Subfertility: Causes, treatment and outcome

Best Practice and Research: Clinical Obstetrics and Gynaecology

Volumn 17, Issue 2, 2003, Pages 169-185

  Adamson, G David ^a,b   Baker, Valerie L ^a  

^a Fertility Physicians of Northern California   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adhesions; Congenital uterine abnormality; Endometriosis; Gonadotrophins; In vitro fertilization (IVF); Infertility; Intra uterine insemination (IUI); Male factor infertility; Myoma; Oligo ovulation; Oocyte donation; Ovulation; Tubal surgery; Unexplained infertility

Indexed keywords

ANTIBIOTIC AGENT; BROMOCRIPTINE; CABERGOLINE; CLOMIFENE; CLOMIFENE CITRATE; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN; FOLLITROPIN; GONADORELIN; GONADOTROPIN; INHIBIN B; LUTEINIZING HORMONE; METFORMIN; METHOTREXATE; PLACEBO; PROGESTERONE; SEX HORMONE; TRACE ELEMENT;

ANOVULATION; CLINICAL TRIAL; COST EFFECTIVENESS ANALYSIS; DRUG EFFICACY; DRUG TOLERABILITY; ENDOMETRIOSIS; EVALUATION; EVIDENCE BASED MEDICINE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; GAMETE INTRAFALLOPIAN TRANSFER; GYNECOLOGIC SURGERY; HEALTH CARE COST; HUMAN; INFERTILITY THERAPY; INTRAUTERINE INSEMINATION; MALE INFERTILITY; MATERNAL AGE; MULTIPLE PREGNANCY; OOCYTE DONATION; OVARY HYPERSTIMULATION; OVARY INSUFFICIENCY; OVULATION INDUCTION; PATIENT COUNSELING; PERITONEUM ADHESION; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; SPERMATOZOON ABNORMALITY; SUBFERTILITY; TREATMENT OUTCOME; UTERINE CERVIX DISEASE; UTERINE TUBE DISEASE; UTERUS MALFORMATION;

EID: 0038103512     PISSN: 15216934     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-6934(02)00146-3     Document Type: Review

References (94)

1. Hull MG & Cahill DJ. Female infertility. Endocrinology and Metabolism Clinics of North America 1998; 27: 851-876.
2. Hull MG, Glazener CM, Kelly NJ et al. Population study of causes, treatment, and outcome of infertility. British Medical Journal 1985; 291: 1693-1697.
3. Knochenhauer ES, Key TJ, Kahsar-Miller M et al. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: A prospective study. Journal of Clinical Endocrinology and Metabolism 1998; 83: 3078-3082.
4. Grodstein F, Goldman MB & Cramer DW. Body mass index and ovulatory infertility. Epidemiology 1994; 5: 247-250.
5. ACOG Committee on Practice Bulletins. Management of infertility caused by ovulatory dysfunction. Obstetrics and Gynecology 2002; 99(2): 347-358.
6. Grainger DA. Incidence and causes of pelvic adhesions. Infertility and Reproductive Medicine Clinics of North America 1994; 5: 391-404.
7. Corfman RS & Badran O. Effect of pelvic adhesions on pelvic pain and fertility. Infertility and Reproductive Medicine Clinics of North America 1994; 5: 405-411.
8. Camus E, Poncelet C, Goffinet F et al. Pregnancy rates after in-vitro fertilization in cases of tubal infertility with and without hydrosalpinx: A meta-analysis of published comparative trials. Human Reproduction 1999; 14: 1243-1249.
9. Practice Committee of the American Society for Reproductive Medicine. Salpingectomy for Hydrosalpinx Prior to IVF. American Society for Reproductive Medicine and Society of Reproductive Surgeons Practice Committee Report, 2001.
10. Rier SE & Yeaman G. Immune aspects of endometriosis: Relevance of the uterine mucosal immune system. In Speroff L & Adamson GD (eds) Seminars in Reproductive Endocrinology; Endometriosis, 15 no. 3, pp 209-220. New York: Thieme, 1997.
11. Kennedy S. Is there a genetic basis to endometriosis? In Speroff L & Adamson GD (eds) Seminars in Reproductive Endocrinology; Endometriosis, 15 no. 3, pp 309-318. New York: Thieme, 1997.
12. Witz CA & Schenken RS. Pathogenesis. In Speroff L & Adamson GD (eds) Seminars in Reproductive Endocrinology; Endometriosis, 15 no. 3, pp 199-208. New York: Thieme, 1997.
13. Olive DL & Schwartz LB. Endometriosis. New England Journal of Medicine 1993; 328: 1759-1769.
14. Tulandi T, Collins JA, Burrows E et al. Treatment-dependent and treatment-independent pregnancy among women with periadnexal adhesions. American Journal of Obstetrics and Gynecology 1990; 162: 354-357.
15. Keltz DM, Olive DL, Kim AH & Arici A. Sonohysterography for screening in recurrent pregnancy loss. Fertility and Sterility 1997; 67: 670-674.
16. Soares SR, Barbosa Dos Reis MM & Camargos AF. Diagnostic accuracy of sonohysterography, transvaginal sonography, and hysterosalpingography in patients with uterine cavity disease. Fertility and Sterility 2000; 73: 406-411.
17. Glazener CM, Kelly NJ & Hull MG. Luteal phase deficiency is not a persistent cause of infertility. Human Reproduction 1998; 3: 213-217.
18. Davis OK, Berkeley AS, Naus GJ et al. The incidence of luteal phase defect in normal, fertile women, determined by serial endometrial biopsies. Fertility and Sterility 1989; 51: 582-586.
19. Practice Committee of the American Society for Reproductive Medicine and Male Infertility Best Practice Policy Committee of the American Urological Association, Inc. Report on Optimal Evaluation of the Infertile Male. American Urological Association Best Practice Policy and American Society for Reproductive Medicine Practice Committee Report, 2001.
20. Practice Committee of the American Society for Reproductive Medicine and Male Infertility Practice Policy Committee of the American Urological Association, Inc. Report on Varicocele and Infertility. American Urological Association Best Practice Policy and American Society for Reproductive Medicine Practice Committee Report, 2001.
21. Wong WY, Thomas CM, Merkus JM et al. Male factor subfertility: Possible causes and the impact of nutritional factors. Fertility and Sterility 2000; 73: 435-442.
22. Mazumdar S & Levine AS. Antisperm antibodies: Aetiology, pathogenesis, diagnosis, and treatment. Fertility and Sterility 1998; 70: 799-810.
23. Kidd SA, Eskenazi B & Wyrobek AJ. Effects of male age on semen quality and fertility: A review of the literature. Fertility and Sterility 2001; 75: 237-248.
24. Dunson DB, Colombo B & Baird D. Changes with age in the level and duration of fertility in the menstrual cycle. Human Reproduction 2002; 17: 1399-1403.
25. Menken J, Trussell J & Larsen U. Age and infertility. Science 1986; 233: 1389-1394.
26. Schwartz D & Mayaux M. Female fecundity as a function of age: Results of artificial insemination in 2193 nulliparous women with azoospermic husbands. New England Journal of Medicine 1982; 306: 404-406.
27. National Cancer for Chronic Disease Prevention and Health Promotion of the Centers for Disease control and prevention. 1999 Assisted Reproductive Technology Success Rates. National Summary and Fertility Clinic Reports. US Department of Health and Human Services Centers for Disease Control and Prevention, 2001.
28. Smith K & Buyalos R. The profound impact of patient age on pregnancy outcome after early detection of fetal cardiac activity. Fertility and Sterility 1996; 65: 35-40.
29. Holman DJ. PhD Thesis: Total fecundability and pregnancy loss in rural Bangladesh. Pennsylvania State University, Philadelphia, PA, 1996.
30. Faddy M, Gosden R, Gougeon A et al. Accelerated disappearance of ovarian follicles in mid-life: Implications for forecasting menopause. Human Reproduction 1992; 7: 1342-1346.
31. Klein NA, Illingworth PJ, Groome NP et al. Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: A study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles. Journal of Clinical Endocrinology and Metabolism 1996; 81: 2742-2745.
32. Battaglia D, Goodwin P, Klein N & Soules M. Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling women. Human Reproduction 1996; 11: 2217-2222.
33. Angell RR. Aneuploidy in older women. Human Reproduction 1994; 9: 1199-2000.
34. Benadiva C, Kligman I & Munne S. Aneuploidy 16 in human embryos increases significantly with maternal age. Fertility and Sterility 1996; 66: 248-255.
35. Lim AS & Tsakok MF. Age-related decline in fertility: A link to degenerative oocytes? Fertility and Sterility 1997; 68: 265-271.
36. Keefe DL, Niven-Fairchild T, Powell S & Buradagunta S. Mitochondrial deoxyribonucleic acid deletions in oocytes and reproductive aging in women. Fertility and Sterility 1995; 64: 577-583.
37. Wu J, Zhang L & Wang Z. Maturation and apoptosis of human oocytes in vitro are age-related. Fertility and Sterility 2000; 74: 1137-1141.
38. Nagele F, O'Connor H, Davies A et al. 2500 outpatient diagnostic hysteroscopies. American Journal of Obstetrics and Gynecology 1996; 88: 87-92.
39. Noci I, Borri P, Chieffi O et al. Aging of the human endometrium: A basic morphological and immunohistochemical study. European Journal of Obstetrics and Gynecology and Reproductive Biology 1995; 63: 181-185.
40. Navot D, Drews M, Bergh P et al. Age-related decline in female infertility is not due to diminished capacity of the uterus to sustain embryo implantation. Fertility and Sterility 1994; 61: 97-101.
41. Gilbert W, Nesbitt T & Danielsen B. Childbearing beyond age 40: Pregnancy outcome in 24,032 cases. Obstetrics and Gynecology 1999; 93: 9-14.
42. Hook E. Rates of chromosome abnormalities at different maternal ages. Obstetrics and Gynecology 1981; 58: 282-285.
43. Hughes C, Collins J & Vandekerchkove P. Clomiphene citrate for ovulation induction in women with oligo-amenorrhoea. Cochrane review. The Cochrane Library, Issue 1. Oxford: Update Software, 2002.
44. Gysler M, March CM, Mishell DJ Jr & Bailey EJ. A decade's experience with an individualized clomiphene treatment regimen including its effect on the postcoital test. Fertility and Sterility 1982; 37: 161-167.
45. Nestler JE, Stovall D, Akhter N et al. Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovarian syndrome. Fertility and Sterility 2002; 77: 209-215.
46. Practice Committee of the American Society for Reproductive Medicine. Use of Insulin Sensitizing Agents in the Treatment of Polycystic Ovary Syndrome. American Society for Reproductive Medicine Practice Committee Report, 2000.
47. Practice Committee of the American Society for Reproductive Medicine. Induction of Ovarian Follicle Development and Ovulation with Exogenous Gonadotrophins. American Society for Reproductive Medicine Practice Committee Report, 1998.
48. Farquhar C, Vandekerckhove P & Lilford R. Laparoscopic drilling by diathermy or laser for ovulation induction in anovulatory polycystic ovarian syndrome. The Cochrane Library, Issue 1. Oxford: Update Software, 2001.
49. Webster J, Piscitelli G, Polli A et al. A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea. Cabergoline Comparative Study Group. New England Journal of Medicine 1994; 331; 942-944.
50. Silverberg KM & Hill GA. Reproductive surgery versus assisted reproductive technologies: Selecting the correct alternative. Journal of Gynecological Surgery 1991; 7: 67-82.
51. Gomel V. Tubal reanastomosis by microsurgery. Fertility and Sterility 1977; 28: 59-65.
52. Henderson SR. The reversibility of female sterilization with the use of microsurgery: A report on 102 patients with more than one year of follow-up. American Journal of Obstetrics and Gynecology 1984; 149: 57-65.
53. Diamond MP. Surgical aspects of infertility. In Sciarra JW (ed.) Gynecology and Obstetrics, 5 pp 1-23. Philadelphia: J.B. Lippincott, 1988.
54. Rodgers K. Pathophysiology of adhesion formation. Infertility and Reproductive Medicine Clinics of North America 1994; 5: 413-426.
55. Cohen MA, Change PL, Uhler M et al. Reproductive outcome after sterilization reversal in women of advanced reproductive age. Journal of Assisted Reproduction and Genetics 1999; 16: 402-404.
56. Strandell A, Lindhard A, Waldenstrom U & Thorburn J. Hydrosalpinx and IVF outcome: Cumulative results after salpingectomy in a randomized controlled trial. Human Reproduction 2001; 16: 2403-2410.
57. Adamson D. Endometriosis: Traditional perspectives, current evidence and future possibilities. International Journal of Fertility 2001; 46: 151-168.
58. Adamson GD, Hurd SJ, Pasta DJ et al. Laparoscopic endometriosis treatment: Is it better? Fertility and Sterility 1993; 59: 35-44.
59. Adamson GD & Pasta DJ. Surgical treatment of endometriosis-associated infertility: Meta-analysis compared with survival analysis. American Journal of Obstetrics and Gynecology 1994; 171: 1488-1505.
60. Marcoux S, Malheux R, Berube S et al. Laparoscopic surgery in infertile women with minimal or mild endometriosis. New England Journal of Medicine 1997; 337: 217-222.
61. Parazzini F. Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: A randomized trial. Gruppo Italiano per lo Studio Dee Endometriosi. Human Reproduction 2000; 15: 2447-2449.
62. Hughes E, Fedorkow D, Colin J & Vandekerckhove P. Ovulation suppression for endometriosis. The Cochrane Library. Oxford: Update Software, 2000.
63. Lessey BA. Medical management of endometriosis and infertility. Fertility and Sterility 2000; 73: 1089-1096.
64. Practice Committee of the American Society for Reproductive Medicine. Myomas and Reproductive Function. American Society for Reproductive Medicine Practice Committee Report, 2001.
65. Lass A, Williams G, Abusheikha N & Brinsden P. The effect of endometrial polyps on outcomes of in vitro fertilization [IVF] cycles. Journal of Assisted Reproductive Genetics 1999; 16: 410-415.
66. Damewood MD & Rock JA. Uterine reconstructive surgery. In Hunt RB (ed.) Atlas of Female Infertility Surgery, 2nd edn, pp 285-314. St. Louis: Mosby Year Book, 1992.
67. Grimbizis GF, Camus M, Tarlatzis BC et al. Clinical implications of uterine malformations and hysteroscopic treatment results. Human Reproduction Review 2001; 7: 161-174.
68. Nagel TC & Malo JW. Hysteroscopic metroplasty in the diethylstilbestrol-exposed uterus and similar nonfusion anomalies: Effects on subsequent reproductive performance; A preliminary report. Fertility and Sterility 1993; 59: 502-506.
69. Katz Z, Ben-Arie A, Lurie S et al. Beneficial effect of hysteroscopic metroplasty on the reproductive outcome in a T-shaped uterus. Gynecologic and Obstetric Investigation 1996; 41: 41-43.
70. Cohlen BJ, Vanderkerckhove P, Te Velde ER & Habbema JDF. Timed intercourse versus intra-uterine insemination with or without ovarian hyperstimulation for subfertility in men. The Cochrane Library, Issue I. Oxford: Update Software, 2002.
71. Subak LL, Adamson GD & Boltz NL. Therapeutic donor insemination: A prospective randomized trial of fresh versus frozen sperm. American Journal of Obstetrics and Gynecology 1992; 166: 1597-1604. Discussion 1604-1606.
72. Guzick DS, Carson SA, Coutifaris C et al. Efficacy of superovulation and intrauterine insemination in the treatment of infertility. National Cooperative Reproductive Medicine Network. New England Journal of Medicine 1999; 340: 177-183.
73. Agarwal S & Buyalos R. Clomiphene citrate with intrauterine insemination: Is it effective therapy in women above the age of 35 years? Fertility and Sterility 1996; 65: 759-763.
74. Corsan G, Trias A, Trout S & Kemmann E. Ovulation induction combined with intrauterine insemination in women 40 years of age and older: Is it worthwhile? Human Reproduction 1996; 11: 1109-1112.
75. Frederick JL, Denker MS, Rojas A et al. Is there a role for ovarian stimulation and intrauterine insemination after age 40? Human Reproduction 1994; 9: 2284-2286.
76. Campana A, Sakkas D, Stalberg A et al. Intrauterine insemination: Evaluation of the results according to the woman's age, sperm quality, total sperm count per insemination and life table analysis. Human Reproduction 1996; 11: 732-736.
77. Brzechffa PR, Daneshmand S & Buyalos RR. Sequential clomiphene citrate and human menopausal gonadotropin with intrauterine insemination: The effect of patient age on clinical outcome. Human Reproduction 1998; 13: 2110-2114.
78. Hull M, Fleming C, Hughes A & McDermott A. The age-related decline in female fecundity: A quantitative controlled study of implanting capacity and survival of individual embryos after in vitro fertilization. Fertility and Sterility 1996; 65: 783-790.
79. Munne S, Alikani M, Tomkin G et al. Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities. Fertility and Sterility 1995; 64: 382-391.
80. Practice Committee of the American Society for Reproductive Medicine. Effectiveness and Treatment for Unexplained Infertility. American Society for Reproductive Medicine Practice Committee Report, 2000.
81. Guzick DS, Sullivan MW, Adamson GD et al. Efficacy of treatment for unexplained infertility. Fertility and Sterility 1998; 70: 207-213.
82. Hughes E, Collins J & Vandekerckhove P. Clomiphene citrate for unexplained subfertility in women. The Cochrane Library, Issue I. Oxford: Update Software, 2002.
83. Kemman E, Ghazi D, Corsan G et al. Does ovulation stimulation improve fertility in women with minimal/mild endometriosis after laser laparoscopy? International Journal of Fertility 1993; 38: 16-21.
84. Silverberg KM, Johnson JV, Olive DL et al. A prospective, randomized trial comparing two different regimens in controlled ovarian hyperstimulation cycles. Fertility and Sterility 1992; 57: 357-361.
85. Habana AE & Palter SF. Is tubal embryo transfer of any value? A meta-analysis and comparison with the Society for Assisted Reproductive Technology database. Fertility and Sterility 2001; 76: 286-293.
86. Meldrum DR, Silverberg KM, Bustillo M & Stokes L. Success rate with repeated cycles of in vitro fertilization-embryo transfer. Fertility and Sterility 1998; 69: 1005-1009.
87. Dokras SA & Olive DL. Endometriosis and assisted reproductive technologies. Clinical Obstetrics and Gynaecology 1999; 42: 687-698.
88. Tinkanen H & Kujansuu E. In vitro fertilization in patients with ovarian endometriomas. Acta Obstetrica et Gynecologica Scandinavica 2000; 79: 119-122.
89. Yanushpolsky EH, Best CL, Jackson KV et al. Effects of endometriomas on oocyte quality, embryo quality, and pregnancy rates in in vitro fertilization cycles: A prospective, case-controlled study. Journal of Assisted Reproductive Technology and Genetics 1998; 15: 193-197.
90. Diaz I, Navarro J, Blasco L et al. Impact of sibling oocytes: Matched case-control study. Fertility and Sterility 2000; 74: 31-34.
91. Simon C, Gutierrez A, Vidal A et al. Outcome of patients with endometriosis in assisted reproduction: Results from in vitro fertilization and oocyte donation. Human Reproduction 1994; 9: 725-729.
92. Sung L, Mukherjee T, Takeshige T et al. Endometriosis is not detrimental to embryo implantation in oocyte recipients. Journal of Assisted Reproduction and Genetics 1997; 14: 152-156.
93. Marcus SF & Edwards RG. High rates of pregnancy after long-term down-regulation of women with severe endometriosis. American Journal of Obstetrics and Gynecology 1994; 171: 812-817.
94. Adamson GD. A 36-year old woman with endometriosis, pelvic pain and infertility. Journal of the American Medical Association 1999; 282: 2347-2354.