A tumor suppressor role for srGAP3 in mammary epithelial cells

Oncogene

Volumn 32, Issue 40, 2013, Pages 4854-4860

  Lahoz, A ^a   Hall, A ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

anchorage independent growth; breast cancer; Rac; srGAP; tumor suppressor

Indexed keywords

EZRIN; MOESIN; MYOSIN LIGHT CHAIN 2; RAC PROTEIN; RADIXIN; RHO KINASE; ROCK PROTEIN; SRGAP3 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; CELL GROWTH; CELL INVASION; CELL TRANSFORMATION; COLONY FORMATION; CONTROLLED STUDY; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MEDIATOR; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; TUMOR SUPPRESSOR GENE;

BREAST NEOPLASMS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; EPIGENESIS, GENETIC; FEMALE; GENES, TUMOR SUPPRESSOR; GTPASE-ACTIVATING PROTEINS; HUMANS; MAMMARY GLANDS, HUMAN;

EID: 84885175898     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.489     Document Type: Article

References (38)

1. Ellenbroek SI, Collard JG. Rho GTPases: Functions and association with cancer. Clin Exp Metastasis 2007; 24: 657-672.
2. Vega FM, Ridley AJ. Rho GTPases in cancer cell biology. FEBS Lett 2008; 582: 2093-2101.
3. Jaffe AB, Hall A. Rho GTPases: Biochemistry and biology. Annu Rev Cell Dev Biol 2005; 21: 247-269.
4. Lazer G, Katzav S. Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy? Cell Signal 2011; 23: 969-979.
5. Xue W, Krasnitz A, Lucito R, Sordella R, Vanaelst L, Cordon-Cardo C et al. DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes Dev 2008; 22: 1439-1444.
6. Yang C, Kazanietz MG. Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac. Biochem J 2007; 403: 1-12.
7. Aspenstrom P. Roles of F-BAR/PCH proteins in the regulation of membrane dynamics and actin reorganization. Int Rev Cell Mol Biol 2009; 272: 1-31.
8. Wong K, Ren XR, Huang YZ, Xie Y, Liu G, Saito H et al. Signal transduction in neuronal migration: Roles of GTPase activating proteins and the small GTPase Cdc42 in the slit-robo pathway. Cell 2001; 107: 209-221.
9. Guerrier S, Coutinho-Budd J, Sassa T, Gresset A, Jordan NV, Chen K et al. The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Cell 2009; 138: 990-1004.
10. Madura T, Yamashita T, Kubo T, Tsuji L, Hosokawa K, Tohyama M. Changes in mRNA of Slit-Robo GTPase-activating protein following facial nerve transection. Brain Res Mol Brain Res 2004; 123: 76-80.
11. Endris V, Wogatzky B, Leimer U, Bartsch D, Zatyka M, Latif F et al. The novel Rho-GTPase activating gene MEGAP/srGAP3 has a putative role in severe mental retardation. Proc Natl Acad Sci USA 2002; 99: 11754-11759.
12. Endris V, Haussmann L, Buss E, Bacon C, Bartsch D, Rappold G. SrGAP3 interacts with lamellipodin at the cell membrane and regulates Rac-dependent cellular protrusions. J Cell Sci 2011; 124(Pt 23): 3941-3955.
13. Yang Y, Marcello M, Endris V, Saffrich R, Fischer R, Trendelenburg MF et al. MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation. Exp Cell Res 2006; 312: 2379-2393.
14. Carlson BR, Lloyd KE, Kruszewski A, Kim IH, Rodriguiz RM, Heindel C et al. WRP/srGAP3 facilitates the initiation of spine Development by an inverse F-BAR domain, and its loss impairs long-term memory. J Neurosci 2011; 31: 2447-2460.
15. Soderling SH, Binns KL, Wayman GA, Davee SM, Ong SH, Pawson T et al. The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol 2002; 4: 970-975.
16. Soderling SH, Guire ES, Kaech S, White J, Zhang F, Schutz K et al. A WAVE-1 and WRP signaling complex regulates spine de nsity, synaptic plasticity, and memory. J Neurosci 2007; 27: 355-365.
17. Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B et al. A genetic screen for candidate tumor suppressors identifies REST. Cell 2005; 121: 837-848.
18. Zhao JJ, Gjoerup OV, Subramanian RR, Cheng Y, Chen W, Roberts TM et al. Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell 2003; 3: 483-495.
19. Chen K, Mi YJ, Ma Y, Fu HL, Jin WL. The mental retardation associated protein, srGAP3 negatively regulates VPA-induced neuronal differentiation of Neuro2A cells. Cell Mol Neurobiol 2011; 31: 675-686.
20. Radvanyi L, Singh-Sandhu D, Gallichan S, Lovitt C, Pedyczak A, Mallo G et al. The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer. Proc Natl Acad Sci USA 2005; 102: 11005-11010.
21. Zhao H, Langerod A, Ji Y, Nowels KW, Nesland JM, Tibshirani R et al. Different gene expression patterns in invasive lobular and ductal carcinomas of the breast. Mol Biol Cell 2004; 15: 2523-2536.
22. Shuib S, McMullan D, Rattenberry E, Barber RM, Rahman F, Zatyka M et al. Microarray based analysis of 3p25-p26 de letions (3p-syndrome). Am J Med Genet A 2009; 149A: 2099-2105.
23. Kristensen LS, Nielsen HM, Hansen LL. Epigenetics and cancer treatment. Eur J Pharmacol 2009; 625: 131-142.
24. Tang YA, Wen WL, Chang JW, Wei TT, Tan YH, Salunke S et al. A novel histone de acetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer. PLoS One 2010; 5: E12417.
25. Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT et al. The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol 2007; 1: 84-96.
26. Han J, Chang H, Giricz O, Lee GY, Baehner FL, Gray JW et al. Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture. PLoS Comput Biol 2010; 6: E1000684.
27. Guo Y, Pakneshan P, Gladu J, Slack A, Szyf M, Rabbani SA. Regulation of DNA methylation in human breast cancer. Effect on the urokinase-type plasminogen activator gene production and tumor invasion. J Biol Chem 2002; 277: 41571-41579.
28. Zajchowski DA, Bartholdi MF, Gong Y, Webster L, Liu HL, Munishkin A et al. Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells. Cancer Res 2001; 61: 5168-5178.
29. Ikebe M, Hartshorne DJ. Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase. J Biol Chem 1985; 260: 10027-10031.
30. Lorentzen A, Bamber J, Sadok A, Elson-Schwab I, Marshall CJ. An ezrin-rich, rigid uropod-like structure directs movement of amoeboid blebbing cells. J Cell Sci 2011; 124(Pt 8): 1256-1267.
31. Sanz-Moreno V, Gadea G, Ahn J, Paterson H, Marra P, Pinner S et al. Rac activation and inactivation control plasticity of tumor cell movement. Cell 2008; 135: 510-523.
32. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 1996; 273: 245-248.
33. Matsui T, Maeda M, Doi Y, Yonemura S, Amano M, Kaibuchi K et al. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J Cell Biol 1998; 140: 647-657.
34. Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM et al. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell 2010; 40: 877-892.
35. Sander EE, ten Klooster JP, Van de lft S, Van Der Kammen RA, Collard JG. Rac downregulates Rho activity: Reciprocal balance between both GTPases de termines cellular morphology and migratory behavior. J Cell Biol 1999; 147: 1009-1022.
36. Zondag GC, Evers EE, ten Klooster JP, Janssen L, Van Der Kammen RA, Collard JG. Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition. J Cell Biol 2000; 149: 775-782.
37. Counter CM, Meyerson M, Eaton EN, Ellisen LW, Caddle SD, Haber DA et al. Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene 1998; 16: 1217-1222.
38. Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R, Raber J et al. Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci USA 2003; 100: 1723-1728.