Adaptive changes in autophagy after UPS impairment in Parkinson's disease

Acta Pharmacologica Sinica

Volumn 34, Issue 5, 2013, Pages 667-673

  Shen, Yu Fei ^a   Tang, Yu ^a   Zhang, Xiao Jie ^a   Huang, Kai Xing ^a   Le, Wei Dong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

autophagosome; autophagylysosomal pathway; Beclin 1; dopaminergic neuron; lactacystin; mTOR; Parkinsons disease; proteasome inhibitor; ubiquitin proteasome system

Indexed keywords

BECLIN 1; LACTACYSTIN; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3; PHOSPHOPROTEIN; PROTEASOME; PROTEIN P62; UBIQUITIN; UNCLASSIFIED DRUG;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BRAIN NERVE CELL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ELECTRON MICROSCOPY; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; IN VIVO STUDY; LEFT HEMISPHERE; MALE; MESENCEPHALON; MOUSE; NERVE CELL DEGENERATION; NEUROBLASTOMA CELL; NONHUMAN; PARKINSON DISEASE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SUBSTANTIA NIGRA;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; HUMANS; MALE; MEMBRANE PROTEINS; MESENCEPHALON; MICE; MICE, INBRED C57BL; NEURONS; PARKINSON DISEASE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; UBIQUITIN;

EID: 84877607073     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.203     Document Type: Article

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