Brown adipose tissue thermogenesis: β3 adrenoreceptors as a potential target for the treatment of obesity in humans

Cardiology in Review

Volumn 21, Issue 6, 2013, Pages 265-269

  Mund, Ross A ^a   Frishman, William H ^b  

^a YALE NEW HAVEN HOSPITAL   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

18F FDG PET CT scans; 3 adrenoreceptor; brown adipose tissue; thermogenesis

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME C; FLUORODEOXYGLUCOSE F 18; MESSENGER RNA; UNCOUPLING PROTEIN 1;

ADIPOCYTE; ARTICLE; BASAL METABOLIC RATE; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CARDIOVASCULAR FUNCTION; CELL DIFFERENTIATION; CELL PROLIFERATION; COLD; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CORE TEMPERATURE; ENERGY EXPENDITURE; ENERGY METABOLISM; ENVIRONMENTAL CHANGE; FOOD INTAKE; GLUCOSE TRANSPORT; HUMAN; MUSCLE FUNCTION; NONHUMAN; NONSHIVERING THERMOGENESIS; OBESITY; OXIDATIVE PHOSPHORYLATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SMOOTH MUSCLE; THERMOGENESIS; WHITE ADIPOSE TISSUE;

ADAPTATION, PHYSIOLOGICAL; ADIPOCYTES; ADIPOSE TISSUE, BROWN; ADRENERGIC BETA-3 RECEPTOR AGONISTS; ADRENERGIC BETA-3 RECEPTOR ANTAGONISTS; COLD TEMPERATURE; DIET; FLUORODEOXYGLUCOSE F18; HUMANS; OBESITY; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTORS, ADRENERGIC, BETA-3; THERMOGENESIS;

EID: 84885472713     PISSN: 10615377     EISSN: 15384683     Source Type: Journal    
DOI: 10.1097/CRD.0b013e31829cabff     Document Type: Article

References (26)

1. Jimenez M, Léger B, Canola K, et al. Beta(1)/beta(2)/beta(3)- adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. FEBS Lett. 2002;530:37-40. (Pubitemid 35248182)
2. Michel MC, Ochodnicky P, Summers RJ. Tissue functions mediated by beta(3)-adrenoceptors-Findings and challenges. Naunyn Schmiedebergs Arch Pharmacol. 2010;382:103-108.
3. Krief S, Lönnqvist F, Raimbault S, et al. Tissue distribution of beta 3-adrenergic receptor mRNA in man. J Clin Invest. 1993;91:344-349. (Pubitemid 23037290)
4. Okamatsu-Ogura Y, Nio-Kobayashi J, Iwanaga T, et al. Possible involvement of uncoupling protein 1 in appetite control by leptin. Exp Biol Med (Maywood). 2011;236:1274-1281.
5. C annon B, Nedergaard J. Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans). Int J Obes (Lond). 2010;34(suppl 1):S7-S16.
6. I nokuma K, Okamatsu-Ogura Y, Omachi A, et al. Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation. Am J Physiol Endocrinol Metab. 2006;290:E1014-E1021.
7. Mattsson CL, Csikasz RI, Chernogubova E, et al. ?1-Adrenergic receptors increase UCP1 in human MADS brown adipocytes and rescue cold-acclimated ?3-adrenergic receptor-knockout mice via nonshivering thermogenesis. Am J Physiol Endocrinol Metab. 2011;301:E1108-E1118.
8. Zhao J, Cannon B, Nedergaard J. Thermogenesis is beta3 but not beta1-adrenergically mediated in rat brown fat cells, even after cold acclimation. Am J Physiol. 1998;275(6 Pt 2):R2002-R2011.
9. C ypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009;360:1509-1517.
10. Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab. 2007;293:E444-E452. (Pubitemid 47205086)
11. V irtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults. N Engl J Med. 2009;360:1518-1525.
12. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med. 2009;360:1500-1508.
13. L ehr L, Kuehne F, Arboit P, et al. Control of 4E-BP1 expression in mouse brown adipose tissue by the beta3-adrenoceptor. FEBS Lett. 2004;576:179-182. (Pubitemid 39330480)
14. W ijers SL, Schrauwen P, van Baak MA, et al. Beta-adrenergic receptor blockade does not inhibit cold-induced thermogenesis in humans: possible involvement of brown adipose tissue. J Clin Endocrinol Metab. 2011;96:E598-E605.
15. Feldmann HM, Golozoubova V, Cannon B, et al. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 2009;9:203-209.
16. E nerbäck S, Jacobsson A, Simpson EM, et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature. 1997;387:90-94. (Pubitemid 27202655)
17. L owell BB, S-Susulic V, Hamann A, et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature. 1993;366:740-742. (Pubitemid 24038513)
18. Golozoubova V, Hohtola E, Matthias A, et al. Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB J. 2001;15:2048-2050.
19. Bachman ES, Dhillon H, Zhang CY, et al. betaAR signaling required for dietinduced thermogenesis and obesity resistance. Science. 2002;297:843-845. (Pubitemid 34839635)
20. Kozak LP. Brown fat and the myth of diet-induced thermogenesis. Cell Metab. 2010;11:263-267.
21. L iu X, Rossmeisl M, McClaine J, et al. Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J Clin Invest. 2003;111:399-407. (Pubitemid 36182217)
22. Beranger GE, Karbiener M, Barquissau V, et al. In vitro brown and "brite"/"beige" adipogenesis: human cellular models and molecular aspects. Biochim Biophys Acta. 2012;1831:905-914.
23. W u J, Boström P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012;150:366-376.
24. Sharp LZ, Shinoda K, Ohno H, et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One. 2012;7:e49452.
25. L owell BB, Bachman ES. Beta-adrenergic receptors, diet-induced thermogenesis, and obesity. J Biol Chem. 2003;278:29385-29388. (Pubitemid 36962316)
26. Frishman WH, Sica DA, eds. Cardiovascular Pharmacotherapeutics. 3rd ed. Minneapolis: Cardiotext; 2011.