Skeletal muscle metabolism limits exercise capacity in patients with chronic heart failure

Circulation

Volumn 98, Issue 18, 1998, Pages 1886-1891

  Okita, Koichi ^a   Yonezawa, Kazuya ^a   Nishijima, Hirotaka ^a   Hanada, Akiko ^a   Ohtsubo, Mitsunori ^a   Kohya, Tetsuro ^a   Murakami, Takeshi ^a   Kitabatake, Akira ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Exercise; Heart failure; Muscles

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CREATINE PHOSPHATE; DIGOXIN; DIURETIC AGENT; VASODILATOR AGENT;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; HEART FAILURE; HEART MUSCLE METABOLISM; HUMAN; MALE; METABOLIC CAPACITY; OXYGEN CONSUMPTION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

EID: 0032480767     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.98.18.1886     Document Type: Article

References (16)

1. Clark AL, Poole-Wilson PA, Coats AJS. Exercise limitation in chronic heart failure: central role of the periphery. J Am Coll Cardiol. 1996;28: 1092-102.
2. Massie BM, Conway M, Rajagopalan B, Yonge R, Frostick S, Ledingham J, Sleight P, Radda G. Skeletal muscle metabolism during exercise under ischemic conditions in congestive heart failure: evidence for abnormalities unrelated to blood flow. Circulation. 1988;78:320-326.
3. Mancini DM, Ferraro N, Tuchler M, Chance B, Wilson JR. Detection of abnormal calf muscle metabolism in patients with heart failure using phosphorus-31 nuclear magnetic resonance. Am J Cardiol. 1988;62: 1234-1240.
4. Sullivan MJ, Green HJ, Cobb FR. Altered skeletal muscle metabolic response to exercise in chronic heart failure: relation to skeletal muscle aerobic enzyme activity. Circulation. 1991;84:1597-1607.
5. Sullivan MJ, Cobb FR. The anaerobic threshold in chronic heart failure: relation to blood lactate, ventilatory basis, reproducibility, and response to exercise training. Circulation. 1990;81(suppl II):II-47-II-58.
6. Schaufelberger M, Eriksson BO, Held P, Swedberg K. Skeletal muscle metabolism during exercise in patients with chronic heart failure. Heart. 1996;76:2929-2934.
7. Harris RC, Edwards RH, Hultman E, Nordesjö L-O, Nylind B, Sahlin K. The time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man. Pflügers Arch. 1976;367:137-142.
8. Mcloughlin P, Popham P, Linton RAF, Bruce RCH, Band DM. Use of arterialized venous blood sampling during incremental exercise tests. J Appl Physiol. 1992;73:937-940.
9. Okita K, Nishijima H, Yonezawa K, Ohtsubo M, Hanada A, Kohya T, Murakami T, Kitabatake A. Skeletal muscle metabolism in maximal bicycle and treadmill exercise distinguished by using in-vivo metabolic freeze method and phosphorus-31 magnetic resonance spectroscopy in normal men. Am J Cardiol. 1998;81:106-109.
10. McCann DJ, Molé PA, Caton JR. Phosphocreatine kinetics in humans during exercise and recovery. Med Sci Sports Exerc. 1995;27:378-389.
11. Fitts RH. Cellular mechanisms of muscle fatigue. Physiol Rev. 1994;74: 49-94.
12. Näveri H, Leinonen H, Härkönen M. Is skeletal muscle creatine depletion the limiting factor of exercise performance in congestive heart failure? Eur Heart J. 1992;13(suppl):434. Abstract.
13. MacRae HS-H, Dennis SC. Lactic acidosis as a facilitator of oxyhemoglobin dissociation during exercise. J Appl Physiol. 1995;78:758-760. Letter, comment.
14. Maskin CS, Forman R, Sonnenblick EH, Frishman WH, LeJemtel TH. Failure of dobutamine to increase exercise capacity despite hemodynamic improvement in severe chronic heart failure. Am J Cardiol. 1983;51: 177-182.
15. Minotti JR, Johoenson EC, Hudson TL, Zuroske G, Fukushima E, Murata G, Wise LE, Chick TW, Icenogle MV. Training-induced skeletal muscle adaptations are independent of systemic adaptations. J Appl Physiol. 1990;68:289-294.
16. Belardinelli R, Georgiou D, Scocco V, Barstow TJ, Purcaro A. Low intensity exercise training in patients with chronic heart failure. J Am Coll Cardiol. 1995;26:975-982.