-
2
-
-
0033105537
-
Cell adhesion mediated drug resistance (CAM-DR): Role of integrins and resistance to apoptosis in human myeloma cell lines
-
Damiano JS, Cress AE, Hazlehurst LA, et al. Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood. 1999;93:1658-1667.
-
(1999)
Blood
, vol.93
, pp. 1658-1667
-
-
Damiano, J.S.1
Cress, A.E.2
Hazlehurst, L.A.3
-
3
-
-
0035502588
-
Cell adhesion is a key determinant in de novo multidrug resistance (MDR): New targets for the prevention of acquired MDR
-
Shain KH, Dalton WS. Cell adhesion is a key determinant in de novo multidrug resistance (MDR): new targets for the prevention of acquired MDR. Mol Cancer Ther. 2001;1:69-78.
-
(2001)
Mol Cancer Ther
, vol.1
, pp. 69-78
-
-
Shain, K.H.1
Dalton, W.S.2
-
4
-
-
0034284054
-
Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity
-
Michigami T, Shimizu N, Williams PJ, et al. Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity. Blood. 2000;96:1953-1960.
-
(2000)
Blood
, vol.96
, pp. 1953-1960
-
-
Michigami, T.1
Shimizu, N.2
Williams, P.J.3
-
5
-
-
0031225483
-
IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade
-
Ogata A, Chauhan D, Teoh G, et al. IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade. J Immunol. 1997;159:2212-2221.
-
(1997)
J Immunol
, vol.159
, pp. 2212-2221
-
-
Ogata, A.1
Chauhan, D.2
Teoh, G.3
-
6
-
-
0035921689
-
Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma
-
Hideshima T, Nakamura N, Chauhan D, et al. Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma. Oncogene. 2001;20:5991-6000.
-
(2001)
Oncogene
, vol.20
, pp. 5991-6000
-
-
Hideshima, T.1
Nakamura, N.2
Chauhan, D.3
-
7
-
-
0032711250
-
IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than Ras/MAP kinase pathway
-
Puthier D, Bataille R, Amiot M. IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than Ras/MAP kinase pathway. Eur J Immunol. 1999;29:3945-3950.
-
(1999)
Eur J Immunol
, vol.29
, pp. 3945-3950
-
-
Puthier, D.1
Bataille, R.2
Amiot, M.3
-
8
-
-
0027212420
-
Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias
-
Corradini P, Ladetto M,Voena C, et al. Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias. Blood. 1993;81:2708-2713.
-
(1993)
Blood
, vol.81
, pp. 2708-2713
-
-
Corradini, P.1
Ladetto, M.2
Voena, C.3
-
9
-
-
0035908493
-
Blocking oncogenic Ras signaling for cancer therapy
-
Adjei AA. Blocking oncogenic Ras signaling for cancer therapy. J Natl Cancer Inst. 2001;93:1062-1074.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1062-1074
-
-
Adjei, A.A.1
-
10
-
-
0036399117
-
Agents targeting ras signaling pathway
-
Dancey JE. Agents targeting ras signaling pathway. Curr Pharm Des. 2002;8:2259-2267.
-
(2002)
Curr Pharm Des
, vol.8
, pp. 2259-2267
-
-
Dancey, J.E.1
-
11
-
-
0030829794
-
Inhibitors of prenyl transferases
-
Sebti S, Hamilton AD. Inhibitors of prenyl transferases. Curr Opin Oncol. 1997;9:557-561.
-
(1997)
Curr Opin Oncol
, vol.9
, pp. 557-561
-
-
Sebti, S.1
Hamilton, A.D.2
-
12
-
-
0033427141
-
Farnesyltransferase inhibitors: Preclinical development
-
Kohl NE. Farnesyltransferase inhibitors: preclinical development. Ann N Y Acad Sci. 1999;886:91-102.
-
(1999)
Ann N Y Acad Sci
, vol.886
, pp. 91-102
-
-
Kohl, N.E.1
-
13
-
-
0035360259
-
Isotype-specific Ras GTP-levels predict the efficacy of farnesyl transferase inhibitors against human astrocytomas regardless of Ras mutational status
-
Feldkamp MM, Lau N, Roncari L, et al. Isotype-specific Ras GTP-levels predict the efficacy of farnesyl transferase inhibitors against human astrocytomas regardless of Ras mutational status. Cancer Res. 2001;61:4425-4431.
-
(2001)
Cancer Res
, vol.61
, pp. 4425-4431
-
-
Feldkamp, M.M.1
Lau, N.2
Roncari, L.3
-
14
-
-
0142014637
-
Cytoreductive effects of farnesyl transferase inhibitors on multiple myeloma tumor cells
-
Shi Y, Gera J, Hsu JH, et al. Cytoreductive effects of farnesyl transferase inhibitors on multiple myeloma tumor cells. Mol Cancer Ther. 2003;2:563-572.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 563-572
-
-
Shi, Y.1
Gera, J.2
Hsu, J.H.3
-
15
-
-
0035893740
-
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitors combinations in preclinical models
-
Lobell RB, Omer CA, Abrams MT, et al. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitors combinations in preclinical models. Cancer Res. 2001;61:8758-8768.
-
(2001)
Cancer Res
, vol.61
, pp. 8758-8768
-
-
Lobell, R.B.1
Omer, C.A.2
Abrams, M.T.3
-
16
-
-
0142046485
-
Genetic response to farnesyltransferase inhibitors: Proapoptotic targets of RhoB
-
Kamasani U, Liu AX, Prendergast GC. Genetic response to farnesyltransferase inhibitors: proapoptotic targets of RhoB. Cancer Biol Ther. 2003;2:273-280.
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 273-280
-
-
Kamasani, U.1
Liu, A.X.2
Prendergast, G.C.3
-
17
-
-
0035667260
-
Progress in prostate cancer chemoprevention: Modulators of promotion and progression
-
Lieberman R, Bermejo C, Akaza H, et al. Progress in prostate cancer chemoprevention: modulators of promotion and progression. Urology. 2001;58:835-842.
-
(2001)
Urology
, vol.58
, pp. 835-842
-
-
Lieberman, R.1
Bermejo, C.2
Akaza, H.3
-
19
-
-
0034795435
-
Farnesyl transferase inhibitors: A novel therapy for breast cancer
-
Johnston SR, Kelland LR. Farnesyl transferase inhibitors: a novel therapy for breast cancer. EndocrRelat Cancer. 2001;8:227-235
-
(2001)
EndocrRelat Cancer
, vol.8
, pp. 227-235
-
-
Johnston, S.R.1
Kelland, L.R.2
-
20
-
-
10744227474
-
Farnesyltransferase inhibitor R115777 in myelodysplastic syndrome: Clinical and biologic activities in the phase I setting
-
In press
-
Kurzrock R, Kantarjian HM, Cortes JE, et al. Farnesyltransferase inhibitor R115777 in myelodysplastic syndrome: clinical and biologic activities in the phase I setting. Blood. 2003. In press.
-
(2003)
Blood
-
-
Kurzrock, R.1
Kantarjian, H.M.2
Cortes, J.E.3
-
21
-
-
0035383789
-
Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase I clinical-laboratory correlative trial
-
Karp JE, Lancet JE, Kaufmann SH, et al. Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase I clinical-laboratory correlative trial. Blood. 2001;97:3361-3369
-
(2001)
Blood
, vol.97
, pp. 3361-3369
-
-
Karp, J.E.1
Lancet, J.E.2
Kaufmann, S.H.3
-
23
-
-
0029898894
-
Protein prenylation: Molecular mechanisms and functional consequences
-
Zhang FL, Casey PJ. Protein prenylation: molecular mechanisms and functional consequences. Annu Rev Biochem. 1996;65:241-269.
-
(1996)
Annu Rev Biochem
, vol.65
, pp. 241-269
-
-
Zhang, F.L.1
Casey, P.J.2
-
24
-
-
0029819604
-
Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: Analysis of the Eastern Cooperative Oncology Group Phase III Trial
-
Liu P, Leong T, Quam L, et al. Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial. Blood. 1996;88:2699-2706.
-
(1996)
Blood
, vol.88
, pp. 2699-2706
-
-
Liu, P.1
Leong, T.2
Quam, L.3
-
25
-
-
0034876702
-
High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis
-
Bezieau S, Devilder MC, Avet-Loiseau H, et al. High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis. Hum Mutat. 2001;18:212-224.
-
(2001)
Hum Mutat
, vol.18
, pp. 212-224
-
-
Bezieau, S.1
Devilder, M.C.2
Avet-Loiseau, H.3
-
26
-
-
0035469865
-
Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentation
-
Kalakonda N, Rothwell DG, Scarffe JH, et al. Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentation. Blood. 2001;8:1555-1560.
-
(2001)
Blood
, vol.8
, pp. 1555-1560
-
-
Kalakonda, N.1
Rothwell, D.G.2
Scarffe, J.H.3
-
27
-
-
0038621230
-
Farnesyl protein transferase inhibitor ZARNESTRA R115777: History of a discovery
-
Venet M, End D, Angibaud P. Farnesyl protein transferase inhibitor ZARNESTRA R115777: history of a discovery. Curr Top Med Chem. 2003;3:1095-1102.
-
(2003)
Curr Top Med Chem
, vol.3
, pp. 1095-1102
-
-
Venet, M.1
End, D.2
Angibaud, P.3
-
28
-
-
0035132538
-
Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
-
End DW, Smets G, Todd AV, et al. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 2001;61:131-137.
-
(2001)
Cancer Res
, vol.61
, pp. 131-137
-
-
End, D.W.1
Smets, G.2
Todd, A.V.3
-
29
-
-
0036284741
-
Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line
-
Smith V, Rowlands MG, Barrie E, et al. Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line. Clin Cancer Res. 2002;8:2002-2009.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2002-2009
-
-
Smith, V.1
Rowlands, M.G.2
Barrie, E.3
-
30
-
-
0038538402
-
Farnesyltransferase inhibitors: A novel approach in the treatment of advanced pancreatic carcinomas
-
Dempke WC. Farnesyltransferase inhibitors: a novel approach in the treatment of advanced pancreatic carcinomas. Anticancer Res. 2003;23:813-818.
-
(2003)
Anticancer Res
, vol.23
, pp. 813-818
-
-
Dempke, W.C.1
-
31
-
-
0036605562
-
Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer
-
Crul M, de Klerk GJ, Swart M, et al. Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer. J Clin Oncol. 2002;20:2726-2735.
-
(2002)
J Clin Oncol
, vol.20
, pp. 2726-2735
-
-
Crul, M.1
De Klerk, G.J.2
Swart, M.3
-
32
-
-
12444301731
-
A phase I trial of the farnesyl protein transferase inhibitor R115777 in combination with gemcitabine and cisplatin in patients with advanced cancer
-
Adjei AA, Croghan GA, Erlichman C, et al. A phase I trial of the farnesyl protein transferase inhibitor R115777 in combination with gemcitabine and cisplatin in patients with advanced cancer. Clin Cancer Res. 2003;9:2520-2526.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2520-2526
-
-
Adjei, A.A.1
Croghan, G.A.2
Erlichman, C.3
-
33
-
-
0038352147
-
Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer
-
Johnston SR, Hickish T, Ellis P, et al. Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer. J Clin Oncol. 2003;21:2492-2499.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2492-2499
-
-
Johnston, S.R.1
Hickish, T.2
Ellis, P.3
-
34
-
-
0038362742
-
Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer
-
Adjei AA, Mauer A, Bruzek L, et al. Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer. J Clin Oncol. 2003;21:1760-1766.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1760-1766
-
-
Adjei, A.A.1
Mauer, A.2
Bruzek, L.3
-
35
-
-
0038413837
-
Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma
-
Cohen SJ, Ho L, Ranganathan S, et al. Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma. J Clin Oncol. 2003;21:1301-1306.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1301-1306
-
-
Cohen, S.J.1
Ho, L.2
Ranganathan, S.3
-
36
-
-
0037328558
-
The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells
-
Bolick SC, Landowski TH, Boulware D, et al. The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells. Leukemia. 2003;17:451-457.
-
(2003)
Leukemia
, vol.17
, pp. 451-457
-
-
Bolick, S.C.1
Landowski, T.H.2
Boulware, D.3
-
37
-
-
0142078327
-
Effect of farnesyl transferase inhibitor R115777 (Zarnestra) on the growth of fresh and cloned myeloma cells in vitro
-
July 3. Epub ahead of print
-
Ochiai N, Uchida R, Fuchida SI, et al. Effect of farnesyl transferase inhibitor R115777 (Zarnestra) on the growth of fresh and cloned myeloma cells in vitro. Blood. 2003:July 3. Epub ahead of print.
-
(2003)
Blood
-
-
Ochiai, N.1
Uchida, R.2
Fuchida, S.I.3
-
38
-
-
0142109941
-
Farnesyl transferase inhibitor R115777 decreases Akt phosphorylation in multiple myeloma cell lines and its apoptotic effects correlate with phosphoAKT expression levels
-
Abstract
-
Mackley PA, Shain KH, Dalton WS, et al. Farnesyl transferase inhibitor R115777 decreases Akt phosphorylation in multiple myeloma cell lines and its apoptotic effects correlate with phosphoAKT expression levels. Blood. 2002:3198. Abstract.
-
(2002)
Blood
, pp. 3198
-
-
Mackley, P.A.1
Shain, K.H.2
Dalton, W.S.3
-
39
-
-
9144241913
-
The farnesyl transferase inhibitor Zarnestra is well tolerated, induces stabilization of disease and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma
-
Submitted
-
Alsina M, Fonseca R, Wilson EF, et al. The farnesyl transferase inhibitor Zarnestra is well tolerated, induces stabilization of disease and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. Blood. 2003. Submitted.
-
(2003)
Blood
-
-
Alsina, M.1
Fonseca, R.2
Wilson, E.F.3
-
40
-
-
0028075566
-
Combination chemotherapy, glucocorticoids, and interferon alfa in the treatment of multiple myeloma: A Southwest Oncology Group study
-
Salmon SE, Crowley JJ, Grogan TM, et al. Combination chemotherapy, glucocorticoids, and interferon alfa in the treatment of multiple myeloma: a Southwest Oncology Group study. J Clin Oncol. 1994;12:2405-2414.
-
(1994)
J Clin Oncol
, vol.12
, pp. 2405-2414
-
-
Salmon, S.E.1
Crowley, J.J.2
Grogan, T.M.3
-
41
-
-
0033986790
-
The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis
-
Jiang K, Coppola D, Crespo NC, et al. The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis. Mol Cell Biol. 2000;20:139-148.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 139-148
-
-
Jiang, K.1
Coppola, D.2
Crespo, N.C.3
|