Pharmacokinetic and pharmacodynamic modeling of humanized anti-factor IX antibody (SB 249417) in humans

Clinical Pharmacology and Therapeutics

Volumn 71, Issue 4, 2002, Pages 235-245

  Chow, Fung Sing ^a,b,c   Benincosa, Lisa J ^a,b   Sheth, Sunita B ^a,b   Wilson, Douglas ^a,b   Davis, Charles B ^a,b   Minthorn, Elisabeth A ^a,b   Jusko, William J ^a,b  

^a GLAXOSMITHKLINE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 9; HUMAN MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN KAPPA CHAIN; SB 249417; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG HALF LIFE; DRUG INFUSION; HUMAN; HUMAN EXPERIMENT; MODEL; NORMAL HUMAN; PARTIAL THROMBOPLASTIN TIME; PHARMACODYNAMICS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STEADY STATE;

ADULT; ANTIBODIES, MONOCLONAL; BINDING SITES, ANTIBODY; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FACTOR IX; HUMANS; INFUSIONS, INTRAVENOUS; MIDDLE AGED; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PARTIAL THROMBOPLASTIN TIME; RECOMBINANT PROTEINS; SINGLE-BLIND METHOD;

EID: 0036224113     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2002.122276     Document Type: Article

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