Pulmonary delivery of DNA vaccine constructs using deacylated PEI elicits immune responses and protects against viral challenge infection

Journal of Controlled Release

Volumn 170, Issue 3, 2013, Pages 452-459

  Mann, Jamie F S ^a   McKay, Paul F ^a   Arokiasamy, Samantha ^a   Patel, Reeyeshkumar K ^b   Klein, Katja ^a   Shattock, Robin J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Gene delivery; HIV 1; Immunity; Influenza; Mucosal; Vaccination

Indexed keywords

BIOMOLECULES; DISEASES; DNA; DRUG THERAPY; GENE TRANSFER; NUCLEIC ACIDS; PATHOGENS; TISSUE; VACCINES;

GENE DELIVERY; HIV-1; IMMUNITY; INFLUENZA; MUCOSAL; VACCINATION;

IMMUNE SYSTEM;

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; 1,2 DIOLEOYL SN GLYCERO 3 PHOSPHOETHANOLAMINE; ANTIVIRUS AGENT; CATION; DNA VACCINE; GLYCOPROTEIN GP 140; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; LIPID EMULSION; NONOXINOL 9; PHOSPHOETHANOLAMINE; PLASMID DNA; POLYETHYLENEIMINE; SQUALENE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CELL VIABILITY; CELLULAR IMMUNITY; COMPLEX FORMATION; CONTROLLED STUDY; DEACYLATION; DNA IMMUNIZATION; DNA TRANSFECTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; GENE DELIVERY SYSTEM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLUENZA A; INFLUENZA VIRUS A; INTRANASAL DRUG ADMINISTRATION; LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARTICLE SIZE; PRIORITY JOURNAL; RESPIRATORY TRACT MUCOSA; SPLEEN CELL; T LYMPHOCYTE; TIGHT JUNCTION; VIRUS LOAD;

GENE DELIVERY; HIV-1; IMMUNITY; INFLUENZA; MUCOSAL; VACCINATION;

ADMINISTRATION, INHALATION; ANIMALS; CACO-2 CELLS; CHO CELLS; CRICETULUS; DNA; EPITHELIUM; FATTY ACIDS, MONOUNSATURATED; FEMALE; GREEN FLUORESCENT PROTEINS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HIV ANTIGENS; HUMANS; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA VACCINES; MALE; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENEIMINE; QUATERNARY AMMONIUM COMPOUNDS; RESPIRATORY MUCOSA; SQUALENE; VACCINES, DNA;

EID: 84885155651     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.06.004     Document Type: Article

References (29)

1. M. Bivas-Benita, L. Bar, G.O. Gillard, D.R. Kaufman, N.L. Simmons, et al, Efficient generation of mucosal and systemic antigen-specific CD8+ T-cell responses following pulmonary DNA immunization, J. Virol. 84 (2010) 5764-5774.
2. M. Bivas-Benita, G.O. Gillard, L. Bar, K.A. White, R.J. Webby, et al, Airway CD8(+) T cells induced by pulmonary DNA immunization mediate protective anti-viral immunity, Mucosal Immunol. 6 (1) (2013) 156-166.
3. G. Minigo, A. Scholzen, C.K. Tang, J.C. Hanley, M. Kalkanidis, et al, Poly-L-lysine-coated nanoparticles: a potent delivery system to enhance DNA vaccine efficacy, Vaccine 25 (2007) 1316-1327. (Pubitemid 46027334)
4. L.S. Klavinskis, L. Gao, C. Barnfield, T. Lehner, S. Parker, Mucosal immunization with DNA-liposome complexes, Vaccine 15 (1997) 818-820. (Pubitemid 27287965)
5. T.W. Kim, H. Chung, I.C. Kwon, H.C. Sung, B.C. Shin, et al, Airway gene transfer using cationic emulsion as a mucosal gene carrier, J. Gene Med. 7 (2005) 749-758. (Pubitemid 40872861)
6. T.W. Kim, Y.J. Kim, H. Chung, I.C. Kwon, H.C. Sung, et al, The role of non-ionic surfactants on cationic lipid mediated gene transfer, J. Control. Release 82 (2002) 455-465. (Pubitemid 34880197)
7. A.C. Hunter, S.M. Moghimi, Cationic carriers of genetic material and cell death: a mitochondrial tale, Biochim. Biophys. Acta 1797 (2010) 1203-1209.
8. A. Beyerle, M. Irmler, J. Beckers, T. Kissel, T. Stoeger, Toxicity pathway focused gene expression profiling of PEI-based polymers for pulmonary applications, Mol. Pharm. 7 (2010) 727-737.
9. H. Chen, Recent advances in mucosal vaccine development, J. Control. Release 67 (2000) 117-128. (Pubitemid 30303828)
10. M. Thomas, J.J. Lu, Q. Ge, C. Zhang, J. Chen, et al, Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung, Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 5679-5684. (Pubitemid 40559619)
11. J.F. Mann, D. Stieh, K. Klein, D.S. de Stegmann, M.P. Cranage, et al., Transferrin conjugation confers mucosal molecular targeting to a model HIV-1 trimeric gp140 vaccine antigen, J. Control. Release 158 (2012) 240-249.
12. M.A. Arias, G.A. Van Roey, J.S. Tregoning, M. Moutaftsi, R.N. Coler, et al, Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140, PLoS One 7 (2012) e41144.
13. S. Liang, K. Mozdzanowska, G. Palladino, W. Gerhard, Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity, J. Immunol. 152 (1994) 1653-1661. (Pubitemid 24075695)
14. J. Holmgren, A.M. Svennerholm, Vaccines against mucosal infections, Curr. Opin. Immunol. 24 (2012) 343-353.
15. M.A. Liu, DNA vaccines: an historical perspective and view to the future, Immunol. Rev. 239 (2011) 62-84.
16. L. Torrieri-Dramard, B. Lambrecht, H.L. Ferreira, T. Van den Berg, D. Klatzmann, et al., Intranasal DNA vaccination induces potent mucosal and systemic immune responses and cross-protective immunity against influenza viruses, Mol. Ther. 19 (2011) 602-611.
17. S.M. Moghimi, P. Symonds, J.C. Murray, A.C. Hunter, G. Debska, et al, A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy, Mol. Ther. 11 (2005) 990-995. (Pubitemid 40724119)
18. M. Thomas, J.J. Lu, C. Zhang, J. Chen, A.M. Klibanov, Identification of novel superior polycationic vectors for gene delivery by high-throughput synthesis and screening of a combinatorial library, Pharm. Res. 24 (2007) 1564-1571. (Pubitemid 46988223)
19. P. Riedl, A. Wieland, K. Lamberth, S. Buus, F. Lemonnier, et al, Elimination of immunodominant epitopes from multispecific DNA-based vaccines allows induction of CD8 T cells that have a striking antiviral potential, J. Immunol. 183 (2009) 370-380.
20. L. Wu, W.P. Kong, G.J. Nabel, Enhanced breadth of CD4 T-cell immunity by DNA prime and adenovirus boost immunization to human immunodeficiency virus Env and Gag immunogens, J. Virol. 79 (2005) 8024-8031. (Pubitemid 40853506)
21. J. Liu, B.A. Ewald, D.M. Lynch, A. Nanda, S.M. Sumida, et al, Modulation of DNA vaccine-elicited CD8+ T-lymphocyte epitope immunodominance hierarchies, J. Virol. 80 (2006) 11991-11997. (Pubitemid 44904348)
22. J.W. Yewdell, J.R. Bennink, Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses, Annu. Rev. Immunol. 17 (1999) 51-88. (Pubitemid 29241119)
23. A. Wieland, P. Riedl, J. Reimann, R. Schirmbeck, Silencing an immunodominant epitope of hepatitis B surface antigen reveals an alternative repertoire of CD8 T cell epitopes of this viral antigen, Vaccine 28 (2009) 114-119.
24. E.J. Im, J.P. Hong, Y. Roshorm, A. Bridgeman, S. Letourneau, et al, Protective efficacy of serially up-ranked subdominant CD8+ T cell epitopes against virus challenges, PLoS Pathog. 7 (2011) e1002041.
25. J. Del Campo, M. Lindqvist, M. Cuello, M. Backstrom, O. Cabrerra, et al, Intranasal immunization with a proteoliposome-derived cochleate containing recombinant gD protein confers protective immunity against genital herpes in mice, Vaccine 28 (2010) 1193-1200.
26. E. Marks, A. Helgeby, J.O. Andersson, K. Schon, N.Y. Lycke, CD4(+) T-cell immunity in the female genital tract is critically dependent on local mucosal immunization, Eur. J. Immunol. 41 (2011) 2642-2653.
27. W.S. Gallichan, K.L. Rosenthal, Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization, J. Exp. Med. 184 (1996) 1879-1890. (Pubitemid 26404478)
28. D.Y. Kim, A. Sato, KS. Fukuyama, H. Sagara, T. Nagatake, et al., The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens, J. Immunol. 186 (2011) 4253-4262.
29. F. Wegmann, K.H. Gartlan, A.M. Harandi, S.A. Brinckmann, M. Coccia, et al, Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens, Nat. Biotechnol. (2012).