Four Amino Acids within a Tandem QxVx Repeat in a Predicted Extended α-Helix of the Smad-Binding Domain of Sip1 Are Necessary for Binding to Activated Smad Proteins

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Conidi, Andrea ^a,b   van den Berghe, Veronique ^a   Leslie, Kris ^b   Stryjewska, Agata ^a   Xue, Hua ^c   Chen, Ye Guang ^c   Seuntjens, Eve ^a   Huylebroeck, Danny ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; BINDING PROTEIN; DNA; GLUTAMINE; PEPTIDE APTAMER; PROTEIN NODAL; SMAD INTERACTING PROTEIN 1; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VALINE;

ALPHA HELIX; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DNA SEQUENCE; EMBRYO; GENE MUTATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLECULAR MODEL; MOUSE; MUTANT; NONHUMAN; PREDICTION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; TANDEM REPEAT;

AMINO ACID SEQUENCE; AMINO ACIDS; APTAMERS, PEPTIDE; CONSERVED SEQUENCE; DNA; DOWN-REGULATION; EPITHELIAL CELLS; GENES, REPORTER; HEK293 CELLS; HUMANS; INTERNEURONS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTANT PROTEINS; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; REPETITIVE SEQUENCES, AMINO ACID; SMAD PROTEINS; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 84885417435     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076733     Document Type: Article

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