The mental retardation associated protein, srGAP3 negatively regulates VPA-induced neuronal differentiation of Neuro2A cells

Cellular and Molecular Neurobiology

Volumn 31, Issue 5, 2011, Pages 675-686

  Chen, Keng ^a   Mi, Ya Jing ^a   Ma, Yue ^a   Fu, Hua Lin ^a   Jin, Wei Lin ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Neuronal differentiation; Rac1; Rho GAP domain; Slit Robo GTPase activating protein; srGAP3

Indexed keywords

ALANINE; ARGININE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RAC1 PROTEIN; SLIT ROBO GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 3; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; GENE MUTATION; HUMAN; HUMAN CELL; MOUSE; NERVE CELL DIFFERENTIATION; NEURITE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; WILD TYPE;

ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; CELL DIFFERENTIATION; CELL LINE, TUMOR; GENE KNOCKDOWN TECHNIQUES; GREEN FLUORESCENT PROTEINS; GTPASE-ACTIVATING PROTEINS; HEK293 CELLS; HUMANS; MENTAL RETARDATION; MICE; NEURONS; RAC1 GTP-BINDING PROTEIN; SUBCELLULAR FRACTIONS; UP-REGULATION; VALPROIC ACID;

EID: 79959623728     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-011-9664-7     Document Type: Article

References (43)

1. Andrews W, Barber M, Hernadez-Miranda LR, Xian J, Rakic S, Sundaresan V, Rabbitts TH, Pannell R, Rabbitts P, Thompson H, Erskine L, Murakami F, Parnavelas JG (2008) The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons. Dev Biol 313:648-658
2. Aspenstrom P (2009) Roles of F-BAR/PCH proteins in the regulation of membrane dynamics and actin reorganization. Int Rev Cell Mol Biol 272:1-31
3. Bacon C, Endris V, Rappold G (2009) Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system. J Comp Neurol 513:224-236
4. Brouns MR, Matheson SF, Settleman J (2001) p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation. Nat Cell Biol 3:361-367 (Pubitemid 32288443)
5. Dingova H, Fukalova J, Maninova M, Philimonenko VV, Hozak P (2009) Ultrastructural localization of actin and actin-binding proteins in the nucleus. Histochem Cell Biol 131:425-434
6. Duan XL, Huang WJ, Wang BR, Song JF, Jin WL, Guo X, Ju G (2003) Construction and expression of prokaryotic expression vector of GAP-43 and preparation of monoclonal antibody against GAP-43. Chin J Cell Mol Immunol 19:480-483
7. Endris V, Wogatzky B, Leimer U, Bartsch D, Zatyka M, Latif F, Maher ER, Tariverdian G, Kirsch S, Karch D, Rappold GA (2002) The novel Rho-GTPase activating gene MEGAP/srGAP3 has a putative role in severe mental retardation. Proc Natl Acad Sci USA 99:11754-11759 (Pubitemid 34994471)
8. Garcia-Mata R, Wennerberg K, Arthur WT, Noren NK, Ellerbroek SM, Burridge K (2006) Analysis of activated GAPs and GEFs in cell lysates. Methods Enzymol 406:425-437 (Pubitemid 43207456)
9. Govek EE, Newey SE, Van Aelst L (2005) The role of the Rho GTPases in neuronal development. Gene Dev 19:1-49 (Pubitemid 40095815)
10. Guerrier S, Coutinho-Budd J, Sassa T, Gresset A, Jordan NV, Chen K, Jin WL, Frost A, Polleux F (2009) The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Cell 138:990-1004
11. Hivert B, Liu Z, Chuang CY, Doherty P, Sundaresan V (2002) Robo1 and Robo2 are homophilic binding molecules that promote axonal growth. Mol Cell Neurosci 21:534-545 (Pubitemid 36062712)
12. Hsieh J, Nakashima K, Kuwabara T, Mejia E, Gage FH (2004) Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proc Natl Acad Sci USA 101:16659-16664 (Pubitemid 39557769)
13. Ito M, Jameson JL, Ito M (1997) Molecular basis of autosomal dominant neurohypophyseal diabetes insipidus. Cellular toxicity caused by the accumulation of mutant vasopressin precursors within the endoplasmic reticulum. J Clin Invest 99:1897-1905 (Pubitemid 27175937)
14. Itoh T, Erdmann KS, Roux A, Habermann B, Werner H, De Camilli P (2005) Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins. Dev Cell 9:791-804 (Pubitemid 41724107)
15. Jin WL, Liu YY, Liu HL, Yang H, Wang Y, Jiao XY, Ju G (2003) Intraneuronal localization of Nogo-A in the rat. J Comp Neurol 458:1-10 (Pubitemid 36255323)
16. Koh CG (2006) Rho GTPases and their regulators in neuronal functions and development. Neurosignals 15:228-237
17. Kozma R, Sarner S, Ahmed S, Lim L (1997) Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid. Mol Cell Biol 17:1201
18. Lanning CC, Daddona JL, Ruiz-Velasco R, Shafer SH, Williams CL (2004) The Rac1 C-terminal polybasic region regulates the nuclear localization and protein degradation of Rac1. J Biol Chem 279:44197
19. Lessard J, Wu JI, Ranish JA, Wan M, Winslow MM, Staahl BT, Wu H, Aebersold R, Graef IA, Crabtree GR (2007) An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron 55:201-215 (Pubitemid 47048906)
20. Marillat V, Cases O, Nguyenf-Ba-Charvet KT, Tessier-Lavigne M, Sotelo C, Chedotal A (2001) Spatiotemporal expression patterns of slit and robo genes in the rat brain. J Comp Neurol 442:130-155
21. Mattar P, Britz O, Johannes C, Nieto M, Ma L, Rebeyka A, Klenin N, Polleux F, Guillemot F, Schuurmans C (2004) A screen for downstream effectors of Neurogenin2 in the embryonic neocortex. Dev Biol 273:373-389 (Pubitemid 39140910)
22. Moon SY, Zang H, Zheng Y (2003) Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. J Biol Chem 278:4151-4159 (Pubitemid 36801152)
23. Nagaraja GM, Kandpal RP (2004) Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. Biochem Biophys Res Commun 313:654-665 (Pubitemid 38021881)
24. Nobes CD, Hall A (1995) Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53-62
25. Regan CM (1985) Therapeutic levels of sodium valproate inhibit mitotic indices in cells of neural origin. Brain Res 347:394-398
26. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410
27. Schubert D, Humphreys S, Baroni C, Cohn M (1969) In vitro differentiation of a mouse neuroblastoma. Proc Natl Acad Sci USA 64:316-323
28. Seo S, Richardson GA, Kroll KL (2005) The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD. Development 132:105-115 (Pubitemid 40207970)
29. Soderling SH, Binns KL, Wayman GA, Davee SM, Ong SH, Pawson T, Scott JD (2002) The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol 4:970-975 (Pubitemid 35469427)
30. Soderling SH, Guire ES, Kaech S, White J, Zhang F, Schutz K, Langeberg LK, Banker G, Raber J, Scott JD (2007) A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. J Neurosci 27:355-365 (Pubitemid 46106009)
31. Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, Pelicci P (1996) An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells. Proc Natl Acad Sci USA 93:695-699 (Pubitemid 26041151)
32. Tsujita K, Suetsugu S, Sasaki N, Furutani M, Oikawa T, Takenawa T (2006) Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. J Cell Biol 172:269-279 (Pubitemid 43112973)
33. Vogt DL, Gray CD, Young WS III, Orellana SA, Malouf AT (2007) ARHGAP4 is a novel RhoGAP that mediates inhibition of cell motility and axon outgrowth. Mol Cell Neurosci 36:332-342 (Pubitemid 47633198)
34. Waltereit R, Kautt S, Bartsch D (2008) Expression of MEGAP mRNA during embryonic development. Gene Expr Patterns 8:307-310
35. Wong K, Ren XR, Huang YZ, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L, Wu JY, Xiong WC, Rao Y (2001) Signal transduction in neuronal migration roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell 107:209-221 (Pubitemid 33035947)
36. Wu G, Vaswani KK, Lu ZH, Ledeen RW (1990) Gangliosides stimulate calcium flux in neuro 2A cells and require exogenous calcium for neuritogenesis. J Neurochem 55:484-491
37. Wu J, Lessard J, Olave IA, Qiu Z, Ghosh A, Graef IA, Crabtree GR (2007) Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron 56:94-108 (Pubitemid 47484177)
38. Yang Y, Marcello M, Endris V, Saffrich R, Fischer R, Trendelenburg MF, Sprengel R, Rappold G (2006) MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation. Exp Cell Res 312:2379-2393 (Pubitemid 43928953)
39. Yao Q, Jin WL, Wang Y, Ju G (2008) Regulated shuttling of Slit-Robo-GTPase activating proteins between nucleus and cytoplasm during brain development. Cell Mol Neurobiol 28:205-221 (Pubitemid 351253073)
40. Yoo AS, Crabtree GR (2009) ATP-dependent chromatin remodeling in neural development. Curr Opin Neurobiol 19:120-126
41. Yuan X, Jin M, Xu X, Song Y, Wu C, Poo M, Duan S (2003) Signalling and crosstalk of Rho GTPases in mediating axon guidance. Nat Cell Biol 5:1-8
42. Yuan BZ, Jefferson AM, Millecchia L, Popescu NC, Reynolds SH (2007) Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells. Exp Cell Res 313:3868-3880 (Pubitemid 47561896)
43. Zeng M, Zhou JN (2008) Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells. Cell Signal 20:659-665