Genomic and gene expression signature of the pre-invasive testicular carcinoma in situ

Cell and Tissue Research

Volumn 322, Issue 1, 2005, Pages 159-165

  Almstrup, Kristian ^a   Ottesen, Anne Marie ^a   Sonne, Si Brask ^a   Hoei Hansen, Christina E ^a   Leffers, Henrik ^a   Rajpert De Meyts, Ewa ^a   Skakkebaek, Niels E ^a  

^a Rigshospitalet   (Denmark)

Author keywords

Carcinoma in situ; Comparative genomic hybridisation; Gene expression; Intratubular germ cell neoplasia; Testicular cancer

Indexed keywords

CARCINOMA IN SITU; CELL PROLIFERATION; CHROMOSOME 12P; CHROMOSOME ABERRATION; CHROMOSOME MAP; COMPARATIVE GENOMIC HYBRIDIZATION; CORRELATION ANALYSIS; DNA MICROARRAY; EMBRYONIC STEM CELL; EPIGENETICS; GENE AMPLIFICATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE LOCUS; GENE SILENCING; GENOMICS; GERM CELL TUMOR; HUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; REVIEW; TESTIS CARCINOMA; TRANSCRIPTION INITIATION;

CARCINOMA IN SITU; CHROMOSOME ABERRATIONS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME; HUMANS; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; STATISTICS; TESTICULAR NEOPLASMS;

EID: 27644431939     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-005-1084-x     Document Type: Review

References (45)

1. Albrechtsen R, Nielsen MH, Skakkebaek NE, Wewer U (1982) Carcinoma in situ of the testis. Some ultrastructural characteristics of germ cells. Acta Pathol Microbiol Immunol Scand A 90:301-303
2. Almstrup K, Hoei-Hansen CE, Wirkner U, Blake J, Schwager C, Ansorge W, Nielsen JE, Skakkebaek NE, Rajpert-De Meyts E, Leffers H (2004) Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling. Cancer Res 64:4736-4743
3. Atkin NB, Baker MC (1982) Specific chromosome change, i(12p), in testicular tumours? Lancet 320:1349
4. Bergstrom R, Adami HO, Mohner M, Zatonski W, Storm H, Ekbom A, Tretli S, Teppo L, Akre O, Hakulinen T (1996) Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon. J Natl Cancer Inst 88:727-733
5. Boisen KA, Kaleva M, Main KM, Virtanen HE, Haavisto AM, Schmidt IM, Chellakooty M, Damgaard IN, Mau C, Reunanen M, Skakkebaek NE, Toppari J (2004) Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries. Lancet 363:1264-1269
6. Draper JS, Smith K, Gokhale P, Moore HD, Maltby E, Johnson J, Meisner L, Zwaka TP, Thomson JA, Andrews PW (2004) Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol 22:53-54
7. Fisher JS (2004) Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. Reproduction 127:305-315
8. Fisher JS, Macpherson S, Marchera N, Sharpe RM (2003) Human "testicular dysgenesis syndrome": a possible model using inutero exposure of the rat to dibutyl phthalate. Hum Reprod 18:1383-1394
9. Giwercman A, Cantell L, Marks A (1991) Placental-like alkaline phosphatase as a marker of carcinoma-in-situ of the testis. Comparison with monoclonal antibodies M2A and 43-9F. APMIS 99:586-594
10. Graaff WE de, Oosterhuis JW, Jong B de, Dam A, Putten WL van, Castedo SM, Sleijfer DT, Schraffordt Koops H (1992) Ploidy of testicular carcinoma in situ. Lab Invest 66:166-168
11. Hemminki K, Li X (2002) Cancer risks in second-generation immigrants to Sweden. Int J Cancer 99:229-237
12. Hemminki K, Li X, Czene K (2002) Cancer risks in first-generation immigrants to Sweden. Int J Cancer 99:218-228
13. Hoei-Hansen CE, Holm M, Rajpert-De Meyts E, Skakkebaek NE (2003) Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer. J Pathol 200:370-374
14. Hoei-Hansen CE, Nielsen JE, Almstrup K, Hansen MA, Skakkebaek NE, Rajpert-DeMeyts E, Leffers H (2004a) Identification of genes differentially expressed in testes containing carcinoma in situ. Mol Hum Reprod 10:423-431
15. Hoei-Hansen CE, Nielsen JE, Almstrup K, Sonne SB, Graem N, Skakkebaek NE, Leffers H, Meyts ER (2004b) Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors. Clin Cancer Res 10:8521-8530
16. Honecker F, Stoop H, Krijger RR de, Chris Lau YF, Bokemeyer C, Looijenga LH (2004) Pathobiological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells. J Pathol 203:849-857
17. Huyghe E, Matsuda T, Thonneau P (2003) Increasing incidence of testicular cancer worldwide: a review. J Urol 170:5-11
18. Jorgensen N, Rajpert-De Meyts E, Graem N, Muller J, Giwercman A, Skakkebaek NE (1995) Expression of immunohistochemical markers for testicular carcinoma in situ by normal human fetal germ cells. Lab Invest 72:223-231
19. Looijenga LH, Rosenberg C, Gurp RJ van, Geelen E, van Echten-Arends J, Jong B de, Mostert M, Wolter Oosterhuis J (2000) Comparative genomic hybridization of microdissected samples from different stages in the development of a seminoma and a non-seminoma. J Pathol 191:187-192
20. Looijenga LH, Stoop H, Leeuw HP de, Gouveia Brazao CA de, Gillis AJ, Roozendaal KE van, Zoelen EJ van, Weber RF, Wolffenbuttel KP, Dekken H van, Honecker F, Bokemeyer C, Perlman EJ, Schneider DT, Kononen J, Sauter G, Oosterhuis JW (2003) POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. Cancer Res 63:2244-2250
21. Moller H (1993) Clues to the aetiology of testicular germ cell tumours from descriptive epidemiology. Eur Urol 23:8-13 (discussion 14-15)
22. Nielsen H, Nielsen M, Skakkebaek NE (1974) The fine structure of possible carcinoma-in-situ in the seminiferous tubules in the testis of four infertile men. Acta Pathol Microbiol Scand A 82:235-248
23. Ottesen AM, Skakkebaek NE, Lundsteen C, Leffers H, Larsen J, Rajpert-De Meyts E (2003) High-resolution comparative genomic hybridization detects extra chromosome arm 12p material in most cases of carcinoma in situ adjacent to overt germ cell tumors, but not before the invasive tumor development. Genes Chromosomes Cancer 38:117-125
24. Ottesen AM, Larsen J, Gerdes T, Larsen JK, Lundsteen C, Skakkebaek NE, Rajpert-De Meyts E (2004) Cytogenetic investigation of testicular carcinoma in situ and early seminoma by high-resolution comparative genomic hybridization analysis of subpopulations flow sorted according to DNA content. Cancer Genet Cytogenet 149:89-97
25. Pera MF (2004) Unnatural selection of cultured human ES cells? Nat Biotechnol 22:42-43
26. Rajpert-De Meyts E, Skakkebaek NE (1994) Expression of the c-kit protein product in carcinoma-in-situ and invasive testicular germ cell tumours. Int J Androl 17:85-92
27. Rajpert-De Meyts E, Kvist M, Skakkebaek NE (1996) Heterogeneity of expression of immunohistochemical tumour markers in testicular carcinoma in situ: pathogenetic relevance. Virchows Arch 428:133-139
28. Rajpert-De Meyts E, Jorgensen N, Brondum-Nielsen K, Muller J, Skakkebaek NE (1998) Developmental arrest of germ cells in the pathogenesis of germ cell neoplasia. APMIS 106:198-204 (discussion 204-206)
29. Rajpert-De Meyts E, Bartkova J, Samson M, Hoei-Hansen CE, Frydelund-Larsen L, Bartek J, Skakkebaek NE (2003) The emerging phenotype of the testicular carcinoma in situ germ cell. APMIS 111:267-278 (discussion 278-279)
30. Rajpert-De Meyts E, Hanstein R, Jorgensen N, Graem N, Vogt PH, Skakkebaek NE (2004) Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads. Hum Reprod 19:1338-1344
31. Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA (2002) "Stemness": transcriptional profiling of embryonic and adult stem cells. Science 298:597-600
32. Rodriguez S, Jafer O, Goker H, Summersgill BM, Zafarana G, Gillis AJ, Gurp RJ van, Oosterhuis JW, Lu YJ, Huddart R, Cooper CS, Clark J, Looijenga LH, Shipley JM (2003) Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2-p12.1. Oncogene 22:1880-1891
33. Rorth M, Rajpert-De Meyts E, Andersson L, Dieckmann KP, Fossa SD, Grigor KM, Hendry WF, Herr HW, Looijenga LH, Oosterhuis JW, Skakkebaek NE (2000) Carcinoma in situ in the testis. Scand J Urol Nephrol Suppl 205:166-186
34. Rosenberg C, Gurp RJ van, Geelen E, Oosterhuis JW, Looijenga LH (2000) Overrepresentation of the short arm of chromosome 12 is related to invasive growth of human testicular seminomas and nonseminomas. Oncogene 19:5858-5862
35. Sato N, Sanjuan IM, Heke M, Uchida M, Naef F, Brivanlou AH (2003) Molecular signature of human embryonic stem cells and its comparison with the mouse. Dev Biol 260:404-413
36. Skakkebaek NE (1972) Possible carcinoma-in-situ of the testis. Lancet 300:516-517
37. Skakkebaek NE, Berthelsen JG, Giwercman A, Muller J (1987) Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int J Androl 10:19-28
38. Skakkebaek NE, Rajpert-De Meyts E, Jorgensen N, Carlsen E, Petersen PM, Giwercman A, Andersen AG, Jensen TK, Andersson AM, Muller J (1998) Germ cell cancer and disorders of spermatogenesis: an environmental connection? APMIS 106:3-11 (discussion 12)
39. Skakkebaek NE, Rajpert-De Meyts E, Main KM (2001) Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 16:972-978
40. Skotheim RI, Lothe RA (2003) The testicular germ cell tumour genome. APMIS 111:136-150 (discussion 50-51)
41. Skotheim RI, Monni O, Mousses S, Fossa SD, Kallioniemi OP, Lothe RA, Kallioniemi A (2002) New insights into testicular germ cell tumorigenesis from gene expression profiling. Cancer Res 62:2359-2364
42. Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO, Thomson JA (2003) Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci USA 100:13350-13355
43. Summersgill B, Osin P, Lu YJ, Huddart R, Shipley J (2001) Chromosomal imbalances associated with carcinoma in situ and associated testicular germ cell tumours of adolescents and adults. Br J Cancer 85:213-220
44. Ulbright TM, Amin MB, Young RH (1999) Tumors of the testis, adnexa, spermatic cord, and scrotum. Armed Forces Institute of Pathology, Washington, DC, USA
45. Weir HK, Marrett LD, Kreiger N, Darlington GA, Sugar L (2000) Pre-natal and peri-natal exposures and risk of testicular germ-cell cancer. Int J Cancer 87:438-443