The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep

Biomaterials

Volumn 34, Issue 38, 2013, Pages 10267-10277

  Alton, Eric W F W ^a   Baker, Alison ^b   Baker, Eilidh ^b   Boyd, A Christopher ^c   Cheng, Seng H ^d   Coles, Rebecca L ^e   Collie, D David S ^b   Davidson, Heather ^c   Davies, Jane C ^a   Gill, Deborah R ^e   Gordon, Catherine ^b   Griesenbach, Uta ^a   Higgins, Tracy ^a   Hyde, Stephen C ^e   Innes, J Alastair ^f   McCormick, Dominique ^e   McGovern, Michael ^c   McLachlan, Gerry ^b   Porteous, David J ^c   Pringle, Ian ^e   Scheule, Ronald K ^d   Shaw, Darren J ^b   Smith, Sionagh ^b   Sumner Jones, Stephanie G ^e   Tennant, Peter ^b   Vrettou, Christina ^b   more..

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d SANOFI   (France)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Epithelium; Gene transfer; Lipid; Lung

Indexed keywords

CATIONIC LIPIDS; EPITHELIUM; INFLAMMATORY RESPONSE; LUNG; MOLECULAR ANALYSIS; PLASMID VECTORS; SERUM CHEMISTRY; TRANSFER AGENTS;

AEROSOLS; GENE THERAPY; GENE TRANSFER; LIPIDS; NUCLEIC ACIDS;

BIOLOGICAL ORGANS;

CATION; DNA; HAPTOGLOBIN; HEMOGLOBIN; LIPID; MESSENGER RNA; PLASMID VECTOR;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; CYSTIC FIBROSIS; ERYTHROCYTE; EVALUATION; FEMALE; FORCED EXPIRATORY VOLUME; FUNCTIONAL RESIDUAL CAPACITY; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; LEUKOCYTE COUNT; LEUKOCYTOSIS; LUNG; LUNG FUNCTION; LUNG LAVAGE; LUNG RESISTANCE; MACROPHAGE; MALE; MORPHOMETRICS; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; REPEATED DRUG DOSE; SAFETY; SHEEP; TOXICITY; WEIGHT GAIN;

MUS; OVIS ARIES;

EPITHELIUM; GENE TRANSFER; LIPID; LUNG;

AEROSOLS; ANIMALS; CYSTIC FIBROSIS; EPITHELIUM; FEMALE; GENE TRANSFER TECHNIQUES; LIPIDS; LUNG; MALE; SHEEP;

EID: 84885388155     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.09.023     Document Type: Article

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