Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action

Neuropharmacology

Volumn 73, Issue , 2013, Pages 111-121

  Swartz, Michael M ^a   Linn, David M ^b   Linn, Cindy L ^a  

^a WESTERN MICHIGAN UNIVERSITY   (United States)

^b GRAND VALLEY STATE UNIVERSITY   (United States)

Author keywords

Excitotoxicity; Neuroprotection; Pig; Retina; Retinal ganglion cells; Tropisetron

Indexed keywords

BUNGAROTOXIN RECEPTOR; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN KINASE B; TROPISETRON;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL SURVIVAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXCITOTOXICITY; IMMUNOCYTOCHEMISTRY; INTERNALIZATION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RETINA GANGLION CELL;

(1R,5S)-8-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-YL 1METHYL-INDOLE-3-CARBOXYLATE; 4-(2-AMINOETHYL) BENZENESULFONYL FLUORIDE HYDROCHLORIDE; 5-HT(3); ACETYLCHOLINE; ACH; AEBSF; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANALYSIS-OF-VARIANCE; ANOVA; CENTRAL NERVOUS SYSTEM; CNS; EDTA; EGTA; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; ETHYLENE GLYCOL TETRAACETIC ACID; ETHYLENEDIAMINETETRAACETIC ACID; EXCITOTOXICITY; FBS; FETAL BOVINE SERUM; GLURS; GLUTAMATE RECEPTORS; GLYCOPROTEIN ORIGINALLY IDENTIFIED IN THYMUS GLAND; IGG; IGM; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MAPK; METHYLLYCACONITINE; MITOGEN ACTIVATED PROTEIN KINASE; MLA; N-METHYL-D-ASPARTATE; NACHR; NERVE GROWTH FACTOR; NEUROPROTECTION; NGF; NICOTINIC ACETYLCHOLINE RECEPTOR; NMDA; PBS; PHENYLMETHYLSULFONYL FLUORIDE; PHOSPHATE BUFFERED SALINE; PIG; PMSF; RETINA; RETINAL GANGLION CELL; RETINAL GANGLION CELLS; RGC; SDS; SEROTONIN; SODIUM DODECYL SULFATE; TEA; TETRAETHYLAMMONIUM CHLORIDE; THY; TROPISETRON; Α7 NACHR;

ACONITINE; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; GLUTAMIC ACID; INDOLES; NEUROPROTECTIVE AGENTS; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, N-METHYL-D-ASPARTATE; RETINAL GANGLION CELLS; SIGNAL TRANSDUCTION; SWINE;

EID: 84885160110     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.05.020     Document Type: Article

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