359, 1674.
    • (2002) Lancet , vol.359 , pp. 1674
    • Lawrenee, D.1
  • 35
    • 0035875455 scopus 로고    scopus 로고
    • Intranasal administration of insulin-like growth faetor-I bypasses the blood-brain barrier and proteets against foeal eerebral isehemie damage.
    • Liu, X.F., Faweett, J.R., Thorne, R.G., DeFor, T.A., and Frey, W.H. 2nd. (2001) Intranasal administration of insulin-like growth faetor-I bypasses the blood-brain barrier and proteets against foeal eerebral isehemie damage. J. Neurol. Sci., 187, 91-97.
    • (2001) J. Neurol. Sci. , vol.187 , pp. 91-97
    • Liu, X.F.1    Faweett, J.R.2    Thorne, R.G.3    DeFor, T.A.4    Frey, W.H.5
  • 36
    • 0027493822 scopus 로고
    • Clinieal pharmaeokineties of oetreotide. Therapeutie applieations in patients with pituitary tumours.
    • Chanson, P., Timsit, J., and Harris, A.G. (1993) Clinieal pharmaeokineties of oetreotide. Therapeutie applieations in patients with pituitary tumours. Clin. Pharmacokinet., 25, 375-391.
    • (1993) Clin. Pharmacokinet. , vol.25 , pp. 375-391
    • Chanson, P.1    Timsit, J.2    Harris, A.G.3
  • 37
    • 0029125922 scopus 로고
    • Ultrasound-mediated transdermal protein delivery.
    • Mitragotri, S., Blanksehtein, D., and Langer, R. (1995) Ultrasound-mediated transdermal protein delivery. Science, 269, 850-853.
    • (1995) Science , vol.269 , pp. 850-853
    • Mitragotri, S.1    Blanksehtein, D.2    Langer, R.3
  • 38
    • 0037423771 scopus 로고    scopus 로고
    • Transdermal iontophoresis of insulin. V. Effeet of terpenes.
    • Pillai, O. and Panehagnula, R. (2003) Transdermal iontophoresis of insulin. V. Effeet of terpenes. J. Control. Release, 88, 287-296.
    • (2003) J. Control. Release , vol.88 , pp. 287-296
    • Pillai, O.1    Panehagnula, R.2
  • 39
    • 0027104246 scopus 로고
    • Effeet of iontophoresis on in vitro skin permeation of an analogue of growth hormone releasing faetor in the hairless guinea pig model.
    • Kumar, S., Char, H., Patel, S., Piemontese, D., Iqbal, K., Maliek, A.W., Neugrosehel, E., and Behl, C.R. (1992) Effeet of iontophoresis on in vitro skin permeation of an analogue of growth hormone releasing faetor in the hairless guinea pig model. J. Pharm. Sci., 81, 635-639.
    • (1992) J. Pharm. Sci. , vol.81 , pp. 635-639
    • Kumar, S.1    Char, H.2    Patel, S.3    Piemontese, D.4    Iqbal, K.5    Maliek, A.W.6    Neugrosehel, E.7    Behl, C.R.8
  • 42
    • 84934440758 scopus 로고    scopus 로고
    • Transdermal drug delivery systems: skin perturbation deviees.
    • Brown, M.B., Traynor, M.J., Martin, G.P., and Akomeah, F.K. (2008) Transdermal drug delivery systems: skin perturbation deviees. Methods Mol. Biol., 437, 119-139.
    • (2008) Methods Mol. Biol. , vol.437 , pp. 119-139
    • Brown, M.B.1    Traynor, M.J.2    Martin, G.P.3    Akomeah, F.K.4
  • 43
    • 1542358759 scopus 로고    scopus 로고
    • Mieroneedles for transdermal drug delivery.
    • Prausnitz, M.R. (2004) Mieroneedles for transdermal drug delivery. Adv. Drug Deliv. Rev., 56, 581-587.
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 581-587
    • Prausnitz, M.R.1
  • 45
    • 0038350680 scopus 로고    scopus 로고
    • Oral peptide and protein delivery: unfulfilled promises?
    • Shen, W.C. (2003) Oral peptide and protein delivery: unfulfilled promises? Drug Discov. Today, 8, 607-608.
    • (2003) Drug Discov. Today , vol.8 , pp. 607-608
    • Shen, W.C.1
  • 48
    • 0027414663 scopus 로고
    • Pharmaeokineties of reeombinant human interferon-beta ser in healthy volunteers and its effeet on serum neopterin.
    • Chiang, J., Gloff, C.A., Yoshizawa, C.N., and Williams, G.J. (1993) Pharmaeokineties of reeombinant human interferon-beta ser in healthy volunteers and its effeet on serum neopterin. Pharm. Res., 10, 567-572.
    • (1993) Pharm. Res. , vol.10 , pp. 567-572
    • Chiang, J.1    Gloff, C.A.2    Yoshizawa, C.N.3    Williams, G.J.4
  • 49
    • 33750690230 scopus 로고    scopus 로고
    • In vivo diffusion of immunoglobulin G in musele: effeets of binding, solute exelusion, and lymphatie removal.
    • Flessner, M.F., Lofthouse, J., and Zakariael, R. (1997) In vivo diffusion of immunoglobulin G in musele: effeets of binding, solute exelusion, and lymphatie removal. Am. J. Physiol., 273, H2783-H2793.
    • (1997) Am. J. Physiol. , vol.273
    • Flessner, M.F.1    Lofthouse, J.2    Zakariael, R.3
  • 50
    • 33749331350 scopus 로고    scopus 로고
    • A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles.
    • Reddy, S.T., Berk, D.A., Jain, R.K., and Swartz, M.A. (2006) A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles. J. Appl. Physiol., 101, 1162-1169.
    • (2006) J. Appl. Physiol. , vol.101 , pp. 1162-1169
    • Reddy, S.T.1    Berk, D.A.2    Jain, R.K.3    Swartz, M.A.4
  • 54
    • 0036914779 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of tenecteplase in fibrinolytic therapy of acute myocardial infarction.
    • Tanswell, P., Modi, N., Combs, D., and Danays, T. (2002) Pharmacokinetics and pharmacodynamics of tenecteplase in fibrinolytic therapy of acute myocardial infarction. Clin. Pharmacokinet., 41, 1229-1245.
    • (2002) Clin. Pharmacokinet. , vol.41 , pp. 1229-1245
    • Tanswell, P.1    Modi, N.2    Combs, D.3    Danays, T.4
  • 55
    • 4143136302 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers.
    • Ramakrishnan, R., Cheung, W.K., Wacholtz, M.C., Minton, N., and Jusko, W.J. (2004) Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers. J. Clin. Pharmacol., 44, 991-1002.
    • (2004) J. Clin. Pharmacol. , vol.44 , pp. 991-1002
    • Ramakrishnan, R.1    Cheung, W.K.2    Wacholtz, M.C.3    Minton, N.4    Jusko, W.J.5
  • 57
    • 84889856889 scopus 로고    scopus 로고
    • Limitations of noncompartmental pharmacokinetic analysis of biotech drugs
    • in Pharmacokinetics and Pharmacodynamics of Biotech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim
    • Straughn, A.B. (2006) Limitations of noncompartmental pharmacokinetic analysis of biotech drugs, in Pharmacokinetics and Pharmacodynamics of Biotech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim, pp. 181-188.
    • (2006) , pp. 181-188
    • Straughn, A.B.1
  • 58
    • 0019974468 scopus 로고
    • Noncompartmental determination of the steady-state volume of distribution for any mode of administration.
    • Perrier, D. and Mayersohn, M. (1982) Noncompartmental determination of the steady-state volume of distribution for any mode of administration. J. Pharm. Sci., 71, 372-373.
    • (1982) J. Pharm. Sci. , vol.71 , pp. 372-373
    • Perrier, D.1    Mayersohn, M.2
  • 59
    • 0019945174 scopus 로고
    • Model-independent steady-state volume of distribution.
    • Straughn, A.B. (1982) Model-independent steady-state volume of distribution. J. Pharm. Sci., 71, 597-598.
    • (1982) J. Pharm. Sci. , vol.71 , pp. 597-598
    • Straughn, A.B.1
  • 60
    • 39149115174 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of peptides and proteins
    • in Pharmaceutical Biotechnology: Concepts and Applications (eds D.J.A. Crommelin, R.D. Sindelar, and B. Meibohm), Informa Healthcare, New York
    • Meibohm, B. and Braeckman, R.A. (2007) Pharmacokinetics and pharmacodynamics of peptides and proteins, in Pharmaceutical Biotechnology: Concepts and Applications (eds D.J.A. Crommelin, R.D. Sindelar, and B. Meibohm), Informa Healthcare, New York, pp. 95-123.
    • (2007) , pp. 95-123
    • Meibohm, B.1    Braeckman, R.A.2
  • 61
    • 0029127007 scopus 로고
    • Receptor-mediated clearance of G-CSF derivative nartograstim in bone marrow of rats.
    • a
    • Kuwabara, T., Uchimura, T., Kobayashi, H., Kobayashi, S., and Sugiyama, Y. (1995a) Receptor-mediated clearance of G-CSF derivative nartograstim in bone marrow of rats. Am. J. Physiol., 269, E1-E9.
    • (1995) Am. J. Physiol. , vol.269
    • Kuwabara, T.1    Uchimura, T.2    Kobayashi, H.3    Kobayashi, S.4    Sugiyama, Y.5
  • 62
    • 0030017103 scopus 로고    scopus 로고
    • The relevance of pharmacokinetics in the development of biotechnology products.
    • Toon, S. (1996) The relevance of pharmacokinetics in the development of biotechnology products. Eur. J. Drug Metab. Pharmacokinet., 21, 93-103.
    • (1996) Eur. J. Drug Metab. Pharmacokinet. , vol.21 , pp. 93-103
    • Toon, S.1
  • 64
    • 0036331674 scopus 로고    scopus 로고
    • A target-mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans.
    • Eppler, S.M., Combs, D.L., Henry, T.D., Lopez, J.J., Ellis, S.G., Yi, J.H., Annex, B.H., McCluskey, E.R., and Zioncheck, T.F. (2002) A target-mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans. Clin. Pharmacol. Ther., 72, 20-32.
    • (2002) Clin. Pharmacol. Ther. , vol.72 , pp. 20-32
    • Eppler, S.M.1    Combs, D.L.2    Henry, T.D.3    Lopez, J.J.4    Ellis, S.G.5    Yi, J.H.6    Annex, B.H.7    McCluskey, E.R.8    Zioncheck, T.F.9
  • 65
    • 0030980940 scopus 로고    scopus 로고
    • Pharmacokinetic studies with recombinant cytokines. Scientific issues and practical considerations.
    • Piscitelli, S.C., Reiss, W.G., Figg, W.D., and Petros, W.P. (1997) Pharmacokinetic studies with recombinant cytokines. Scientific issues and practical considerations. Clin. Pharmacokinet., 32, 368-381.
    • (1997) Clin. Pharmacokinet. , vol.32 , pp. 368-381
    • Piscitelli, S.C.1    Reiss, W.G.2    Figg, W.D.3    Petros, W.P.4
  • 66
    • 0026674156 scopus 로고
    • Competition for binding to insulin-like growth faetor (IGF) binding protein-2, 3, 4, and 5 by the IGFs and IGF analogs.
    • Clemmons, D.R., Dehoff, M.L., Busby, W.H., Bayne, M.L., and Caseieri, M.A. (1992) Competition for binding to insulin-like growth faetor (IGF) binding protein-2, 3, 4, and 5 by the IGFs and IGF analogs. Endocrinology, 131, 890-895.
    • (1992) Endocrinology , vol.131 , pp. 890-895
    • Clemmons, D.R.1    Dehoff, M.L.2    Busby, W.H.3    Bayne, M.L.4    Caseieri, M.A.5
  • 67
    • 0026488120 scopus 로고
    • The role of pharmaeokineties in the development of bioteehnologieally derived agents.
    • Wills, R.J. and Ferraiolo, B.L. (1992) The role of pharmaeokineties in the development of bioteehnologieally derived agents. Clin. Pharmacokinet., 23, 406-414.
    • (1992) Clin. Pharmacokinet. , vol.23 , pp. 406-414
    • Wills, R.J.1    Ferraiolo, B.L.2
  • 69
    • 84885528087 scopus 로고
    • A kinetie/dynamie perspeetive of a peptide and protein: GRF and rHuIFN-alpha-2a
    • in Petides, Peptoids, and Proteins (eds P. Garzone, W. Colburn, and M. Mokotoff), Harvey Whitney Books, Cineinnati, OH
    • Wills, R. (1991) A kinetie/dynamie perspeetive of a peptide and protein: GRF and rHuIFN-alpha-2a, in Petides, Peptoids, and Proteins (eds P. Garzone, W. Colburn, and M. Mokotoff), Harvey Whitney Books, Cineinnati, OH, pp. 117-127.
    • (1991) , pp. 117-127
    • Wills, R.1
  • 70
    • 0026541509 scopus 로고
    • Pharmaeokineties of peptides and proteins: opportunities and ehallenges.
    • MeMartin, C. (1992) Pharmaeokineties of peptides and proteins: opportunities and ehallenges. Adv. Drug Res., 22, 39-106.
    • (1992) Adv. Drug Res. , vol.22 , pp. 39-106
    • MeMartin, C.1
  • 71
    • 84885525737 scopus 로고    scopus 로고
    • Pharmaeokineties of protein-and nueleotide-based drugs
    • in Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids (ed. R.I. Mahato), CRC Press, Boea Raton
    • Meibohm, B. (2004) Pharmaeokineties of protein-and nueleotide-based drugs, in Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids (ed. R.I. Mahato), CRC Press, Boea Raton, pp. 275-294.
    • (2004) , pp. 275-294
    • Meibohm, B.1
  • 72
    • 0002979228 scopus 로고
    • Biological Barriers to Protein Delivery
    • Plenum Press, New York.
    • Meijer, D. and Ziegler, K. (1993) Biological Barriers to Protein Delivery, Plenum Press, New York.
    • (1993)
    • Meijer, D.1    Ziegler, K.2
  • 74
    • 0033001525 scopus 로고    scopus 로고
    • Ultrastruetural model for size seleetivity in glomerular filtration.
    • Edwards, A., Daniels, B.S., and Deen, W.M. (1999) Ultrastruetural model for size seleetivity in glomerular filtration. Am. J. Physiol., 276, F892-F902.
    • (1999) Am. J. Physiol. , vol.276
    • Edwards, A.1    Daniels, B.S.2    Deen, W.M.3
  • 75
    • 0003118736 scopus 로고
    • Renal filtration, transport and metabolism of proteins
    • in The Kidney: Physiology and Pathophysiology (eds D. Seldin and G. Giebiseh), Raven Press, New York
    • Maaek, T., Park, C., and Camargo, M. (1985) Renal filtration, transport and metabolism of proteins, in The Kidney: Physiology and Pathophysiology (eds D. Seldin and G. Giebiseh), Raven Press, New York, pp. 1773-1803.
    • (1985) , pp. 1773-1803
    • Maaek, T.1    Park, C.2    Camargo, M.3
  • 76
    • 0033323788 scopus 로고    scopus 로고
    • Disposition of reeombinant human interleukin-10 in subjeets with various degrees of renal funetion.
    • Andersen, S., Lambreeht, L., Swan, S., Cutler, D., Radwanski, E., Affrime, M., and Garaud, J. (1999) Disposition of reeombinant human interleukin-10 in subjeets with various degrees of renal funetion. J. Clin. Pharmacol., 39, 1015-1020.
    • (1999) J. Clin. Pharmacol. , vol.39 , pp. 1015-1020
    • Andersen, S.1    Lambreeht, L.2    Swan, S.3    Cutler, D.4    Radwanski, E.5    Affrime, M.6    Garaud, J.7
  • 77
    • 0033659819 scopus 로고    scopus 로고
    • Physiologieal and pharmaeologieal implieations of peptide transporters, PEPT1 and PEPT2.
    • Inui, K., Terada, T., Masuda, S., and Saito, H. (2000) Physiologieal and pharmaeologieal implieations of peptide transporters, PEPT1 and PEPT2. Nephrol. Dial. Transplant., 15 (Suppl 6), 11-13.
    • (2000) Nephrol. Dial. Transplant. , vol.15 Suppl 6 , pp. 11-13
    • Inui, K.1    Terada, T.2    Masuda, S.3    Saito, H.4
  • 78
    • 0017701073 scopus 로고
    • Renal extraetion, filtration, absorption, and eatabolism of growth hormone.
    • Johnson, V. and Maaek, T. (1977) Renal extraetion, filtration, absorption, and eatabolism of growth hormone. Am. J. Physiol., 233, F185-F196.
    • (1977) Am. J. Physiol. , vol.233
    • Johnson, V.1    Maaek, T.2
  • 79
    • 0028265795 scopus 로고
    • Studies on the renal kineties of growth hormone (GH) and on the GH reeeptor and related effeets in animals.
    • Krogsgaard Thomsen, M., Friis, C., Sehested Hansen, B., Johansen, P., Esehen, C., Nowak, J., and Poulsen, K. (1994) Studies on the renal kineties of growth hormone (GH) and on the GH reeeptor and related effeets in animals. J. Pediatr. Endocrinol., 7, 93-105.
    • (1994) J. Pediatr. Endocrinol. , vol.7 , pp. 93-105
    • Thomsen, M.K.1    Friis, C.2    Hansen, B.S.3    Johansen, P.4    Esehen, C.5    Nowak, J.6    Poulsen, K.7
  • 80
    • 0026756089 scopus 로고
    • Low density lipoprotein reeeptor-related protein/alpha 2-maeroglobulin reeeptor is an hepatie reeeptor for tissue-type plasminogen aetivator.
    • Bu, G., Williams, S., Striekland, D.K., and Sehwartz, A.L. (1992) Low density lipoprotein reeeptor-related protein/alpha 2-maeroglobulin reeeptor is an hepatie reeeptor for tissue-type plasminogen aetivator. Proc. Natl. Acad. Sci. U.S.A., 89, 7427-7431.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 7427-7431
    • Bu, G.1    Williams, S.2    Striekland, D.K.3    Sehwartz, A.L.4
  • 81
    • 0025063975 scopus 로고
    • Clearanee of tissue plasminogen aetivator by mannose and galaetose reeeptors in the liver.
    • Smedsrod, B. and Einarsson, M. (1990) Clearanee of tissue plasminogen aetivator by mannose and galaetose reeeptors in the liver. Thromb. Haemost., 63, 60-66.
    • (1990) Thromb. Haemost. , vol.63 , pp. 60-66
    • Smedsrod, B.1    Einarsson, M.2
  • 82
    • 0027998106 scopus 로고
    • Pharmaeologie target-mediated drug disposition.
    • b
    • Levy, G. (1994b) Pharmaeologie target-mediated drug disposition. Clin. Pharmacol. Ther., 56, 248-252.
    • (1994) Clin. Pharmacol. Ther. , vol.56 , pp. 248-252
    • Levy, G.1
  • 83
    • 0029053166 scopus 로고
    • Saturable uptake of a reeombinant human granuloeyte eolony-stimulating faetor derivative, nartograstim, by the bone marrow and spleen of rats in vivo.
    • b
    • Kuwabara, T., Uehimura, T., Takai, K., Kobayashi, H., Kobayashi, S., and Sugiyama, Y. (1995b) Saturable uptake of a reeombinant human granuloeyte eolony-stimulating faetor derivative, nartograstim, by the bone marrow and spleen of rats in vivo. J. Pharmacol. Exp. Ther., 273, 1114-1122.
    • (1995) J. Pharmacol. Exp. Ther. , vol.273 , pp. 1114-1122
    • Kuwabara, T.1    Uehimura, T.2    Takai, K.3    Kobayashi, H.4    Kobayashi, S.5    Sugiyama, Y.6
  • 84
    • 0028013741 scopus 로고
    • Nonlinear pharmaeokineties of reeombinant human maerophage eolony-stimulating faetor (M-CSF) in rats.
    • Bauer, R.J., Gibbons, J.A., Bell, D.P., Luo, Z.P., and Young, J.D. (1994) Nonlinear pharmaeokineties of reeombinant human maerophage eolony-stimulating faetor (M-CSF) in rats. J. Pharmacol. Exp. Ther., 268, 152-158.
    • (1994) J. Pharmacol. Exp. Ther. , vol.268 , pp. 152-158
    • Bauer, R.J.1    Gibbons, J.A.2    Bell, D.P.3    Luo, Z.P.4    Young, J.D.5
  • 86
    • 34548229364 scopus 로고    scopus 로고
    • FcRn: the neonatal Fc receptor comes of age.
    • Roopenian, D.C. and Akilesh, S. (2007) FcRn: the neonatal Fc receptor comes of age. Nat. Rev. Immunol., 7, 715-725.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 715-725
    • Roopenian, D.C.1    Akilesh, S.2
  • 87
    • 54249138516 scopus 로고    scopus 로고
    • Monoclonal antibody pharmacokinetics and pharmacodynamics.
    • Wang, W., Wang, E.Q., and Balthasar, J.P. (2008) Monoclonal antibody pharmacokinetics and pharmacodynamics. Clin. Pharmacol. Ther., 84, 548-558.
    • (2008) Clin. Pharmacol. Ther. , vol.84 , pp. 548-558
    • Wang, W.1    Wang, E.Q.2    Balthasar, J.P.3
  • 88
    • 77956388219 scopus 로고    scopus 로고
    • Population pharmacokinetics of therapeutic monoclonal antibodies.
    • Dirks, N.L. and Meibohm, B. (2010) Population pharmacokinetics of therapeutic monoclonal antibodies. Clin. Pharmacokinet., 49, 633-659.
    • (2010) Clin. Pharmacokinet. , vol.49 , pp. 633-659
    • Dirks, N.L.1    Meibohm, B.2
  • 89
    • 33846050957 scopus 로고    scopus 로고
    • Kinetics of FcRn-mediated recycling of IgG and albumin in human: pathophysiology and therapeutic implications using a simplified mechanism-based model.
    • Kim, J., Hayton, W.L., Robinson, J.M., and Anderson, C. L. (2007) Kinetics of FcRn-mediated recycling of IgG and albumin in human: pathophysiology and therapeutic implications using a simplified mechanism-based model. Clin. Immunol., 122, 146-155.
    • (2007) Clin. Immunol. , vol.122 , pp. 146-155
    • Kim, J.1    Hayton, W.L.2    Robinson, J.M.3    Anderson, C.L.4
  • 90
    • 0036598634 scopus 로고    scopus 로고
    • Bioequivalence and the immunogenicity of biopharmaceuticals.
    • Schellekens, H. (2002) Bioequivalence and the immunogenicity of biopharmaceuticals. Nat. Rev. Drug Discov., 1, 457-462.
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 457-462
    • Schellekens, H.1
  • 91
    • 0036861899 scopus 로고    scopus 로고
    • Immunogenicity of therapeutic proteins: clinical implications and future prospects.
    • 1720-1740. discussion
    • Schellekens, H. (2002) Immunogenicity of therapeutic proteins: clinical implications and future prospects. Clin. Ther., 24, 1720-1740. discussion 1719.
    • (2002) Clin. Ther. , vol.24 , pp. 1719
    • Schellekens, H.1
  • 92
    • 46149124807 scopus 로고    scopus 로고
    • How to predict and prevent the immunogenicity of therapeutic proteins.
    • Schellekens, H. (2008) How to predict and prevent the immunogenicity of therapeutic proteins. Biotechnol. Annu. Rev., 14, 191-202.
    • (2008) Biotechnol. Annu. Rev. , vol.14 , pp. 191-202
    • Schellekens, H.1
  • 94
    • 84885517914 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of peptides and proteins
    • in Pharmaceutical Biotechnology: Concepts and Applications (eds D.J.A. Crommelin, R.D. Sindelar, and B. Meibohm), Informa Healthcare, New York
    • Schellekens, H. and Jiskoot, W. (2007) Pharmacokinetics and pharmacodynamics of peptides and proteins, in Pharmaceutical Biotechnology: Concepts and Applications (eds D.J.A. Crommelin, R.D. Sindelar, and B. Meibohm), Informa Healthcare, New York, pp. 125-132.
    • (2007) , pp. 125-132
    • Schellekens, H.1    Jiskoot, W.2
  • 95
    • 0002411258 scopus 로고
    • Potential effects of antibody induction by protein drugs
    • in Protein Pharmacokinetics and Metabolism (eds B.L. Ferraiolo, M.A. Mohler, and C.A. Gloff), Plenum Press, New York
    • Working, P.K. (1992) Potential effects of antibody induction by protein drugs, in Protein Pharmacokinetics and Metabolism (eds B.L. Ferraiolo, M.A. Mohler, and C.A. Gloff), Plenum Press, New York, pp. 73-92.
    • (1992) , pp. 73-92
    • Working, P.K.1
  • 96
    • 0042999388 scopus 로고    scopus 로고
    • Pegaspargase: a review of clinical studies.
    • Graham, M.L. (2003) Pegaspargase: a review of clinical studies. Adv. Drug Deliv. Rev., 55, 1293-1302.
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 1293-1302
    • Graham, M.L.1
  • 97
    • 84889817808 scopus 로고    scopus 로고
    • Custom-tailored pharmacokinetics and pharmacodynamics via chemical modifications of biotech drugs
    • in Pharmacokinetics and Pharmacodynamics of Boptech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim
    • Veronese, F.M. and Caliceti, P. (2006) Custom-tailored pharmacokinetics and pharmacodynamics via chemical modifications of biotech drugs, in Pharmacokinetics and Pharmacodynamics of Boptech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim, pp. 271-294.
    • (2006) , pp. 271-294
    • Veronese, F.M.1    Caliceti, P.2
  • 98
    • 84889815803 scopus 로고    scopus 로고
    • Exposure-reponse relationships for therapeutic biologics
    • in Pharmacokinetics and Pharmacodynamics of Biotech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim
    • Tabrizi, M. and Roskos, L.K. (2006) Exposure-reponse relationships for therapeutic biologics, in Pharmacokinetics and Pharmacodynamics of Biotech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim, pp. 295-330.
    • (2006) , pp. 295-330
    • Tabrizi, M.1    Roskos, L.K.2
  • 99
    • 32444438731 scopus 로고    scopus 로고
    • Elimination mechanisms of therapeutic monoclonal antibodies.
    • Tabrizi, M.A., Tseng, C.M., and Roskos, L.K. (2006) Elimination mechanisms of therapeutic monoclonal antibodies. Drug Discov. Today, 11, 81-88.
    • (2006) Drug Discov. Today , vol.11 , pp. 81-88
    • Tabrizi, M.A.1    Tseng, C.M.2    Roskos, L.K.3
  • 100
    • 4344707565 scopus 로고    scopus 로고
    • Exposure Response Relationships: Guidance for Industry.
    • CDER/FDA, Rockville: US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research.
    • CDER/FDA (2003) Exposure Response Relationships: Guidance for Industry. Rockville: US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research.
    • (2003)
  • 101
    • 0023013622 scopus 로고
    • Kinetics of drug action: an overview.
    • Levy, G. (1986) Kinetics of drug action: an overview. J. Allergy Clin. Immunol., 78, 754-761.
    • (1986) J. Allergy Clin. Immunol. , vol.78 , pp. 754-761
    • Levy, G.1
  • 102
    • 0028075942 scopus 로고
    • Mechanism-based pharmacodynamic modeling.
    • a
    • Levy, G. (1994a) Mechanism-based pharmacodynamic modeling. Clin. Pharmacol. Ther., 56, 356-358.
    • (1994) Clin. Pharmacol. Ther. , vol.56 , pp. 356-358
    • Levy, G.1
  • 103
    • 13144282659 scopus 로고    scopus 로고
    • Efficacy, pharmacodynamics, and pharmacokinetics of CGP 51901, an anti-immunoglobulin E chimeric monoclonal antibody, in patients with seasonal allergic rhinitis.
    • Racine-Poon, A., Botta, L., Chang, T.W., Davis, F.M., Gygax, D., Liou, R.S., Rohane, P., Staehelin, T., van Steijn, A.M., and Frank, W. (1997) Efficacy, pharmacodynamics, and pharmacokinetics of CGP 51901, an anti-immunoglobulin E chimeric monoclonal antibody, in patients with seasonal allergic rhinitis. Clin. Pharmacol. Ther., 62, 675-690.
    • (1997) Clin. Pharmacol. Ther. , vol.62 , pp. 675-690
    • Racine-poon, A.1    Botta, L.2    Chang, T.W.3    Davis, F.M.4    Gygax, D.5    Liou, R.S.6    Rohane, P.7    Staehelin, T.8    Steijn, A.M.V.9    Frank, W.10
  • 105
    • 0018394195 scopus 로고
    • Simultaneous modeling of pharmaeokineties and pharmaeodynamies: applieation to d-tuboeurarine.
    • Sheiner, L.B., Stanski, D.R., Vozeh, S., Miller, R.D., and Ham, J. (1979) Simultaneous modeling of pharmaeokineties and pharmaeodynamies: applieation to d-tuboeurarine. Clin. Pharmacol. Ther., 25, 358-371.
    • (1979) Clin. Pharmacol. Ther. , vol.25 , pp. 358-371
    • Sheiner, L.B.1    Stanski, D.R.2    Vozeh, S.3    Miller, R.D.4    Ham, J.5
  • 107
    • 0031762361 scopus 로고    scopus 로고
    • Pharmaeokineties and pharmaeodynamies of growth hormonereleasing peptide-2: a phase I study in ehildren.
    • Pihoker, C., Kearns, G.L., Freneh, D., and Bowers, C.Y. (1998) Pharmaeokineties and pharmaeodynamies of growth hormonereleasing peptide-2: a phase I study in ehildren. J. Clin. Endocrinol. Metab., 83, 1168-1172.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 1168-1172
    • Pihoker, C.1    Kearns, G.L.2    Freneh, D.3    Bowers, C.Y.4
  • 108
    • 0027769745 scopus 로고
    • Comparision of four basie models of indireet pharmaeodynamie responses.
    • Dayneka, N.L., Garg, V., and Jusko, W.J. (1993) Comparision of four basie models of indireet pharmaeodynamie responses. J. Pharmocokinet. Biopharm., 21, 457-478.
    • (1993) J. Pharmocokinet. Biopharm. , vol.21 , pp. 457-478
    • Dayneka, N.L.1    Garg, V.2    Jusko, W.J.3
  • 109
    • 0031890386 scopus 로고    scopus 로고
    • Charaeteristies of indireet pharmaeodynamie models and applieations to elinieal drug responses.
    • Sharma, A. and Jusko, W. (1998) Charaeteristies of indireet pharmaeodynamie models and applieations to elinieal drug responses. Br. J. Clin. Pharmacol., 45, 229-239.
    • (1998) Br. J. Clin. Pharmacol. , vol.45 , pp. 229-239
    • Sharma, A.1    Jusko, W.2
  • 110
    • 0032882959 scopus 로고    scopus 로고
    • Role of baseline parameters in determining indireet pharmaeodynamie responses.
    • Sun, Y.N. and Jusko, W.J. (1999) Role of baseline parameters in determining indireet pharmaeodynamie responses. J. Pharm. Sci., 88, 987-990.
    • (1999) J. Pharm. Sci. , vol.88 , pp. 987-990
    • Sun, Y.N.1    Jusko, W.J.2
  • 111
    • 32244436150 scopus 로고    scopus 로고
    • Pharmaeokineties/pharmaeodynamies of nondepleting anti-CD4 monoelonal antibody (TRX1) in healthy human volunteers.
    • Ng, C.M., Stefanieh, E., Anand, B.S., Fielder, P.J., and Vaiekus, L. (2006) Pharmaeokineties/pharmaeodynamies of nondepleting anti-CD4 monoelonal antibody (TRX1) in healthy human volunteers. Pharm. Res., 23, 95-103.
    • (2006) Pharm. Res. , vol.23 , pp. 95-103
    • Ng, C.M.1    Stefanieh, E.2    Anand, B.S.3    Fielder, P.J.4    Vaiekus, L.5
  • 112
    • 33748748732 scopus 로고    scopus 로고
    • Development and evaluation of a population pharmaeokinetie-pharmaeodynamie model of darbepoetin alfa in patients with nonmyeloid malignaneies undergoing multieyele ehemotherapy.
    • Agoram, B., Heatherington, A.C., and Gastonguay, M.R. (2006) Development and evaluation of a population pharmaeokinetie-pharmaeodynamie model of darbepoetin alfa in patients with nonmyeloid malignaneies undergoing multieyele ehemotherapy. AAPS J., 8, E552-E563.
    • (2006) AAPS J. , vol.8
    • Agoram, B.1    Heatherington, A.C.2    Gastonguay, M.R.3
  • 114
    • 65549156693 scopus 로고    scopus 로고
    • Coneepts and ehallenges in quantitative pharmaeology and model-based drug development.
    • Zhang, L., Pfister, M., and Meibohm, B. (2008) Coneepts and ehallenges in quantitative pharmaeology and model-based drug development. AAPS J., 10, 552-559.
    • (2008) AAPS J. , vol.10 , pp. 552-559
    • Zhang, L.1    Pfister, M.2    Meibohm, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.