Small molecule inhibitors of protein interaction with glycosaminoglycans (SMIGs), a novel class of bioactive agents with anti-inflammatory properties

Biochimica et Biophysica Acta - General Subjects

Volumn 1840, Issue 1, 2014, Pages 245-254

  Harris, Nicholas ^a,b   Kogan, Faina Yurgenzon ^a   Il'Kova, Gabriela ^c,e   Juhas, Stefan ^c,f   Lahmy, Orly ^a   Gregor, Yevgeniya I ^a   Koppel, Juraj ^c   Zhuk, Regina ^a   Gregor, Paul ^a,d,e  

^a Rimonyx Pharmaceuticals Ltd   (Israel)

^b ORT BRAUDE COLLEGE   (Israel)

^c INSTITUTE OF ANIMAL PHYSIOLOGY   (Slovakia)

^d GISMO Therapeutics Inc   (United States)

^e GYN FIV as   (Slovakia)

^f INSTITUTE OF ANIMAL PHYSIOLOGY AND GENETICS   (Czech Republic)

Author keywords

Cytokine; Glycosaminoglycan; Heparan sulfate; Heparin binding protein; Inflammation; L selectin

Indexed keywords

2 [[4 [(DIETHYLAMINO)SULFONYL]BENZOYL]AMINO] 3 (BENZOTHIAZOL 2 YL) 6 ETHYL 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE; 2 [[4 [(ETHYLBUTYLAMINO)SULFONYL]BENZOYL]AMINO] 3 (BENZOTHIAZOL 2 YL) 6 ETHYL 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE; 2 [[4 [[ETHYL(PHENYLMETHYL)AMINO]SULFONYL]BENZOYL]AMINO] 6 ETHYL 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXAMIDE; 2 [[[4 (3,4 DIHYDRO 1(2H)QUINOLINYL)SULFONYL]BENZOYL]AMINO] 4,5,6,7 TETRAHYDRO 5,5,7,7 TETRAMETHYLTHIENO[2,3 C]PYRIDINE 3 CARBOXAMIDE; 2 [[[4 (3,4 DIHYDRO 2(1H) ISOQUINOLINYL)SULFONYL]BENZOYL]AMINO] 6 (1 METHYLETHYL) 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDINE 3 CARBOXAMIDE; AMYLOID BETA PROTEIN INHIBITOR; ANTIINFLAMMATORY AGENT; CHLOROQUINE; DEXAMETHASONE; DICLOFENAC; FUCOIDIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10 INHIBITOR; GLYCOSAMINOGLYCAN; INDOMETACIN; INTERLEUKIN 6 INHIBITOR; INTERLEUKIN 8 INHIBITOR; RADEZOLID; RX 0023; RX 0025; RX 0222; RX 101; RX 102; RX 104; RX 105; RX 106; RX 110; RX 111; SELECTIN INHIBITOR; SMALL MOLECULE INHIBITOR; TILORONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DRUG BINDING; DRUG DOSE COMPARISON; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PAW EDEMA; PERITONITIS; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VALIDATION STUDY;

ANIMALIA; BOVINAE;

CYTOKINE; DELAYED-TYPE HYPERSENSITIVITY; DTH; GAG; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; HEPARIN BINDING PROTEIN; HS-GAG; INFLAMMATION; L-SELECTIN; SMALL MOLECULE INHIBITORS OF PROTEIN INTERACTION WITH GLYCOSAMINOGLYCANS; SMIG OR SMIGS; VASCULAR ENDOTHELIAL GROWTH FACTOR; VEGF;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CATTLE; CHEMOKINES; CYTOKINES; EDEMA; GLYCOSAMINOGLYCANS; HEPARIN; HEPARITIN SULFATE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNOGLOBULIN G; INFLAMMATION; L-SELECTIN; LEUKOCYTES; MICE; MICE, INBRED BALB C; MICE, INBRED ICR; MOLECULAR STRUCTURE; NEUTROPHILS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; SMALL MOLECULE LIBRARIES;

EID: 84885344093     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.09.023     Document Type: Article

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