-
1
-
-
84885546982
-
Biosimilars and Follow-On Biologies Report: The Global Outlook 2009-2024.
-
(accessed 8 February 2012)
-
Visiongain (2009) Biosimilars and Follow-On Biologies Report: The Global Outlook 2009-2024. http://www.visiongain.eom (accessed 8 February 2012)
-
(2009)
-
-
Visiongain1
-
2
-
-
84885549353
-
Follow-on Biologies: Intellectual Property and Innovation Issues.
-
A Congressional Researeh Serviee Report for Congress.
-
Sehaeht, W. and Thomas, J. (2007) Follow-on Biologies: Intellectual Property and Innovation Issues. A Congressional Researeh Serviee Report for Congress.
-
(2007)
-
-
Sehaeht, W.1
Thomas, J.2
-
3
-
-
84885491238
-
Biologies in perspeetiee: Expanded elinieal options amid greater eost serutiny
-
AARP Publie Poliey Institute.
-
Rueker, N.L. (2007) Biologies in perspeetiee: Expanded elinieal options amid greater eost serutiny, AARP Publie Poliey Institute.
-
(2007)
-
-
Rueker, N.L.1
-
4
-
-
46949105562
-
(Re)defining biopharmaeeutieal.
-
Rader, R.A. (2008) (Re)defining biopharmaeeutieal. Nat. Biotechnol., 26, 743-751.
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 743-751
-
-
Rader, R.A.1
-
5
-
-
0020315441
-
Kineties of pharmaeologie response.
-
Holford, N.H. and Sheiner, L.B. (1982) Kineties of pharmaeologie response. Pharmacol. Ther., 16, 143-166.
-
(1982)
Pharmacol. Ther.
, vol.16
, pp. 143-166
-
-
Holford, N.H.1
Sheiner, L.B.2
-
6
-
-
0032974197
-
Modeling of pharmaeokinetie/pharmaeodynamie (PK/PD) relationships: eoneepts and perspeetives.
-
Derendorf, H. and Meibohm, B. (1999) Modeling of pharmaeokinetie/pharmaeodynamie (PK/PD) relationships: eoneepts and perspeetives. Pharm. Res., 16, 176-185.
-
(1999)
Pharm. Res.
, vol.16
, pp. 176-185
-
-
Derendorf, H.1
Meibohm, B.2
-
7
-
-
0030819215
-
Basie eoneepts of pharmaeokinetie/pharmaeodynamie (PK/PD) modelling.
-
Meibohm, B. and Derendorf, H. (1997) Basie eoneepts of pharmaeokinetie/pharmaeodynamie (PK/PD) modelling. Int. J. Clin. Pharmacol. Ther., 35,401-413.
-
(1997)
Int. J. Clin. Pharmacol. Ther.
, vol.35
, pp. 401-413
-
-
Meibohm, B.1
Derendorf, H.2
-
8
-
-
84889822280
-
Pharmaeokineties of peptides and proteins
-
in Pharmacokinetics and Pharmacodynamics of Biotech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim
-
Tang, L. and Meibohm, B. (2006) Pharmaeokineties of peptides and proteins, in Pharmacokinetics and Pharmacodynamics of Biotech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim, pp. 17-44.
-
(2006)
, pp. 17-44
-
-
Tang, L.1
Meibohm, B.2
-
9
-
-
33846600867
-
Paving the eritieal path: how ean elinieal pharmaeology help aehieve the vision?
-
Lesko, L.J. (2007) Paving the eritieal path: how ean elinieal pharmaeology help aehieve the vision? Clin. Pharmacol. Ther., 81,170-177.
-
(2007)
Clin. Pharmacol. Ther.
, vol.81
, pp. 170-177
-
-
Lesko, L.J.1
-
10
-
-
0036144662
-
Pharmacokinetic/pharmacodynamic studies in drug product development.
-
Meibohm, B. and Derendorf, H. (2002) Pharmacokinetic/pharmacodynamic studies in drug product development. J. Pharm. Sci., 91, 18-31.
-
(2002)
J. Pharm. Sci.
, vol.91
, pp. 18-31
-
-
Meibohm, B.1
Derendorf, H.2
-
11
-
-
77950295526
-
The current role of model-based drug development.
-
Suryawanshi, S., Zhang, L., Pfister, M., and Meibohm, B. (2010) The current role of model-based drug development. Expert Opin. Drug Discov., 5, 311-321.
-
(2010)
Expert Opin. Drug Discov.
, vol.5
, pp. 311-321
-
-
Suryawanshi, S.1
Zhang, L.2
Pfister, M.3
Meibohm, B.4
-
12
-
-
4344634877
-
Pharmacokinetic aspects of biotechnology products.
-
Tang, L., Persky, A.M., Hochhaus, G., and Meibohm, B. (2004) Pharmacokinetic aspects of biotechnology products. J. Pharm. Sci., 93, 2184-2204.
-
(2004)
J. Pharm. Sci.
, vol.93
, pp. 2184-2204
-
-
Tang, L.1
Persky, A.M.2
Hochhaus, G.3
Meibohm, B.4
-
13
-
-
0035409904
-
IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer.
-
Herbst, R.S., Kim, E.S., and Harari, P.M. (2001) IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer. Expert Opin. Biol. Ther., 1, 719-732.
-
(2001)
Expert Opin. Biol. Ther.
, vol.1
, pp. 719-732
-
-
Herbst, R.S.1
Kim, E.S.2
Harari, P.M.3
-
14
-
-
0031791711
-
Novel approaches for oral delivery of macromolecules.
-
Fasano, A. (1998) Novel approaches for oral delivery of macromolecules. J. Pharm. Sci., 87, 1351-1356.
-
(1998)
J. Pharm. Sci.
, vol.87
, pp. 1351-1356
-
-
Fasano, A.1
-
15
-
-
0141997761
-
Emerging trends in oral delivery of peptide and protein drugs.
-
Mahato, R.I., Narang, A.S., Thoma, L., and Miller, D.D. (2003) Emerging trends in oral delivery of peptide and protein drugs. Crit. Rev. Ther. Drug Carrier Syst., 20, 153-214.
-
(2003)
Crit. Rev. Ther. Drug Carrier Syst.
, vol.20
, pp. 153-214
-
-
Mahato, R.I.1
Narang, A.S.2
Thoma, L.3
Miller, D.D.4
-
16
-
-
18944386159
-
A study of the pharmacokinetics and safety of recombinant activated factor VII in healthy Caucasian and Japanese subjects.
-
Fridberg, M.J., Hedner, U., Roberts, H.R., and Erhardtsen, E. (2005) A study of the pharmacokinetics and safety of recombinant activated factor VII in healthy Caucasian and Japanese subjects. Blood Coagul. Fibrinolysis, 16, 259-266.
-
(2005)
Blood Coagul. Fibrinolysis
, vol.16
, pp. 259-266
-
-
Fridberg, M.J.1
Hedner, U.2
Roberts, H.R.3
Erhardtsen, E.4
-
17
-
-
0035366382
-
Clinical evaluation of once-weekly dosing of epoetin alfa in chemotherapy patients: improvements in hemoglobin and quality of life are similar to three-times-weekly dosing.
-
Gabrilove, J.L., Cleeland, C.S., Livingston, R.B., Sarokhan, B., Winer, E., and Einhorn, L.H. (2001) Clinical evaluation of once-weekly dosing of epoetin alfa in chemotherapy patients: improvements in hemoglobin and quality of life are similar to three-times-weekly dosing. J. Clin. Oncol., 19, 2875-2882.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 2875-2882
-
-
Gabrilove, J.L.1
Cleeland, C.S.2
Livingston, R.B.3
Sarokhan, B.4
Winer, E.5
Einhorn, L.H.6
-
18
-
-
0025977812
-
Clinical pharmacokinetics of epoetin (recombinant human erythropoietin).
-
Macdougall, I.C., Roberts, D.E., Coles, G.A., and Williams, J.D. (1991) Clinical pharmacokinetics of epoetin (recombinant human erythropoietin). Clin. Pharmacokinet., 20, 99-113.
-
(1991)
Clin. Pharmacokinet.
, vol.20
, pp. 99-113
-
-
Macdougall, I.C.1
Roberts, D.E.2
Coles, G.A.3
Williams, J.D.4
-
19
-
-
0022668268
-
Pharmacokinetics of gonadotropin-releasing hormone and its analogs.
-
Handelsman, D.J. and Swerdloff, R.S. (1986) Pharmacokinetics of gonadotropin-releasing hormone and its analogs. Endocr. Rev., 7, 95-105.
-
(1986)
Endocr. Rev.
, vol.7
, pp. 95-105
-
-
Handelsman, D.J.1
Swerdloff, R.S.2
-
20
-
-
0036073843
-
Clinical pharmacokinetics of depot leuprorelin.
-
Periti, P., Mazzei, T., and Mini, E. (2002) Clinical pharmacokinetics of depot leuprorelin. Clin. Pharmacokinet., 41, 485-504.
-
(2002)
Clin. Pharmacokinet.
, vol.41
, pp. 485-504
-
-
Periti, P.1
Mazzei, T.2
Mini, E.3
-
21
-
-
2842572177
-
Peptide, peptoid, and protein pharmacokinetics/pharmacodynamics
-
in Petides, Peptoids, and Proteins (eds P. Garzone, W. Colburn, and M. Mokotoff), Harvey Whitney Books, Cincinnati, OH
-
Colburn, W. (1991) Peptide, peptoid, and protein pharmacokinetics/pharmacodynamics, in Petides, Peptoids, and Proteins (eds P. Garzone, W. Colburn, and M. Mokotoff), Harvey Whitney Books, Cincinnati, OH, pp. 94-115.
-
(1991)
, pp. 94-115
-
-
Colburn, W.1
-
22
-
-
0034020054
-
Lymphatic transport of proteins after subcutaneous administration.
-
Porter, C.J. and Charman, S.A. (2000) Lymphatic transport of proteins after subcutaneous administration. J. Pharm. Sci., 89, 297-310.
-
(2000)
J. Pharm. Sci.
, vol.89
, pp. 297-310
-
-
Porter, C.J.1
Charman, S.A.2
-
23
-
-
0025287316
-
Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration.
-
Supersaxo, A., Hein, W.R., and Steffen, H. (1990) Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration. Pharm. Res., 7, 167-169.
-
(1990)
Pharm. Res.
, vol.7
, pp. 167-169
-
-
Supersaxo, A.1
Hein, W.R.2
Steffen, H.3
-
24
-
-
0023804898
-
Recombinant human interferon alpha-2a: delivery to lymphoid tissue by selected modes of application.
-
Supersaxo, A., Hein, W., Gallati, H., and Steffen, H. (1988) Recombinant human interferon alpha-2a: delivery to lymphoid tissue by selected modes of application. Pharm. Res., 5, 472-476.
-
(1988)
Pharm. Res.
, vol.5
, pp. 472-476
-
-
Supersaxo, A.1
Hein, W.2
Gallati, H.3
Steffen, H.4
-
25
-
-
8944248248
-
Points to consider in correlating bioassays and immunoassays in the quantitation of peptides and proteins
-
in Petides, Peptoids, and Proteins (eds P. Garzone, W. Colburn, and M. Mokotoff), Harvey Whitney Books, Cincinnati, OH
-
Chen, A., Baker, D., and Ferraiolo, B. (1991) Points to consider in correlating bioassays and immunoassays in the quantitation of peptides and proteins, in Petides, Peptoids, and Proteins (eds P. Garzone, W. Colburn, and M. Mokotoff), Harvey Whitney Books, Cincinnati, OH, pp. 54-71.
-
(1991)
, pp. 54-71
-
-
Chen, A.1
Baker, D.2
Ferraiolo, B.3
-
26
-
-
0027492969
-
Renal, metabolic, and hemodynamic side-effects of interleukin-2 and/or interferon alpha: evidence of a risk/benefit advantage of subcutaneous therapy.
-
Schomburg, A., Kirchner, H., and Atzpodien, J. (1993) Renal, metabolic, and hemodynamic side-effects of interleukin-2 and/or interferon alpha: evidence of a risk/benefit advantage of subcutaneous therapy. J. Cancer Res. Clin. Oncol., 119, 745-755.
-
(1993)
J. Cancer Res. Clin. Oncol.
, vol.119
, pp. 745-755
-
-
Schomburg, A.1
Kirchner, H.2
Atzpodien, J.3
-
27
-
-
6044257275
-
Clinical pharmacokinetics and pharmacodynamics of inhaled insulin.
-
Patton, J.S., Bukar, J.G., and Eldon, M.A. (2004) Clinical pharmacokinetics and pharmacodynamics of inhaled insulin. Clin. Pharmacokinet., 43, 781-801.
-
(2004)
Clin. Pharmacokinet.
, vol.43
, pp. 781-801
-
-
Patton, J.S.1
Bukar, J.G.2
Eldon, M.A.3
-
28
-
-
21544464003
-
Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial.
-
Skyler, J.S., Weinstock, R.S., Raskin, P., Yale, J.F., Barrett, E., Gerich, J.E., and Gerstein, H.C. (2005) Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial. Diabetes Care, 28, 1630-1635.
-
(2005)
Diabetes Care
, vol.28
, pp. 1630-1635
-
-
Skyler, J.S.1
Weinstock, R.S.2
Raskin, P.3
Yale, J.F.4
Barrett, E.5
Gerich, J.E.6
Gerstein, H.C.7
-
29
-
-
4644372272
-
Effieaey and safety of inhaled insulin (exubera) eompared with subeutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, eomparative trial.
-
Hollander, P.A., Blonde, L., Rowe, R., Mehta, A.E., Milburn, J.L., Hershon, K.S., Chiasson, J.L., and Levin, S.R. (2004) Effieaey and safety of inhaled insulin (exubera) eompared with subeutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, eomparative trial. Diabetes Care, 27, 2356-2362.
-
(2004)
Diabetes Care
, vol.27
, pp. 2356-2362
-
-
Hollander, P.A.1
Blonde, L.2
Rowe, R.3
Mehta, A.E.4
Milburn, J.L.5
Hershon, K.S.6
Chiasson, J.L.7
Levin, S.R.8
-
30
-
-
10744228212
-
Dose-response relationships of inhaled insulin delivered via the Aerodose insulin inhaler and subeutaneously injeeted insulin in patients with type 2 diabetes.
-
Kim, D., Mudaliar, S., Chinnapongse, S., Chu, N., Boies, S.M., Davis, T., Perera, A.D., Fishman, R.S., Shapiro, D.A., and Henry, R. (2003) Dose-response relationships of inhaled insulin delivered via the Aerodose insulin inhaler and subeutaneously injeeted insulin in patients with type 2 diabetes. Diabetes Care, 26, 2842-2847.
-
(2003)
Diabetes Care
, vol.26
, pp. 2842-2847
-
-
Kim, D.1
Mudaliar, S.2
Chinnapongse, S.3
Chu, N.4
Boies, S.M.5
Davis, T.6
Perera, A.D.7
Fishman, R.S.8
Shapiro, D.A.9
Henry, R.10
-
31
-
-
0035313228
-
Emerging protein delivery methods.
-
Cleland, J.L., Daugherty, A., and Mrsny, R. (2001) Emerging protein delivery methods. Curr. Opin. Biotechnol., 12, 212-219.
-
(2001)
Curr. Opin. Biotechnol.
, vol.12
, pp. 212-219
-
-
Cleland, J.L.1
Daugherty, A.2
Mrsny, R.3
-
32
-
-
0034826771
-
Treating diabetes with aerosolized insulin.
-
Laube, B.L. (2001) Treating diabetes with aerosolized insulin. Chest, 120, 99S-106S.
-
(2001)
Chest
, vol.120
-
-
Laube, B.L.1
-
33
-
-
0039600350
-
Pharmaceutical Biotechnology: A Programmed Text
-
Teehnomie Pub. Co., Laneaster, PA.
-
Zito, S.W. (1997) Pharmaceutical Biotechnology: A Programmed Text, Teehnomie Pub. Co., Laneaster, PA.
-
(1997)
-
-
Zito, S.W.1
-
34
-
-
0037062327
-
Intranasal delivery eould be used to administer drugs direetly to the brain.
-
Lawrenee, D. (2002) Intranasal delivery eould be used to administer drugs direetly to the brain. Lancet, 359, 1674.
-
(2002)
Lancet
, vol.359
, pp. 1674
-
-
Lawrenee, D.1
-
35
-
-
0035875455
-
Intranasal administration of insulin-like growth faetor-I bypasses the blood-brain barrier and proteets against foeal eerebral isehemie damage.
-
Liu, X.F., Faweett, J.R., Thorne, R.G., DeFor, T.A., and Frey, W.H. 2nd. (2001) Intranasal administration of insulin-like growth faetor-I bypasses the blood-brain barrier and proteets against foeal eerebral isehemie damage. J. Neurol. Sci., 187, 91-97.
-
(2001)
J. Neurol. Sci.
, vol.187
, pp. 91-97
-
-
Liu, X.F.1
Faweett, J.R.2
Thorne, R.G.3
DeFor, T.A.4
Frey, W.H.5
-
36
-
-
0027493822
-
Clinieal pharmaeokineties of oetreotide. Therapeutie applieations in patients with pituitary tumours.
-
Chanson, P., Timsit, J., and Harris, A.G. (1993) Clinieal pharmaeokineties of oetreotide. Therapeutie applieations in patients with pituitary tumours. Clin. Pharmacokinet., 25, 375-391.
-
(1993)
Clin. Pharmacokinet.
, vol.25
, pp. 375-391
-
-
Chanson, P.1
Timsit, J.2
Harris, A.G.3
-
37
-
-
0029125922
-
Ultrasound-mediated transdermal protein delivery.
-
Mitragotri, S., Blanksehtein, D., and Langer, R. (1995) Ultrasound-mediated transdermal protein delivery. Science, 269, 850-853.
-
(1995)
Science
, vol.269
, pp. 850-853
-
-
Mitragotri, S.1
Blanksehtein, D.2
Langer, R.3
-
38
-
-
0037423771
-
Transdermal iontophoresis of insulin. V. Effeet of terpenes.
-
Pillai, O. and Panehagnula, R. (2003) Transdermal iontophoresis of insulin. V. Effeet of terpenes. J. Control. Release, 88, 287-296.
-
(2003)
J. Control. Release
, vol.88
, pp. 287-296
-
-
Pillai, O.1
Panehagnula, R.2
-
39
-
-
0027104246
-
Effeet of iontophoresis on in vitro skin permeation of an analogue of growth hormone releasing faetor in the hairless guinea pig model.
-
Kumar, S., Char, H., Patel, S., Piemontese, D., Iqbal, K., Maliek, A.W., Neugrosehel, E., and Behl, C.R. (1992) Effeet of iontophoresis on in vitro skin permeation of an analogue of growth hormone releasing faetor in the hairless guinea pig model. J. Pharm. Sci., 81, 635-639.
-
(1992)
J. Pharm. Sci.
, vol.81
, pp. 635-639
-
-
Kumar, S.1
Char, H.2
Patel, S.3
Piemontese, D.4
Iqbal, K.5
Maliek, A.W.6
Neugrosehel, E.7
Behl, C.R.8
-
40
-
-
0034712895
-
Transdermal iontophoretie delivery of salmon ealeitonin.
-
Chang, S.L., Hofmann, G.A., Zhang, L., Deftos, L.J., and Banga, A.K. (2000) Transdermal iontophoretie delivery of salmon ealeitonin. Int. J. Pharm., 200, 107-113.
-
(2000)
Int. J. Pharm.
, vol.200
, pp. 107-113
-
-
Chang, S.L.1
Hofmann, G.A.2
Zhang, L.3
Deftos, L.J.4
Banga, A.K.5
-
41
-
-
0034802529
-
Iontophoretie pulsatile transdermal delivery of human parathyroid hormone
-
Suzuki, Y., Iga, K., Yanai, S., Matsumoto, Y., Kawase, M., Fukuda, T., Adaehi, H., Higo, N., and Ogawa, Y. (2001) Iontophoretie pulsatile transdermal delivery of human parathyroid hormone (1-34). J. Pharm. Pharmacol., 53, 1227-1234.
-
(2001)
J. Pharm. Pharmacol.
, vol.53
, pp. 1227-1234
-
-
Suzuki, Y.1
Iga, K.2
Yanai, S.3
Matsumoto, Y.4
Kawase, M.5
Fukuda, T.6
Adaehi, H.7
Higo, N.8
Ogawa, Y.9
-
42
-
-
84934440758
-
Transdermal drug delivery systems: skin perturbation deviees.
-
Brown, M.B., Traynor, M.J., Martin, G.P., and Akomeah, F.K. (2008) Transdermal drug delivery systems: skin perturbation deviees. Methods Mol. Biol., 437, 119-139.
-
(2008)
Methods Mol. Biol.
, vol.437
, pp. 119-139
-
-
Brown, M.B.1
Traynor, M.J.2
Martin, G.P.3
Akomeah, F.K.4
-
43
-
-
1542358759
-
Mieroneedles for transdermal drug delivery.
-
Prausnitz, M.R. (2004) Mieroneedles for transdermal drug delivery. Adv. Drug Deliv. Rev., 56, 581-587.
-
(2004)
Adv. Drug Deliv. Rev.
, vol.56
, pp. 581-587
-
-
Prausnitz, M.R.1
-
44
-
-
3042809905
-
Transdermal delivery of insulin using mieroneedles in vivo.
-
Martanto, W., Davis, S.P., Holiday, N.R., Wang, J., Gill, H.S., and Prausnitz, M.R. (2004) Transdermal delivery of insulin using mieroneedles in vivo. Pharm. Res., 21, 947-952.
-
(2004)
Pharm. Res.
, vol.21
, pp. 947-952
-
-
Martanto, W.1
Davis, S.P.2
Holiday, N.R.3
Wang, J.4
Gill, H.S.5
Prausnitz, M.R.6
-
45
-
-
0038350680
-
Oral peptide and protein delivery: unfulfilled promises?
-
Shen, W.C. (2003) Oral peptide and protein delivery: unfulfilled promises? Drug Discov. Today, 8, 607-608.
-
(2003)
Drug Discov. Today
, vol.8
, pp. 607-608
-
-
Shen, W.C.1
-
46
-
-
0034865283
-
Oral delivery of biologieally aetive parathyroid hormone.
-
Leone-Bay, A., Sato, M., Paton, D., Hunt, A.H., Sarubbi, D., Carozza, M., Chou, J., MeDonough, J., and Baughman, R.A. (2001) Oral delivery of biologieally aetive parathyroid hormone. Pharm. Res., 18, 964-970.
-
(2001)
Pharm. Res.
, vol.18
, pp. 964-970
-
-
Leone-bay, A.1
Sato, M.2
Paton, D.3
Hunt, A.H.4
Sarubbi, D.5
Carozza, M.6
Chou, J.7
MeDonough, J.8
Baughman, R.A.9
-
47
-
-
0342437513
-
Improvement of oral peptide bioavailability: peptidomimeties and prodrug strategies.
-
Pauletti, G.M., Gangwar, S., Siahaan, T.J., Jeffrey, A., and Borehardt, R.T. (1997) Improvement of oral peptide bioavailability: peptidomimeties and prodrug strategies. Adv. Drug Deliv. Rev., 27, 235-256.
-
(1997)
Adv. Drug Deliv. Rev.
, vol.27
, pp. 235-256
-
-
Pauletti, G.M.1
Gangwar, S.2
Siahaan, T.J.3
Jeffrey, A.4
Borehardt, R.T.5
-
48
-
-
0027414663
-
Pharmaeokineties of reeombinant human interferon-beta ser in healthy volunteers and its effeet on serum neopterin.
-
Chiang, J., Gloff, C.A., Yoshizawa, C.N., and Williams, G.J. (1993) Pharmaeokineties of reeombinant human interferon-beta ser in healthy volunteers and its effeet on serum neopterin. Pharm. Res., 10, 567-572.
-
(1993)
Pharm. Res.
, vol.10
, pp. 567-572
-
-
Chiang, J.1
Gloff, C.A.2
Yoshizawa, C.N.3
Williams, G.J.4
-
49
-
-
33750690230
-
In vivo diffusion of immunoglobulin G in musele: effeets of binding, solute exelusion, and lymphatie removal.
-
Flessner, M.F., Lofthouse, J., and Zakariael, R. (1997) In vivo diffusion of immunoglobulin G in musele: effeets of binding, solute exelusion, and lymphatie removal. Am. J. Physiol., 273, H2783-H2793.
-
(1997)
Am. J. Physiol.
, vol.273
-
-
Flessner, M.F.1
Lofthouse, J.2
Zakariael, R.3
-
50
-
-
33749331350
-
A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles.
-
Reddy, S.T., Berk, D.A., Jain, R.K., and Swartz, M.A. (2006) A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles. J. Appl. Physiol., 101, 1162-1169.
-
(2006)
J. Appl. Physiol.
, vol.101
, pp. 1162-1169
-
-
Reddy, S.T.1
Berk, D.A.2
Jain, R.K.3
Swartz, M.A.4
-
51
-
-
0036141796
-
Pharmacokinetics and pharmacodynamics of AJW200, a humanized monoclonal antibody to von Willebrand factor, in monkeys.
-
Kageyama, S., Yamamoto, H., Nakazawa, H., Matsushita, J., Kouyama, T., Gonsho, A., Ikeda, Y., and Yoshimoto, R. (2002) Pharmacokinetics and pharmacodynamics of AJW200, a humanized monoclonal antibody to von Willebrand factor, in monkeys. Arterioscler. Thromb. Vasc. Biol., 22, 187-192.
-
(2002)
Arterioscler. Thromb. Vasc. Biol.
, vol.22
, pp. 187-192
-
-
Kageyama, S.1
Yamamoto, H.2
Nakazawa, H.3
Matsushita, J.4
Kouyama, T.5
Gonsho, A.6
Ikeda, Y.7
Yoshimoto, R.8
-
52
-
-
34247550908
-
Pharmacokinetics of recombinant activated factor VII in trauma patients with severe bleeding.
-
Klitgaard, T., Tabanera y Palacios, R., Boffard, K.D., Iau, P.T., Warren, B., Rizoli, S., Rossaint, R., Kluger, Y., and Riou, B. (2006) Pharmacokinetics of recombinant activated factor VII in trauma patients with severe bleeding. Crit. Care., 10, R104.
-
(2006)
Crit. Care.
, vol.10
-
-
Klitgaard, T.1
Palacios, R.T.Y.2
Boffard, K.D.3
Iau, P.T.4
Warren, B.5
Rizoli, S.6
Rossaint, R.7
Kluger, Y.8
Riou, B.9
-
53
-
-
0036224113
-
Pharmacokinetic and pharmacodynamic modeling of humanized anti-factor IX antibody (SB 249417) in humans.
-
Chow, F.S., Benincosa, L.J., Sheth, S.B., Wilson, D., Davis, C.B., Minthorn, E.A., and Jusko, W.J. (2002) Pharmacokinetic and pharmacodynamic modeling of humanized anti-factor IX antibody (SB 249417) in humans. Clin. Pharmacol. Ther., 71, 235-245.
-
(2002)
Clin. Pharmacol. Ther.
, vol.71
, pp. 235-245
-
-
Chow, F.S.1
Benincosa, L.J.2
Sheth, S.B.3
Wilson, D.4
Davis, C.B.5
Minthorn, E.A.6
Jusko, W.J.7
-
54
-
-
0036914779
-
Pharmacokinetics and pharmacodynamics of tenecteplase in fibrinolytic therapy of acute myocardial infarction.
-
Tanswell, P., Modi, N., Combs, D., and Danays, T. (2002) Pharmacokinetics and pharmacodynamics of tenecteplase in fibrinolytic therapy of acute myocardial infarction. Clin. Pharmacokinet., 41, 1229-1245.
-
(2002)
Clin. Pharmacokinet.
, vol.41
, pp. 1229-1245
-
-
Tanswell, P.1
Modi, N.2
Combs, D.3
Danays, T.4
-
55
-
-
4143136302
-
Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers.
-
Ramakrishnan, R., Cheung, W.K., Wacholtz, M.C., Minton, N., and Jusko, W.J. (2004) Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers. J. Clin. Pharmacol., 44, 991-1002.
-
(2004)
J. Clin. Pharmacol.
, vol.44
, pp. 991-1002
-
-
Ramakrishnan, R.1
Cheung, W.K.2
Wacholtz, M.C.3
Minton, N.4
Jusko, W.J.5
-
56
-
-
33847167546
-
Pharmacokinetics and safety of golimumab, a fully human anti-TNF-alpha monoclonal antibody, in subjects with rheumatoid arthritis.
-
Zhou, H., Jang, H., Fleischmann, R.M., Bouman-Thio, E., Xu, Z., Marini, J.C., Pendley, C., Jiao, Q., Shankar, G., Marciniak, S.J., et al. (2007) Pharmacokinetics and safety of golimumab, a fully human anti-TNF-alpha monoclonal antibody, in subjects with rheumatoid arthritis. J. Clin. Pharmacol., 47, 383-396.
-
(2007)
J. Clin. Pharmacol.
, vol.47
, pp. 383-396
-
-
Zhou, H.1
Jang, H.2
Fleischmann, R.M.3
Bouman-thio, E.4
Xu, Z.5
Marini, J.C.6
Pendley, C.7
Jiao, Q.8
Shankar, G.9
Marciniak, S.J.10
-
57
-
-
84889856889
-
Limitations of noncompartmental pharmacokinetic analysis of biotech drugs
-
in Pharmacokinetics and Pharmacodynamics of Biotech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim
-
Straughn, A.B. (2006) Limitations of noncompartmental pharmacokinetic analysis of biotech drugs, in Pharmacokinetics and Pharmacodynamics of Biotech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim, pp. 181-188.
-
(2006)
, pp. 181-188
-
-
Straughn, A.B.1
-
58
-
-
0019974468
-
Noncompartmental determination of the steady-state volume of distribution for any mode of administration.
-
Perrier, D. and Mayersohn, M. (1982) Noncompartmental determination of the steady-state volume of distribution for any mode of administration. J. Pharm. Sci., 71, 372-373.
-
(1982)
J. Pharm. Sci.
, vol.71
, pp. 372-373
-
-
Perrier, D.1
Mayersohn, M.2
-
59
-
-
0019945174
-
Model-independent steady-state volume of distribution.
-
Straughn, A.B. (1982) Model-independent steady-state volume of distribution. J. Pharm. Sci., 71, 597-598.
-
(1982)
J. Pharm. Sci.
, vol.71
, pp. 597-598
-
-
Straughn, A.B.1
-
60
-
-
39149115174
-
Pharmacokinetics and pharmacodynamics of peptides and proteins
-
in Pharmaceutical Biotechnology: Concepts and Applications (eds D.J.A. Crommelin, R.D. Sindelar, and B. Meibohm), Informa Healthcare, New York
-
Meibohm, B. and Braeckman, R.A. (2007) Pharmacokinetics and pharmacodynamics of peptides and proteins, in Pharmaceutical Biotechnology: Concepts and Applications (eds D.J.A. Crommelin, R.D. Sindelar, and B. Meibohm), Informa Healthcare, New York, pp. 95-123.
-
(2007)
, pp. 95-123
-
-
Meibohm, B.1
Braeckman, R.A.2
-
61
-
-
0029127007
-
Receptor-mediated clearance of G-CSF derivative nartograstim in bone marrow of rats.
-
a
-
Kuwabara, T., Uchimura, T., Kobayashi, H., Kobayashi, S., and Sugiyama, Y. (1995a) Receptor-mediated clearance of G-CSF derivative nartograstim in bone marrow of rats. Am. J. Physiol., 269, E1-E9.
-
(1995)
Am. J. Physiol.
, vol.269
-
-
Kuwabara, T.1
Uchimura, T.2
Kobayashi, H.3
Kobayashi, S.4
Sugiyama, Y.5
-
62
-
-
0030017103
-
The relevance of pharmacokinetics in the development of biotechnology products.
-
Toon, S. (1996) The relevance of pharmacokinetics in the development of biotechnology products. Eur. J. Drug Metab. Pharmacokinet., 21, 93-103.
-
(1996)
Eur. J. Drug Metab. Pharmacokinet.
, vol.21
, pp. 93-103
-
-
Toon, S.1
-
63
-
-
0027415287
-
Altered pharmacokinetics of recombinant human deoxyribonuclease in rats due to the presence of a binding protein.
-
Mohler, M., Cook, J., Lewis, D., Moore, J., Sinicropi, D., Championsmith, A., Ferraiolo, B., and Mordenti, J. (1993) Altered pharmacokinetics of recombinant human deoxyribonuclease in rats due to the presence of a binding protein. Drug Metab. Dispos., 21, 71-75.
-
(1993)
Drug Metab. Dispos.
, vol.21
, pp. 71-75
-
-
Mohler, M.1
Cook, J.2
Lewis, D.3
Moore, J.4
Sinicropi, D.5
Championsmith, A.6
Ferraiolo, B.7
Mordenti, J.8
-
64
-
-
0036331674
-
A target-mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans.
-
Eppler, S.M., Combs, D.L., Henry, T.D., Lopez, J.J., Ellis, S.G., Yi, J.H., Annex, B.H., McCluskey, E.R., and Zioncheck, T.F. (2002) A target-mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans. Clin. Pharmacol. Ther., 72, 20-32.
-
(2002)
Clin. Pharmacol. Ther.
, vol.72
, pp. 20-32
-
-
Eppler, S.M.1
Combs, D.L.2
Henry, T.D.3
Lopez, J.J.4
Ellis, S.G.5
Yi, J.H.6
Annex, B.H.7
McCluskey, E.R.8
Zioncheck, T.F.9
-
65
-
-
0030980940
-
Pharmacokinetic studies with recombinant cytokines. Scientific issues and practical considerations.
-
Piscitelli, S.C., Reiss, W.G., Figg, W.D., and Petros, W.P. (1997) Pharmacokinetic studies with recombinant cytokines. Scientific issues and practical considerations. Clin. Pharmacokinet., 32, 368-381.
-
(1997)
Clin. Pharmacokinet.
, vol.32
, pp. 368-381
-
-
Piscitelli, S.C.1
Reiss, W.G.2
Figg, W.D.3
Petros, W.P.4
-
66
-
-
0026674156
-
Competition for binding to insulin-like growth faetor (IGF) binding protein-2, 3, 4, and 5 by the IGFs and IGF analogs.
-
Clemmons, D.R., Dehoff, M.L., Busby, W.H., Bayne, M.L., and Caseieri, M.A. (1992) Competition for binding to insulin-like growth faetor (IGF) binding protein-2, 3, 4, and 5 by the IGFs and IGF analogs. Endocrinology, 131, 890-895.
-
(1992)
Endocrinology
, vol.131
, pp. 890-895
-
-
Clemmons, D.R.1
Dehoff, M.L.2
Busby, W.H.3
Bayne, M.L.4
Caseieri, M.A.5
-
67
-
-
0026488120
-
The role of pharmaeokineties in the development of bioteehnologieally derived agents.
-
Wills, R.J. and Ferraiolo, B.L. (1992) The role of pharmaeokineties in the development of bioteehnologieally derived agents. Clin. Pharmacokinet., 23, 406-414.
-
(1992)
Clin. Pharmacokinet.
, vol.23
, pp. 406-414
-
-
Wills, R.J.1
Ferraiolo, B.L.2
-
68
-
-
0031718055
-
First-pass metabolism of peptide drugs in rat perfused liver.
-
Taki, Y., Sakane, T., Nadai, T., Sezaki, H., Amidon, G.L., Langguth, P., and Yamashita, S. (1998) First-pass metabolism of peptide drugs in rat perfused liver. J. Pharm. Pharmacol., 50, 1013-1018.
-
(1998)
J. Pharm. Pharmacol.
, vol.50
, pp. 1013-1018
-
-
Taki, Y.1
Sakane, T.2
Nadai, T.3
Sezaki, H.4
Amidon, G.L.5
Langguth, P.6
Yamashita, S.7
-
69
-
-
84885528087
-
A kinetie/dynamie perspeetive of a peptide and protein: GRF and rHuIFN-alpha-2a
-
in Petides, Peptoids, and Proteins (eds P. Garzone, W. Colburn, and M. Mokotoff), Harvey Whitney Books, Cineinnati, OH
-
Wills, R. (1991) A kinetie/dynamie perspeetive of a peptide and protein: GRF and rHuIFN-alpha-2a, in Petides, Peptoids, and Proteins (eds P. Garzone, W. Colburn, and M. Mokotoff), Harvey Whitney Books, Cineinnati, OH, pp. 117-127.
-
(1991)
, pp. 117-127
-
-
Wills, R.1
-
70
-
-
0026541509
-
Pharmaeokineties of peptides and proteins: opportunities and ehallenges.
-
MeMartin, C. (1992) Pharmaeokineties of peptides and proteins: opportunities and ehallenges. Adv. Drug Res., 22, 39-106.
-
(1992)
Adv. Drug Res.
, vol.22
, pp. 39-106
-
-
MeMartin, C.1
-
71
-
-
84885525737
-
Pharmaeokineties of protein-and nueleotide-based drugs
-
in Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids (ed. R.I. Mahato), CRC Press, Boea Raton
-
Meibohm, B. (2004) Pharmaeokineties of protein-and nueleotide-based drugs, in Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids (ed. R.I. Mahato), CRC Press, Boea Raton, pp. 275-294.
-
(2004)
, pp. 275-294
-
-
Meibohm, B.1
-
72
-
-
0002979228
-
Biological Barriers to Protein Delivery
-
Plenum Press, New York.
-
Meijer, D. and Ziegler, K. (1993) Biological Barriers to Protein Delivery, Plenum Press, New York.
-
(1993)
-
-
Meijer, D.1
Ziegler, K.2
-
73
-
-
0034799334
-
Struetural determinants of glomerular permeability.
-
Deen, W.M., Lazzara, M.J., and Myers, B.D. (2001) Struetural determinants of glomerular permeability. Am. J. Physiol. Renal. Physiol., 281, F579-F596.
-
(2001)
Am. J. Physiol. Renal. Physiol.
, vol.281
-
-
Deen, W.M.1
Lazzara, M.J.2
Myers, B.D.3
-
74
-
-
0033001525
-
Ultrastruetural model for size seleetivity in glomerular filtration.
-
Edwards, A., Daniels, B.S., and Deen, W.M. (1999) Ultrastruetural model for size seleetivity in glomerular filtration. Am. J. Physiol., 276, F892-F902.
-
(1999)
Am. J. Physiol.
, vol.276
-
-
Edwards, A.1
Daniels, B.S.2
Deen, W.M.3
-
75
-
-
0003118736
-
Renal filtration, transport and metabolism of proteins
-
in The Kidney: Physiology and Pathophysiology (eds D. Seldin and G. Giebiseh), Raven Press, New York
-
Maaek, T., Park, C., and Camargo, M. (1985) Renal filtration, transport and metabolism of proteins, in The Kidney: Physiology and Pathophysiology (eds D. Seldin and G. Giebiseh), Raven Press, New York, pp. 1773-1803.
-
(1985)
, pp. 1773-1803
-
-
Maaek, T.1
Park, C.2
Camargo, M.3
-
76
-
-
0033323788
-
Disposition of reeombinant human interleukin-10 in subjeets with various degrees of renal funetion.
-
Andersen, S., Lambreeht, L., Swan, S., Cutler, D., Radwanski, E., Affrime, M., and Garaud, J. (1999) Disposition of reeombinant human interleukin-10 in subjeets with various degrees of renal funetion. J. Clin. Pharmacol., 39, 1015-1020.
-
(1999)
J. Clin. Pharmacol.
, vol.39
, pp. 1015-1020
-
-
Andersen, S.1
Lambreeht, L.2
Swan, S.3
Cutler, D.4
Radwanski, E.5
Affrime, M.6
Garaud, J.7
-
77
-
-
0033659819
-
Physiologieal and pharmaeologieal implieations of peptide transporters, PEPT1 and PEPT2.
-
Inui, K., Terada, T., Masuda, S., and Saito, H. (2000) Physiologieal and pharmaeologieal implieations of peptide transporters, PEPT1 and PEPT2. Nephrol. Dial. Transplant., 15 (Suppl 6), 11-13.
-
(2000)
Nephrol. Dial. Transplant.
, vol.15 Suppl 6
, pp. 11-13
-
-
Inui, K.1
Terada, T.2
Masuda, S.3
Saito, H.4
-
78
-
-
0017701073
-
Renal extraetion, filtration, absorption, and eatabolism of growth hormone.
-
Johnson, V. and Maaek, T. (1977) Renal extraetion, filtration, absorption, and eatabolism of growth hormone. Am. J. Physiol., 233, F185-F196.
-
(1977)
Am. J. Physiol.
, vol.233
-
-
Johnson, V.1
Maaek, T.2
-
79
-
-
0028265795
-
Studies on the renal kineties of growth hormone (GH) and on the GH reeeptor and related effeets in animals.
-
Krogsgaard Thomsen, M., Friis, C., Sehested Hansen, B., Johansen, P., Esehen, C., Nowak, J., and Poulsen, K. (1994) Studies on the renal kineties of growth hormone (GH) and on the GH reeeptor and related effeets in animals. J. Pediatr. Endocrinol., 7, 93-105.
-
(1994)
J. Pediatr. Endocrinol.
, vol.7
, pp. 93-105
-
-
Thomsen, M.K.1
Friis, C.2
Hansen, B.S.3
Johansen, P.4
Esehen, C.5
Nowak, J.6
Poulsen, K.7
-
80
-
-
0026756089
-
Low density lipoprotein reeeptor-related protein/alpha 2-maeroglobulin reeeptor is an hepatie reeeptor for tissue-type plasminogen aetivator.
-
Bu, G., Williams, S., Striekland, D.K., and Sehwartz, A.L. (1992) Low density lipoprotein reeeptor-related protein/alpha 2-maeroglobulin reeeptor is an hepatie reeeptor for tissue-type plasminogen aetivator. Proc. Natl. Acad. Sci. U.S.A., 89, 7427-7431.
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 7427-7431
-
-
Bu, G.1
Williams, S.2
Striekland, D.K.3
Sehwartz, A.L.4
-
81
-
-
0025063975
-
Clearanee of tissue plasminogen aetivator by mannose and galaetose reeeptors in the liver.
-
Smedsrod, B. and Einarsson, M. (1990) Clearanee of tissue plasminogen aetivator by mannose and galaetose reeeptors in the liver. Thromb. Haemost., 63, 60-66.
-
(1990)
Thromb. Haemost.
, vol.63
, pp. 60-66
-
-
Smedsrod, B.1
Einarsson, M.2
-
82
-
-
0027998106
-
Pharmaeologie target-mediated drug disposition.
-
b
-
Levy, G. (1994b) Pharmaeologie target-mediated drug disposition. Clin. Pharmacol. Ther., 56, 248-252.
-
(1994)
Clin. Pharmacol. Ther.
, vol.56
, pp. 248-252
-
-
Levy, G.1
-
83
-
-
0029053166
-
Saturable uptake of a reeombinant human granuloeyte eolony-stimulating faetor derivative, nartograstim, by the bone marrow and spleen of rats in vivo.
-
b
-
Kuwabara, T., Uehimura, T., Takai, K., Kobayashi, H., Kobayashi, S., and Sugiyama, Y. (1995b) Saturable uptake of a reeombinant human granuloeyte eolony-stimulating faetor derivative, nartograstim, by the bone marrow and spleen of rats in vivo. J. Pharmacol. Exp. Ther., 273, 1114-1122.
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.273
, pp. 1114-1122
-
-
Kuwabara, T.1
Uehimura, T.2
Takai, K.3
Kobayashi, H.4
Kobayashi, S.5
Sugiyama, Y.6
-
84
-
-
0028013741
-
Nonlinear pharmaeokineties of reeombinant human maerophage eolony-stimulating faetor (M-CSF) in rats.
-
Bauer, R.J., Gibbons, J.A., Bell, D.P., Luo, Z.P., and Young, J.D. (1994) Nonlinear pharmaeokineties of reeombinant human maerophage eolony-stimulating faetor (M-CSF) in rats. J. Pharmacol. Exp. Ther., 268, 152-158.
-
(1994)
J. Pharmacol. Exp. Ther.
, vol.268
, pp. 152-158
-
-
Bauer, R.J.1
Gibbons, J.A.2
Bell, D.P.3
Luo, Z.P.4
Young, J.D.5
-
85
-
-
0023404771
-
Macrophages specifically regulate the concentration of their own growth factor in the circulation.
-
Bartoeei, A., Mastrogiannis, D.S., Migliorati, G., Stoekert, R.J., Wolkoff, A.W., and Stanley, E.R. (1987) Macrophages specifically regulate the concentration of their own growth factor in the circulation. Proc. Natl. Acad. Sci. U.S.A., 84, 6179-6183.
-
(1987)
Proc. Natl. Acad. Sci. U.S.A.
, vol.84
, pp. 6179-6183
-
-
Bartoeei, A.1
Mastrogiannis, D.S.2
Migliorati, G.3
Stoekert, R.J.4
Wolkoff, A.W.5
Stanley, E.R.6
-
86
-
-
34548229364
-
FcRn: the neonatal Fc receptor comes of age.
-
Roopenian, D.C. and Akilesh, S. (2007) FcRn: the neonatal Fc receptor comes of age. Nat. Rev. Immunol., 7, 715-725.
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 715-725
-
-
Roopenian, D.C.1
Akilesh, S.2
-
87
-
-
54249138516
-
Monoclonal antibody pharmacokinetics and pharmacodynamics.
-
Wang, W., Wang, E.Q., and Balthasar, J.P. (2008) Monoclonal antibody pharmacokinetics and pharmacodynamics. Clin. Pharmacol. Ther., 84, 548-558.
-
(2008)
Clin. Pharmacol. Ther.
, vol.84
, pp. 548-558
-
-
Wang, W.1
Wang, E.Q.2
Balthasar, J.P.3
-
88
-
-
77956388219
-
Population pharmacokinetics of therapeutic monoclonal antibodies.
-
Dirks, N.L. and Meibohm, B. (2010) Population pharmacokinetics of therapeutic monoclonal antibodies. Clin. Pharmacokinet., 49, 633-659.
-
(2010)
Clin. Pharmacokinet.
, vol.49
, pp. 633-659
-
-
Dirks, N.L.1
Meibohm, B.2
-
89
-
-
33846050957
-
Kinetics of FcRn-mediated recycling of IgG and albumin in human: pathophysiology and therapeutic implications using a simplified mechanism-based model.
-
Kim, J., Hayton, W.L., Robinson, J.M., and Anderson, C. L. (2007) Kinetics of FcRn-mediated recycling of IgG and albumin in human: pathophysiology and therapeutic implications using a simplified mechanism-based model. Clin. Immunol., 122, 146-155.
-
(2007)
Clin. Immunol.
, vol.122
, pp. 146-155
-
-
Kim, J.1
Hayton, W.L.2
Robinson, J.M.3
Anderson, C.L.4
-
90
-
-
0036598634
-
Bioequivalence and the immunogenicity of biopharmaceuticals.
-
Schellekens, H. (2002) Bioequivalence and the immunogenicity of biopharmaceuticals. Nat. Rev. Drug Discov., 1, 457-462.
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 457-462
-
-
Schellekens, H.1
-
91
-
-
0036861899
-
Immunogenicity of therapeutic proteins: clinical implications and future prospects.
-
1720-1740. discussion
-
Schellekens, H. (2002) Immunogenicity of therapeutic proteins: clinical implications and future prospects. Clin. Ther., 24, 1720-1740. discussion 1719.
-
(2002)
Clin. Ther.
, vol.24
, pp. 1719
-
-
Schellekens, H.1
-
92
-
-
46149124807
-
How to predict and prevent the immunogenicity of therapeutic proteins.
-
Schellekens, H. (2008) How to predict and prevent the immunogenicity of therapeutic proteins. Biotechnol. Annu. Rev., 14, 191-202.
-
(2008)
Biotechnol. Annu. Rev.
, vol.14
, pp. 191-202
-
-
Schellekens, H.1
-
93
-
-
0036898144
-
Pharmacokinetics and biodistribution of genetically engineered antibodies.
-
Batra, S.K., Jain, M., Wittel, U.A., Chauhan, S.C., and Colcher, D. (2002) Pharmacokinetics and biodistribution of genetically engineered antibodies. Curr. Opin. Biotechnol., 13, 603-608.
-
(2002)
Curr. Opin. Biotechnol.
, vol.13
, pp. 603-608
-
-
Batra, S.K.1
Jain, M.2
Wittel, U.A.3
Chauhan, S.C.4
Colcher, D.5
-
94
-
-
84885517914
-
Pharmacokinetics and pharmacodynamics of peptides and proteins
-
in Pharmaceutical Biotechnology: Concepts and Applications (eds D.J.A. Crommelin, R.D. Sindelar, and B. Meibohm), Informa Healthcare, New York
-
Schellekens, H. and Jiskoot, W. (2007) Pharmacokinetics and pharmacodynamics of peptides and proteins, in Pharmaceutical Biotechnology: Concepts and Applications (eds D.J.A. Crommelin, R.D. Sindelar, and B. Meibohm), Informa Healthcare, New York, pp. 125-132.
-
(2007)
, pp. 125-132
-
-
Schellekens, H.1
Jiskoot, W.2
-
95
-
-
0002411258
-
Potential effects of antibody induction by protein drugs
-
in Protein Pharmacokinetics and Metabolism (eds B.L. Ferraiolo, M.A. Mohler, and C.A. Gloff), Plenum Press, New York
-
Working, P.K. (1992) Potential effects of antibody induction by protein drugs, in Protein Pharmacokinetics and Metabolism (eds B.L. Ferraiolo, M.A. Mohler, and C.A. Gloff), Plenum Press, New York, pp. 73-92.
-
(1992)
, pp. 73-92
-
-
Working, P.K.1
-
96
-
-
0042999388
-
Pegaspargase: a review of clinical studies.
-
Graham, M.L. (2003) Pegaspargase: a review of clinical studies. Adv. Drug Deliv. Rev., 55, 1293-1302.
-
(2003)
Adv. Drug Deliv. Rev.
, vol.55
, pp. 1293-1302
-
-
Graham, M.L.1
-
97
-
-
84889817808
-
Custom-tailored pharmacokinetics and pharmacodynamics via chemical modifications of biotech drugs
-
in Pharmacokinetics and Pharmacodynamics of Boptech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim
-
Veronese, F.M. and Caliceti, P. (2006) Custom-tailored pharmacokinetics and pharmacodynamics via chemical modifications of biotech drugs, in Pharmacokinetics and Pharmacodynamics of Boptech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim, pp. 271-294.
-
(2006)
, pp. 271-294
-
-
Veronese, F.M.1
Caliceti, P.2
-
98
-
-
84889815803
-
Exposure-reponse relationships for therapeutic biologics
-
in Pharmacokinetics and Pharmacodynamics of Biotech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim
-
Tabrizi, M. and Roskos, L.K. (2006) Exposure-reponse relationships for therapeutic biologics, in Pharmacokinetics and Pharmacodynamics of Biotech Drugs (ed. B. Meibohm), Wiley-VCH Verlag GmbH, Weinheim, pp. 295-330.
-
(2006)
, pp. 295-330
-
-
Tabrizi, M.1
Roskos, L.K.2
-
99
-
-
32444438731
-
Elimination mechanisms of therapeutic monoclonal antibodies.
-
Tabrizi, M.A., Tseng, C.M., and Roskos, L.K. (2006) Elimination mechanisms of therapeutic monoclonal antibodies. Drug Discov. Today, 11, 81-88.
-
(2006)
Drug Discov. Today
, vol.11
, pp. 81-88
-
-
Tabrizi, M.A.1
Tseng, C.M.2
Roskos, L.K.3
-
100
-
-
4344707565
-
Exposure Response Relationships: Guidance for Industry.
-
CDER/FDA, Rockville: US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research.
-
CDER/FDA (2003) Exposure Response Relationships: Guidance for Industry. Rockville: US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research.
-
(2003)
-
-
-
101
-
-
0023013622
-
Kinetics of drug action: an overview.
-
Levy, G. (1986) Kinetics of drug action: an overview. J. Allergy Clin. Immunol., 78, 754-761.
-
(1986)
J. Allergy Clin. Immunol.
, vol.78
, pp. 754-761
-
-
Levy, G.1
-
102
-
-
0028075942
-
Mechanism-based pharmacodynamic modeling.
-
a
-
Levy, G. (1994a) Mechanism-based pharmacodynamic modeling. Clin. Pharmacol. Ther., 56, 356-358.
-
(1994)
Clin. Pharmacol. Ther.
, vol.56
, pp. 356-358
-
-
Levy, G.1
-
103
-
-
13144282659
-
Efficacy, pharmacodynamics, and pharmacokinetics of CGP 51901, an anti-immunoglobulin E chimeric monoclonal antibody, in patients with seasonal allergic rhinitis.
-
Racine-Poon, A., Botta, L., Chang, T.W., Davis, F.M., Gygax, D., Liou, R.S., Rohane, P., Staehelin, T., van Steijn, A.M., and Frank, W. (1997) Efficacy, pharmacodynamics, and pharmacokinetics of CGP 51901, an anti-immunoglobulin E chimeric monoclonal antibody, in patients with seasonal allergic rhinitis. Clin. Pharmacol. Ther., 62, 675-690.
-
(1997)
Clin. Pharmacol. Ther.
, vol.62
, pp. 675-690
-
-
Racine-poon, A.1
Botta, L.2
Chang, T.W.3
Davis, F.M.4
Gygax, D.5
Liou, R.S.6
Rohane, P.7
Staehelin, T.8
Steijn, A.M.V.9
Frank, W.10
-
104
-
-
0032410915
-
Pharmacokinetics and leukocyte responses of recombinant human interleukin-10.
-
Radwanski, E., Chakraborty, A., Van Wart, S., Huhn, R.D., Cutler, D.L., Affrime, M.B., and Jusko, W.J. (1998) Pharmacokinetics and leukocyte responses of recombinant human interleukin-10. Pharm. Res., 15, 1895-1901.
-
(1998)
Pharm. Res.
, vol.15
, pp. 1895-1901
-
-
Radwanski, E.1
Chakraborty, A.2
Wart, S.V.3
Huhn, R.D.4
Cutler, D.L.5
Affrime, M.B.6
Jusko, W.J.7
-
105
-
-
0018394195
-
Simultaneous modeling of pharmaeokineties and pharmaeodynamies: applieation to d-tuboeurarine.
-
Sheiner, L.B., Stanski, D.R., Vozeh, S., Miller, R.D., and Ham, J. (1979) Simultaneous modeling of pharmaeokineties and pharmaeodynamies: applieation to d-tuboeurarine. Clin. Pharmacol. Ther., 25, 358-371.
-
(1979)
Clin. Pharmacol. Ther.
, vol.25
, pp. 358-371
-
-
Sheiner, L.B.1
Stanski, D.R.2
Vozeh, S.3
Miller, R.D.4
Ham, J.5
-
106
-
-
0030424369
-
Pharmaeologie eharaeterization of CHIR 2279, an N-substituted glyeine peptoid with high-affinity binding for alpha 1-adrenoeeptors.
-
Gibbons, J.A., Haneoek, A.A., Vitt, C.R., Knepper, S., Buekner, S.A., Brune, M.E., Milieie, I., Kerwin, J.F. Jr., Riehter, L.S., Taylor, E.W., et al. (1996) Pharmaeologie eharaeterization of CHIR 2279, an N-substituted glyeine peptoid with high-affinity binding for alpha 1-adrenoeeptors. J. Pharmacol. Exp. Ther., 277, 885-899.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.277
, pp. 885-899
-
-
Gibbons, J.A.1
Haneoek, A.A.2
Vitt, C.R.3
Knepper, S.4
Buekner, S.A.5
Brune, M.E.6
Milieie, I.7
Kerwin Jr., J.F.8
Riehter, L.S.9
Taylor, E.W.10
-
107
-
-
0031762361
-
Pharmaeokineties and pharmaeodynamies of growth hormonereleasing peptide-2: a phase I study in ehildren.
-
Pihoker, C., Kearns, G.L., Freneh, D., and Bowers, C.Y. (1998) Pharmaeokineties and pharmaeodynamies of growth hormonereleasing peptide-2: a phase I study in ehildren. J. Clin. Endocrinol. Metab., 83, 1168-1172.
-
(1998)
J. Clin. Endocrinol. Metab.
, vol.83
, pp. 1168-1172
-
-
Pihoker, C.1
Kearns, G.L.2
Freneh, D.3
Bowers, C.Y.4
-
108
-
-
0027769745
-
Comparision of four basie models of indireet pharmaeodynamie responses.
-
Dayneka, N.L., Garg, V., and Jusko, W.J. (1993) Comparision of four basie models of indireet pharmaeodynamie responses. J. Pharmocokinet. Biopharm., 21, 457-478.
-
(1993)
J. Pharmocokinet. Biopharm.
, vol.21
, pp. 457-478
-
-
Dayneka, N.L.1
Garg, V.2
Jusko, W.J.3
-
109
-
-
0031890386
-
Charaeteristies of indireet pharmaeodynamie models and applieations to elinieal drug responses.
-
Sharma, A. and Jusko, W. (1998) Charaeteristies of indireet pharmaeodynamie models and applieations to elinieal drug responses. Br. J. Clin. Pharmacol., 45, 229-239.
-
(1998)
Br. J. Clin. Pharmacol.
, vol.45
, pp. 229-239
-
-
Sharma, A.1
Jusko, W.2
-
110
-
-
0032882959
-
Role of baseline parameters in determining indireet pharmaeodynamie responses.
-
Sun, Y.N. and Jusko, W.J. (1999) Role of baseline parameters in determining indireet pharmaeodynamie responses. J. Pharm. Sci., 88, 987-990.
-
(1999)
J. Pharm. Sci.
, vol.88
, pp. 987-990
-
-
Sun, Y.N.1
Jusko, W.J.2
-
111
-
-
32244436150
-
Pharmaeokineties/pharmaeodynamies of nondepleting anti-CD4 monoelonal antibody (TRX1) in healthy human volunteers.
-
Ng, C.M., Stefanieh, E., Anand, B.S., Fielder, P.J., and Vaiekus, L. (2006) Pharmaeokineties/pharmaeodynamies of nondepleting anti-CD4 monoelonal antibody (TRX1) in healthy human volunteers. Pharm. Res., 23, 95-103.
-
(2006)
Pharm. Res.
, vol.23
, pp. 95-103
-
-
Ng, C.M.1
Stefanieh, E.2
Anand, B.S.3
Fielder, P.J.4
Vaiekus, L.5
-
112
-
-
33748748732
-
Development and evaluation of a population pharmaeokinetie-pharmaeodynamie model of darbepoetin alfa in patients with nonmyeloid malignaneies undergoing multieyele ehemotherapy.
-
Agoram, B., Heatherington, A.C., and Gastonguay, M.R. (2006) Development and evaluation of a population pharmaeokinetie-pharmaeodynamie model of darbepoetin alfa in patients with nonmyeloid malignaneies undergoing multieyele ehemotherapy. AAPS J., 8, E552-E563.
-
(2006)
AAPS J.
, vol.8
-
-
Agoram, B.1
Heatherington, A.C.2
Gastonguay, M.R.3
-
113
-
-
28844447448
-
Population eell life span models for effeets of drugs following indireet meehanisms of aetion.
-
Perez-Ruixo, J.J., Kimko, H.C., Chow, A.T., Piotrovsky, V., Krzyzanski, W., and Jusko, W.J. (2005) Population eell life span models for effeets of drugs following indireet meehanisms of aetion. J. Pharmacokinet. Pharmacodyn., 32, 767-793.
-
(2005)
J. Pharmacokinet. Pharmacodyn.
, vol.32
, pp. 767-793
-
-
Perez-ruixo, J.J.1
Kimko, H.C.2
Chow, A.T.3
Piotrovsky, V.4
Krzyzanski, W.5
Jusko, W.J.6
-
114
-
-
65549156693
-
Coneepts and ehallenges in quantitative pharmaeology and model-based drug development.
-
Zhang, L., Pfister, M., and Meibohm, B. (2008) Coneepts and ehallenges in quantitative pharmaeology and model-based drug development. AAPS J., 10, 552-559.
-
(2008)
AAPS J.
, vol.10
, pp. 552-559
-
-
Zhang, L.1
Pfister, M.2
Meibohm, B.3
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