Induction of control genes in intestinal gluconeogenesis is sequential during fasting and maximal in diabetes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 286, Issue 3 49-3, 2004, Pages

  Mithieux, Gilles ^a   Bady, Isabelle ^a   Gautier, Amandine ^a   Croset, Martine ^a   Rajas, Fabienne ^a   Zitoun, Carine ^a  

^a INSERM   (France)

Author keywords

Glucose 6 phosphatase; Glutaminase; Glycerokinase; Phosphoenolpyruvate carboxykinase

Indexed keywords

GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUTAMINASE; GLYCEROL KINASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DIABETES MELLITUS; DIET RESTRICTION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INDUCTION; GENE EXPRESSION; GENE INDUCTION; GLUCONEOGENESIS; INTESTINE; ISOTOPE LABELING; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT; REGULATOR GENE; STREPTOZOCIN DIABETES;

EID: 1442325359     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00299.2003     Document Type: Article

References (44)

1. Adrogue H. Glucose homeostasis and the kidney. Kidney Int 42: 1266-1282, 1992.
2. Anderson J. Glucose metabolism in jejunal mucosa of fed, fasted, and streptozotocin-diabetic rats. Am J Physiol 226: 226-229, 1974.
3. Assimacopoulos-Jeannet F and Jeanrenault B. Insulin activates 6-phosphofructo-2-kinase and pyruvate kinase in the liver. J Biol Chem 265: 7202-7206, 1990.
4. Baginsky E, Foa P, and Zak B. Glucose-6-phosphatase. In: Methods of Enzymatic Analysis, edited by Bergmeyer HU. New York: Academic, 1974, p. 876-880.
5. Bergmeyer H, Gawehn K, and Grassl M. Enzymes as biochemical reagents. In: Methods of Enzymatic Analysis, edited by Bergmeyer HU. New York: Academic, 1974, p. 425-522.
6. Bergmeyer HU and Bernt E. Glutamate-pyruvate transaminase. In: Methods of Enzymatic Analysis, edited by Bergmeyer HU. New York: Academic, 1974, p. 732-750.
7. Bismut H, Hers H, and Van Schaftingen E. Conversion of fructose to glucose in rabbit small intestine. Eur J Biochem 213: 721-726, 1993.
8. Burant C, Flink S, De Paoli A, Chen J, Lee W, Heoliger M, Buse J, and Chang E. Small intestine hexose transport in experimental diabetes. Increased transporter mRNA and protein expression in enterocytes. J Clin Invest 93: 578-585, 1994.
9. Cersosimo E, Williams P, and Radosewith P. Role of glutamine in adaptations in nitrogen metabolism during fasting. Am J Physiol Endocrinol Metab 250: E622-E628, 1986.
10. Chatelain F, Pegorier J, Minassian C, Bruni N, Tarpin S, Girard J, and Mithieux G. Development and regulation of glucose-6-phosphatase gene expression in rat liver, intestine and kidney. Diabetes 47: 882-889, 1998.
11. Croset M, Rajas F, Zitoun C, Hurot J, Montano S, and Mithieux G. Rat small intestine is an insulin-sensitive gluconeogenic organ. Diabetes 50: 740-746, 2001.
12. Dyer J, Wood IS, Palejwala A, Ellis A, and Shirazi-Beechey SP. Expression of monosaccharide transporters in intestine of diabetic humans. Am J Physiol Gastrointest Liver Physiol 282: G241-G248, 2002.
13. Fedorak R, Cheeseman CI, Thomson AB, and Porter VM. Altered glucose carrier expression: mechanism of intestinal adaptation during streptozotocin-induced diabetes in rats. Am J Physiol Gastrointest Liver Physiol 261: G585-G591, 1991.
14. Friedmann B, Goodman EH Jr, and Weinhouse S. Liver glycogen synthesis in intact alloxan diabetic rats. J Biol Chem 238: 2899-2905, 1963.
15. Friedmann B, Goodman EH Jr, and Weinhouse S. Dietary and hormonal effects on gluconeogenesis in the rat. J Biol Chem 240: 3729-3735, 1965.
16. Froesh R. Essential fructosuria and hereditary fructose intolerance. In: The Metabolic Basis of Inherited Disease, edited by Stanbury J, Wyngaarden J, and Fredrickson D. New York: McGraw-Hill, 1972, p. 131-138.
17. Gardner R. A sensitive colorimetric assay for mitochondrial α-glycero-phosphate dehydrogenase. Anal Biochem 59: 272-276, 1974.
18. Guignot L and Mithieux G. Mechanisms by which insulin, associated or not with glucose, may inhibit hepatic glucose production in the rat. Am J Physiol Endocrinol Metab 277: E984-E989, 1999.
19. Hahn P and Smale FA. Phosphoenolpyruvate carboxykinase in the small intestine of developing rodents. J Nutr 115: 986-989, 1982.
20. Hahn P and Wei-Ning H. Gluconeogenesis from lactate in the small intestinal mucosa of suckling rats. Pediatr Res 20: 1321-1323, 1986.
21. Halimi S, Assimacopoulos-Jeannet F, Terretaz J, and Jeanrenault B. Differential effect of steady-state hyperinsulinemia and hyperglycemia on hepatic glycogenolysis and glycolysis in rats. Diabetologia 30: 268-272, 1987.
22. Hsu L and Tarver H. Distribution of the activity of various hydrolases, transaminases, and glutamic dehydrogenases in the digestive tracts of fed and fasted rats. Gastroenterology 53: 78-87, 1967.
23. Jomain-Baum M and Schramm V. Kinetic mechanism of phosphoenolpyruvate carboxykinase (GTP) from rat liver cytosol. J Biol Chem 253: 3648-3659, 1978.
24. Katz J. Use of isotopes for the study of glucose metabolism in vivo. In: Techniques in Metabolic Research, edited by Komberg HL. Amsterdam: Elsevier/North Holland, 1979, B207: p, 1-22.
25. Kong S, Hall J, Cooper D, and McCauley R. Starvation alters the activity and mRNA level of glutaminase and glutamine synthetase in the rat intestine. J Nutr Biochem 11: 393-400, 2000.
26. Mevorach M, Giacca A, Aharon Y, Hawkins M, Shamoon H, and Rossetti L. Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus. J Clin Invest 102: 744-753, 1998.
27. Minassian C, Ajzannay A, Riou J, and Mithieux G. Investigation of the mechanism of glycogen rebound in the liver of 72-hour fasted rats. J Biol Chem 269: 16585-16588, 1994.
28. Minassian C, Zitoun C, and Mithieux G. Differential time course of liver and kidney glucose-6 phosphatase activity during long-term fasting in rat correlates with differential time course of messenger RNA level. Mol Cell Biochem 155: 37-41, 1996.
29. Mithieux G. New knowledge regarding glucose-6 phosphatase gene and protein and their roles in the regulation of glucose metabolism. Eur J Endocrinol 136: 137-145, 1997.
30. Mithieux G. New data and concepts on glutamine and glucose metabolism in the gut. Curr Opin Clin Nutr Metab Care 4: 267-271, 2001.
31. Mithieux G, Vidal H, Zitoun C, Bruni N, Daniele N, and Minassian C. Glucose-6-phosphatase mRNA and activity are increased to the same extent in kidney and liver of diabetic rats. Diabetes 45: 891-896, 1996.
32. Mittelman S and Bergman R. Liver glucose production in health and diabetes. Curr Opin Endocrinol Diabetes 5: 126-135, 1999.
33. Owen OE, Felig P, Morgan AP, Wahren J, and Cahill GF. Liver and kidney metabolism during prolonged starvation. J Clin Invest 48: 574-583, 1969.
34. Passonneau J and Lowry OH. Specific methods and procedures. In: Enzymatic Analysis. A Pratical Guide, edited by Passonneau J. Totowa, NJ: Humana, 1993, p. 260-261.
35. Rajas F, Bruni N, Montano S, Zitoun C, and Mithieux G. The glucose-6 phosphatase gene is expressed in human and rat small intestine: regulation of expression in fasted and diabetic rats. Gastroenterology 117: 132-139, 1999.
36. Rajas F, Croset M, Zitoun C, Montano S, and Mithieux G. Induction of PEPCK gene expression in insulinopenia in rat small intestine. Diabetes 49: 1165-1168, 2000.
37. Reshef L, Hanson R, and Ballard F. A possible physiological role for glyceroneogenesis in rat adipose tissue. J Biol Chem 245: 5979-5984, 1970.
38. Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, and Hu M. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. J Clin Invest 92: 1126-1134, 1993.
39. Sambrook J, Frittsch E, and Maniatis T. Molecular Cloning: a Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor, 1989.
40. Van de Werve G, Sestoft L, Folke M, and Kristensen LO. The onset of liver glycogen synthesis in fasted-refed rats. Diabetes 33: 944-949, 1984.
41. Watford M. Glutamine metabolism in rat small intestine: synthesis of three-carbon products in isolated enterocytes. Biochim Biophys Acta 1200: 73-78, 1994.
42. Windmueller H. Metabolism of vascular and luminal glutamine by intestinal mucosa in vivo. In: Glutamine Metabolism in Mammalian Tissues, edited by Haüssinger D and Sies H. Berlin: Springer-Verlag, 1984, p. 61-67.
43. Windmueller HG and Spaeth AE. Identification of ketone bodies and glutamine as the major respiratory fuels in vivo for postabsorptive rat small intestine. J Biol Chem 253: 69-76, 1978.
44. Wolfe RR. Specific applications: glucose metabolism. In: Tracers in Metabolic Research, edited by Wolfe RR. New York: Liss, 1984, chapt. 9, p. 113-125.