Pharmacokinetics of recombinant activated factor VII in trauma patients with severe bleeding

Critical Care

Volumn 10, Issue 4, 2006, Pages

  Klitgaard, Thomas ^a   Palacios, Rene Tabanera ^a   Boffard, Kenneth D ^b   Iau, Philip T C ^c   Warren, Brian ^d   Rizoli, Sandro ^e   Rossaint, Rolf ^f   Kluger, Yoram ^g   Riou, Bruno ^h  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^d STELLENBOSCH UNIVERSITY   (South Africa)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^g Haifa Medical Center Rothschild   (Israel)

^h PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; RECOMBINANT BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 7A; RECOMBINANT FVIIA; RECOMBINANT PROTEIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLEEDING; BLOOD CLOTTING; BLUNT TRAUMA; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; COVARIANCE; DOUBLE BLIND PROCEDURE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE REGIMEN; DRUG HALF LIFE; ERYTHROCYTE TRANSFUSION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; PENETRATING TRAUMA; POPULATION MODEL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TIME TO MAXIMUM PLASMA CONCENTRATION; BLOOD; COMPARATIVE STUDY; HEMORRHAGE; WOUNDS, NONPENETRATING; WOUNDS, PENETRATING;

ADULT; DOUBLE-BLIND METHOD; FACTOR VII; FACTOR VIIA; FEMALE; HEMORRHAGE; HUMANS; MALE; RECOMBINANT PROTEINS; WOUNDS, NONPENETRATING; WOUNDS, PENETRATING;

EID: 34247550908     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc4977     Document Type: Article

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