-
1
-
-
22144493303
-
HIF-1α: A master regulator of innate host defenses?
-
16007247 10.1172/JCI25740 1:CAS:528:DC%2BD2MXlvF2qsbg%3D
-
Zarember KA, Malech HL (2005) HIF-1α: a master regulator of innate host defenses? J Clin Invest 115:1702-1704
-
(2005)
J Clin Invest
, vol.115
, pp. 1702-1704
-
-
Zarember, K.A.1
Malech, H.L.2
-
2
-
-
0037423948
-
HIF-1α is essential for myeloid cell-mediated inflammation
-
12628185 10.1016/S0092-8674(03)00154-5 1:CAS:528:DC%2BD3sXitFykurY%3D
-
Cramer T, Yamanishi Y, Clausen BE, Forster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V et al (2003) HIF-1α is essential for myeloid cell-mediated inflammation. Cell 112:645-657
-
(2003)
Cell
, vol.112
, pp. 645-657
-
-
Cramer, T.1
Yamanishi, Y.2
Clausen, B.E.3
Forster, I.4
Pawlinski, R.5
Mackman, N.6
Haase, V.H.7
Jaenisch, R.8
Corr, M.9
Nizet, V.10
-
4
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
1448077 1:CAS:528:DyaK3sXltFShsr0%3D
-
Semenza GL, Wang GL (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12:5447-5454
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
5
-
-
0031733828
-
Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3α
-
9840812 1:CAS:528:DyaK1cXnslKhsLg%3D
-
Gu YZ, Moran SM, Hogenesch JB, Wartman L, Bradfield CA (1998) Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3α. Gene Expr 7:205-213
-
(1998)
Gene Expr
, vol.7
, pp. 205-213
-
-
Gu, Y.Z.1
Moran, S.M.2
Hogenesch, J.B.3
Wartman, L.4
Bradfield, C.A.5
-
6
-
-
0035812789
-
Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: Suppression of HIF-mediated gene expression by HIF-3alpha
-
11573933 10.1006/bbrc.2001.5659 1:CAS:528:DC%2BD3MXntV2gu7g%3D
-
Hara S, Hamada J, Kobayashi C, Kondo Y, Imura N (2001) Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha. Biochem Biophys Res Commun 287:808-813
-
(2001)
Biochem Biophys Res Commun
, vol.287
, pp. 808-813
-
-
Hara, S.1
Hamada, J.2
Kobayashi, C.3
Kondo, Y.4
Imura, N.5
-
7
-
-
0031000736
-
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development
-
9113979 10.1073/pnas.94.9.4273 1:CAS:528:DyaK2sXjtVyitbY%3D
-
Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y (1997) A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A 94:4273-4278
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 4273-4278
-
-
Ema, M.1
Taya, S.2
Yokotani, N.3
Sogawa, K.4
Matsuda, Y.5
Fujii-Kuriyama, Y.6
-
8
-
-
40949115368
-
Biology of HIF-1α
-
18259201 10.1038/cdd.2008.12 1:CAS:528:DC%2BD1cXjtl2jurc%3D
-
Weidemann A, Johnson RS (2008) Biology of HIF-1α. Cell Death Differ 15:621-627
-
(2008)
Cell Death Differ
, vol.15
, pp. 621-627
-
-
Weidemann, A.1
Johnson, R.S.2
-
9
-
-
31444444162
-
Integration of oxygen signaling at the consensus HRE
-
16234508
-
Wenger RH, Stiehl DP, Camenisch G (2005) Integration of oxygen signaling at the consensus HRE. Sci STKE 2005:re12
-
(2005)
Sci STKE
, vol.2005
, pp. 12
-
-
Wenger, R.H.1
Stiehl, D.P.2
Camenisch, G.3
-
10
-
-
0017767027
-
Tissue PO2 changes in acute inflammation
-
350019 1:STN:280:DyaE1c7osVWmtQ%3D%3D
-
Silver IA (1977) Tissue PO2 changes in acute inflammation. Adv Exp Med Biol 94:769-774
-
(1977)
Adv Exp Med Biol
, vol.94
, pp. 769-774
-
-
Silver, I.A.1
-
11
-
-
22144492953
-
HIF-1α expression regulates the bactericidal capacity of phagocytes
-
16007254 10.1172/JCI23865 1:CAS:528:DC%2BD2MXlvF2qtrc%3D
-
Peyssonnaux C, Datta V, Cramer T, Doedens A, Theodorakis EA, Gallo RL, Hurtado-Ziola N, Nizet V, Johnson RS (2005) HIF-1α expression regulates the bactericidal capacity of phagocytes. J Clin Invest 115:1806-1815
-
(2005)
J Clin Invest
, vol.115
, pp. 1806-1815
-
-
Peyssonnaux, C.1
Datta, V.2
Cramer, T.3
Doedens, A.4
Theodorakis, E.A.5
Gallo, R.L.6
Hurtado-Ziola, N.7
Nizet, V.8
Johnson, R.S.9
-
12
-
-
0037108303
-
Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis
-
12351415 10.1182/blood-2002-02-0454 1:CAS:528:DC%2BD38XotVGhtLs%3D
-
Mecklenburgh KI, Walmsley SR, Cowburn AS, Wiesener M, Reed BJ, Upton PD, Deighton J, Greening AP, Chilvers ER (2002) Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis. Blood 100:3008-3016
-
(2002)
Blood
, vol.100
, pp. 3008-3016
-
-
Mecklenburgh, K.I.1
Walmsley, S.R.2
Cowburn, A.S.3
Wiesener, M.4
Reed, B.J.5
Upton, P.D.6
Deighton, J.7
Greening, A.P.8
Chilvers, E.R.9
-
13
-
-
33745686086
-
Activation of hypoxia-inducible factor 1 during macrophage differentiation
-
16481368 10.1152/ajpcell.00614.2005 1:CAS:528:DC%2BD28XntFGis7Y%3D
-
Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, Arai T, Fukuda K, Kita T, Adachi T et al (2006) Activation of hypoxia-inducible factor 1 during macrophage differentiation. Am J Physiol Cell Physiol 291:C104-C113
-
(2006)
Am J Physiol Cell Physiol
, vol.291
-
-
Oda, T.1
Hirota, K.2
Nishi, K.3
Takabuchi, S.4
Oda, S.5
Yamada, H.6
Arai, T.7
Fukuda, K.8
Kita, T.9
Adachi, T.10
-
14
-
-
36248996487
-
Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1α-dependent manner
-
17675562 10.1189/jlb.0307195 1:CAS:528:DC%2BD2sXht1KqsbrK
-
Anand RJ, Gribar SC, Li J, Kohler JW, Branca MF, Dubowski T, Sodhi CP, Hackam DJ (2007) Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1α-dependent manner. J Leukoc Biol 82:1257-1265
-
(2007)
J Leukoc Biol
, vol.82
, pp. 1257-1265
-
-
Anand, R.J.1
Gribar, S.C.2
Li, J.3
Kohler, J.W.4
Branca, M.F.5
Dubowski, T.6
Sodhi, C.P.7
Hackam, D.J.8
-
15
-
-
79959963922
-
Hypoxia: A double-edged sword of immunity
-
10.1007/s00109-011-0724-8 1:CAS:528:DC%2BC3MXnt1Kru78%3D
-
Sica A, Melillo G, Varesio L (2011) Hypoxia: a double-edged sword of immunity. J Mol Med (Berl) 89:657-665
-
(2011)
J Mol Med (Berl)
, vol.89
, pp. 657-665
-
-
Sica, A.1
Melillo, G.2
Varesio, L.3
-
16
-
-
55749095015
-
Divergent effects of hypoxia on dendritic cell functions
-
18694997 10.1182/blood-2008-02-142091 1:CAS:528:DC%2BD1cXhtlCntrjM
-
Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen IH, Sozzani S, Austyn JM, Mantovani A, Sica A (2008) Divergent effects of hypoxia on dendritic cell functions. Blood 112:3723-3734
-
(2008)
Blood
, vol.112
, pp. 3723-3734
-
-
Mancino, A.1
Schioppa, T.2
Larghi, P.3
Pasqualini, F.4
Nebuloni, M.5
Chen, I.H.6
Sozzani, S.7
Austyn, J.M.8
Mantovani, A.9
Sica, A.10
-
17
-
-
57149114568
-
Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile
-
18725395 10.1189/jlb.0208082 1:CAS:528:DC%2BD1cXhsVKhsrfN
-
Elia AR, Cappello P, Puppo M, Fraone T, Vanni C, Eva A, Musso T, Novelli F, Varesio L, Giovarelli M (2008) Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile. J Leukoc Biol 84:1472-1482
-
(2008)
J Leukoc Biol
, vol.84
, pp. 1472-1482
-
-
Elia, A.R.1
Cappello, P.2
Puppo, M.3
Fraone, T.4
Vanni, C.5
Eva, A.6
Musso, T.7
Novelli, F.8
Varesio, L.9
Giovarelli, M.10
-
18
-
-
40349093192
-
Transcriptome of hypoxic immature dendritic cells: Modulation of chemokine/receptor expression
-
18314479 10.1158/1541-7786.MCR-07-0391 1:CAS:528:DC%2BD1cXisVWhsrg%3D
-
Ricciardi A, Elia AR, Cappello P, Puppo M, Vanni C, Fardin P, Eva A, Munroe D, Wu X, Giovarelli M et al (2008) Transcriptome of hypoxic immature dendritic cells: modulation of chemokine/receptor expression. Mol Cancer Res 6:175-185
-
(2008)
Mol Cancer Res
, vol.6
, pp. 175-185
-
-
Ricciardi, A.1
Elia, A.R.2
Cappello, P.3
Puppo, M.4
Vanni, C.5
Fardin, P.6
Eva, A.7
Munroe, D.8
Wu, X.9
Giovarelli, M.10
Varesio, L.11
-
19
-
-
44449117540
-
Hypoxia and hypoxia-inducible factor-1α modulate lipopolysaccharide-induced dendritic cell activation and function
-
18354193 1:CAS:528:DC%2BD1cXjsVKqsbk%3D
-
Jantsch J, Chakravortty D, Turza N, Prechtel AT, Buchholz B, Gerlach RG, Volke M, Glasner J, Warnecke C, Wiesener MS et al (2008) Hypoxia and hypoxia-inducible factor-1α modulate lipopolysaccharide-induced dendritic cell activation and function. J Immunol 180:4697-4705
-
(2008)
J Immunol
, vol.180
, pp. 4697-4705
-
-
Jantsch, J.1
Chakravortty, D.2
Turza, N.3
Prechtel, A.T.4
Buchholz, B.5
Gerlach, R.G.6
Volke, M.7
Glasner, J.8
Warnecke, C.9
Wiesener, M.S.10
-
20
-
-
0033181324
-
Interleukin-1β and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1
-
10477681 1:CAS:528:DyaK1MXmtVaiu7g%3D
-
Hellwig-Burgel T, Rutkowski K, Metzen E, Fandrey J, Jelkmann W (1999) Interleukin-1β and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1. Blood 94:1561-1567
-
(1999)
Blood
, vol.94
, pp. 1561-1567
-
-
Hellwig-Burgel, T.1
Rutkowski, K.2
Metzen, E.3
Fandrey, J.4
Jelkmann, W.5
-
21
-
-
0347334750
-
IL-1beta-mediated up-regulation of HIF-1α via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
-
12958148 1:CAS:528:DC%2BD3sXovFOhsb0%3D
-
Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L (2003) IL-1beta-mediated up-regulation of HIF-1α via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J 17:2115-2117
-
(2003)
FASEB J
, vol.17
, pp. 2115-2117
-
-
Jung, Y.J.1
Isaacs, J.S.2
Lee, S.3
Trepel, J.4
Neckers, L.5
-
22
-
-
2542443138
-
Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1α
-
15169887 10.1128/MCB.24.12.5223-5234.2004 1:CAS:528:DC%2BD2cXkvFOqtrc%3D
-
Wakisaka N, Kondo S, Yoshizaki T, Murono S, Furukawa M, Pagano JS (2004) Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1α. Mol Cell Biol 24:5223-5234
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5223-5234
-
-
Wakisaka, N.1
Kondo, S.2
Yoshizaki, T.3
Murono, S.4
Furukawa, M.5
Pagano, J.S.6
-
23
-
-
0034282553
-
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α
-
10987301 1:CAS:528:DC%2BD3cXmsFWhsLs%3D
-
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS (2000) The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α. Cancer Res 60:4873-4880
-
(2000)
Cancer Res
, vol.60
, pp. 4873-4880
-
-
Sodhi, A.1
Montaner, S.2
Patel, V.3
Zohar, M.4
Bais, C.5
Mesri, E.A.6
Gutkind, J.S.7
-
24
-
-
80052364757
-
Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1 α (HIF1α) and result in differential HIF1α-dependent gene expression
-
21685248 10.1189/jlb.1210683 1:CAS:528:DC%2BC3MXht1SisLvF
-
Jantsch J, Wiese M, Schodel J, Castiglione K, Glasner J, Kolbe S, Mole D, Schleicher U, Eckardt KU, Hensel M et al (2011) Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1 α (HIF1α) and result in differential HIF1α-dependent gene expression. J Leukoc Biol 90:551-562
-
(2011)
J Leukoc Biol
, vol.90
, pp. 551-562
-
-
Jantsch, J.1
Wiese, M.2
Schodel, J.3
Castiglione, K.4
Glasner, J.5
Kolbe, S.6
Mole, D.7
Schleicher, U.8
Eckardt, K.U.9
Hensel, M.10
-
25
-
-
7944224442
-
Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
-
15542432 10.1016/j.ccr.2004.09.026 1:CAS:528:DC%2BD2cXhtVGlurjN
-
Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS (2004) Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6:485-495
-
(2004)
Cancer Cell
, vol.6
, pp. 485-495
-
-
Tang, N.1
Wang, L.2
Esko, J.3
Giordano, F.J.4
Huang, Y.5
Gerber, H.P.6
Ferrara, N.7
Johnson, R.S.8
-
26
-
-
39049088951
-
Dendritic cells and cytokines in human inflammatory and autoimmune diseases
-
18258476 10.1016/j.cytogfr.2007.10.004 1:CAS:528:DC%2BD1cXhsleksLk%3D
-
Blanco P, Palucka AK, Pascual V, Banchereau J (2008) Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev 19:41-52
-
(2008)
Cytokine Growth Factor Rev
, vol.19
, pp. 41-52
-
-
Blanco, P.1
Palucka, A.K.2
Pascual, V.3
Banchereau, J.4
-
27
-
-
0035062021
-
Interleukin-10 and the interleukin-10 receptor
-
11244051 10.1146/annurev.immunol.19.1.683 1:CAS:528:DC%2BD3MXivFKgu70%3D
-
Moore KW, de Waal MR, Coffman RL, O'Garra A (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19:683-765
-
(2001)
Annu Rev Immunol
, vol.19
, pp. 683-765
-
-
Moore, K.W.1
De Waal, M.R.2
Coffman, R.L.3
O'Garra, A.4
-
28
-
-
84867335615
-
A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection
-
10.1007/s00109-012-0882-3 1:CAS:528:DC%2BC38Xht1egtrfI
-
Okumura CY, Hollands A, Tran DN, Olson J, Dahesh S, von Kockritz-Blickwede M, Thienphrapa W, Corle C, Jeung SN, Kotsakis A et al (2012) A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection. J Mol Med (Berl) 90:1079-1089
-
(2012)
J Mol Med (Berl)
, vol.90
, pp. 1079-1089
-
-
Okumura, C.Y.1
Hollands, A.2
Tran, D.N.3
Olson, J.4
Dahesh, S.5
Von Kockritz-Blickwede, M.6
Thienphrapa, W.7
Corle, C.8
Jeung, S.N.9
Kotsakis, A.10
-
29
-
-
0035917313
-
2 sensing
-
11292862 10.1126/science.1059817 1:CAS:528:DC%2BD3MXjtVentbw%3D
-
2 sensing. Science 292:464-468
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin, Jr.W.G.10
-
30
-
-
77956203432
-
Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1α and dendritic cell maturation under normoxic conditions
-
20539755 10.1371/journal.pone.0010983
-
Spirig R, Djafarzadeh S, Regueira T, Shaw SG, von Garnier C, Takala J, Jakob SM, Rieben R, Lepper PM (2010) Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1α and dendritic cell maturation under normoxic conditions. PLoS One 5:e0010983
-
(2010)
PLoS One
, vol.5
, pp. 0010983
-
-
Spirig, R.1
Djafarzadeh, S.2
Regueira, T.3
Shaw, S.G.4
Von Garnier, C.5
Takala, J.6
Jakob, S.M.7
Rieben, R.8
Lepper, P.M.9
-
31
-
-
64849087205
-
Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1α transcription factor
-
19234213 10.4049/jimmunol.0801710 1:CAS:528:DC%2BD1MXitFKgsrc%3D
-
Acosta-Iborra B, Elorza A, Olazabal IM, Martin-Cofreces NB, Martin-Puig S, Miro M, Calzada MJ, Aragones J, Sanchez-Madrid F, Landazuri MO (2009) Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1α transcription factor. J Immunol 182:3155-3164
-
(2009)
J Immunol
, vol.182
, pp. 3155-3164
-
-
Acosta-Iborra, B.1
Elorza, A.2
Olazabal, I.M.3
Martin-Cofreces, N.B.4
Martin-Puig, S.5
Miro, M.6
Calzada, M.J.7
Aragones, J.8
Sanchez-Madrid, F.9
Landazuri, M.O.10
-
32
-
-
72949119535
-
Reoxygenation of hypoxia-differentiated dendritic cells induces Th1 and Th17 cell differentiation
-
19910049 10.1016/j.molimm.2009.09.038 1:CAS:528:DC%2BC3cXjsF2n
-
Wang Q, Liu C, Zhu F, Liu F, Zhang P, Guo C, Wang X, Li H, Ma C, Sun W et al (2010) Reoxygenation of hypoxia-differentiated dendritic cells induces Th1 and Th17 cell differentiation. Mol Immunol 47:922-931
-
(2010)
Mol Immunol
, vol.47
, pp. 922-931
-
-
Wang, Q.1
Liu, C.2
Zhu, F.3
Liu, F.4
Zhang, P.5
Guo, C.6
Wang, X.7
Li, H.8
Ma, C.9
Sun, W.10
Zhang, Y.11
Chen, W.12
Zhang, L.13
-
33
-
-
68249153389
-
Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin
-
19740309 10.1111/j.1365-2567.2008.02954.x
-
Yang M, Ma C, Liu S, Sun J, Shao Q, Gao W, Zhang Y, Li Z, Xie Q, Dong Z et al (2009) Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin. Immunology 128:e237-e249
-
(2009)
Immunology
, vol.128
-
-
Yang, M.1
Ma, C.2
Liu, S.3
Sun, J.4
Shao, Q.5
Gao, W.6
Zhang, Y.7
Li, Z.8
Xie, Q.9
Dong, Z.10
Qu, X.11
-
34
-
-
78649876180
-
Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD
-
21115615 10.1681/ASN.2010010116 1:CAS:528:DC%2BC3MXktVGh
-
Bernhardt WM, Wiesener MS, Scigalla P, Chou J, Schmieder RE, Gunzler V, Eckardt KU (2010) Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD. J Am Soc Nephrol 21:2151-2156
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 2151-2156
-
-
Bernhardt, W.M.1
Wiesener, M.S.2
Scigalla, P.3
Chou, J.4
Schmieder, R.E.5
Gunzler, V.6
Eckardt, K.U.7
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