Blocking kinetics of memantine on NR1a/2A receptors recorded in inside-out and outside-out patches from Xenopus oocytes

Journal of Neural Transmission

Volumn 115, Issue 10, 2008, Pages 1367-1373

  Parsons, Chris G ^a   Gilling, Kate E ^a   Jatzke, Claudia ^a  

^a MERZ PHARMACEUTICALS GMBH   (Germany)

Author keywords

Inside out; Kinetics; Memantine; N Methyl D Aspartate (NMDA); NR1a 2A; Outside out; Patch clamp; Uncompetitive antagonist; Voltage dependency; Xenopus oocytes

Indexed keywords

MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION RESPONSE; DRUG INHIBITION; DRUG RECEPTOR BINDING; FEMALE; HIPPOCAMPUS; INTRACELLULAR RECORDING; MEMBRANE CURRENT; NERVE CELL CULTURE; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR DENSITY; SYNAPTIC MEMBRANE; VOLTAGE CLAMP; WHOLE CELL; XENOPUS LAEVIS;

ANIMALS; EXCITATORY AMINO ACID ANTAGONISTS; MEMANTINE; OOCYTES; PATCH-CLAMP TECHNIQUES; RECEPTORS, N-METHYL-D-ASPARTATE; XENOPUS;

EID: 52449098734     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-008-0087-7     Document Type: Article

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