Shh signaling, negatively regulated by BMP signaling, inhibits the osteo/dentinogenic differentiation potentials of mesenchymal stem cells from apical papilla

Molecular and Cellular Biochemistry

Volumn 383, Issue 1-2, 2013, Pages 85-93

  Jiang, Qingsong ^a   Yin, Xiaonan ^b   Shan, Zhaochen ^a   Ma, Yushi ^a   Ma, Ping ^a   Du, Juan ^a   Fan, Zhipeng ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b Qingdao Construction Group   (China)

Author keywords

BMP signaling; Mesenchymal stem cells; Osteo dentinogenic differentiation; Shh signaling; Smoothened (SMO)

Indexed keywords

BONE MORPHOGENETIC PROTEIN; MUTANT PROTEIN; RECOMBINANT PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ANIMAL EXPERIMENT; ARTICLE; BONE DEVELOPMENT; CONTROLLED STUDY; DOWN REGULATION; GENE; GENE EXPRESSION REGULATION; GLI1 GENE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SMO GENE; TISSUE REGENERATION; TOOTH DEVELOPMENT; UPREGULATION;

ERINACEIDAE;

ALKALINE PHOSPHATASE; ANIMALS; BONE MORPHOGENETIC PROTEINS; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; DENTAL PAPILLA; DENTINOGENESIS; DOWN-REGULATION; HEDGEHOG PROTEINS; HUMANS; MESENCHYMAL STROMAL CELLS; MICE; MICE, NUDE; MUTANT PROTEINS; OSTEOGENESIS; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84885423310     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1757-9     Document Type: Article

References (45)

1. Prockop DJ (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:71-74
2. Phinney DG, Prockop DJ (2007) Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair - current views. Stem Cells 25:2896-2902
3. Gronthos S, Mankani M, Brahim J et al (2000) Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 97:13625-13630
4. Seo BM, Miura M, Gronthos S et al (2004) Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364:149-155
5. Sonoyama W, Liu Y, Fang D et al (2006) Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS One 1:e79
6. Iwata T, Yamato M, Zhang Z et al (2010) Validation of human periodontal ligament-derived cells as a reliable source for cytotherapeutic use. J Clin Periodontol 37:1088-1099
7. Wang S, Mu J, Fan Z et al (2012) Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla. Stem Cell Res 8:346-356
8. Gimble JM, Zvonic S, Floyd ZE et al (2006) Playing with bone and fat. J Cell Biochem 98:251-266
9. Rosen CJ, Bouxsein ML (2006) Mechanisms of disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol 2:35-43
10. Spinella-Jaegle S, Rawad G, Kawai S et al (2001) Sonic Hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation. J Cell Sci 114:2085-2094
11. McMahon AP, Ingham PW, Tabin CJ (2003) Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol 53:1-114
12. Kimura H, Ng JMY, Curran T (2008) Transient inhibition of the hedgehog pathway in young mice cause permanent defects in bone structure. Cancer Cell 13:249-260
13. Pathi S, Pagan-Westphal S, Baker DP et al (2001) Comparative biological responses to human Sonic, Indian, and Desert Hedgehog. Mech Dev 106:107-117
14. Hynes M, Stone DM, Dowd M et al (1997) Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 19:15-26
15. Ingham PW, McMahon AP (2001) Hedgehog signaling in animal development: paradigms and principles. Genes Dev 15:3059-3087
16. Ruel L, Rodriguez R, Gallet A et al (2003) Stability and association of Smoothened, Costal2 and fused with Cubitus interruptus are regulated by Hedgehog. Nat Cell Biol 5:907-913
17. Kasper M, Regl G, Frischauf AM et al (2006) GLI transcription factors: mediators of oncogenic Hedgehog signalling. Eur J Cancer 42:437-445
18. Ruizi Altaba A, Mas C, Stecca B (2007) The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol 17:438-447
19. Wu X, Walker J, Zhang J (2004) Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol 11:1229-1238
20. Beloti MM, Bellesini LS, Rosa AL (2005) Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int 29:537-541
21. Cai JQ, Huang YZ, Chen XH et al (2012) Sonic Hedgehog enhances the proliferation and osteogenic differentiation of bone marrow-derived mesenchymal stem cells. Cell Biol Int 36:349-355
22. Oliveira FS, Bellesini LS, Defino HL et al (2012) Hedgehog signaling and osteoblast gene expression are regulated by purmorphamine in human mesenchymal stem cells. J Cell Biochem 113:204-208
23. Plaisant M, Fontaine C, Cousin W et al (2009) Activation of hedgehog signaling inhibits osteoblast differentiation of human mesenchymal stem cells. Stem Cells 27:703-713
24. Shimizu H, Julius MA, Giarre M et al (1997) Transformation by Wnt family proteins correlates with regulation of beta-catenin. Cell Growth Differ 8:1349-1358
25. Chang J, Sonoyama W, Wang Z et al (2007) Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK. J Biol Chem 282:30938-30948
26. Taipale J, Cooper MK, Maiti T et al (2002) Patched acts catalytically to suppress the activity of Smoothened. Nature 418:892-897
27. Zhao Y, Tong C, Jiang J (2007) Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 450:252-259
28. Lamm ML, Catbagan WS, Laciak RJ et al (2002) Sonic Hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev Biol 249:349-366
29. Hooper JE, Scott MP (2005) Communicating with Hedgehogs. Nat Rev Mol Cell Biol 6:306-317
30. Riobo NA, Manning DR (2007) Pathways of signal transduction employed by vertebrate Hedgehogs. Biochem J 403:369-379
31. Zehentner BK, Leser U, Burtscher H (2000) BMP-2 and Sonic Hedgehog have contrary effects on adipocyte-like differentiation of C3H10T1/2 cells. DNA Cell Biol 19:275-281
32. Shea CM, Edgar CM, Einhorn TA et al (2003) BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis. J Cell Biochem 90:1112-1127
33. Van den Brink GR, Hardwick JC, Nielsen C et al (2002) Sonic Hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut 51:628-633
34. Rios I, Alvarez-Rodríguez R, Martí E et al (2004) Bmp2 antagonizes Sonic Hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling. Development 131:3159-3168
35. Shaw A, Gipp J, Bushman W (2010) Exploration of Shh and BMP paracrine signaling in a prostate cancer xenograft. Differentiation 79:41-47
36. Arthur A, Rychkov G, Shi S et al (2008) Adult human dental pulp stem cells differentiate towards functionally active neurons under appropriate environmental cues. Stem Cells 26:1787-1795
37. Liu Y, Zheng Y, Ding G et al (2008) Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells 26:1065-1073
38. Miura M, Gronthos S, Zhao M et al (2003) SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA 100:5807-5812
39. Ding G, Liu Y, Wang W et al (2010) Allogeneic periodontal ligament stem cell therapy for periodontitis in swine. Stem Cells 28:1829-1838
40. Hardcastle Z, Hui CC, Sharpe PT (1999) The Shh signalling pathway in early tooth development. Cell Mol Biol (Noisy-le-grand) 45:567-578
41. Laufer E, Nelson CE, Johnson RL et al (1994) Sonic Hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79:993-1003
42. Bhardwaj G, Murdoch B, Wu D et al (2001) Sonic Hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol 2:172-180
43. Elia D, Madhala D, Ardon E et al (2007) Sonic Hedgehog promotes proliferation and differentiation of adult muscle cells: involvement of MAPK/ERK and PI3K/Akt pathways. Biochim Biophys Acta 1773:1438-1446
44. Martínez C, Smith PC, Rodriguez JP et al (2011) Sonic Hedgehog stimulates proliferation of human periodontal ligament stem cells. J Dent Res 90:483-488
45. Van der Horst G, Farih-Sips H, Löwik CW et al (2003) Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells. Bone 33:899-910