Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity

Journal of Neurochemistry

Volumn 127, Issue 2, 2013, Pages 283-298

  Yoon, Hyesook ^a   Radulovic, Maja ^a   Wu, Jianmin ^a   Blaber, Sachiko I ^b   Blaber, Michael ^b   Fehlings, Michael G ^c   Scarisbrick, Isobel A ^a  

^a MAYO CLINIC   (United States)

^b FLORIDA STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

axon; neurodegeneration; spinal cord injury; thrombin; trauma

Indexed keywords

BIM PROTEIN; GLUTAMIC ACID; KALLIKREIN 6; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; THROMBIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME RELEASE; FEMALE; GENE DELETION; GRANULE CELL; IN VITRO STUDY; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; NERVE CELL LESION; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA SEQUENCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SPINAL CORD INJURY;

AXON; NEURODEGENERATION; SPINAL CORD INJURY; THROMBIN; TRAUMA;

ANIMALS; CELLS, CULTURED; CEREBELLUM; FEMALE; GLUTAMIC ACID; KALLIKREINS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR NEURONS; NEURONS; NEUROTOXICITY SYNDROMES; RECEPTOR, PAR-1; RECEPTOR, PAR-2; RNA; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD INJURIES; THROMBIN;

MURINAE;

EID: 84885422046     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12293     Document Type: Article

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