Expression of verocytotoxic Escherichia coli antigens in tobacco seeds and evaluation of gut immunity after oral administration in mouse model

Journal of Veterinary Science

Volumn 14, Issue 3, 2013, Pages 263-270

  Rossi, Luciana ^a   Di Giancamillo, Alessia ^a   Reggi, Serena ^b   Domeneghini, Cinzia ^a   Baldi, Antonella ^a   Sala, Vittorio ^a   Dell'Orto, Vittorio ^a   Coddens, Annelies ^c   Cox, Eric ^c   Fogher, Corrado ^d  

^a UNIVERSITY OF MILAN   (Italy)

^b Plantechno srl   (Italy)

^c GHENT UNIVERSITY   (Belgium)

^d UNIVERSITÀ CATTOLICA DEL SACRO CUORE   (Italy)

Author keywords

Agrobacterium tumefaciens; Edible vaccines; Escherichia coli; Pig; Verocytotoxins

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL VACCINE; ESCHERICHIA COLI PROTEIN; FEDA PROTEIN, E COLI; FIMBRIA PROTEIN; SHIGA TOXIN 2 B SUBUNIT; VEROTOXIN 2; VIRULENCE FACTOR;

AGROBACTERIUM TUMEFACIENS; ANIMAL; ANIMAL DISEASE; ANIMAL MODEL; ARTICLE; BAGG ALBINO MOUSE; EDEMA DISEASE OF SWINE; EDIBLE VACCINES; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; FEMALE; GENETIC ENGINEERING; GENETICS; IMMUNOLOGY; INTESTINE; METABOLISM; MICROBIOLOGY; MOUSE; ORAL DRUG ADMINISTRATION; PATHOGENICITY; PATHOLOGY; PLANT SEED; SHIGA TOXIN PRODUCING ESCHERICHIA COLI; SWINE; TOBACCO; TRANSGENIC PLANT; VEROCYTOTOXINS;

AGROBACTERIUM TUMEFACIENS; EDIBLE VACCINES; ESCHERICHIA COLI; PIG; VEROCYTOTOXINS;

ADMINISTRATION, ORAL; AGROBACTERIUM TUMEFACIENS; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; EDEMA DISEASE OF SWINE; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; FEMALE; FIMBRIAE PROTEINS; GENETIC ENGINEERING; INTESTINES; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; PLANTS, GENETICALLY MODIFIED; SEEDS; SHIGA TOXIN 2; SHIGA-TOXIGENIC ESCHERICHIA COLI; SWINE; TOBACCO; VIRULENCE FACTORS;

EID: 84885335859     PISSN: 1229845X     EISSN: 1976555X     Source Type: Journal    
DOI: 10.4142/jvs.2013.14.3.263     Document Type: Article

References (34)

1. Cheng D, Sun H, Xu J, Gao S. Prevalence of fimbial colonization factors F18ab and F18ac in Escherichia coli isolates from weaned piglets with edema and/or diarrhea in China. Vet Microbiol 2005, 110, 35-39.
2. Chen X, Gao S, Jiao X, Liu XF. Prevalence of serogroups and virulence factors of Escherichia coli strains isolated from pigs with postweaning diarrhoea in eastern China. Vet Microbiol 2004, 103, 13-20.
3. Coddens A, Diswall M, Ångström J, Brelmer ME, Goddeeris B, Cox E, Teneberg S. Recognition of blood group ABH type 1 determinants by the FedF adhesin of F18-fimbriated Escherichia coli. J Biol Chem 2009, 284,9713-9726.
4. Daniell H, Singh ND, Mason H, Streatfield SJ. Plant-made vaccine antigens and biopharmaceuticals. Trends Plant Sci2009, 14, 669-679.
5. Di Giancamillo A, Vitari F, Bosi G, Savoini G, Domeneghini C. The chemical code of porcine enteric neurons and the number of enteric glial cells are altered by dietary probiotics. Neurogastroenterol Motil 2010, 22, e271-278.
6. Doyle JJ, Doyle JL. A rapid DNA isolation procedure for small quantities of fresh leaf tissue. Phytochem Bull 1987,19, 11-15.
7. Fagan PK, Hornitzky MA, Bettelheim KA, Djordjevic SP. Detection of Shiga-like toxin (stx1 and stx2), intimin (eaeA) and enterohemorrhagic Escherichia coli (EHEC) hemolysin (EHEC hlyA) genes in animal feces by multiplex PCR. Appl Environ Microbiol 1999, 65, 868-872.
8. Fischer R, Stoger E, Schillberg S, Christou P, Twyman RM. Plant-based production of biopharmaceuticals. Currt Opin Plant Biol 2004, 7, 152-158.
9. Floss DM, Falkenburg D, Conrad U. Production of vaccines and therapeutic antibodies for veterinary applications in transgenic plants: an overview. Transgenic Res 2007, 16, 315-332.
10. Franke S, Gunzer F, Wieler LH, Baljer G, Karch H. Construction of recombinant Shiga-like toxin-IIv (SLT-IIv) and its use in monitoring the SLT-IIv antibody status of pigs. Vet Microbiol 1995, 43, 41-52.
11. Giddings G, Allison G, Brooks D, Carter A. Transgenic plants as factories for biopharmaceuticals. Nat Biotechnol 2000, 18, 1151-1155.
12. Hong TTT, Linh NQ, Ogle B, Lindberg JE. Survey on the prevalence of diarrhoea in pre-weaning piglets and on feeding systems as contributing risk factors in smallholdings in Central Vietnam. Trop Anim Health Prod 2006, 38, 397-405.
13. Horsch RB, Fry JE, Hoffmann NL, Eichholtz D, Roger SG, Fraley RT. A simple and general method for transferring genes into plants. Science 1985, 227, 1229-1231.
14. Imberechts H, De Greve H, Lintermans P. The pathogenesis of edema disease in pigs. Vet Microbiol 1992, 31, 221-233.
15. Kolotilin I, Kaldis A, Devriendt B, Joensuu J, Cox E, Menassa R. Production of a subunit vaccine candidate against porcine post-weaning diarrhea in high-biomass transplastomic tobacco. PLoS One 2012, 7, e42405.
16. Mason HS, Warzecha H, Mor T, Arntzen CJ. Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine. Trends Mol Med 2002, 8, 324-329.
17. Nochi T, Takagi H, Yuki Y, Yang L, Masumura T, Mejima M, Nakanishi U, Matsumura A, Uozumi A, Hiroi T, Morita S, Tanaka K, Takaiwa F, Kiyono H. Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination. Proc Natl Acad Sci U S A 2007, 104, 10986-10991.
18. O'Brien AD, Holmes RK. Shiga and Shiga-like toxins. Microbiol Rev 1987, 51, 206-220.
19. Reggi S, Marchetti S, Patti T, De Amicis F, Cariati R, Bembi B, Fogher C. Recombinant human acid ß-glucosidase stored in tobacco seed is stable, active and taken up by human fibroblasts. Plant Mol Biol 2005, 57, 101-113.
20. Rippinger P, Bertschinger HU, Imberechts H, Nagy B, Sorg I, Stamm M, Wild P, Wittig W. Designations F18ab and F18ac for the related fimbrial types F107, 2134P and 8813 of Escherichia coli isolated from porcine postweaning diarrhoea and from oedema disease. Vet Microbiol 1995, 45, 281-295.
21. Rossi L, Reggi S, Di Giancamillo A, Domeneghini C, Pinotti L, Fogher C, Baldi A. Oral administration of tobacco seeds expressing antigenic proteins in mice Balb-C: a model of edile vaccines for oedema disease. Ital J Anim Sci 2003, 2 (Suppl), 7-9.
22. Rossi L, Baldi A, Dell'Orto V, Reggi S, Fogher C. Expression of flak flagellin from Salmonella Typhimurium in tobacco seeds. IOSRJP 2012, 2, 19-22.
23. Sambrook J, Russell DW. Molecular Cloning: A Laboratory Manual. 3rd ed. pp. 7.31-7.44, Cold Spring Harbour Laboratory Press, New York, 2001.
24. Santi L, Giritch A, Roy CJ, Marillonnet S, Klimyuk V, Gleba Y, Webb R, Arntzen CJ, Mason HS. Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system. Proc Natl Acad Sci U S A 2006, 103, 861-866.
25. Sarrazin E, Bertschinger HU. Role of fimbriae F18 for actively acquired immunity against porcine enterotoxigenic Escherichia coli. Vet Microbiol 1997, 54, 133-144.
26. Smeds A, Hemmann K, Jakava-Viljanen M, Pelkonen S, Imberechts H, Palva A. Characterization of the adhesin of Escherichia coli F18 fimbriae. Infect Immun 2001, 69, 7941-7945.
27. da Silva AS, Valadares GF, Penatti MPA, Brito BG, da Silva Leite D. Escherichia coli strains from edema disease: O serogroups, and genes for Shiga toxin, enterotoxins, and F18 fimbriae. Vet Microbiol 2001, 80, 227-233.
28. Streatfield SJ, Jilka JM, Hood EE, Turner DD, Bailey MR, Mayor JM, Woodard SL, Beifuss KK, Horn ME, Delaney DE, Tizard IR, Howard JA. Plant-based vaccines: unique advantages. Vaccine 2001, 19, 2742-2748.
29. Tiels P, Verdonck F, Coddens A, Ameloot P, Goddeeris B, Cox E. Monoclonal antibodies reveal a weak interaction between the F18 fimbrial adhesin FedF and the major subunit FedA. Vet Microbiol 2007, 119, 115-120.
30. Tiels P, Verdonck F, Coddens A, Goddeeris B, Cox E. The excretion of F18+ E. coli is reduced after oral immunisation of pigs with a FedF and F4 fimbriae conjugate. Vaccine 2008, 26, 2154-2163.
31. Walmsley AM, Arntzen CJ. Plants for delivery of edible vaccines. Curr Opin Biotechnol 2000, 11, 126-129.
32. Wang L, Liu B, Kong Q, Steinrück H, Krause G, Beutin L, Feng L. Molecular markers for detection of pathogenic Escherichia coli strains belonging to serogroups O138 and O139. Vet Microbiol 2005, 111, 181-190.
33. Weiner HL, van Rees EP. Mucosal tolerance. Immunol Lett 1999, 69, 3-4.
34. Yahong H, Liang W, Pan A, Zhou Z, Wang Q, Huang C, Chen J, Zhang D. Protective immune response of bacterially-derived recombinant FaeG in piglets. J Microbiol 2006, 44, 548-555.