Iontophoretic pulsatile transdermal delivery of human parathyroid hormone (1-34)

Journal of Pharmacy and Pharmacology

Volumn 53, Issue 9, 2001, Pages 1227-1234

  Suzuki, Y ^a   Iga, K ^a   Yanai, S ^a   Matsumoto, Y ^a   Kawase, M ^a   Fukuda, T ^a   Adachi, H ^b   Higo, N ^b   Ogawa, Y ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b HISAMITSU PHARMACEUTICAL CO INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE[1-34];

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DERMIS; DOG; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; ELECTRIC RESISTANCE; HAIR FOLLICLE; HUMAN; IONTOPHORESIS; MALE; MEMBRANE CURRENT; NONHUMAN; OSTEOPOROSIS; POROSITY; PULSATILE DRUG RELEASE; RAT; SKIN ELECTRODE; SKIN FUNCTION; THICKNESS;

ABSORPTION; ADMINISTRATION, CUTANEOUS; ANIMALS; AREA UNDER CURVE; DOGS; ELECTRIC STIMULATION; IONTOPHORESIS; MALE; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034802529     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357011776676     Document Type: Article

References (25)

1. Act 3 integment
2. Hydrogel-based iontophoretic delivery devices for transdermal delivery of peptide/protein drugs
3. Iontophoresis and electroporation: Comparisons and contrasts
4. Scanning electrochemical microscopy of iontophoretic transport in hairless mouse skin. Analysis of the relative contributions of diffusion, migration, and electroosmosis to transport in hair follicles
5. Peripheral metabolism of PTH: Fate of biologically active amino terminus in vivo
6. Methods for in vitro percutaneous absorption studies II: Animal models for human skin
7. Anabolic actions of parathyroid hormone on bone
8. Iontophoretic delivery of peptide drugs
9. Iontophoresis: Electrorepulsion and electroosmosis
10. Pulse amplitude and frequency modulation of parathyroid hormone in plasma
11. Effects of continuous and intermittent administration and inhibition of resorption on the anabolic response of bone to parathyroid hormone
12. Estimation of drug absorption rates using a deconvolution method with nonequal sampling times
13. Dermal histology of hairless rat derived from Wistar strain
14. Randomized controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on estrogen with osteoporosis
15. Production of hPTH (1-34) via a recombinant DNA technique
16. New iontophoretic transdermal administration of beta blocker metoprolol
17. Animal models for transdermal drug delivery
18. Transdermal ion migration
19. PTH: A future role in the management of osteoporosis?
20. Modulation of the anabolic effect of synthetic human parathyroid hormone fragment (1-34) in the bone of growing rats by variations in the dosage regimen
21. Electrically-assisted transdermal drug delivery
22. A small dose of human parathyroid hormone(1-34) increased bone mass in the lumbar vertebrae in patients with senile osteoporosis
23. Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: Differential effects of intermittent and continuous administration
24. Comparison of the effects of intermittent and continuous administration of human parathyroid hormone(1-34) on rat bone