메뉴 건너뛰기




Volumn 714, Issue 1-3, 2013, Pages 170-177

H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulphonamide) induces autophagy independently of protein kinase A inhibition

Author keywords

Akt; Autophagy; H89; Protein kinase A

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TARGET OF RAPAMYCIN KINASE;

EID: 84885415578     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.06.018     Document Type: Article
Times cited : (18)

References (35)
  • 3
    • 2442645050 scopus 로고    scopus 로고
    • The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae
    • DOI 10.1074/jbc.M400272200
    • Budovskaya, Y.V., Stephan, J.S., Reggiori, F., Klionsky, D.J., Herman, P.K., 2004. The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae. J. Biol. Chem. 279, 20663-20671. (Pubitemid 38656461)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.20 , pp. 20663-20671
    • Budovskaya, Y.V.1    Stephan, J.S.2    Reggiori, F.3    Klionsky, D.J.4    Herman, P.K.5
  • 6
    • 78649253559 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin promotes cyclic AMP-induced differentiation of NG108-15 cells
    • Chin, T.Y., Kao, C.H., Wang, H.Y., Huang, W.P., Ma, K.H., Chueh, S.H., 2010. Inhibition of the mammalian target of rapamycin promotes cyclic AMP-induced differentiation of NG108-15 cells. Autophagy 6, 1139-1156.
    • (2010) Autophagy , vol.6 , pp. 1139-1156
    • Chin, T.Y.1    Kao, C.H.2    Wang, H.Y.3    Huang, W.P.4    Ma, K.H.5    Chueh, S.H.6
  • 7
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies, S.P., Reddy, H., Caivano, M., Cohen, P., 2000. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105.
    • (2000) Biochem. J. , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 9
    • 0029860018 scopus 로고    scopus 로고
    • Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89
    • DOI 10.1074/jbc.271.42.26157
    • Engh, R.A., Girod, A., Kinzel, V., Huber, R., Bossemeyer, D., 1996. Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoqui-nolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J. Biol. Chem. 271, 26157-26164. (Pubitemid 26347460)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.42 , pp. 26157-26164
    • Engh, R.A.1    Girod, A.2    Kinzel, V.3    Huber, R.4    Bossemeyer, D.5
  • 10
    • 35848959917 scopus 로고    scopus 로고
    • Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy
    • Fujiwara, K., Iwado, E., Mills, G.B., Sawaya, R., Kondo, S., Kondo, Y., 2007. Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy. Int. J. Oncol. 31, 753-760.
    • (2007) Int. J. Oncol. , vol.31 , pp. 753-760
    • Fujiwara, K.1    Iwado, E.2    Mills, G.B.3    Sawaya, R.4    Kondo, S.5    Kondo, Y.6
  • 13
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • DOI 10.1126/science.290.5497.1717
    • Klionsky, D.J., Emr, S.D., 2000. Autophagy as a regulated pathway of cellular degradation. Science 290, 1717-1721. (Pubitemid 32004796)
    • (2000) Science , vol.290 , Issue.5497 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 14
    • 33847791170 scopus 로고    scopus 로고
    • The many faces of H89: A review
    • DOI 10.1111/j.1527-3466.2006.00261.x
    • Lochner, A., Moolman, J.A., 2006. The many faces of H89: a review. Cardiovasc. Drug Rev. 24, 261-274. (Pubitemid 46435008)
    • (2006) Cardiovascular Drug Reviews , vol.24 , Issue.3-4 , pp. 261-274
    • Lochner, A.1    Moolman, J.A.2
  • 15
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • DOI 10.1016/j.cell.2004.11.046, PII S009286740401150X
    • Lum, J.J., Bauer, D.E., Kong, M., Harris, M.H., Li, C., Lindsten, T., Thompson, C.B., 2005. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120, 237-248. (Pubitemid 40174766)
    • (2005) Cell , vol.120 , Issue.2 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5    Lindsten, T.6    Thompson, C.B.7
  • 16
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • DOI 10.1038/nrm2239, PII NRM2239
    • Maiuri, M.C., Zalckvar, E., Kimchi, A., Kroemer, G., 2007. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 8, 741-752. (Pubitemid 47312826)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 18
    • 4344595626 scopus 로고    scopus 로고
    • Regulation and role of autophagy in mammalian cells
    • DOI 10.1016/j.biocel.2004.02.002, PII S1357272504000536
    • Meijer, A.J., Codogno, P., 2004. Regulation and role of autophagy in mammalian cells. Int. J. Biochem. Cell Biol. 36, 2445-2462. (Pubitemid 39119758)
    • (2004) International Journal of Biochemistry and Cell Biology , vol.36 , Issue.12 , pp. 2445-2462
    • Meijer, A.J.1    Codogno, P.2
  • 19
    • 1942456523 scopus 로고    scopus 로고
    • Specific roles for the P13K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: Study in the 5T33MM model
    • DOI 10.1038/sj.bjc.6601613
    • Menu, E., Kooijman, R., Van Valckenborgh, E., Asosingh, K., Bakkus, M., Van Camp, B., Vanderkerken, K., 2004. Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model. Br. J. Cancer 90, 1076-1083. (Pubitemid 38495831)
    • (2004) British Journal of Cancer , vol.90 , Issue.5 , pp. 1076-1083
    • Menu, E.1    Kooijman, R.2    Van Valckenborgh, E.3    Asosingh, K.4    Bakkus, M.5    Van Camp, B.6    Vanderkerken, K.7
  • 21
    • 48849116430 scopus 로고    scopus 로고
    • Pharmacological PKA inhibition: All may not be what it seems
    • re4
    • Murray, A.J., 2008. Pharmacological PKA inhibition: all may not be what it seems. Sci. Signal 1, re4.
    • (2008) Sci. Signal , vol.1
    • Murray, A.J.1
  • 22
    • 0032512636 scopus 로고    scopus 로고
    • Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
    • DOI 10.1074/jbc.273.7.3963
    • Noda, T., Ohsumi, Y., 1998. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J. Biol. Chem. 273, 3963-3966. (Pubitemid 28103257)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.7 , pp. 3963-3966
    • Noda, T.1    Ohsumi, Y.2
  • 25
    • 0030740005 scopus 로고    scopus 로고
    • The modular phosphorylation and activation of p70s6k
    • Pullen, N., Thomas, G., 1997. The modular phosphorylation and activation of p70s6k. FEBS Lett. 410, 78-82.
    • (1997) FEBS Lett. , vol.410 , pp. 78-82
    • Pullen, N.1    Thomas, G.2
  • 26
    • 57649227693 scopus 로고    scopus 로고
    • Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
    • Sarkar, S., Ravikumar, B., Floto, R.A., Rubinsztein, D.C., 2009. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 16, 46-56.
    • (2009) Cell Death Differ. , vol.16 , pp. 46-56
    • Sarkar, S.1    Ravikumar, B.2    Floto, R.A.3    Rubinsztein, D.C.4
  • 27
    • 4344563878 scopus 로고    scopus 로고
    • Role and regulation of starvation-induced autophagy in the Drosophila fat body
    • DOI 10.1016/j.devcel.2004.07.009, PII S153458070400245X
    • Scott, R.C., Schuldiner, O., Neufeld, T.P., 2004. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 7, 167-178. (Pubitemid 39145023)
    • (2004) Developmental Cell , vol.7 , Issue.2 , pp. 167-178
    • Scott, R.C.1    Schuldiner, O.2    Neufeld, T.P.3
  • 28
    • 0026584008 scopus 로고
    • Autophagy and other vacuolar protein degradation mechanisms
    • Seglen, P.O., Bohley, P., 1992. Autophagy and other vacuolar protein degradation mechanisms. Experientia 48, 158-172.
    • (1992) Experientia , vol.48 , pp. 158-172
    • Seglen, P.O.1    Bohley, P.2
  • 29
    • 80052385974 scopus 로고    scopus 로고
    • Bacterial toxins can inhibit host cell autophagy through cAMP generation
    • Shahnazari, S., Namolovan, A., Mogridge, J., Kim, P.K., Brumell, J.H., 2011. Bacterial toxins can inhibit host cell autophagy through cAMP generation. Autophagy 7, 957-965.
    • (2011) Autophagy , vol.7 , pp. 957-965
    • Shahnazari, S.1    Namolovan, A.2    Mogridge, J.3    Kim, P.K.4    Brumell, J.H.5
  • 30
    • 80053391464 scopus 로고    scopus 로고
    • CAMP induces autophagy via a novel pathway involving ERK, cyclin E and beclin 1
    • Ugland, H., Naderi, S., Brech, A., Collas, P., Blomhoff, H.K., 2011. cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1. Autophagy 7, 1199-1211.
    • (2011) Autophagy , vol.7 , pp. 1199-1211
    • Ugland, H.1    Naderi, S.2    Brech, A.3    Collas, P.4    Blomhoff, H.K.5
  • 31
    • 0032568921 scopus 로고    scopus 로고
    • Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies
    • DOI 10.1074/jbc.273.26.16621
    • Weng, Q.P., Kozlowski, M., Belham, C., Zhang, A., Comb, M.J., Avruch, J., 1998. Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies. J. Biol. Chem. 273, 16621-16629. (Pubitemid 28311452)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.26 , pp. 16621-16629
    • Weng, Q.-P.1    Kozlowski, M.2    Belham, C.3    Zhang, A.4    Comb, M.J.5    Avruch, J.6
  • 33
    • 84863387579 scopus 로고    scopus 로고
    • Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy
    • Xu, X., Chen, K., Kobayashi, S., Timm, D., Liang, Q., 2012. Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy. J. Pharmacol. Exp. Ther. 341, 183-195.
    • (2012) J. Pharmacol. Exp. Ther. , vol.341 , pp. 183-195
    • Xu, X.1    Chen, K.2    Kobayashi, S.3    Timm, D.4    Liang, Q.5
  • 34
    • 0033035897 scopus 로고    scopus 로고
    • ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells
    • Zhang, W., Lee, J.C., Kumar, S., Gowen, M., 1999. ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells. J. Bone Miner. Res. 14, 528-535. (Pubitemid 29153385)
    • (1999) Journal of Bone and Mineral Research , vol.14 , Issue.4 , pp. 528-535
    • Zhang, W.1    Lee, J.C.2    Kumar, S.3    Gowen, M.4
  • 35
    • 36448968532 scopus 로고    scopus 로고
    • FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
    • DOI 10.1016/j.cmet.2007.11.004, PII S1550413107003397
    • Zhao, J., Brault, J.J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S.H., Goldberg, A.L., 2007. FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab. 6, 472-483. (Pubitemid 350163056)
    • (2007) Cell Metabolism , vol.6 , Issue.6 , pp. 472-483
    • Zhao, J.1    Brault, J.J.2    Schild, A.3    Cao, P.4    Sandri, M.5    Schiaffino, S.6    Lecker, S.H.7    Goldberg, A.L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.