-
1
-
-
0022371924
-
Free drug measurements: Methodology and clinical significance
-
Kwong TC (1985) Free drug measurements: Methodology and clinical significance. Clin Chim Acta 151: 193.
-
(1985)
Clin Chim Acta
, vol.151
, pp. 193
-
-
Kwong, T.C.1
-
2
-
-
0021368529
-
Rational for monitoring free drug level
-
Levy RH, Moreland TA (1984) Rational for monitoring free drug level. Clin Pharmacokinet 9 (Suppl 1): 1.
-
(1984)
Clin Pharmacokinet
, vol.9
, Issue.1 SUPPL.
, pp. 1
-
-
Levy, R.H.1
Moreland, T.A.2
-
3
-
-
0022969880
-
Free drug concentration monitoring in clinical practice: Rationale and current status
-
Svensson CK, Woodruff MN, Baxter JG, Lalka D (1986) Free drug concentration monitoring in clinical practice: Rationale and current status. Clin Pharmacokinet 11: 450.
-
(1986)
Clin Pharmacokinet
, vol.11
, pp. 450
-
-
Svensson, C.K.1
Woodruff, M.N.2
Baxter, J.G.3
Lalka, D.4
-
4
-
-
33750725432
-
Determination of human plasma protein binding of baicalin by ultrafiltration and high-performance liquid chromatography
-
Tang Y, Zhu H, Zhang Y, Huang C (2006) Determination of human plasma protein binding of baicalin by ultrafiltration and high-performance liquid chromatography. Biomed Chromatogr 20: 1116-1119.
-
(2006)
Biomed Chromatogr
, vol.20
, pp. 1116-1119
-
-
Tang, Y.1
Zhu, H.2
Zhang, Y.3
Huang, C.4
-
5
-
-
0019952227
-
Importance of protein binding for the interpretation of serum and plasma drug concentrations
-
Greenblatt DJ, Sellers EM, Koch-Weser J (1982) Importance of protein binding for the interpretation of serum and plasma drug concentrations. J Clin Pharmacol 22: 259-263.
-
(1982)
J Clin Pharmacol
, vol.22
, pp. 259-263
-
-
Greenblatt, D.J.1
Sellers, E.M.2
Koch-Weser, J.3
-
6
-
-
0028078870
-
Drug binding in plasma
-
Herve F, Urien S, Albengres E, Duche J (1994) Drug binding in plasma. Clin Pharmacokinet 25 (1): 44-58.
-
(1994)
Clin Pharmacokinet
, vol.25
, Issue.1
, pp. 44-58
-
-
Herve, F.1
Urien, S.2
Albengres, E.3
Duche, J.4
-
7
-
-
0033822309
-
Determination of the free fraction and relative free fraction of drugs strongly bound to plasma proteins
-
Schuhmacher J, Buhner K, Witt-Laido A (2000) Determination of the free fraction and relative free fraction of drugs strongly bound to plasma proteins. J Pharm Sci 89: 1008-1021.
-
(2000)
J Pharm Sci
, vol.89
, pp. 1008-1021
-
-
Schuhmacher, J.1
Buhner, K.2
Witt-Laido, A.3
-
8
-
-
0021933045
-
Responsiveness to oral diazepam in the elderly: Relationship to total and free plasma concentrations
-
Swift CG, Ewin JM, Clark P, Stevenson IH (1985) Responsiveness to oral diazepam in the elderly: Relationship to total and free plasma concentrations. Br J Clin Pharmacol 20 (2): 111-118.
-
(1985)
Br J Clin Pharmacol
, vol.20
, Issue.2
, pp. 111-118
-
-
Swift, C.G.1
Ewin, J.M.2
Clark, P.3
Stevenson, I.H.4
-
9
-
-
0020511430
-
Plasma and tissue binding considerations in drug disposition
-
Wilkinson GR (1983) Plasma and tissue binding considerations in drug disposition. Drug Metab Rev 14: 427-465.
-
(1983)
Drug Metab Rev
, vol.14
, pp. 427-465
-
-
Wilkinson, G.R.1
-
10
-
-
0019370331
-
Concepts basic to pharmacokinetics
-
Tozer TN (1981) Concepts basic to pharmacokinetics. Pharmacol Ther 12: 109-131.
-
(1981)
Pharmacol Ther
, vol.12
, pp. 109-131
-
-
Tozer, T.N.1
-
11
-
-
34447503927
-
The importance of plasma protein binding in drug discovery
-
Trainor GL (2007) The importance of plasma protein binding in drug discovery. Expert Opin Drug Discov 2 (1): 51-64.
-
(2007)
Expert Opin Drug Discov
, vol.2
, Issue.1
, pp. 51-64
-
-
Trainor, G.L.1
-
12
-
-
34648813134
-
High throughput screening of physiochemical properties and in vitro ADME profiling in drug discovery
-
Wan H, Holmen AG (2007) High throughput screening of physiochemical properties and in vitro ADME profiling in drug discovery. Comb Chem High Throughput Screen 50: 4606-4615.
-
(2007)
Comb Chem High Throughput Screen
, vol.50
, pp. 4606-4615
-
-
Wan, H.1
Holmen, A.G.2
-
13
-
-
0017099526
-
Plasma and tissue protein binding of drugs in pharmacokinetics
-
Jusko WJ, Gretch M (1976) Plasma and tissue protein binding of drugs in pharmacokinetics. Drug Metab Rev 5 (1): 42-139.
-
(1976)
Drug Metab Rev
, vol.5
, Issue.1
, pp. 42-139
-
-
Jusko, W.J.1
Gretch, M.2
-
14
-
-
0023129495
-
Plasma protein binding of drugs in the elderly
-
Wallace WM, Verbeek RK (1987) Plasma protein binding of drugs in the elderly. Clin Pharmacokinet 12: 40-72.
-
(1987)
Clin Pharmacokinet
, vol.12
, pp. 40-72
-
-
Wallace, W.M.1
Verbeek, R.K.2
-
15
-
-
0025302891
-
Disease-induced variations in plasma protein levels
-
Zini R, Riant P, Barre J, Tillement JP (1990) Disease-induced variations in plasma protein levels. Clin Pharmacokinet 19 (2): 147-159.
-
(1990)
Clin Pharmacokinet
, vol.19
, Issue.2
, pp. 147-159
-
-
Zini, R.1
Riant, P.2
Barre, J.3
Tillement, J.P.4
-
16
-
-
0018867602
-
Lidocaine plasma protein binding
-
Routledge PA, Barchowsky A, Bjornsson A, Kitchell BB, Shand DG (1980) Lidocaine plasma protein binding. Clin Pharmacol Ther 26 (3): 336-347.
-
(1980)
Clin Pharmacol Ther
, vol.26
, Issue.3
, pp. 336-347
-
-
Routledge, P.A.1
Barchowsky, A.2
Bjornsson, A.3
Kitchell, B.B.4
Shand, D.G.5
-
17
-
-
0035038596
-
Development of a high throughput equilibrium dialysis method
-
Kariv I, Cao H, Oldenburg KR (2001) Development of a high throughput equilibrium dialysis method. J Pharm Sci 90: 580-587.
-
(2001)
J Pharm Sci
, vol.90
, pp. 580-587
-
-
Kariv, I.1
Cao, H.2
Oldenburg, K.R.3
-
18
-
-
0029922030
-
Drug-protein binding studies new trends in analytical and experimental methodology
-
Oravcova J, Bohs B, Lindner W (1996) Drug-protein binding studies new trends in analytical and experimental methodology. J Chromatogr B 677: 1-28.
-
(1996)
J Chromatogr B
, vol.677
, pp. 1-28
-
-
Oravcova, J.1
Bohs, B.2
Lindner, W.3
-
19
-
-
33646492476
-
Measurement of drug-protein binding by immobilized human serum albumin-HPLC and comparison with ultrafiltration
-
Singh SS, Mehta J (2006) Measurement of drug-protein binding by immobilized human serum albumin-HPLC and comparison with ultrafiltration. J Chromatogr B 834: 108-116.
-
(2006)
J Chromatogr B
, vol.834
, pp. 108-116
-
-
Singh, S.S.1
Mehta, J.2
-
21
-
-
84886145896
-
-
eds., 7th ed. New York, NY: MacMillan, 12, 54, 889
-
Gilman AG, Goodman LS, Rall TW, Murad F, eds. Goodman and Gilman' s The Pharmacological Basis of Therapeutics, 7th ed., New York, NY: MacMillan, 1985: 12, 54, 889, 1664-1735.
-
Goodman and Gilman's The Pharmacological Basis of Therapeutics
, vol.54
, pp. 1664-1735
-
-
Gilman, A.G.1
Goodman, L.S.2
Rall, T.W.3
Murad, F.4
-
22
-
-
0026457029
-
Methods of determining plasma and tissue binding of drugs
-
Pacifici GM, Viani A (1992) Methods of determining plasma and tissue binding of drugs. Clin Pharmacokinet 23: 449-468.
-
(1992)
Clin Pharmacokinet
, vol.23
, pp. 449-468
-
-
Pacifici, G.M.1
Viani, A.2
-
23
-
-
0025697267
-
Methods of drug protein binding determinations
-
Sebille B (1990) Methods of drug protein binding determinations. Fundam Clin Pharmacol 4 (Suppl 2): 151-161.
-
(1990)
Fundam Clin Pharmacol
, vol.4
, Issue.2 SUPPL.
, pp. 151-161
-
-
Sebille, B.1
-
24
-
-
0020041039
-
Equilibrium dialysis for determination of protein binding of imipramine-evaluation of a method
-
Kristensen CB, Gram LF (1982) Equilibrium dialysis for determination of protein binding of imipramine-evaluation of a method. Acta Pharmacol Toxicol (Copenh) 50: 129-135.
-
(1982)
Acta Pharmacol Toxicol (Copenh)
, vol.50
, pp. 129-135
-
-
Kristensen, C.B.1
Gram, L.F.2
-
26
-
-
0021959569
-
Factors affecting the measurement of lidocaine protein binding by equilibrium dialysis in human serum
-
Ponganis KV, Stanski DR (1985) Factors affecting the measurement of lidocaine protein binding by equilibrium dialysis in human serum. J Pharm Sci 74 (1): 57-60.
-
(1985)
J Pharm Sci
, vol.74
, Issue.1
, pp. 57-60
-
-
Ponganis, K.V.1
Stanski, D.R.2
-
27
-
-
33747174872
-
Determination of drug plasma protein binding by solid phase microextraction
-
Musteata FM, Pawliszyn J, Qian MG, Wu JT, Miwa GT (2006) Determination of drug plasma protein binding by solid phase microextraction. J Pharm Sci 95(8): 1712-1722.
-
(2006)
J Pharm Sci
, vol.95
, Issue.8
, pp. 1712-1722
-
-
Musteata, F.M.1
Pawliszyn, J.2
Qian, M.G.3
Wu, J.T.4
Miwa, G.T.5
-
28
-
-
0142217486
-
Shift in pH of biological fluids during storage and processing: Effect on bioanalysis
-
Fura A, Harper TW, Zhang H, Fung L, Shyu WC (2003) Shift in pH of biological fluids during storage and processing: Effect on bioanalysis. J Pharm Biomed Anal 32: 513-522.
-
(2003)
J Pharm Biomed Anal
, vol.32
, pp. 513-522
-
-
Fura, A.1
Harper, T.W.2
Zhang, H.3
Fung, L.4
Shyu, W.C.5
-
29
-
-
84886167829
-
Alternative Automated Methods for Free Fraction Determination in Tissue and Plasma
-
Boston, MA
-
Lloyd TL, Ghupur A, Chun A, Sears S, Liu Z (2009) Alternative Automated Methods for Free Fraction Determination in Tissue and Plasma. Applied Pharmaceutical Analysis Conference on September 16, 2009, in Boston, MA.
-
(2009)
Applied Pharmaceutical Analysis Conference on September
, vol.16
, pp. 2009
-
-
Lloyd, T.L.1
Ghupur, A.2
Chun, A.3
Sears, S.4
Liu, Z.5
-
30
-
-
55749099657
-
Validation of a rapid equilibrium dialysis approach for the measurement of plasma protein binding
-
Waters NJ, Jones R, Williams G, Sohal B (2007) Validation of a rapid equilibrium dialysis approach for the measurement of plasma protein binding. J Pharm Sci 97 (10): 4586-4595.
-
(2007)
J Pharm Sci
, vol.97
, Issue.10
, pp. 4586-4595
-
-
Waters, N.J.1
Jones, R.2
Williams, G.3
Sohal, B.4
-
31
-
-
0031915533
-
Rapid determination of oral pharmacokinetics and plasma free fraction using cocktail approaches: Methods and applications
-
Allen MC, Shah TS, Day WW (1998) Rapid determination of oral pharmacokinetics and plasma free fraction using cocktail approaches: Methods and applications. Pharm Res 15 (1): 93-97.
-
(1998)
Pharm Res
, vol.15
, Issue.1
, pp. 93-97
-
-
Allen, M.C.1
Shah, T.S.2
Day, W.W.3
-
32
-
-
0036891924
-
Microsomal protein concentration modifies the apparent inhibitory potency of CYP3A inhibitors
-
Tran TH, Von Moltke LL, Venkatakrishnan K, Granda BW, Gibbs MA, Obach RS, Harmatz JS, Greenblatt DJ (2002) Microsomal protein concentration modifies the apparent inhibitory potency of CYP3A inhibitors. Drug Metab Dispos 30 (12): 1441-1445.
-
(2002)
Drug Metab Dispos
, vol.30
, Issue.12
, pp. 1441-1445
-
-
Tran, T.H.1
Von Moltke, L.L.2
Venkatakrishnan, K.3
Granda, B.W.4
Gibbs, M.A.5
Obach, R.S.6
Harmatz, J.S.7
Greenblatt, D.J.8
-
33
-
-
33645045860
-
Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids
-
Taylor S, Harker A (2005) Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids. J Pharm Biomed Anal 41: 299-303.
-
(2005)
J Pharm Biomed Anal
, vol.41
, pp. 299-303
-
-
Taylor, S.1
Harker, A.2
-
34
-
-
0141537961
-
Semi-automatic high-throughput determination of plasma protein binding using a 96-well plate filtrate assembly and fast liquid chromatography-tandem mass spectrometry
-
Fung EN, Chen YH, Lau YY (2003) Semi-automatic high-throughput determination of plasma protein binding using a 96-well plate filtrate assembly and fast liquid chromatography-tandem mass spectrometry. J Chromatogr B 795: 187-194.
-
(2003)
J Chromatogr B
, vol.795
, pp. 187-194
-
-
Fung, E.N.1
Chen, Y.H.2
Lau, Y.Y.3
-
35
-
-
34648813134
-
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery
-
Wan H, Rehngren M, Giordanetto F, Bergstrom F, Tunek A (2007) High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery. J Med Chem 50: 4606-4615.
-
(2007)
J Med Chem
, vol.50
, pp. 4606-4615
-
-
Wan, H.1
Rehngren, M.2
Giordanetto, F.3
Bergstrom, F.4
Tunek, A.5
-
36
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.1
-
37
-
-
0037407697
-
Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein binding
-
Banker MJ, Clark TH, Williams JA (2002) Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein binding. J Pharm Sci 92: 967-974.
-
(2002)
J Pharm Sci
, vol.92
, pp. 967-974
-
-
Banker, M.J.1
Clark, T.H.2
Williams, J.A.3
-
38
-
-
0021044384
-
Errors in estimating the unbound fraction of drugs due to the volume shift in equilibrium dialysis
-
Huang J (1983) Errors in estimating the unbound fraction of drugs due to the volume shift in equilibrium dialysis. J Pharm Sci 72: 1358-1359.
-
(1983)
J Pharm Sci
, vol.72
, pp. 1358-1359
-
-
Huang, J.1
-
39
-
-
0020962854
-
Influence of volume shifts on drug binding during equilibrium dialysis: Correction and attenuation
-
Lima J, MacKichan JJ, Libertin N, Sabino J (1983) Influence of volume shifts on drug binding during equilibrium dialysis: Correction and attenuation. J Pharmacokinet Biopharm 11: 483-498.
-
(1983)
J Pharmacokinet Biopharm
, vol.11
, pp. 483-498
-
-
Lima, J.1
MacKichan, J.J.2
Libertin, N.3
Sabino, J.4
-
40
-
-
0021276141
-
Fluid shifts and other factors affecting plasma protein binding of prednisolone by equilibrium dialysis
-
Boudinot FD, Jusko WJ (1984) Fluid shifts and other factors affecting plasma protein binding of prednisolone by equilibrium dialysis. J Pharm Sci 73: 774-780.
-
(1984)
J Pharm Sci
, vol.73
, pp. 774-780
-
-
Boudinot, F.D.1
Jusko, W.J.2
-
41
-
-
0021950576
-
Simultaneous correction for volume shifts and leakage in equilibrium dialysis protein binding experiments
-
Khor SP, Wu HJ, Boxenbaum H (1985) Simultaneous correction for volume shifts and leakage in equilibrium dialysis protein binding experiments. Int J Pharm 23: 109-113.
-
(1985)
Int J Pharm
, vol.23
, pp. 109-113
-
-
Khor, S.P.1
Wu, H.J.2
Boxenbaum, H.3
-
42
-
-
0023197956
-
Computation of the effect of Donnan equilibrium on pH in equilibrium dialysis
-
Mapleson WW (1987) Computation of the effect of Donnan equilibrium on pH in equilibrium dialysis. J Pharmacol Methods 17: 231-242.
-
(1987)
J Pharmacol Methods
, vol.17
, pp. 231-242
-
-
Mapleson, W.W.1
-
43
-
-
0015507411
-
Measurements of the molecular weight variability of plasma low density lipoproteins among normals and subjects with hyper-b-lipoproteinemia
-
Fisher WR, Hammond MG, Warmke GL (1972) Measurements of the molecular weight variability of plasma low density lipoproteins among normals and subjects with hyper-b-lipoproteinemia. Biochemistry 11: 519-525.
-
(1972)
Biochemistry
, vol.11
, pp. 519-525
-
-
Fisher, W.R.1
Hammond, M.G.2
Warmke, G.L.3
-
44
-
-
0021806854
-
Equilibrium dialysis, ultrafiltration and ultracentrifugation compared for determining the plasma-protein-binding characteristics of valproic acid
-
Barre J, Chamouard JM, Houin G, Tillement JP (1985) Equilibrium dialysis, ultrafiltration and ultracentrifugation compared for determining the plasma-protein-binding characteristics of valproic acid. Clin Chem 31: 60-64.
-
(1985)
Clin Chem
, vol.31
, pp. 60-64
-
-
Barre, J.1
Chamouard, J.M.2
Houin, G.3
Tillement, J.P.4
-
45
-
-
0028256512
-
Protein binding of tirilazad (U-74006) in human, Sprague-Dawley rat, beagle dog and cynomolgus monkey serum
-
Bombardt PA, Brewer JE, Johnson MG (1994) Protein binding of tirilazad (U-74006) in human, Sprague-Dawley rat, beagle dog and cynomolgus monkey serum. J Pharmacol Exp Ther 269: 145-150.
-
(1994)
J Pharmacol Exp Ther
, vol.269
, pp. 145-150
-
-
Bombardt, P.A.1
Brewer, J.E.2
Johnson, M.G.3
-
46
-
-
0344365022
-
Methods in drug protein binding analysis
-
Kuemmerle H, Shibuya T, Tillement J.P eds. Oxford, U.K: Elsevier Science
-
Zini R Methods in drug protein binding analysis. In Human Pharmacology. The Basis of Clinical Pharmacology, Kuemmerle H, Shibuya T, Tillement JP eds. Oxford, UK: Elsevier Science, 1991: 235-282.
-
(1991)
Human Pharmacology. The Basis of Clinical Pharmacology
, pp. 235-282
-
-
Zini, R.1
-
47
-
-
0017756159
-
Evaluation of methods to determine protein-binding of drugs. Equilibrium dialysis, ultrafiltration, ultracentrifugation, gel filtration
-
Kurz H, Trunk H, Weitz B (1977) Evaluation of methods to determine protein-binding of drugs. Equilibrium dialysis, ultrafiltration, ultracentrifugation, gel filtration. Arzneimittelforschung 27: 1373-1380.
-
(1977)
Arzneimittelforschung
, vol.27
, pp. 1373-1380
-
-
Kurz, H.1
Trunk, H.2
Weitz, B.3
-
48
-
-
0023251121
-
Cyclosporin: Measurement of fraction unbound in plasma
-
Legg B, Rowland M (1987) Cyclosporin: Measurement of fraction unbound in plasma. J Pharm Pharmacol 39: 599-603.
-
(1987)
J Pharm Pharmacol
, vol.39
, pp. 599-603
-
-
Legg, B.1
Rowland, M.2
-
49
-
-
1842534877
-
Evaluation of the protein binding ratio of drugs by a micro-scale ultracentrifugation method
-
Nakai D, Kumamoto K, Sakikawa C, Kosaka T, Tokui T (2003) Evaluation of the protein binding ratio of drugs by a micro-scale ultracentrifugation method. J Pharm Sci 93 (4): 847-854.
-
(2003)
J Pharm Sci
, vol.93
, Issue.4
, pp. 847-854
-
-
Nakai, D.1
Kumamoto, K.2
Sakikawa, C.3
Kosaka, T.4
Tokui, T.5
-
50
-
-
84886217785
-
-
Cross-validation of a reduced volume, semi-automated ultracentrifugation process for assessing protein binding in plasma and microsomes to improve efficiency and capacity. Eastern Analytical Symposium, Somerset, NJ, November
-
Adams W, Ghupur A, Lloyd TL (2009) Cross-validation of a reduced volume, semi-automated ultracentrifugation process for assessing protein binding in plasma and microsomes to improve efficiency and capacity. Eastern Analytical Symposium, Somerset, NJ, November 18, 2009.
-
(2009)
, vol.18
, pp. 2009
-
-
Adams, W.1
Ghupur, A.2
Lloyd, T.L.3
-
51
-
-
33644618915
-
Determination of the extent of protein binding of antibiotics by means of an automated continuous ultrafiltration method
-
Heinze A, Holzgrabe U (2006) Determination of the extent of protein binding of antibiotics by means of an automated continuous ultrafiltration method. Int J Pharm 311: 108-112.
-
(2006)
Int J Pharm
, vol.311
, pp. 108-112
-
-
Heinze, A.1
Holzgrabe, U.2
-
52
-
-
0029122420
-
Automated analysis of free and total concentrations of three antiepileptic drugs in plasma with on-line dialysis and high-performance liquid chromatography
-
Johansen K, Krogh M, Andresen AT, Christophersen AS, Lehne G, Rasmussen KE (2005) Automated analysis of free and total concentrations of three antiepileptic drugs in plasma with on-line dialysis and high-performance liquid chromatography. J Chromatogr B 669 (2): 281-288.
-
(2005)
J Chromatogr B
, vol.669
, Issue.2
, pp. 281-288
-
-
Johansen, K.1
Krogh, M.2
Andresen, A.T.3
Christophersen, A.S.4
Lehne, G.5
Rasmussen, K.E.6
-
53
-
-
0038442626
-
Automated determination of free mycophenolic acid and its glucuronide in plasma from renal allograft recipients
-
Mandla R, Line PD, Midtvedt K, Bergan S (2003) Automated determination of free mycophenolic acid and its glucuronide in plasma from renal allograft recipients. Ther Drug Monit 25 (3): 407-414.
-
(2003)
Ther Drug Monit
, vol.25
, Issue.3
, pp. 407-414
-
-
Mandla, R.1
Line, P.D.2
Midtvedt, K.3
Bergan, S.4
-
54
-
-
33847378085
-
AAPS-FDA workshop white paper: Microdialysis principles, application, and regulatory perspectives report from the joint AAPS-FDA workshop, November 4-5, 2005, Nashville, TN
-
Chaurasia CS, et al. (2007) AAPS-FDA workshop white paper: Microdialysis principles, application, and regulatory perspectives report from the joint AAPS-FDA workshop, November 4-5, 2005, Nashville, TN. AAPS J 9 (1): 48-59.
-
(2007)
AAPS J
, vol.9
, Issue.1
, pp. 48-59
-
-
Chaurasia, C.S.1
-
55
-
-
0025994730
-
Microdialysis-principles and applications for studies in animals and man
-
Ungerstedt U (1991) Microdialysis-principles and applications for studies in animals and man. J Intern Med 230: 365-373.
-
(1991)
J Intern Med
, vol.230
, pp. 365-373
-
-
Ungerstedt, U.1
-
56
-
-
0027932979
-
The effect of inhibition of synthesis, release, metabolism and uptake on the microdialysis extraction fraction of dopamine
-
Smith AD, Justice JB (1994) The effect of inhibition of synthesis, release, metabolism and uptake on the microdialysis extraction fraction of dopamine. J Neurosci 54: 75-82.
-
(1994)
J Neurosci
, vol.54
, pp. 75-82
-
-
Smith, A.D.1
Justice, J.B.2
-
57
-
-
77955933364
-
Drug-protein binding: A critical review of analytical tools
-
Vuignier K, Schappler J, Veuthey JL, Carrupt PA, Martel S (2010) Drug-protein binding: A critical review of analytical tools. Anal Bioanal Chem 398: 53-66.
-
(2010)
Anal Bioanal Chem
, vol.398
, pp. 53-66
-
-
Vuignier, K.1
Schappler, J.2
Veuthey, J.L.3
Carrupt, P.A.4
Martel, S.5
-
58
-
-
18644382732
-
Early absorption and distribution analysis of antitumor and anti-AIDS drugs: Lipid membrane and plasma protein interactions
-
Cimitan S, Lindgren MT, Bertucci C, Danielson UH (2005) Early absorption and distribution analysis of antitumor and anti-AIDS drugs: Lipid membrane and plasma protein interactions. J Med Chem 48 (10): 3536-3546.
-
(2005)
J Med Chem
, vol.48
, Issue.10
, pp. 3536-3546
-
-
Cimitan, S.1
Lindgren, M.T.2
Bertucci, C.3
Danielson, U.H.4
-
59
-
-
13344250393
-
Why you should be using more SPR biosensor technology
-
Rich RL, Myszka DG (2004) Why you should be using more SPR biosensor technology. Drug Discov Today Technol 1: 301-308.
-
(2004)
Drug Discov Today Technol
, vol.1
, pp. 301-308
-
-
Rich, R.L.1
Myszka, D.G.2
-
60
-
-
41849121510
-
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin
-
Lazaro E, Lowe PJ, Briand X, Faller B (2008) New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin. J Med Chem 51: 2009-2017.
-
(2008)
J Med Chem
, vol.51
, pp. 2009-2017
-
-
Lazaro, E.1
Lowe, P.J.2
Briand, X.3
Faller, B.4
-
62
-
-
1842482952
-
High-throughput determination of the free fraction of drugs strongly bound to plasma proteins
-
Schuhmacher J, Kohlsdorfer C, Buhner K, Brandenburger T, Kruk R (2004) High-throughput determination of the free fraction of drugs strongly bound to plasma proteins. J Pharm Sci 93: 816-830.
-
(2004)
J Pharm Sci
, vol.93
, pp. 816-830
-
-
Schuhmacher, J.1
Kohlsdorfer, C.2
Buhner, K.3
Brandenburger, T.4
Kruk, R.5
-
63
-
-
9944250646
-
Synthesis and chromatographic properties of an HPLC chiral stationary phase based upon human serum-albumin
-
Domenici E, Bertucci C, Salvadori P, Felix G, Cahagne I, Motellier S, Wainer IW (1990) Synthesis and chromatographic properties of an HPLC chiral stationary phase based upon human serum-albumin. Chromatographia 29: 170-176.
-
(1990)
Chromatographia
, vol.29
, pp. 170-176
-
-
Domenici, E.1
Bertucci, C.2
Salvadori, P.3
Felix, G.4
Cahagne, I.5
Motellier, S.6
Wainer, I.W.7
-
64
-
-
0242579902
-
Drug affinity to immobilized target bio-polymers by high-performance liquid chromatography and capillary electrophoresis
-
Bertucci C, Bartolini M, Gotti R, Andrisano V (2003) Drug affinity to immobilized target bio-polymers by high-performance liquid chromatography and capillary electrophoresis. J Chromatogr B 797: 111-129.
-
(2003)
J Chromatogr B
, vol.797
, pp. 111-129
-
-
Bertucci, C.1
Bartolini, M.2
Gotti, R.3
Andrisano, V.4
-
65
-
-
27644512443
-
Immobilization of alpha(1)-acid glycoprotein for chromatographic studies of drug-protein binding
-
Xuan H, Hage DS (2005) Immobilization of alpha(1)-acid glycoprotein for chromatographic studies of drug-protein binding. Anal Biochem 346: 300-310.
-
(2005)
Anal Biochem
, vol.346
, pp. 300-310
-
-
Xuan, H.1
Hage, D.S.2
-
66
-
-
71749091417
-
Analysis of drug interactions with high-density lipoprotein by high-performance affinity chromatography
-
Chen S, Sobansky MR, Hage DS (2010) Analysis of drug interactions with high-density lipoprotein by high-performance affinity chromatography. Anal Biochem 397: 107-114.
-
(2010)
Anal Biochem
, vol.397
, pp. 107-114
-
-
Chen, S.1
Sobansky, M.R.2
Hage, D.S.3
-
67
-
-
3042623987
-
The Hummel-Dreyer method: Impact in pharmacology
-
Soltes L (2004) The Hummel-Dreyer method: Impact in pharmacology. Biomed Chromatogr 18: 259-271.
-
(2004)
Biomed Chromatogr
, vol.18
, pp. 259-271
-
-
Soltes, L.1
-
68
-
-
0030822425
-
Recent advances in chromatographic and electrophoretic methods for the study of drug-protein interactions
-
Hage DS, Tweed SA (1997) Recent advances in chromatographic and electrophoretic methods for the study of drug-protein interactions. J Chromatogr B 699: 499-525.
-
(1997)
J Chromatogr B
, vol.699
, pp. 499-525
-
-
Hage, D.S.1
Tweed, S.A.2
-
69
-
-
0032698669
-
Identification, quantitation and characterization of biomolecules by capillary electrophoretic analysis of binding interactions
-
Heegaard NHH, Kennedy RT (1999) Identification, quantitation and characterization of biomolecules by capillary electrophoretic analysis of binding interactions. Electrophoresis 20: 3122-3133.
-
(1999)
Electrophoresis
, vol.20
, pp. 3122-3133
-
-
Heegaard, N.H.H.1
Kennedy, R.T.2
-
70
-
-
0036874825
-
Influence of nonspecific brain and plasma binding on C.N.S exposure: Implications for rational drug discovery
-
Kalvass JC, Maurer TS (2002) Influence of nonspecific brain and plasma binding on CNS exposure: Implications for rational drug discovery. Biopharm Drug Dispos 23: 327-338.
-
(2002)
Biopharm Drug Dispos
, vol.23
, pp. 327-338
-
-
Kalvass, J.C.1
Maurer, T.S.2
-
71
-
-
45949107902
-
On the rate and extent of drug delivery to the brain
-
Hammarlund-Udenaes M, Friden M, Syvanen S, Gupta A (2007) On the rate and extent of drug delivery to the brain. Pharm Res 25 (8): 1737-1750.
-
(2007)
Pharm Res
, vol.25
, Issue.8
, pp. 1737-1750
-
-
Hammarlund-Udenaes, M.1
Friden, M.2
Syvanen, S.3
Gupta, A.4
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