Duodenal-jejunal bypass surgery Up-regulates the expression of the hepatic insulin signaling proteins and the key regulatory enzymes of intestinal gluconeogenesis in diabetic goto-kakizaki rats

Obesity Surgery

Volumn 23, Issue 11, 2013, Pages 1734-1742

  Sun, Dong ^a   Wang, Kexin ^a   Yan, Zhibo ^a   Zhang, Guangyong ^a   Liu, Shaozhuang ^a   Liu, Fengjun ^a   Hu, Chunxiao ^a   Hu, Sanyuan ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Bariatric surgery; Duodenal jejunal bypass; Gluconeogenesis; Goto Kakizaki rat; Hepatic insulin signaling

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATASE ALPHA; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; INSULIN RECEPTOR SUBSTRATE 2; INTESTINE ENZYME; PEPTIDE YY; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOENOLPYRUVATE CARBOXYKINASE 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BYPASS SURGERY; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; DUODENAL JEJUNAL BYPASS; ENZYME REGULATION; FOOD INTAKE; GLUCOGENESIS; GLUCOSE METABOLISM; MALE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DOWN-REGULATION; DUODENUM; GASTRIC BYPASS; GLUCAGON-LIKE PEPTIDE 1; GLUCONEOGENESIS; GLUCOSE-6-PHOSPHATASE; INCRETINS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JEJUNUM; LIVER; MALE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); RATS; RATS, INBRED STRAINS; REMISSION INDUCTION; SIGNAL TRANSDUCTION; UP-REGULATION; WEIGHT LOSS;

EID: 84885476477     PISSN: 09608923     EISSN: 17080428     Source Type: Journal    
DOI: 10.1007/s11695-013-0985-0     Document Type: Article

References (41)

1. Schauer PR, Kashyap SR, Wolski K, et al. Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med. 2012;366(17):1567-76.
2. Rubino F, Marescaux J. Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease. Ann Surg. 2004;239(1):1-11.
3. 2 (LBMI). Obes Surg. 2009;19(3):307-12.
4. Kindel TL, Yoder SM, Seeley RJ, et al. Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism. J Gastrointest Surg. 2009;13(10):1762-72.
5. de Luis D, Domingo M, Romero A, et al. Effects of duodenal-jejunal exclusion on beta cell function and hormonal regulation in Goto-Kakizaki rats. Am J Surg. 2012;204(2):242-7.
6. de Moura EG, Martins BC, Lopes GS, et al. Metabolic improvements in obese type 2 diabetes subjects implanted for 1 year with an endoscopically deployed duodenal-jejunal bypass liner. Diabetes Technol Ther. 2012;14(2):183-9.
7. Rubino F, Forgione A, Cummings DE, et al. The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann Surg. 2006;244(5):741-9.
8. Castagneto-Gissey L, Mingrone G. Insulin sensitivity and secretion modifications after bariatric surgery. J Endocrinol Investig. 2012;35(7):692-8.
9. van Dielen FM, Nijhuis J, Rensen SS, et al. Early insulin sensitivity after restrictive bariatric surgery, inconsistency between HOMA-IR and steady-state plasma glucose levels. Surg Obes Relat Dis. 2010;6(4):340-4.
10. Smith U, Axelsen M, Carvalho E, et al. Insulin signaling and action in fat cells: associations with insulin resistance and type 2 diabetes. Ann N Y Acad Sci. 1999;892:119-26.
11. Fick LJ, Belsham DD. Nutrient sensing and insulin signaling in neuropeptide-expressing immortalized, hypothalamic neurons: a cellular model of insulin resistance. Cell Cycle. 2010;9(16):3186-93.
12. Rondinone CM, Wang LM, Lonnroth P, et al. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A. 1997;94(8):4171-5.
13. Withers DJ, Gutierrez JS, Towery H, et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature. 1998;391(6670):900-4.
14. Suzuki R, Tobe K, Aoyama M, et al. Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice. J Biol Chem. 2004;279(24):25039-49.
15. Bonhomme S, Guijarro A, Keslacy S, et al. Gastric bypass up-regulates insulin signaling pathway. Nutrition. 2011;27(1):73-80.
16. Gavin TP, Sloan 3rd RC, Lukosius EZ, et al. Duodenal-jejunal bypass surgery does not increase skeletal muscle insulin signal transduction or glucose disposal in Goto-Kakizaki type 2 diabetic rats. Obes Surg. 2011;21(2):231-7.
17. Croset M, Rajas F, Zitoun C, et al. Rat small intestine is an insulin-sensitive gluconeogenic organ. Diabetes. 2001;50(4):740-6.
18. Mithieux G. New data and concepts on glutamine and glucose metabolism in the gut. Curr Opin Clin Nutr Metab Care. 2001;4(4):267-71.
19. Rajas F, Bruni N, Montano S, et al. The glucose-6 phosphatase gene is expressed in human and rat small intestine: regulation of expression in fasted and diabetic rats. Gastroenterology. 1999;117(1):132-9.
20. Rajas F, Croset M, Zitoun C, et al. Induction of PEPCK gene expression in insulinopenia in rat small intestine. Diabetes. 2000;49(7):1165-8.
21. Mithieux G, Bady I, Gautier A, et al. Induction of control genes in intestinal gluconeogenesis is sequential during fasting and maximal in diabetes. Am J Physiol Endocrinol Metab. 2004;286(3):E370-5.
22. Mithieux G. The new functions of the gut in the control of glucose homeostasis. Curr Opin Clin Nutr Metab Care. 2005;8(4):445-9.
23. Mithieux G, Andreelli F, Magnan C. Intestinal gluconeogenesis: key signal of central control of energy and glucose homeostasis. Curr Opin Clin Nutr Metab Care. 2009;12(4):419-23.
24. Troy S, Soty M, Ribeiro L, et al. Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice. Cell Metab. 2008;8(3):201-11.
25. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-9.
26. Donglei Z, Liesheng L, Xun J, et al. Effects and mechanism of duodenal-jejunal bypass and sleeve gastrectomy on GLUT2 and glucokinase in diabetic Goto-Kakizaki rats. Eur J Med Res. 2012;17(1):15.
27. Shin AC, Zheng H, Townsend RL, et al. Meal-induced hormone responses in a rat model of Roux-en-Y gastric bypass surgery. Endocrinology. 2010;151(4):1588-97.
28. van den Hoek AM, Heijboer AC, Voshol PJ, et al. Chronic PYY3-36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 mice. Am J Physiol Endocrinol Metab. 2007;292(1):E238-45.
29. Mingrone G. Role of the incretin system in the remission of type 2 diabetes following bariatric surgery. Nutr Metab Cardiovasc Dis. 2008;18(8):574-9.
30. Salinari S, Bertuzzi A, Asnaghi S, et al. First-phase insulin secretion restoration and differential response to glucose load depending on the route of administration in type 2 diabetic subjects after bariatric surgery. Diabetes Care. 2009;32(3):375-80.
31. Pacheco D, de Luis DA, Romero A, et al. The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats. Am J Surg. 2007;194(2):221-4.
32. Clements RH, Gonzalez QH, Long CI, et al. Hormonal changes after Roux-en Y gastric bypass for morbid obesity and the control of type-II diabetes mellitus. Am Surg. 2004;70(1):1-4. discussion 4-5.
33. Yan Z, Chen W, Liu S, et al. Myocardial insulin signaling and glucose transport are up-regulated in Goto-Kakizaki type 2 diabetic rats after ileal transposition. Obes Surg. 2012;22(3):493-501.
34. Valverde AM, Burks DJ, Fabregat I, et al. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes. 2003;52(9):2239-48.
35. Hatakeyama H, Kanzaki M. Molecular basis of insulin-responsive GLUT4 trafficking systems revealed by single molecule imaging. Traffic. 2011;12(12):1805-20.
36. She P, Burgess SC, Shiota M, et al. Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. Diabetes. 2003;52(7):1649-54.
37. Xu H, Yang Q, Shen M, et al. Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells. J Biol Chem. 2005;280(43):36013-8.
38. Trinh KY, O'Doherty RM, Anderson P, et al. Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats. J Biol Chem. 1998;273(47):31615-20.
39. Mithieux G. A synergy between incretin effect and intestinal gluconeogenesis accounting for the rapid metabolic benefits of gastric bypass surgery. Curr Diab Rep. 2012;12(2):167-71.
40. Hayes MT, Foo J, Besic V, et al. Is intestinal gluconeogenesis a key factor in the early changes in glucose homeostasis following gastric bypass? Obes Surg. 2011;21(6):759-62.
41. Shin AC, Zheng H, Berthoud HR. Vagal innervation of the hepatic portal vein and liver is not necessary for Roux-en-Y gastric bypass surgery-induced hypophagia, weight loss, and hypermetabolism. Ann Surg. 2012;255(2):294-301.