Population cell life span models for effects of drugs following indirect mechanisms of action

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 32, Issue 5-6, 2005, Pages 767-793

  Perez Ruixo, Juan J ^a   Kimko, Hui C ^b   Chow, Andrew T ^b   Piotrovsky, Vladimir ^a   Krzyzanski, Wojciech ^c   Jusko, William J ^c  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Cell lifespan; Cytotoxicity; Delay deferential equations; Hematological effects; Indirect response models

Indexed keywords

ANTINEOPLASTIC AGENT;

ALGORITHM; CELL CYCLE; CELL MATURATION; COMPUTER MODEL; COMPUTER PROGRAM; COMPUTER SIMULATION; CONFERENCE PAPER; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; FIRST PASS EFFECT; HEMATOPOIESIS; LIFESPAN; MATHEMATICAL MODEL; PRIORITY JOURNAL; SENESCENCE; STATISTICAL MODEL;

ALGORITHMS; ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMATOPOIETIC CELL GROWTH FACTORS; HEMATOPOIETIC STEM CELLS; HUMANS; MODELS, BIOLOGICAL; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; PHARMACEUTICAL PREPARATIONS; SOFTWARE; TIME FACTORS;

EID: 28844447448     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-005-0019-1     Document Type: Conference Paper

References (22)

1. M. Loeffler H.E. Wichmann 1985 Structure of the model H.E. Wichmann M. Loeffler Mathematical Modeling of Cell Proliferation: Stem Cell Regulation in Hemopoiesis, vol I. CRC Press Inc. Boca Raton
2. M.C. Mackey 1996 Mathematical models of hematopoietic cell replication and control H.G. Othamer F.R. Adler M.A. Lewis J.C Dallon The Art of Mathematical Modeling: Case Studies in Ecology, Physiology and Biofluids. Prentice Hall New York 149 178
3. M. Loeffler K. Pantel H. Wulff H.E. Wichmann 1989 A mathematical model of erythropoiesis in mice and rats, Part 1: Structure of the model Cell Tissue Kinet. 22 13 30
4. S. Schmitz H. Franke J. Brusis H.E. Wichmann 1993 Quantification of the cell kinetic effects of G-CSF using a model of human granulopoiesis Exp. Hematol. 21 755 760
5. H.E. Wichmann M.D. Gerhardts H. Spechtmeyer R. Gross 1979 Mathematical model of thrombopoiesis in rats Cell Tissue Kinet. 12 551 567
6. L.A. Harker L.K. Roskos U.M. Marzec R.C. Carter J.K. Cherry B. Sundell E.N. Cheung D. Terry W. Sheridan 2000 Effects of megakaryocyte growth and development factor on platelet production, platelet life span, platelet function in healthy human volunteers Blood 95 2514 2522
7. L.E. Friberg A. Freijs M. Sandstrom M.O. Karlsson 2000 Semiphysiological model for the time course of leukocytes after varying schedules of 5-fluorouracil in rats J. Pharmacol. Exp. Ther. 295 734 740
8. J. Belair M.C. Mackey J.M. Mahaffy 1995 Age-structured and two-delay models for erythropoiesis Math. Biosci. 128 317 346
9. D.E. Uehlinger F.A. Gotch L.B. Sheiner 1992 A pharmacodynamic model of erythropoietin therapy in uremic anemia. Clin Pharmacol. Ther 51 76 89
10. W. Krzyzanski R. Ramakrishnan W.J. Jusko 1999 Basic models for agents that alter production of natural cells J. Pharmacokin. Biopharm. 27 467 489
11. R. Ramakrishnan W.K. Cheung F. Farrell L. Joffee W.J. Jusko 2003 Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after intravenous and subcutaneous dose administration in cynomolgus monkeys J. Pharmacol. Exp. Ther. 306 324 331
12. R. Ramakrishnan W.K. Cheung M.C. Wacholtz N. Minton W.J. Jusko 2004 Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers J. Clin.Pharmacol. 44 991 1002
13. W. Krzyzanski W.J. Jusko M.C. Wacholtz N. Minton W.K. Cheung 2005 Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after multiple subcutaneous doses in healthy subjects Eur. J. Pharm. Sci. 26 295 306 (submitted)
14. W. Krzyzanski W.J. Jusko 2002 Multiple-pool cell lifespan model of haematologic effects of anticancer agents. J. Pharmacokin Pharmacodyn. 29 311 337
15. R.D. Driver 1977 Ordinary and Delay Differential Equations Springer-Verlag New York
16. S. L. Beal and L. B. Sheiner. NONMEM Users Guides. San Francisco: NONMEM Project Group, Univ. Calif. (1989).
17. E. Hairer S.P. Norsett G. Wanner 1993 Solving Ordinary Differential Equations I: Nonstiff Problems Springer Berlin
18. N.L. Dayneka V. Garg W.J. Jusko 1993 Comparison of four basic models of indirect pharmacodynamic responses J. Pharmacokinet. Biopharm. 21 457 478
19. W.J. Jusko 1971 Pharmacodynamics of chemotherapeutic effects: dose-time-response relationships for phase-nonspecific agents J. Pharm. Sci. 60 892 895
20. W.J. Jusko 1973 A pharmacodynamic model for cell-cycle-specific chemotherapeutic agents J. Pharmacokin. Biopharm. 1 175 201
21. L.B. Sheiner S.L. Beal 1981 Some suggestions for measuring predictive performance J. Pharmacokin. Biopharm. 9 503 512
22. P. Girard. Data transformation and Parameter Transformations in NONMEM, The Population Approach Group in Europe Eleventh Meeting, Paris, France, 2002: http://www.page-meeting.org/default.asp?id = 22&keuze = program