Sonic hedgehog stimulates proliferation of human periodontal ligament stem cells

Journal of Dental Research

Volumn 90, Issue 4, 2011, Pages 483-488

  Martinez C ^a,b   Smith, P C ^b   Rodriguez, J P ^a   Palma, V ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

human periodontal ligament stem cells; primary cilia; proliferation; Sonic hedgehog

Indexed keywords

CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLI1 PROTEIN, HUMAN; GLI2 PROTEIN, HUMAN; KRUPPEL LIKE FACTOR; MEMBRANE ANTIGEN; MORPHOLINE DERIVATIVE; NUCLEAR PROTEIN; PATCHED RECEPTORS; PURINE DERIVATIVE; PURMORPHAMINE; SHH PROTEIN, HUMAN; SMO PROTEIN, HUMAN; SONIC HEDGEHOG PROTEIN; STRO 1 ANTIGEN, HUMAN; STRO-1 ANTIGEN, HUMAN; TRANSCRIPTION FACTOR;

ADOLESCENT; ADULT; AUTOCRINE EFFECT; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SEPARATION; COMPARATIVE STUDY; CONFERENCE PAPER; CULTURE MEDIUM; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; EUKARYOTIC FLAGELLUM; HUMAN; PERIODONTAL LIGAMENT; PHYSIOLOGY; STEM CELL; ULTRASTRUCTURE;

ADOLESCENT; ADULT; ANTIGENS, SURFACE; AUTOCRINE COMMUNICATION; CELL COUNT; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SEPARATION; CILIA; CULTURE MEDIA, CONDITIONED; HEDGEHOG PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MORPHOLINES; NUCLEAR PROTEINS; PERIODONTAL LIGAMENT; PURINES; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; STEM CELLS; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 79954569502     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034510391797     Document Type: Conference Paper

References (36)

1. Christensen ST, Ott CM (2007). A ciliary signaling switch. Science 317: 330-331. (Pubitemid 47106363)
2. Cobourne M., Sharpe P. (2005). Sonic hedgehog signaling and the developing tooth. Curr Top Dev Biol 65: 255-287.
3. Dassule HR, Lewis P., Bei M., Maas R., McMahon AP (2000). Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127: 4775-4785.
4. Fendrich V., Esni F., Garay MV, Feldmann G., Habbe N., Jensen JN, et al. (2008). Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology 135: 621-631.
5. Feng F., Akiyama K., Liu Y., Yamaza T., Wang TM, Cheng JH, et al. (2010). Utility of PDL progenitors for in vivo tissue regeneration: a report of 3 cases. Oral Dis 16: 20-28.
6. Gritli-Linde A., Bei M., Maas R., Zhang X., Linde A., McMahon A. (2002). Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 129: 5323-5337. (Pubitemid 36040329)
7. Hardcastle Z., Mo R., Hui CC, Sharpe PT (1998). The Shh signalling pathway in tooth development: defects in Gli2and Gli3 mutants. Development 125: 2803-2811. (Pubitemid 28410205)
8. Huang GT, Gronthos S., Shi S. (2009). Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res 88: 792-806.
9. Ingram W., Wicking C., Grimmond SM, Forrest AR, Wainwright BJ (2002). Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells. Oncogene 21: 8196-8205. (Pubitemid 35454424)
10. Ivanovski S., Gronthos S., Bartold PM (2006). Stem cells in the periodontal ligament. Oral Dis 12: 358-363. (Pubitemid 43926812)
11. Jiang J., Hui CC (2008). Hedgehog signaling in development and cancer. Dev Cell 15: 801-812.
12. Jo YY, Lee HJ, Kook SY, Choung HW, Park JY, Chung JH, et al. (2007). Isolation and characterization of postnatal stem cells from human dental tissues. Tissue Eng 13: 767-773.
13. Karhadkar SS, Bova GS, Abdallah N., Dhara S., Gardner D., Maitra A., et al. (2004). Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 471: 707-712. (Pubitemid 39382619)
14. Kiefer J. (2010). Diverse connections between primary cilia and hedgehog signaling. Dev Dyn 239: 1255-1262.
15. King PJ, Guasti L., Laufer E. (2008). Hedgehog signalling in endocrine development and disease. J Endocrinol 198: 439-450.
16. Ko HC, Han JS, Bächle M., Jang JH, Shin SW, Kim DJ (2008). Initial osteoblast-like cell response to pure titanium and zirconia/alumina ceramics. Dent Mater 23: 1349-1355. (Pubitemid 47391007)
17. Lin NH, Menicanin D., Mrozik K., Gronthos S., Bartold PM (2008). Putative stem cells in regenerating human periodontium. J Periodontal Res 43: 514-523.
18. Lin NH, Gronthos S., Bartold PM (2009). Stem cells and future periodontal regeneration. Periodontol 2000 51: 239-251.
19. Lin Z., Navarro VP, Kempeinen KM, Franco LM, Jin O., Sugai JV, et al. (2010). LMP1 regulates periodontal ligament progenitor cell proliferation and differentiation. Bone 47: 55-64.
20. Liu Y., Zheng Y., Ding G., Fang D., Zhang C., Bartold PM, et al. (2008). Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells 26: 1065-1073.
21. Lossdörfer S., Götz W., Jäger A. (2005). PTH(1-34) affects osteoprotegerin production in human PDL cells in vitro. J Dent Res 84: 634-638. (Pubitemid 43827845)
22. Marichal N., García G., Radmilovich M., Trujillo-Cenóz O., Russo RE (2009). Enigmatic central canal contacting cells: immature neurons in "standby mode"? J Neurosci 29: 10010-10024.
23. Mas C., Ruiz i Altaba A. (2010). Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations. Biochem Pharmacol 80: 712-723.
24. Nakatomi M., Morita I., Eto K., Ota MS (2006). Sonic hedgehog signaling is important in tooth root development. J Dent Res 85: 427-431. (Pubitemid 43799259)
25. Psaltis PJ, Paton S., See F., Arthur A., Martin S., Itescu S., et al. (2010). Enrichment for STRO-1 expression enhances the cardiovascular paracrine activity of human bone marrow-derived mesenchymal cell populations J Cell Physiol 223: 530-540
26. Regl G., Neill G., Eichberger T., Kasper M., Ikram M., Koller J., et al. (2002). Human GLI2 and GLI1 are part of a positive feedback mechanism in basal cell carcinoma. Oncogene 21: 5529-5539. (Pubitemid 34983542)
27. Rohatgi R., Milenkovic L., Scott M. (2007). Patched1 regulates hedgehog signaling at the primary cilium. Science 317: 372-376. (Pubitemid 47106377)
28. Sanchez P., Hernandez AM, Stecca B., Kahler A., DeGueme AM, Beyna M., et al. (2004). Inhibition of prostate cancer proliferation by interference with Sonic Hedgehog-Gli1 signaling. Proc Natl Acad Sci USA 101: 12561-12566. (Pubitemid 39122063)
29. Seo B., Miura M., Gronthos S., Bartold PM, Batouli S., Brahim J., et al. (2004). Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364: 149-155. (Pubitemid 38891686)
30. Stecca B., Ruiz I. Altaba A. (2009). A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers. EMBO J 28: 663-676.
31. Taipale J., Chen J., Cooper M., Wang B., Mann R., Scott MP, et al. (2000). Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406: 1005-1009.
32. Trubiani O., Di Primio R., Traini T., Pizzicannella J., Scarano A., Piattelli A., et al. (2005). Morphological and cytofluorimetric analysis of adult mesenchymal stem cells expanded ex vivo from periodontal ligament. Int J Immunopathol Pharmacol 18: 213-221. (Pubitemid 40825884)
33. Wang Y., Zhou Z., Walsh CT, McMahon P. (2009). Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci USA 106: 2623-2628.
34. Wong SY, Reiter J. (2008). The primary cilium at the crossroads of mammalian Hedgehog signaling. Curr Top Dev Biol 85: 225-260.
35. Wong SY, Seol AD, So PL, Ermilov AN, Bichakjian CK, Epstein EH Jr, et al. (2009). Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nat Med 15: 1055-1061.
36. Xu J., Wang W., Kapila Y., Lotz J., Kapila S. (2009). Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells Stem Cells Dev 18: 487-496.