Angiotensin-(1-7) through AT2 receptors mediates tyrosine hydroxylase degradation via the ubiquitin-proteasome pathway

Journal of Neurochemistry

Volumn 109, Issue 2, 2009, Pages 326-335

  Lopez Verrilli, María A ^a   Pirola, Carlos J ^b   Pascual, Mariano M ^a   Dominici, Fernando P ^a   Turyn, Daniel ^a   Gironacci, Mariela M ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b INSTITUTO DE INVESTIGACIONES MÉDICAS ALFREDO LANARI   (Argentina)

Author keywords

Angiotensin (1 7); AT2 receptors; Neuronal cultures; Spontaneously hypertensive rats; Tyrosine hydroxylase; Ubiquitin proteasome pathway

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN II [3-8]; ANGIOTENSIN III; ANGIOTENSIN V; ANGIOTENSIN VI; ANGIOTENSIN VII; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; HEPTAPEPTIDE; PROTEASOME; SERINE; TRITIUM OXIDE; TYROSINE; TYROSINE 3 MONOOXYGENASE; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; WESTERN BLOTTING;

ANGIOTENSIN I; ANIMALS; CELLS, CULTURED; HORSES; MALE; PEPTIDE FRAGMENTS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, ANGIOTENSIN; SIGNAL TRANSDUCTION; TYROSINE 3-MONOOXYGENASE; UBIQUITIN;

RATTUS;

EID: 62649166390     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.05912.x     Document Type: Article

References (45)

1. 1 receptor antagonist. J. Biol. Chem. 26, 39721 39726.
2. Adamo A. M., Besio Moreno M., Soto E. F. Pasquini J. M. (1994) Ubiquitin-protein conjugates in different structures of the central nervous system of the rat. J. Neurosci. Res. 38, 358 364.
3. Becker L. K., Etelvino G. M., Walther T., Santos R. A. Campagnole-Santos M. J. (2007) Immunofluoresce localization of the receptor Mas in cardiovascular-related areas of the rat brain. Am. J. Physiol. Heart Circ. Physiol. 293, H1416 H1424.
4. Bobrovskaya L., Dunkley P. R. Dickson P. W. (2004) Phosphorylation of Ser19 increases both phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells. J. Neurochem. 90, 857 864.
5. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248 254.
6. Diz D. I. Ferrario C. M. 1996) Angiotensin receptor heterogeneity in the dorsal medulla oblongata as defined by angiotensin-(1-7). in Recent Advances in Cellular and Molecular Aspects of Angiotensin Receptors (Raizada M. K., ed.) pp. 225 235. Plenum Press, New York, USA.
7. Dunkley P. R., Bobrovskaya L., Graham M. E., von Nagy-Felsobuki E. I. Dickson P. W. (2004) Tyrosine hydroxylase phosphorylation: regulation and consequences. J. Neurochem. 91, 1025 1043.
8. Felix D., Khosla M. C., Barnes K. L., Imboden H., Montani B. Ferrario C. M. (1991) Neurophysiological responses to angiotensin-(1-7). Hypertension 17, 1111 1114.
9. Ferrario C., Chappell M., Tallant A., Brosnihan B. Diz D. (1997) Counterregulatory actions of angiotensin-(1-7). Hypertension 30, 535 541.
10. Fujisawa H. Okuno S. (2005) Regulatory mechanisms of tyrosine hydroxylase. Biochem. Biophys. Res. Comun. 338, 271 276.
11. Funakoshi H., Okuno S. Fujisawa H. (1991) Different effects on activity caused by phosphorylation of tyrosine hydroxylase at serine 40 by three multifunctional protein kinases. J. Biol. Chem. 266, 15614 15620.
12. Gao L., Wang W. Z., Wang W. Zucker I. H. (2008) Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla potential mechanism for sympathetic overactivity in heart failure. Hypertension 52, 708 714.
13. Gironacci M. M., Coba M. Peña C. (1999) Angiotensin-(1-7) binds at the type 1 angiotensin II receptors in rat renal cortex. Regul. Pept. 84, 51 54.
14. Gironacci M. M., Vatta M., Rodriguez-Fermepin M., Fernandez B. E. Peña C. (2000) Angiotensin-(1-7) reduces norepinephrine release through a nitric oxide mechanism in rat hypothalamus. Hypertension 35, 1248 1252.
15. Gironacci M., Valera M. S., Yujnovsky I. Peña C. (2004a) Angiotensin-(1-7) inhibitory mechanism of norepinephrine release in hypertensive rats. Hypertension 44, 783 787.
16. Gironacci M. M., Yujnovsky I., Gorzalczany S., Taira C. Peña C. (2004b) Angiotensin-(1-7) inhibits the angiotensin II-enhanced norepinephrine release in coarcted hypertensive rats. Regul. Pept. 118, 45 49.
17. Glickman M. H. Ciechanover A. (2002) The ubiquitin-proteasome proteolytic pathway. Physiol. Rev. 82, 373 428.
18. Höcht C., Opezzo J. A. W., Gironacci M. M., Peña C. Taira C. A. (2006) Hypothalamic cardiovascular effects of angiotensin-(1-7) in spontaneously hypertensive rats. Regul. Pept. 135, 39 44.
19. Höcht C., Gironacci M. M., Mayer M. A., Schuman M., Bertera F. M. Taira C. A. (2008) Involvement of angiotensin-(1-7) in the hypothalamic hypotensive effect of captopril in sinoaortic denervated rats. Regul. Pept. 146, 58 66.
20. Horiuchi M., Hamai M., Cui T., Iwai M. Minokoshi Y. (1999) Cross talk between angiotensin II type 1 and type 2 receptors: cellular mechanism of angiotensin type 2 receptor-mediated cell growth inhibition. Hypertens. Res. 22, 67 74.
21. Jaiswal N., Tallant E. A., Diz D. I., Khosla M. C. Ferrario C. M. (1991) Subtype 2 angiotensin receptors mediate prostaglandin synthesis in human astrocytes. Hypertension 17, 1115 1120.
22. Karamyan V. T. Speth R. C. 2007) Enzymatic pathways of the brain renin-angiotensin system: unsolved problems and continuing challenges. Regul. Pept. 143 (1-3 15 27.
23. Kornitzer D. Ciechanover A. (2000) Modes of regulation of ubiquitin mediated protein degradation. J. Cell. Physiol. 182, 1 11.
24. Kubo T., Amano M., Ishizuka T. Ozaki S. (1993) Beta-alanine and taurine microinjected into the rat caudal ventrolateral medulla increase blood pressure. Clin. Exp. Hypertens. 15, 585 597.
25. Kumai T., Tateishi T., Tanaka M., Watanabe M., Shimizu H. Kobayashi S. (2001) Tyrosine hydroxylase antisense gene therapy causes hypotensive effects in the spontaneously hypertensive rats. J. Hypertens. 19, 1769 1773.
26. Lehmann I. T., Bobrovskaya L., Gordon S. L., Dunkley P. R. Dickson P. W. (2006) Differential regulation on the human tyrosine hydroxylase isoforms via hierarchical phosphorylation. J. Biol. Chem. 281, 17644 17651.
27. Ma F. Y., Grattan D. R., Bobrovskaya L., Dunkley P. R. Bunn S. (2004) Angiotensin II regulates tyrosine hydroxylase activity and mRNA expression in rat mediobasal hypothalamic cultures: the role of specific protein kinases. J. Neurochem. 90, 431 441.
28. Pereyra-Alfonso S., Rodriguez de Lores Arnaiz G. Peña C. (2007) Phosphoinositide hydrolysis increase by angiotensin-(1-7) in neonatal rat brain. Regul. Pept. 140, 162 167.
29. Rao F., Zhang L., Wessel J. et al. (2007) Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo. Circulation 116, 993 1006.
30. Reja V., Goodchild A. K. Pilowski P. M. (2002a) Catecholamine-related gene expression correlates with blood pressures in SHR. Hypertension 40, 342 347.
31. Reja V., Goodchild A. K., Phillips J. K. Pilowsky P. M. (2002b) Tyrosine hydroxylase gene expression in ventrolateral medulla oblongata of WKY and SHR: a quantitative real-time polymerase chain reaction study. Auton. Neurosci. 98, 79 84.
32. Saavedra J. M. (2005) Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities. Cell. Mol. Neurobiol. 25, 485 512.
33. Santos R. A., Simoes e Silva A. C., Maric C. et al. (2003) Ang-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc. Natl Acad. Sci. USA 100, 8258 8263.
34. Santos R. A., Ferreira A. J. Simões E Silva A. C. (2008) Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis. Exp. Physiol. 93 (5 519 527.
35. Sasamura H., Dzau V. J. Pratt R. E. (1994) Desensitization of angiotensin receptor function. Kidney Int. 46, 1499 1501.
36. Sumners C., Richards E. M., Tang W. Raizada M. K. (1993) Angiotensin II type 2 receptor expression in neuronal cultures from spontaneously hypertensive rat brain. Regul. Pept. 44 (2 181 188.
37. Takekoshi K., Ishii K., Shibuya S., Kawakami Y., Isobe K. Nakai T. (2002) Angiotensin II type 2 receptor counter-regulates type 1 receptor in catecholamine synthesis in cultured porcine adrenal medullary chromaffin cells. Hypertension 39, 142 148.
38. Taniyama Y., Hitomi H., Shah A., Alexander R. W. Griendling K. K. (2005) Mechanisms of reactive oxygen species-dependent downregulation of insulin receptor substrate-1 by angiotensin II. Arterioescler. Thromb. Vasc. Biol. 25, 1142 1147.
39. Timmermans P. B., Wong P. C., Chiu A. T., Herblin W. F., Benfield P., Carini D. J., Lee R. J., Wexler R. R., Saye J. A. Smith R. D. (1993) Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol. Rev. 45, 205 251.
40. Trask A. J. Ferrario C. M. (2007) Angiotensin-(1-7): pharmacology and new perspectives in cardiovascular treatments. Cardiovasc. Drug Rev. 25 (2 162 174.
41. Veersingham S. J. Raizada M. K. (2003) Brain renin-angiotensin system in hypertension. Br. J. Pharmacol. 139, 191 202.
42. Walters P. E., Gaspari T. A. Widdop R. E. (2005) Angiotensin-(1-7) acts as a vasodepressor agent vis angiotensin II type 2 receptors in conscious rats. Hypertension 2005, 45.
43. de Wardener H. E. (2001) The hypothalamus and hypertension. Physiol. Rev. 81, 1599 1658.
44. Wyss J. M. Carlson S. H. (1999) The role of the central nervous system in hypertension. Curr. Hypertens. Rep. 1, 246 253.
45. Yu K., Lu D., Rowland N. E. Raizada M. K. (1996) Angiotensin II regulation of tyrosine hydroxylase gene expression in the neuronal cultures of normotensive and spontaneously hypertensive rats. Endocrinology 137, 3566 3576.