Role of cAMP in the regulation of hepatocytic autophagy

European Journal of Biochemistry

Volumn 236, Issue 1, 1996, Pages 163-170

  Holen, I ^a   Gordon, P B ^a   Stromhaug, P E ^a   Seglen, P O ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Autophage; cAMP; Hepatocyte; Liver; Rat

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 3 METHYLADENINE; 5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE 3',5' THIOPHOSPHATE; 6N BENZOYL CYCLIC AMP; 7 DEACETYLFORSKOLIN; 8 BROMO CYCLIC AMP; 8 BROMOADENOSINE 3',5' CYCLIC THIOPHOSPHATE; 8 MERCAPTOMETHYL CYCLIC AMP; ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; AMINO ACID; AURANTIIN; BUCLADESINE; CYCLIC AMP; CYCLIC AMP DERIVATIVE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; FORSKOLIN DERIVATIVE; GENISTEIN; GLUCAGON; K 252A; KT 5720; KT 5823; KT 5926; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE INHIBITOR; STAUROSPORINE; THEOPHYLLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; IN VITRO STUDY; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

EID: 0029962950     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.00163.x     Document Type: Article

References (49)

1. 1 Holtzman, E. (1989) Lysosomes. Plenum Press, New York and London.
2. 2 Mortimore, G. E. (1987) Mechanism and regulation of induced and basal protein degradation in liver, in Lysosomes: their role in protein breakdown ( Glaumann, H. & Ballard, F. J., eds) pp. 415–443, Academic Press, London.
3. 3 Seglen, P. O. (1987) Regulation of autophagic protein degradation in isolated liver cells, in Lysosomes: their role in protein breakdown ( Glaumann, H. & Ballard, F. J., eds) pp. 369–414, Academic Press, London.
4. 4 Kopitz, J., Kisen, G. Ø., Gordon, P. B., Bohley, P. & Seglen, P. O. (1990) Non‐selective autophagy of cytosolic enzymes in isolated rat hepatocytes, J. Cell Biol. 111, 941–953.
5. 5 Pfeifer, U. (1987) Functional morphology of the lysosomal apparatus, in Lysosomes: their role in protein breakdown ( Glaumann, H. & Ballard, F. J., eds) pp. 3–59, Academic Press, London.
6. 6 Seglen, P. O. & Bohley, P. (1992) Autophagy and other vacuolar protein degradation mechanisms, Experientia 48, 158–172.
7. 7 Schworer, C. M. & Mortimore, G. E. (1979) Glucagon‐induced autophagy and proteolysis in rat liver: mediation by selective deprivation of intracellular amino acids, Proc. Natl Acad. Sci. USA 76, 3169–3173.
8. 8 Gordon, P. B., Kisen, G. Ø., Kovács, A. L. & Seglen, P. O. (1989) Experimental characterization of the autophagic‐lysosomal pathway in isolated rat hepatocytes, Biochem. Soc. Symp. 55, 129–143.
9. 9 Gordon, P. B., Holen, I. & Seglen, P. O. (1991) Effects of adrenergic agonists and antagonists on autophagic activity in isolated rat liver cells, Biomed. Biochim. Acta 50, 383–387.
10. 10 Holen, I., Gordon, P. B. & Seglen, P. O. (1992) Protein kinasedependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity, Biochem. J. 284, 633–636.
11. 11 Holen, I., Gordon, P. B. & Seglen, P. O. (1993) Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors, Eur. J. Biochem. 215, 113–122.
12. 12 Scott, J. D. (1991) Cyclic nucleotide‐dependent protein kinases, Pharmac. Ther. 50, 123–145.
13. 13 Tang, W.‐J. & Gilman, A. G. (1992) Adenylyl cyclases, Cell 70, 869–872.
14. 14 Hopgood, M. F., Clark, M. G. & Ballard, F. J. (1980) Protein degradation in hepatocyte monolayers. Effects of glucagon, adenosine 3′:5′‐cyclic monophosphate and insulin, Biochem. J. 186, 71–79.
15. 15 Blommaart, P. J. E., Zonneveld, D., Meijer, A. J. & Lamers, W. H. (1993) Effects of intracellular amino acid concentrations, cyclic AMP, and dexamethasone on lysosomal proteolysis in primary cultures of perinatal rat hepatocytes, J. Biol. Chem. 268, 1610–1617.
16. 16 Rosa, F. (1971) Ultrastructure changes produced by glucagon, cyclic 3′5′‐AMP and epinephrine on perfused rat livers, J. Ultrastr. Res. 34, 205–213.
17. 17 Arstila, A. U., Shelburne, J. D. & Trump, B. F. (1972) Studies on cellular autophagocytosis: A histochemical study on sequential alterations of mitochondria in the glucagon‐induced autophagic vacuoles of rat liver, Lab. Invest. 27, 317–323.
18. 18 Shelburne, J. D., Arstila, A. U. & Trump, B. F. (1973) Studies on cellular autophagocytosis. Cyclic AMP‐ and dibuturyl cyclic AMP‐stimulated autophagy in rat liver, Am. J. Pathol. 72, 521–540.
19. 19 Seglen, P. O., Kovács, A. L. & Gordon, P. B. (1991) Autophagic protein degradation in hepatocytes, in Regulation of hepatic function ( Grunnet, N. & Quistorff, B., eds) pp. 358–367, Munksgaard, Copenhagen.
20. 20 Holen, I., Gordon, P. B. & Seglen, P. O. (1991) Role of cyclic nucleotides in the control of hepatic autophagy, Biomed. Biochim. Acta 50, 389–392.
21. 21 Seglen, P. O. (1976) Preparation of isolated rat liver cells, Methods Cell Biol. 13, 29–83.
22. 22 Seglen, P. O. Gordon, P. B., Tolleshaug, H. & Høyvik, H. (1986) Use of [ 3 H]raffinose as a specific probe of autophagic sequestration, Exp. Cell Res. 162, 273–277.
23. 23 Seglen, P. O. Grinde, B. & Solheim, A. E. (1979) Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin, Eur J. Biochem. 95, 215–225.
24. 24 Kovács, A. L., Grinde, B. & Seglen, P. O. (1981) Inhibition of autophagic vacuole formation and protein degradation by amino acids in isolated hepatocytes, Exp. Cell Res. 133, 431–436.
25. 25 Laurenza, A., McHugh Sutkowski, E. & Seamon, K. B. (1989) Forskolin: A specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action Trends Pharmacol. Sci. 10, 442–447.
26. 26 Seglen, P. O. & Gordon, P. B. (1982) 3‐Methyladenine: a specific inhibitor of autophagicysosomal protein degradation in isolated rat hepatocytes, Proc. Natl Acad. Sci. USA 79, 1889–1892.
27. 27 Yokozaki, H., Tortora, G., Pepe, S., Maronde, E., Genieser, H.‐G., Jastorff, B. & Cho‐Chung, Y. S. (1992) Unhydrolyzablc analogues of adenosine 3′: 5′‐monophosphate demonstrating growth inhibition and differentiation in human cancer cells, Cancer Res. 52, 2504–2508.
28. 28 Posternak, T. & Weimann, G. (1974) The preparation of acylated derivatives of cyclic nucleotides, Methods Enzymol. 38, 399–409.
29. 29 Sandberg, M., Butt, E., Nolte, C., Fischer, L., Halbrügge, M., Beltman, J., Jahnsen, T., Genieser, H.‐G., Jastorff, B. & Walter, U. (1991) Characterization of S p‐5,6–dichloro‐1‐β‐d‐ribofuranosyl‐benzimidazole‐3′,5′‐monophosphorothioate (S p‐5,6‐DCIcBiMPS) as a potent and specific activator of cyclic‐AMP‐dependent protein kinase in cell extracts and intact cells, Biochem. J. 279, 521–527.
30. 30 Van Lookeren Campagne, M. M., Villalba Diaz, F., Jastorff, B., Winkler, E., Genieser, H.‐G. & Kessin, R. H. (1990) Characterization of the yeast low K m cAMP‐phosphodiesterase with cAMP analogues. Applications in mammalian cells that express the yeast PDE2 gene, J. Biol. Chem. 265, 5847–5854.
31. 31 Hidaka, H., Inagaki, M., Kawamoto, S. & Sasaki, Y. (1984) Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C, Biochemistry 23, 5036–5041.
32. 32 Kase, H., Iwahashi, K., Nakanishi, S., Matsuda, Y., Yamada, K., Takahashi, M., Murakata, C., Sato, A. & Kaneko, M. (1987) K‐252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide‐dependent protein kinases, Biochem. Biophys. Res. Commun. 142, 436–440.
33. 33 Hidaka, H. & Kobayashi, R. (1992) Pharmacology of protein kinase inhibitors, Annu. Rev. Pharmacol. Toxicol. 32, 377–397.
34. 34 Tamaoki, T., Nomoto, H., Takahashi, I., Kato, Y., Morimoto, M. & Tomita, F. (1986) Staurosporine, a potent inhibitor of phospholipid/Ca 2+ dependent protein kinase, Biochem. Biophys. Res. Commun. 135, 397–402.
35. 35 Gordon, P. B., Holen, I. & Seglen, P. O. (1995) Protection, by naringin and some other flavonoids, of hepatocytic autophagy and endocytosis against inhibition by okadaic acid, J. Biol. Chem. 270, 5830–5838.
36. 36 Nakanishi, S., Yamada, K., Iwahashi, K., Kuroda, K. & Kase, H. (1990) KT5926, a potent and selective inhibitor of myosin light chain kinase, Mol. Pharmacol. 37, 482–488.
37. 37 Tokumitsu, H., Chijiwa, T., Hagiwara, M., Mizutani, A., Terasawa, M. & Hidaka, H. (1990) KN‐62, 1–[ N,O ‐bis‐(5‐isoquinolinesulfonyl)‐ N ‐methyl‐L‐tyrosyl]‐4‐phenylpiperazine, a specific inhibitor of Ca 2+ /calmodulin‐dependent protein kinase 11, J. Biol. Chem. 265, 4315–4320.
38. 38 Häussinger, D., Hallbrucker, C., Vom Dahl, S., Decker, S., Schweizer, U., Lang, F. & Gerok, W. (1991) Cell volume is a major determinant of proteolysis control in liver, FEBS Lett. 283, 10–72.
39. 39 Poli, A., Gordon, P. B., Schwarze, P. E., Grinde, B. & Seglen, P. O. (1981) Effects of insulin and anchorage on hepatocytic protein metabolism and amino acid transport, J. Cell Sci. 48, 1–18.
40. 40 Thoresen, G. H., Sand, T.‐E., Refsnes, M., Dajani, O. F., Guren, T. K., Gladhaug, I. P., Killi, A. & Christoffersen, T. (1990) Dual effects of glucagon and cyclic AMP on DNA synthesis in cultured rat hepatocytes: Stimulatory regulation in early G 1 and inhibition shortly before the S phase entry, J. Cell. Physiol. 144, 523–530.
41. 41 Miotto, G., Venerando, R., Marin, O., Siliprandi, N. & Mortimore, G. E. (1994) lnhibition of macroautophagy and proteolysis in the isolated rat hepatocyte by a nontransportable derivative of the multiple antigen peptide Leu 8 ‐Lys 4 ‐Lys 2 ‐Lys‐βAla, J. Biol. Chem. 269, 25348–25353.
42. 42 Blommaart, E. F. C., Luiken, J. J. F. P., Blommaart, P. J. E., Van Woerkom, G. M. & Meijer, A. J. (1995) Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes, J. Biol. Chem. 270, 2320–2326.
43. 43 Gordon, P. B. & Seglen, P. O. (1982) 6–Substituted purines: a novel class of inhibitors of endogenous protein degradation in isolated rat hepatocytes, Arch. Biochem. Biophys. 217, 282–294.
44. 44 Gordon, P. B., Holen, I., Fosse, M., Røtnes, S. & Seglen, P. O. (1993) Dependence of hepatocytic autophagy on intracellularly sequestered calcium, J. Biol. Chem. 268, 26107–26112.
45. 45 Combettes, L., Berthon, H., Binet, A. & Claret, M. (1986) Glucagon and vasopressin interactions on Ca 2+ movements in isolated hepatocytes, Biochem. J. 237, 675–683.
46. 46 Blackmore, P. F. & Exton, J. H. (1986) Studies on the hepatic calcium‐mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate, J. Biol. Chem. 261, 11056–11063.
47. 47 Staddon, J. M. & Hansford, R. G. (1986) 4β‐Phorbol 12‐myristate 13‐acetate attenuates the glucagon‐induced increase in cytoplasmic free Ca 2+ concentration in isolated rat hepatocytes, Biochem. J. 238, 737–743.
48. 48 Burgess, G. M., Bird, G. S. J., Obie, J. F. & Putney, J. W. Jr (1991) The mechanism for synergism between phospholipase C‐ and adenylylcyclase‐linked hormones in liver. Cyclic AMP‐dependent kinase augments inositol trisphosphate‐mediated Ca 2+ mobilization without increasing the cellular levels of inositol polyphosphates, J. Biol. Chem. 266, 4172–4181.
49. 49 Ferris, C. D., Cameron, A. M., Bredt, D. S., Huganir, R. L. & Snyder, S. H. (1991) Inositol 1,4,5‐trisphosphate receptor is phosphorylated by cyclic AMP‐dependent protein kinase at Serines 1755 and 1589, Biochem. Biophys. Res Commun. 175, 192–198.