-
1
-
-
74849124984
-
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy
-
Armour, S.M., Baur, J.A., Hsieh, S.N., Land-Bracha, A., Thomas, S.M., Sinclair, D.A., 2009. Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging (Albany NY) 1, 515-528.
-
(2009)
Aging (Albany NY)
, vol.1
, pp. 515-528
-
-
Armour, S.M.1
Baur, J.A.2
Hsieh, S.N.3
Land-Bracha, A.4
Thomas, S.M.5
Sinclair, D.A.6
-
2
-
-
19944434059
-
Inhibition of macroautophagy triggers apoptosis
-
DOI 10.1128/MCB.25.3.1025-1040.2005
-
Boya, P., Gonzalez-Polo, R.A., Casares, N., Perfettini, J.L., Dessen, P., Larochette, N., Metivier, D., Meley, D., Souquere, S., Yoshimori, T., Pierron, G., Codogno, P., Kroemer, G., 2005. Inhibition of macroautophagy triggers apoptosis. Mol. Cell Biol. 25, 1025-1040. (Pubitemid 40165810)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.3
, pp. 1025-1040
-
-
Boya, P.1
Gonzalez-Polo, R.-A.2
Casares, N.3
Perfettini, J.-L.4
Dessen, P.5
Larochette, N.6
Metivier, D.7
Meley, D.8
Souquere, S.9
Yoshimori, T.10
Pierron, G.11
Codogno, P.12
Kroemer, G.13
-
3
-
-
2442645050
-
The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae
-
DOI 10.1074/jbc.M400272200
-
Budovskaya, Y.V., Stephan, J.S., Reggiori, F., Klionsky, D.J., Herman, P.K., 2004. The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae. J. Biol. Chem. 279, 20663-20671. (Pubitemid 38656461)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.20
, pp. 20663-20671
-
-
Budovskaya, Y.V.1
Stephan, J.S.2
Reggiori, F.3
Klionsky, D.J.4
Herman, P.K.5
-
4
-
-
25444459688
-
An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase
-
DOI 10.1073/pnas.0501046102
-
Budovskaya, Y.V., Stephan, J.S., Deminoff, S.J., Herman, P.K., 2005. An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. U S A 102, 13933-13938. (Pubitemid 41377681)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.39
, pp. 13933-13938
-
-
Budovskaya, Y.V.1
Stephan, J.S.2
Deminoff, S.J.3
Herman, P.K.4
-
5
-
-
77955875002
-
Regulation of the autophagy protein LC3 by phosphorylation
-
Cherra 3rd, S.J., Kulich, S.M., Uech, G., Balasubramani, M., Mountzouris, J., Day, B.W., Chu, C.T., 2010. Regulation of the autophagy protein LC3 by phosphorylation. J. Cell Biol. 190, 533-539.
-
(2010)
J. Cell Biol.
, vol.190
, pp. 533-539
-
-
Cherra III, S.J.1
Kulich, S.M.2
Uech, G.3
Balasubramani, M.4
Mountzouris, J.5
Day, B.W.6
Chu, C.T.7
-
6
-
-
78649253559
-
Inhibition of the mammalian target of rapamycin promotes cyclic AMP-induced differentiation of NG108-15 cells
-
Chin, T.Y., Kao, C.H., Wang, H.Y., Huang, W.P., Ma, K.H., Chueh, S.H., 2010. Inhibition of the mammalian target of rapamycin promotes cyclic AMP-induced differentiation of NG108-15 cells. Autophagy 6, 1139-1156.
-
(2010)
Autophagy
, vol.6
, pp. 1139-1156
-
-
Chin, T.Y.1
Kao, C.H.2
Wang, H.Y.3
Huang, W.P.4
Ma, K.H.5
Chueh, S.H.6
-
7
-
-
0034306450
-
Specificity and mechanism of action of some commonly used protein kinase inhibitors
-
Davies, S.P., Reddy, H., Caivano, M., Cohen, P., 2000. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105.
-
(2000)
Biochem. J.
, vol.351
, pp. 95-105
-
-
Davies, S.P.1
Reddy, H.2
Caivano, M.3
Cohen, P.4
-
8
-
-
53749104349
-
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
-
Degtyarev, M., De Mazière, A., Orr, C., Lin, J., Lee, B.B., Tien, J.Y., Prior, W.W., van Dijk, S., Wu, H., Gray, D.C., Davis, D.P., Stern, H.M., Murray, L.J., Hoeflich, K.P., Klumperman, J., Friedman, L.S., Lin, K., 2008. Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. J. Cell Biol. 183, 101-116.
-
(2008)
J. Cell Biol.
, vol.183
, pp. 101-116
-
-
Degtyarev, M.1
De Mazière, A.2
Orr, C.3
Lin, J.4
Lee, B.B.5
Tien, J.Y.6
Prior, W.W.7
Van Dijk, S.8
Wu, H.9
Gray, D.C.10
Davis, D.P.11
Stern, H.M.12
Murray, L.J.13
Hoeflich, K.P.14
Klumperman, J.15
Friedman, L.S.16
Lin, K.17
-
9
-
-
0029860018
-
Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89
-
DOI 10.1074/jbc.271.42.26157
-
Engh, R.A., Girod, A., Kinzel, V., Huber, R., Bossemeyer, D., 1996. Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoqui-nolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J. Biol. Chem. 271, 26157-26164. (Pubitemid 26347460)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.42
, pp. 26157-26164
-
-
Engh, R.A.1
Girod, A.2
Kinzel, V.3
Huber, R.4
Bossemeyer, D.5
-
10
-
-
35848959917
-
Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy
-
Fujiwara, K., Iwado, E., Mills, G.B., Sawaya, R., Kondo, S., Kondo, Y., 2007. Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy. Int. J. Oncol. 31, 753-760.
-
(2007)
Int. J. Oncol.
, vol.31
, pp. 753-760
-
-
Fujiwara, K.1
Iwado, E.2
Mills, G.B.3
Sawaya, R.4
Kondo, S.5
Kondo, Y.6
-
11
-
-
0029962950
-
Role of cAMP in the regulation of hepatocytic autophagy
-
Holen, I., Gordon, P.B., Strømhaug, P.E., Seglen, P.O., 1996. Role of cAMP in the regulation of hepatocytic autophagy. Eur. J. Biochem. 236, 163-170. (Pubitemid 26075657)
-
(1996)
European Journal of Biochemistry
, vol.236
, Issue.1
, pp. 163-170
-
-
Holen, I.1
Gordon, P.B.2
Stromhaug, P.E.3
Seglen, P.O.4
-
12
-
-
0034329418
-
LC3, a mammalian homologue of yeast apg8p, is localized in autophagosome membranes after processing
-
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., Yoshimori, T., 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720-5728.
-
(2000)
EMBO J.
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
Yamamoto, A.4
Kirisako, T.5
Noda, T.6
Kominami, E.7
Ohsumi, Y.8
Yoshimori, T.9
-
13
-
-
0034537290
-
Autophagy as a regulated pathway of cellular degradation
-
DOI 10.1126/science.290.5497.1717
-
Klionsky, D.J., Emr, S.D., 2000. Autophagy as a regulated pathway of cellular degradation. Science 290, 1717-1721. (Pubitemid 32004796)
-
(2000)
Science
, vol.290
, Issue.5497
, pp. 1717-1721
-
-
Klionsky, D.J.1
Emr, S.D.2
-
14
-
-
33847791170
-
The many faces of H89: A review
-
DOI 10.1111/j.1527-3466.2006.00261.x
-
Lochner, A., Moolman, J.A., 2006. The many faces of H89: a review. Cardiovasc. Drug Rev. 24, 261-274. (Pubitemid 46435008)
-
(2006)
Cardiovascular Drug Reviews
, vol.24
, Issue.3-4
, pp. 261-274
-
-
Lochner, A.1
Moolman, J.A.2
-
15
-
-
12944303650
-
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
-
DOI 10.1016/j.cell.2004.11.046, PII S009286740401150X
-
Lum, J.J., Bauer, D.E., Kong, M., Harris, M.H., Li, C., Lindsten, T., Thompson, C.B., 2005. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120, 237-248. (Pubitemid 40174766)
-
(2005)
Cell
, vol.120
, Issue.2
, pp. 237-248
-
-
Lum, J.J.1
Bauer, D.E.2
Kong, M.3
Harris, M.H.4
Li, C.5
Lindsten, T.6
Thompson, C.B.7
-
16
-
-
34548188741
-
Self-eating and self-killing: Crosstalk between autophagy and apoptosis
-
DOI 10.1038/nrm2239, PII NRM2239
-
Maiuri, M.C., Zalckvar, E., Kimchi, A., Kroemer, G., 2007. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 8, 741-752. (Pubitemid 47312826)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.9
, pp. 741-752
-
-
Maiuri, M.C.1
Zalckvar, E.2
Kimchi, A.3
Kroemer, G.4
-
17
-
-
36448940798
-
FoxO3 controls autophagy in skeletal muscle in vivo
-
DOI 10.1016/j.cmet.2007.11.001, PII S1550413107003361
-
Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S.J., Di Lisi, R., Sandri, C., Zhao, J., Goldberg, A.L., Schiaffino, S., Sandri, M., 2007. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab. 6, 458-471. (Pubitemid 350163055)
-
(2007)
Cell Metabolism
, vol.6
, Issue.6
, pp. 458-471
-
-
Mammucari, C.1
Milan, G.2
Romanello, V.3
Masiero, E.4
Rudolf, R.5
Del Piccolo, P.6
Burden, S.J.7
Di Lisi, R.8
Sandri, C.9
Zhao, J.10
Goldberg, A.L.11
Schiaffino, S.12
Sandri, M.13
-
18
-
-
4344595626
-
Regulation and role of autophagy in mammalian cells
-
DOI 10.1016/j.biocel.2004.02.002, PII S1357272504000536
-
Meijer, A.J., Codogno, P., 2004. Regulation and role of autophagy in mammalian cells. Int. J. Biochem. Cell Biol. 36, 2445-2462. (Pubitemid 39119758)
-
(2004)
International Journal of Biochemistry and Cell Biology
, vol.36
, Issue.12
, pp. 2445-2462
-
-
Meijer, A.J.1
Codogno, P.2
-
19
-
-
1942456523
-
Specific roles for the P13K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: Study in the 5T33MM model
-
DOI 10.1038/sj.bjc.6601613
-
Menu, E., Kooijman, R., Van Valckenborgh, E., Asosingh, K., Bakkus, M., Van Camp, B., Vanderkerken, K., 2004. Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model. Br. J. Cancer 90, 1076-1083. (Pubitemid 38495831)
-
(2004)
British Journal of Cancer
, vol.90
, Issue.5
, pp. 1076-1083
-
-
Menu, E.1
Kooijman, R.2
Van Valckenborgh, E.3
Asosingh, K.4
Bakkus, M.5
Van Camp, B.6
Vanderkerken, K.7
-
20
-
-
0035911162
-
Dissection of autophagosome formation using apg5-deficient mouse embryonic stem cells
-
Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y., Yoshimori, T., 2001. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J. Cell Biol. 152, 657-668.
-
(2001)
J. Cell Biol.
, vol.152
, pp. 657-668
-
-
Mizushima, N.1
Yamamoto, A.2
Hatano, M.3
Kobayashi, Y.4
Kabeya, Y.5
Suzuki, K.6
Tokuhisa, T.7
Ohsumi, Y.8
Yoshimori, T.9
-
21
-
-
48849116430
-
Pharmacological PKA inhibition: All may not be what it seems
-
re4
-
Murray, A.J., 2008. Pharmacological PKA inhibition: all may not be what it seems. Sci. Signal 1, re4.
-
(2008)
Sci. Signal
, vol.1
-
-
Murray, A.J.1
-
22
-
-
0032512636
-
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
-
DOI 10.1074/jbc.273.7.3963
-
Noda, T., Ohsumi, Y., 1998. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J. Biol. Chem. 273, 3963-3966. (Pubitemid 28103257)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.7
, pp. 3963-3966
-
-
Noda, T.1
Ohsumi, Y.2
-
23
-
-
67650337799
-
Inhibitor hijacking of akt activation
-
Okuzumi, T., Fiedler, D., Zhang, C., Gray, D.C., Aizenstein, B., Hoffman, R., Shokat, K.M., 2009. Inhibitor hijacking of Akt activation. Nat. Chem. Biol. 5, 484-493.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 484-493
-
-
Okuzumi, T.1
Fiedler, D.2
Zhang, C.3
Gray, D.C.4
Aizenstein, B.5
Hoffman, R.6
Shokat, K.M.7
-
24
-
-
77957911956
-
Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)
-
Pearce, L.R., Alton, G.R., Richter, D.T., Kath, J.C., Lingardo, L., Chapman, J., Hwang, C., Alessi, D.R., 2010. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem. J. 431, 245-255.
-
(2010)
Biochem. J.
, vol.431
, pp. 245-255
-
-
Pearce, L.R.1
Alton, G.R.2
Richter, D.T.3
Kath, J.C.4
Lingardo, L.5
Chapman, J.6
Hwang, C.7
Alessi, D.R.8
-
25
-
-
0030740005
-
The modular phosphorylation and activation of p70s6k
-
Pullen, N., Thomas, G., 1997. The modular phosphorylation and activation of p70s6k. FEBS Lett. 410, 78-82.
-
(1997)
FEBS Lett.
, vol.410
, pp. 78-82
-
-
Pullen, N.1
Thomas, G.2
-
26
-
-
57649227693
-
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
-
Sarkar, S., Ravikumar, B., Floto, R.A., Rubinsztein, D.C., 2009. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 16, 46-56.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 46-56
-
-
Sarkar, S.1
Ravikumar, B.2
Floto, R.A.3
Rubinsztein, D.C.4
-
27
-
-
4344563878
-
Role and regulation of starvation-induced autophagy in the Drosophila fat body
-
DOI 10.1016/j.devcel.2004.07.009, PII S153458070400245X
-
Scott, R.C., Schuldiner, O., Neufeld, T.P., 2004. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 7, 167-178. (Pubitemid 39145023)
-
(2004)
Developmental Cell
, vol.7
, Issue.2
, pp. 167-178
-
-
Scott, R.C.1
Schuldiner, O.2
Neufeld, T.P.3
-
28
-
-
0026584008
-
Autophagy and other vacuolar protein degradation mechanisms
-
Seglen, P.O., Bohley, P., 1992. Autophagy and other vacuolar protein degradation mechanisms. Experientia 48, 158-172.
-
(1992)
Experientia
, vol.48
, pp. 158-172
-
-
Seglen, P.O.1
Bohley, P.2
-
29
-
-
80052385974
-
Bacterial toxins can inhibit host cell autophagy through cAMP generation
-
Shahnazari, S., Namolovan, A., Mogridge, J., Kim, P.K., Brumell, J.H., 2011. Bacterial toxins can inhibit host cell autophagy through cAMP generation. Autophagy 7, 957-965.
-
(2011)
Autophagy
, vol.7
, pp. 957-965
-
-
Shahnazari, S.1
Namolovan, A.2
Mogridge, J.3
Kim, P.K.4
Brumell, J.H.5
-
30
-
-
80053391464
-
CAMP induces autophagy via a novel pathway involving ERK, cyclin E and beclin 1
-
Ugland, H., Naderi, S., Brech, A., Collas, P., Blomhoff, H.K., 2011. cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1. Autophagy 7, 1199-1211.
-
(2011)
Autophagy
, vol.7
, pp. 1199-1211
-
-
Ugland, H.1
Naderi, S.2
Brech, A.3
Collas, P.4
Blomhoff, H.K.5
-
31
-
-
0032568921
-
Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies
-
DOI 10.1074/jbc.273.26.16621
-
Weng, Q.P., Kozlowski, M., Belham, C., Zhang, A., Comb, M.J., Avruch, J., 1998. Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies. J. Biol. Chem. 273, 16621-16629. (Pubitemid 28311452)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.26
, pp. 16621-16629
-
-
Weng, Q.-P.1
Kozlowski, M.2
Belham, C.3
Zhang, A.4
Comb, M.J.5
Avruch, J.6
-
32
-
-
42249106042
-
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
-
DOI 10.1038/nchembio.79, PII NCHEMBIO79
-
Williams, A., Sarkar, S., Cuddon, P., Ttofi, E.K., Saiki, S., Siddiqi, F.H., Jahreiss, L., Fleming, A., Pask, D., Goldsmith, P., O'Kane, C.J., Floto, R.A., Rubinsztein, D.C., 2008. Novel targets for Huntington's disease in an mTOR-independent autop-hagy pathway. Nat. Chem. Biol. 4, 295-305. (Pubitemid 351550888)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.5
, pp. 295-305
-
-
Williams, A.1
Sarkar, S.2
Cuddon, P.3
Ttofi, E.K.4
Saiki, S.5
Siddiqi, F.H.6
Jahreiss, L.7
Fleming, A.8
Pask, D.9
Goldsmith, P.10
O'Kane, C.J.11
Floto, R.A.12
Rubinsztein, D.C.13
-
33
-
-
84863387579
-
Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy
-
Xu, X., Chen, K., Kobayashi, S., Timm, D., Liang, Q., 2012. Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy. J. Pharmacol. Exp. Ther. 341, 183-195.
-
(2012)
J. Pharmacol. Exp. Ther.
, vol.341
, pp. 183-195
-
-
Xu, X.1
Chen, K.2
Kobayashi, S.3
Timm, D.4
Liang, Q.5
-
34
-
-
0033035897
-
ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells
-
Zhang, W., Lee, J.C., Kumar, S., Gowen, M., 1999. ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells. J. Bone Miner. Res. 14, 528-535. (Pubitemid 29153385)
-
(1999)
Journal of Bone and Mineral Research
, vol.14
, Issue.4
, pp. 528-535
-
-
Zhang, W.1
Lee, J.C.2
Kumar, S.3
Gowen, M.4
-
35
-
-
36448968532
-
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
-
DOI 10.1016/j.cmet.2007.11.004, PII S1550413107003397
-
Zhao, J., Brault, J.J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S.H., Goldberg, A.L., 2007. FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab. 6, 472-483. (Pubitemid 350163056)
-
(2007)
Cell Metabolism
, vol.6
, Issue.6
, pp. 472-483
-
-
Zhao, J.1
Brault, J.J.2
Schild, A.3
Cao, P.4
Sandri, M.5
Schiaffino, S.6
Lecker, S.H.7
Goldberg, A.L.8
|