Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast cancer by silencing manganese superoxide dismutase (MnSOD)

Biomaterials

Volumn 34, Issue 38, 2013, Pages 10228-10237

  Cho, Soo Kyung ^a   Pedram, Ali ^b,c   Levin, Ellis R ^b,c   Kwon, Young Jik ^a,c  

^a University of California at Irvine   (United States)

^b VA LONG BEACH HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Drug resistant tumor model; Gene therapy; RNA interference; Stimuli responsive nanoparticles

Indexed keywords

CORE-SHELL NANOPARTICLES; ENDOSOMAL COMPARTMENTS; HISTOLOGICAL OBSERVATIONS; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; STIMULI-RESPONSIVE; TUMOR MODELS;

BODY FLUIDS; CELL DEATH; CHEMOTHERAPY; DISEASES; ELECTROPHORESIS; GENE THERAPY; NANOPARTICLES; OXYGEN; PHOTOPOLYMERIZATION; RESTORATION; RNA; TUMORS;

SHELLS (STRUCTURES);

ACETAL; HEPARAN SULFATE; MANGANESE SUPEROXIDE DISMUTASE; NANOPARTICLE; POLYAMIDOAMINE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TAMOXIFEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER RESISTANCE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; GEL ELECTROPHORESIS; GENE SILENCING; GENETIC TRANSFECTION; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; POLYMERIZATION; PRIORITY JOURNAL; RNA INTERFERENCE;

APOPTOSIS; DRUG-RESISTANT TUMOR MODEL; GENE THERAPY; RNA INTERFERENCE; STIMULI-RESPONSIVE NANOPARTICLES;

ACIDS; ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE SILENCING; HUMANS; MICE; MICE, NUDE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; SUPEROXIDE DISMUTASE; TAMOXIFEN;

EID: 84885373235     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.09.003     Document Type: Article

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