Oxidative stress induced by HIV-1 reverse transcriptase modulates the enzyme's performance in gene immunization

Human Vaccines and Immunotherapeutics

Volumn 9, Issue 10, 2013, Pages 2111-2119

  Isaguliants, Maria ^a,b   Smirnova, Olga ^c   Ivanov, Alexander V ^c   Kilpelainen, Athina ^a   Kuzmenko, Yulia ^c   Petkov, Stefan ^a   Latanova, Anastasia ^c   Krotova, Olga ^b,c   Engström, Gunnel ^a   Karpov, Vadim ^c   Kochetkov, Sergey ^c   Wahren, Britta ^a   Starodubova, Elizaveta ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b D I IVANOVSKY INSTITUTE OF VIROLOGY   (Russian Federation)

^c ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

Author keywords

DNA immunization; HIV 1 reverse transcriptase; Oxidative stress; Reactive oxygen species; Transcription factor Nrf2

Indexed keywords

GAMMA INTERFERON; HEME OXYGENASE 1; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INTERLEUKIN 2; LAMIVUDINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RITONAVIR; RNA DIRECTED DNA POLYMERASE; SAQUINAVIR; STAVUDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL STRAIN; CELLULAR DISTRIBUTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA RESPONSIVE ELEMENT; ELECTROPORATION; ENZYME ACTIVITY; ENZYME REGULATION; EXPERIMENTAL MOUSE; GENE; GENE EXPRESSION; GENETIC IMMUNIZATION; GENETIC VARIABILITY; HO 1 GENE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOGENICITY; IN VIVO GENE TRANSFER; MOUSE; NONHUMAN; NQO1 GENE; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN EXPRESSION; QUANTITATIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RT GENE; TRANSCRIPTION REGULATION; VIRAL GENE DELIVERY SYSTEM;

DNA IMMUNIZATION; HIV-1 REVERSE TRANSCRIPTASE; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR NRF2;

AIDS VACCINES; ANIMALS; CELL LINE; GENE EXPRESSION PROFILING; HIV REVERSE TRANSCRIPTASE; HUMANS; IMMUNIZATION; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; VACCINES, DNA;

EID: 84885163803     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.25813     Document Type: Article

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