Magnolol inhibits LPS-induced inflammatory response in uterine epithelial cells: Magnolol inhibits LPS-induced inflammatory response

Inflammation

Volumn 36, Issue 5, 2013, Pages 997-1003

  Luo, Jia ^a   Xu, Yanwen ^b   Zhang, Minfang ^b   Gao, Ling ^b   Fang, Cong ^b   Zhou, Canquan ^b  

^a Dongguan Kanghua Hospital   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

cytokine; LPS; magnolol; MAPK; NF B; TLR4

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MAGNOLOL; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG STRUCTURE; ENDOMETRIUM CELL; ENZYME PHOSPHORYLATION; FEMALE; INFLAMMATION; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

MAGNOLIA OFFICINALIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIPHENYL COMPOUNDS; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; ENDOMETRITIS; ENZYME ACTIVATION; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; I-KAPPA B PROTEINS; INFLAMMATION; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIGNANS; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; UTERUS;

EID: 84885182523     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-013-9631-1     Document Type: Article

References (28)

1. Sheldon, I.M., E.J. Williams, A.N. Miller, D.M. Nash, and S. Herath. 2008. Uterine diseases in cattle after parturition. The Veterinary Journal 176: 115-121.
2. Akira, S., K. Takeda, and T. Kaisho. 2001. Toll-like receptors: critical proteins linking innate and acquired immunity. Nature Immunology 2: 675-680.
3. Beutler, B., K. Hoebe, X. Du, and R.J. Ulevitch. 2003. How we detect microbes and respond to them: the Toll-like receptors and their transducers. Journal of Leukocyte Biology 74: 479-485.
4. Takayama, K., K. Zeitoun, R.T. Gunby, H. Sasano, B.R. Carr, et al. 1998. Treatment of severe postmenopausal endometriosis with an aromatase inhibitor. Fertility and Sterility 69: 709-713.
5. Lebovic, D.I., M.D. Mueller, and R.N. Taylor. 2001. Immunobiology of endometriosis. Fertility and Sterility 75: 1-10.
6. da Silva, Correia J., K. Soldau, U. Christen, P.S. Tobias, and R.J. Ulevitch. 2001. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. The Journal of Biological Chemistry 276: 21129-21135.
7. Nagai, Y., S. Akashi, M. Nagafuku, M. Ogata, Y. Iwakura, et al. 2002. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nature Immunology 3: 667-672.
8. Akashi, S., Y. Nagai, H. Ogata, M. Oikawa, K. Fukase, et al. 2001. Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition. International Immunology 13: 1595-1599.
9. Medzhitov, R., and J.C. Kagan. 2006. Phosphoinositide-mediated adaptor recruitment controls toll-like receptor signaling. Cell 125: 943-955.
10. Ikeda, K., and H. Nagase. 2002. Magnolol has the ability to induce apoptosis in tumor cells. Biological and Pharmaceutical Bulletin 25: 1546-1549.
11. Park, J., J. Lee, E. Jung, Y. Park, K. Kim, et al. 2004. In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp. European Journal of Pharmacology 496: 189-195.
12. Lee, J., E. Jung, J. Park, K. Jung, S. Lee, et al. 2005. Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappa B activation signaling. Planta Medica 71: 338-343.
13. Huo, M., N. Chen, G. Chi, X. Yuan, S. Guan, et al. 2012. Traditional medicine alpinetin inhibits the inflammatory response in Raw 264.7 cells and mouse models. International Immunopharmacology 12: 241-248.
14. Li, M.H., G. Kothandan, S.J. Cho, T.T.H. Pham, Y.H. Nan, et al. 2010. Magnolol inhibits LPS-induced NF-kappa B/Rel activation by blocking p38 kinase in murine macrophages. Korean Journal of Physiology & Pharmacology 14: 353-358.
15. Lai, C.S., Y.S. Lai, D.H. Kuo, C.H. Wu, C.T. Ho, et al. 2011. Magnolol potently suppressed lipopolysaccharide-induced iNOS and COX-2 expression via downregulating MAPK and NF-kappa B signaling pathways. Journal of Functional Foods 3: 198-206.
16. Fahey, J.V., J.A. Wright, L. Shen, J.M. Smith, M. Ghosh, et al. 2008. Estradiol selectively regulates innate immune function by polarized human uterine epithelial cells in culture. Mucosal Immunology 1: 317-325.
17. Schaefer, T.M., K. Desouza, J.V. Fahey, K.W. Beagley, and C.R. Wira. 2004. Toll-like receptor (TLR) expression and TLR-mediated cytokine/chemokine production by human uterine epithelial cells. Immunology 112: 428-436.
18. Soboll, G., L. Shen, and C.R. Wira. 2006. Expression of toll-like receptors (TLR) and responsiveness to TLR agonists by polarized mouse uterine epithelial cells in culture. Biology of Reproduction 75: 131-139.
19. Choi, E.M., and J.K. Hwang. 2005. Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages. Fitoterapia 76: 608-613.
20. Connolly, M.K., A.S. Bedrosian, J. Mallen-St Clair, A.P. Mitchell, J. Ibrahim, et al. 2009. In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. The Journal of Clinical Investigation 119: 3213-3225.
21. Maskrey, B.H., I.L. Megson, P.D. Whitfield, and A.G. Rossi. 2011. Mechanisms of resolution of inflammation: a focus on cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 31: 1001-1006.
22. Kishimoto, T., T. Taga, K. Yamasaki, T. Matsuda, B. Tang, et al. 1989. Normal and abnormal regulation of human B cell differentiation by a new cytokine, BSF2/IL-6. Advances in cirrhosis, Hyperammonemia, and Hepatic encephalopathy 254: 135-143.
23. Romano, M., M. Sironi, C. Toniatti, N. Polentarutti, P. Fruscella, et al. 1997. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6: 315-325.
24. Dey, N., T. Liu, R.P. Garofalo, and A. Casola. 2011. TAK1 regulates NF-KappaB and AP-1 activation in airway epithelial cells following RSV infection. Virology 418: 93-101.
25. Wang, R., M. Zhang, W. Zhou, P.T. Ly, F. Cai, et al. 2011. NF-kappaB signaling inhibits ubiquitin carboxyl-terminal hydrolase L1 gene expression. Journal of Neurochemistry 116: 1160-1170.
26. Karin, M., and Y. Ben-Neriah. 2000. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annual Review of Immunology 18: 621-663.
27. Rao, K.M. 2001. MAP kinase activation in macrophages. Journal of Leukocyte Biology 69: 3-10.
28. Jiang, J.X., Y. Zhang, S.H. Ji, P. Zhu, and Z.G. Wang. 2002. Kinetics of mitogen-activated protein kinase family in lipopolysaccharide-stimulated mouse Kupffer cells and their role in cytokine production. Shock 18: 336-341.