A novel cell-processing method 'AgarCytos' in conjunction with OCT3/4 and PLAP to detect intratubular germ cell neoplasia in non-obstructive azoospermia using remnants of testicular sperm extraction specimens

Human Reproduction

Volumn 28, Issue 10, 2013, Pages 2608-2620

  Hessel, M ^a   Ramos, L ^a   Hulsbergen, A F C ^a   D'hauwers, K W M ^a   Braat, D D M ^a   Hulsbergen Van De Kaa, C A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

IGCN; OCT3 4; PLAP; screening; TESE

Indexed keywords

ALKALINE PHOSPHATASE; EOSIN; HEMATOXYLIN; OCTAMER TRANSCRIPTION FACTOR 4; PLACENTAL LIKE ALKALINE PHOSPHATASE; UNCLASSIFIED DRUG;

ADULT; AGARCYTOS; ARTICLE; AZOOSPERMIA; CANCER DIAGNOSIS; COHORT ANALYSIS; CRYOPRESERVATION; DIAGNOSTIC PROCEDURE; GERM CELL TUMOR; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INCIDENCE; INTERMETHOD COMPARISON; INTRATUBULAR GERM CELL NEOPLASIA; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; NON-EPITHELIAL TUMORS; ORCHIECTOMY; POPULATION; PREVALENCE; PROSPECTIVE STUDY; RISK FACTOR; RISK REDUCTION; SEMINOMA; SPERMATOZOON; TESTICULAR SPERM EXTRACTION; TESTIS BIOPSY;

IGCN; OCT3/4; PLAP; SCREENING; TESE;

ADULT; ALKALINE PHOSPHATASE; AZOOSPERMIA; CELL CULTURE TECHNIQUES; COHORT STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; LOGISTIC MODELS; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; OCTAMER TRANSCRIPTION FACTOR-3; SEMINIFEROUS TUBULES; SEMINOMA; SPERM RETRIEVAL;

EID: 84885147319     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/det311     Document Type: Article

References (64)

1. Adamopoulos DA, Koukkou EG. Value of FSH and inhibin-B measurements in the diagnosis of azoospermia- A clinician's overview. Int J Androl 2010; 33:e109-e113.
2. Adamson GD, Baker VL. Subfertility: Causes, treatment and outcome. Best Pract Res Clin Obstet Gynaecol 2003;17:169-185.
3. Almstrup K, Ottesen AM, Sonne SB, Hoei-Hansen CE, Leffers H, Rajpert-de Meyts E, Skakkebæk NE. Genomic and gene expression signature of the pre-invasive testicular carcinoma in situ. Cell Tissue Res 2005; 322:159-165.
4. Almstrup K, Lippert M, Mogensen HO, Nielsen JE, Hansen JD, Daugaard G, Jørgensen N, FogedNT, Skakkebæk NE, Rajpert-De Meyts E. Screening of subfertile men for testicular carcinoma in situ by an automated image analysis-based cytological test of the ejaculate. Int J Androl 2011; 34:e21-e30. Discussion e30-1.
5. Banz-Jansen C, Nikorowitch C, Drechsler T, Felberbaum R, Schmutzler A, Diedrich K, Finas D. Incindence of testicular malignancies and correlation to risk factors in a TESE population of subfertile men. Arch Gynecol Obstet 2012;285:247-253.
6. Berthelsen JG, Skakkebæk NE. Value of testicular biopsy in diagnosing carcinoma in situ testis. Scand J Urol Nephrol 1981;15:165-168.
7. Bhasin S, de Kretser DM, Baker HW. Clinical review 64: Pathophysiology and natural history of male infertility. J Clin Endocrinol Metab 1994; 79:1525-1529.
8. Burns WR, Sabanegh E, Dada R, Rein B, Agarwal A. Is male infertility a forerunner to cancer?. Int Braz J Urol 2010;36:527-536.
9. Cooperberg MR, Chi T, Jad A, Cha I, Turek PJ. Variability in testis biopsy interpretation: Implications for male infertility care in the era of intracytoplasmic sperm injection. Fertil Steril 2005;84:672-677.
10. de Jong J, Stoop H, Dohle GR, Bangma CH, Kliffen M, van Esser JWJ, van den Bent M, Kros JM, Oosterhuis JW, Looijenga LHJ. Diagnostic value of OCT3/4 for pre-invasive and invasive testicular germ cell tumours. J Pathol 2005;206:242-249.
11. Dieckmann K-P, Loy V. False-negative biopsies for the diagnosis of testicular intraepithelial neoplasia (TIN)-an update. Eur Urol 2003;43:516-521.
12. Dieckmann K-P, Pichlmeier U. Clinical epidemiology of testicular germ cell tumors. World J Urol 2004;22:2-14.
13. Dieckmann K-P, Kulejewski M, Pichlmeier U, Loy V. Diagnosis of contralateral testicular intraepithelial neoplasia (TIN) in patients with testicular germ cell cancer: Systematic two-site biopsies are more sensitive than a single random biopsy. Eur Urol 2007a;51:175-183. Discussion 183-5.
14. Dieckmann K-P, Linke J, Loy V. Immunostaining for placental alkaline phosphatase on fine-needle aspiration specimens to detect noninvasive testicular cancer: A prospective evaluation in cryptorchid men. BJU 2007b;99:209.
15. Dieckmann K-P, Kulejewski M, Heinemann V, Loy V. Testicular biopsy for early cancer detection-objectives, technique and controversies. Int J Androl 2011;34:e7-13.
16. Elzinga-Tinke JE, Sirre ME, Looijenga LHJ, van Casteren NJ, Wildhagen MF, Dohle GR. The predictive value of testicular ultrasound abnormalities for carcinoma in situ of the testis in men at risk for testicular cancer. Int J Androl 2010;33:597-603.
17. Everaert K, de Croo I, KerckhaertW, Dekuyper P, Dhont M, van der Elst J, de Sutter P, Comhaire F, Mahmoud A, Lumen N. Long term effects of micro-surgical testicular sperm extraction on androgen status in patients with non obstructive azoospermia. BMC Urol 2006;6:9.
18. Forman D, Pike MC, Davey G, Dawson S, Baker K, Chilvers CED, Oliver RTD, Coupland CAC. Aetiology of testicular cancer: Association with congenital abnormalities, age at puberty, infertility, and exercise. BMJ 1994;308:1393-1399.
19. Gallagher RP, Huchcroft S, Phillips N, Hill GB, Coldman AJ, Copping C, Lee T. Physical activity, medical history, and risk of testicular cancer (alberta and british columbia, canada). Cancer Causes Control 1995; 6:395-406.
20. Hoei-Hansen CE, Holm M, Rajpert-de Meyts E, Skakkebæk NE. Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer. J Pathol 2003;200:370-374.
21. Hoei-Hansen CE, Olesen IA, Jørgensen N, Carlsen E, Holm M, Almstrup K, Leffers H, Rajpert-De Meyts E. Current approaches for detection of carcinoma in situ testis. Int J Androl 2007;30:398-404.
22. Holstein AF, Lauke H. Histologic diagnostics of early testicular germ-cell tumor. Int J Urol 1996;3:165-172.
23. Honig SC, Lipschultz LI, Jarow J. Significant medical pathology uncovered by a comprehensive male infertility evaluation. Fertil Steril 1994; 62:1028-1034.
24. Ikinger U, Wurster K, Terwey B, Moü hring K. Microcalcifications in testicular malignancy: Diagnostic tool in occult tumor?. Urology 1982; 19:525-528.
25. Jacobsen R, Bostofte E, Engholm G, Hansen J, Olsen JH, Skakkebæk NE, Møller H. Risk of testicular cancer in men with abnormal semen characteristics: Cohort study. BMJ 2000;321:789-792.
26. Jungwirth A, Giwercman A, Tournaye H, Diemer T, Kopa Z, Dohle G, Krausz C; EAUWorking Group on Male Infertility. European association of urology guidelines on male infertility: The 2012 update. Eur Urol 2012; 62:324-332.
27. Kalsi J, Thum MY, Muneer A, Abdullah H, Minhas S. In the era of micro-dissection sperm retrieval (m-TESE) is an isolated testicular biopsy necessary in the management of men with non-obstructive azoospermia?. BJU Int 2012;109:418-424.
28. Kerstens HMJ, Robben JCM, Poddighe PJ, Melchers WJG, Boonstra H, de Wilde PCM, Macville MVE, Hanselaar AGJM. Agarcyto: A novel cell-processing method for multiple molecular diagnostic analysis of the uterine cervix. J Histochem Cytochem 2000;48:709-718.
29. Kim W, Rosen MA, Langer JE, Banner MP, Siegelman ES, Ramchandani P. US-MR imaging correlation in pathologic conditions of the scrotum. Radiographics 2007;27:1239-1253.
30. Kliesch S, Thomaidis T, Schuütte B, Puühse G, Kater B, Roth S, Bergmann M. Update on the diagnostic safety for detection of testicular intraepithelial neoplasia (TIN). APMIS 2003;111:70-75.
31. Kubik-Huch RA, Hailemariam S, Hamm B. CT and MRI of the male genital tract: Radiologic-pathologic correlation. Eur Radiol 1999;9:16-28.
32. KWF Kankerbestrijding. Rapport kanker in Nederland tot 2020; trends en prognoses. Bijlage zaadbalkanker. http://repository.kwfkankerbestrijding. nl//PublishingImages/SCK-bijlage%2026.%20Zaadbalkanker.pdf (January 2013, date last accessed).
33. Levin HS. Testicular biopsy in the study of male infertility. Hum Pathol 1979; 10:569-584.
34. Lip SZL, Murchison LED, Cullis PS, Govan L, Carachi R. Ameta-analysis of the risk of boys with isolated cryptorchidism developing testicular cancer in later life. Arch Dis Child 2013;98:20-26.
35. Looijenga LHJ, Hersmus R, Oosterhuis JW, Cools MC, Drop SLS, Wolffenbuttel KP. Tumor risk in disorders of sex development (DSD). Best Pract Res Clin Endocrinol Metab 2007;21:480-495.
36. Mancini M, Carmignani L, Gazzano G, Sagone P, Gadda F, Bosari S, Rocco F, Colpi GM. High prevalence of testicular cancer in azoospermic men without spermatogenesis. Hum Reprod 2007;22:1042-1046.
37. Manning M, Junemann K, Alken P. Decrease in testosterone blood concentrations after testicular sperm extraction for intracytoplasmic sperm injection in azoospermic men. Lancet 1998;352:37.
38. McLachlan RI, Rajpert-de Meyts E, Hoei-Hansen CE, de Kretser DM, Skakkebæk NE. Histological evaluation of the human testis-approaches to optimizing the clinical value of the assessment: Mini review. Hum Reprod 2007;22:2-16.
39. Møller H, Skakkebæk NE. Risk of testicular cancer in subfertile men: Case-control study. BMJ 1999;318:559-562.
40. Negri L, Benaglia R, Fiamengo B, Pizzocaro A, Albani E, Levi Setti PE. Cancer risk in male factor-infertility. Placenta 2008;29:S178-S183.
41. NVOG(Dutch Society of Obstetrics and Gynaecology) guideline 'Mannelijke subfertiliteit'. http://nvog-documenten.nl (December 2012, date last accessed).
42. Olesen IA, Hoei-Hansen CE, Skakkebæk NE, Petersen JH, Rajpert-de Meyts E, Jørgensen N. Testicular carcinoma in situ in subfertile danish men. Int J Androl 2007;30:406-411. Discussion 412.
43. Oosterhuis JW, Looijenga LHJ. Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer 2005;5:210-222.
44. Oosterhuis JW, Stoop H, Dohle G, Boellaard W, van Casteren N, Wolffenbuttel KP, Looijenga LHJ. A pathologist's view on the testis biopsy. Int J Androl 2011;34:e14-e19. Discussion e20.
45. Raheem AA, Garaffa G, Rushwan N, de Luca F, Zacharakis E, Raheem TA, Freeman A, Serhal P, Harper JC, Ralph D. Testicular histopathology as a predictor of a positive sperm retrieval in men with non-obstructive azoospermia. BJU Int 2013;111:492-499.
46. Rajpert-De Meyts E. Developmental model for the pathogenesis of testicular carcinoma in situ: Genetic and environmental aspects. Hum Reprod Update 2006;12:303-323.
47. Rajpert-De Meyts E, Jørgensen N, Brøndum-Nielsen K, Muüller J, Skakkebæk NE. Developmental arrest of germ cells in the pathogenesis of germ cell neoplasia. APMIS 1998;106:198-204. Discussion 204-6.
48. Raman JD, Nobert CF, Goldstein M. Increased incidence of testicular cancer in men presenting with infertility and abnormal semen analysis. J Urol 2005; 174:1819-1822.
49. Rørth M, Rajpert-De Meyts E, Andersson L, Dieckmann K-P, Fosså D, Grigor KM, Hendry WF, Herr HW, Looijenga LHJ, Oosterhuis JW et al. Carcinoma in situ in the testis. Scand J Urol Nephrol Suppl 2000;205:166-186.
50. Silber SJ. Microsurgical TESE and the distribution of spermatogenesis in non-obstructive azoospermia. Hum Reprod 2000;15:2278-2284.
51. Skakkebæk NE, Rajpert-de Meyts E, Main KM. Testicular dysgenesis syndrome: An increasingly common developmental disorder with environmental aspects. Hum Reprod 2001;16:972-978.
52. Stoop H, Honecker F, van de Geijn GJM, Gillis AJM, Cools MC, de Boer M, Bokemeyer C, Wolffenbuttel KP, Drop SLS, de Krijger RR et al. Stem cell factor as a novel diagnostic marker for early malignant germ cells. J Pathol 2008;216:43-54.
53. Su LM, Palermo GD, Goldstein M, Veeck LL, Rosenwaks Z, Schlegel PN. Testicular sperm extraction with intracytoplasmic sperm injection for nonobstructive azoospermia: Testicular histology can predict success of sperm retrieval. J Urol 1999;161:112-116.
54. Takada S, Tsujimura A, Ueda T, Matsuoka Y, Takao T, Miyagawa Y, Koga M, Takeyama M, Okamoto Y, Matsumiya K et al. Androgen decline in patients with nonobstructive azoospermia after microdissection testicular sperm extraction. Urology 2008;72:114-118.
55. TanI B, Ang KK, Ching BC, Mohan C, Toh CK, Tan MH. Testicularmicrolithiasis predicts concurrent testicular germ cell tumors and intratubular germ cell neoplasia of unclassified type in adults. Cancer 2010;116:4520-4532.
56. Tavolini IM, Bettella A, Boscolo Berto R, Bassi PF, Longo R, Menegazzo M, Garolla A, Foresta C. Immunostaining for placental alkaline phosphatase on fine-needle aspiration specimens to detect noninvasive testicular cancer: A prospective evaluationincryptorchidmen. BJU2006;97:950-954.
57. Tournaye H, Verheyen G, Nagy P, Ubaldi F, Goossens A, Silber S, van Steirteghem AC, Devroey P. Are there any predictive factors for successful testicular sperm recovery in azoospermic patients?. Hum Reprod 1997;12:80-86.
58. van Casteren NJ, Boellaard WPA, Dohle GR, Weber RFA, Kuizinga MC, Stoop H, Oosterhuis WJ, Looijenga LHJ. Heterogeneous distribution of ITGCNU in an adult testis: Consequences for biopsy-based diagnosis. Int J Surg Pathol 2008a;16:21-24.
59. van Casteren NJ, Stoop H, Dohle GR, de Wit R, Oosterhuis JW, Looijenga LHJ. Noninvasive detection of testicular carcinoma in situ in semen using OCT3/4. Eur Urol 2008b;54:153-160.
60. van Casteren NJ, Looijenga LHJ, Dohle GR. Testicular microlithiasis and carcinoma in situ overview and proposed clinical guideline. Int J Androl 2009a;32:279-287.
61. van Casteren NJ, de Jong J, Stoop H, Steyerberg EW, de Bekker-Grob EW, Dohle GR, Oosterhuis JW, Looijenga LHJ. Evaluation of testicular biopsies for carcinoma in situ: Immunohistochemistry is mandatory. Int J Androl 2009b;32:666-674.
62. Verheyen G, Vernaeve V, van Landuyt L, Tournaye H, Devroey P, van Steirteghem A. Should diagnostic testicular sperm retrieval followed by cryopreservation for later ICSI be the procedure of choice for all patients with non-obstructive azoospermia?. Hum Reprod 2004; 19:2822-2830.
63. Walsh TJ, Croughan MS, Schembri M, Chan JM, Turek PJ. Increased risk of testicular germ cell cancer among infertile men. Arch Intern Med 2009; 169:351-356.
64. Wohlfahrt-Veje C, Main KM, Skakkebæk NE. Testicular dysgenesis syndrome: Foetal origin of adult reproductive problems. Clin Endocrinol 2009;71:459-465.