Testicular microlithiasis predicts concurrent testicular germ cell tumors and intratubular germ cell neoplasia of unclassified type in adults: A meta-analysis and systematic review

Cancer

Volumn 116, Issue 19, 2010, Pages 4520-4532

  Tan, Iain B ^a   Ang, Kai K ^a   Ching, Boon C ^a   Mohan, Chandra ^b   Toh, Chee K ^a   Tan, Min H ^a  

^a DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

Germ cell neoplasms; Meta analysis; Testicular carcinoma in situ; Testicular microlithiasis

Indexed keywords

ARTICLE; DATA BASE; ECHOGRAPHY; FOLLOW UP; GERM CELL TUMOR; HUMAN; MEDICAL LITERATURE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PUBLICATION; RISK FACTOR; STONE FORMATION; SYSTEMATIC REVIEW; TESTICULAR INTRATUBULAR GERM CELL NEOPLASIA OF UNCLASSIFIED TYPE; TESTICULAR MICROLITHIASIS; ADULT; COMPLICATION; COMPUTER PROGRAM; LITHIASIS; MALE; META ANALYSIS; NEOPLASMS, GERM CELL AND EMBRYONAL; TESTICULAR NEOPLASMS; TIME;

ADULT; FOLLOW-UP STUDIES; HUMANS; LITHIASIS; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; RISK FACTORS; SOFTWARE DESIGN; TESTICULAR NEOPLASMS; TIME FACTORS;

EID: 77956523833     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.25231     Document Type: Article

References (61)

1. von Eckardstein S, Tsakmakidis G, Kamischke A, Rolf C, Nieschlag E. Sonographic testicular microlithiasis as an indicator of premalignant conditions in normal and infertile men. J Androl. 2001;22:818-824.
2. Serter S, Gumus B, Unlu M, et al. Prevalence of testicular microlithiasis in an asymptomatic population. Scand J Urol Nephrol. 2006;40:212-214.
3. Peterson AC, Bauman JM, Light DE, McMann LP, Costabile RA. The prevalence of testicular microlithiasis in an asymptomatic population of men 18 to 35 years old. J Urol. 2001;166:2061-2064.
4. Coffey J, Huddart RA, Elliott F, et al. Testicular microlithiasis as a familial risk factor for testicular germ cell tumour. Br J Cancer. 2007;97:1701-1706.
5. Riebel T, Herrmann C, Wit J, Sellin S. Ultrasonographic late results after surgically treated cryptorchidism. Pediatr Radiol. 2000;30:151-155.
6. Husmann DA. Cryptorchidism and its relationship to testicular neoplasia and microlithiasis. Urology. 2005;66:424-426.
7. Patel RP, Kolon TF, Huff DS, et al. Testicular microlithiasis and antisperm antibodies following testicular biopsy in boys with cryptorchidism. J Urol. 2005;174:2008-2010; discussion 2010.
8. Aizenstein RI, DiDomenico D, Wilbur AC, O'Neil HK. Testicular microlithiasis: association with male infertility. J Clin Ultrasound. 1998;26:195-198.
9. de Gouveia Brazao CA, Pierik FH, Oosterhuis JW, Dohle GR, Looijenga LH, Weber RF. Bilateral testicular microlithiasis predicts the presence of the precursor of testicular germ cell tumors in subfertile men. J Urol. 2004;171:158-160.
10. Ikinger U, Wurster K, Terwey B, Mohring K. Microcalcifications in testicular malignancy: diagnostic tool in occult tumor?Urology. 1982;19:525-528.
11. Lawrentschuk N, Brough SJ, de Ryke RJ. Testicular microlithiasis: a case report and review of the literature. ANZ J Surg. 2003;73:364-366.
12. McEniff N, Doherty F, Katz J, Schrager CA, Klauber G. Yolk sac tumor of the testis discovered on a routine annual sonogram in a boy with testicular microlithiasis. AJR Am J Roentgenol. 1995;164:971-972.
13. Wells GA, Shea B, O'Connell D, et al. The Newcastle- Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. Ottawa Health Research Institute, Ottawa, Ontario, Canada: Ottawa Health Research Institute. Available at: http://www.ohri.ca/ programs/clinical-epidemiology/ oxford.htm Accessed October 15, 2009.
14. Taggart DP, D'Amico R, Altman DG. Effect of arterial revascularisation on survival: a systematic review of studies comparing bilateral and single internal mammary arteries. Lancet. 2001;358:870-875.
15. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-188.
16. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539-1558.
17. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629-634.
18. Negri L, Benaglia R, Fiamengo B, Pizzocaro A, Albani E, Levi Setti PE. Cancer risk in male factor-infertility. Placenta. 2008;29(suppl B):178-183.
19. Kosan M, Gonulalan U, Ugurlu O, Oztekin V, Akdemir O, Adsan O. Testicular microlithiasis in patients with scrotal symptoms and its relationship to testicular tumors. Urology. 2007;70:1184-1186.
20. van Casteren NJ, Looijenga LH, Dohle GR. Testicular microlithiasis and carcinoma in situ overview and proposed clinical guideline. Int J Androl. 2009;32:279-287.
21. Meissner A, Mamoulakis C, de la Rosette JJ, Laguna Pes MP. Clinical update on testicular microlithiasis. Curr Opin Urol. 2009;19:15-18.
22. Hoei-Hansen CE, Rajpert-De Meyts E, Daugaard G, Skakkebaek NE. Carcinoma in situ testis, the progenitor of testicular germ cell tumours: a clinical review. Ann Oncol. 2005;16:863-868.
23. Oosterhuis JW, Looijenga LH. Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer. 2005;5:210-222.
24. von der Maase H, Rorth M, Walbom-Jorgensen S, et al. Carcinoma in situ of contralateral testis in patients with testicular germ cell cancer: study of 27 cases in 500 patients. BMJ (Clin Res Ed). 1986;293:1398-1401.
25. Skakkebaek NE, Berthelsen JG, Muller J. Carcinoma-in-situ of the undescended testis. Urol Clin North Am. 1982;9:377-385.
26. Dieckmann KP, Kulejewski M, Pichlmeier U, Loy V. Diagnosis of contralateral testicular intraepithelial neoplasia (TIN) in patients with testicular germ cell cancer: systematic 2-site biopsies are more sensitive than a single random biopsy. Eur Urol. 2007;51:175-183; discussion 183-185.
27. Oliver RT, Mason MD, Mead GM, et al. Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomised trial. Lancet. 2005;366:293-300.
28. Tandstad T, Dahl O, Cohn-Cedermark G, et al. Risk-adapted treatment in clinical stage I nonseminomatous germ cell testicular cancer: the SWENOTECA management program. J Clin Oncol. 2009;27:2122-2128.
29. Petersen PM, Giwercman A, Daugaard G, et al. Effect of graded testicular doses of radiotherapy in patients treated for carcinoma-in-situ in the testis. J Clin Oncol. 2002;20:1537-1543.
30. Guzman Martinez-Valls PL, Hita Villaplana G, Fernandez Aparicio T, Minana Lopez B, Martinez Diaz F, Sanchez Gascon F. [Significance and management of testicular microlithiasis]. Arch Esp Urol. 2003;56:472-477.
31. Thomas K, Wood SJ, Thompson AJ, Pilling D, Lewis-Jones DI. The incidence and significance of testicular microlithiasis in a subfertile population. Br J Radiol. 2000;73:494-497.
32. Korde LA, Premkumar A, Mueller C, et al. Increased prevalence of testicular microlithiasis in men with familial testicular cancer and their relatives. Br J Cancer. 2008;99:1748-1753.
33. Skakkebaek NE. Testicular dysgenesis syndrome. Horm Res. 2003;60(suppl 3):49-49.
34. Renshaw AA. Testicular calcifications: incidence, histology and proposed pathological criteria for testicular microlithiasis. J Urol. 1998;160:1625-1628.
35. Bennett HF, Middleton WD, Bullock AD, Teefey SA. Testicular microlithiasis: US follow-up. Radiology. 2001;218:359-363.
36. Middleton WD, Teefey SA, Santillan CS. Testicular microlithiasis: prospective analysis of prevalence and associated tumor. Radiology. 2002;224:425-428.
37. Frush DP, Kliewer MA, Madden JF. Testicular microlithiasis and subsequent development of metastatic germ cell tumor. AJR Am J Roentgenol. 1996;167:889-890.
38. Parra BL, Venable DD, Gonzalez E, Eastham JA. Testicular microlithiasis as a predictor of intratubular germ cell neoplasia. Urology. 1996;48:797-799.
39. Skyrme RJ, Fenn NJ, Jones AR, Bowsher WG. Testicular microlithiasis in a UK population: its incidence, associations and follow-up. BJU Int. 2000;86:482-485.
40. Sanli O, Kadioglu A, Atar M, Acar O, Nane I. Grading of classical testicular microlithiasis has no effect on the prevalence of associated testicular tumors. Urol Int. 2008;80:310-316.
41. Ou SM, Lee SS, Tang SH, et al. Testicular microlithiasis in Taiwanese men. Arch Androl. 2007;53:339-344.
42. Ahmad I, Krishna NS, Clark R, Nairn R, Al-Saffar N. Testicular microlithiasis: prevalence and risk of concurrent and interval development of testicular tumor in a referred population. Int Urol Nephrol. 2007;39:1177-1181.
43. Lam DL, Gerscovich EO, Kuo MC, McGahan JP. Testicular microlithiasis: our experience of 10 years. J Ultrasound Med. 2007;26:867-873.
44. Sakamoto H, Shichizyou T, Saito K, et al. Testicular microlithiasis identified ultrasonographically in Japanese adult patients: prevalence and associated conditions. Urology. 2006;68:636-641.
45. Miller FN, Rosairo S, Clarke JL, Sriprasad S, Muir GH, Sidhu PS. Testicular calcification and microlithiasis: association with primary intra-testicular malignancy in 3477 patients. Eur Radiol. 2007;17:363-369.
46. Otite U, Webb JA, Oliver RT, Badenoch DF, Nargund VH. Testicular microlithiasis: is it a benign condition with malignant potential?Eur Urol. Nov. 2001;40:538-542.
47. Bach AM, Hann LE, Hadar O, et al. Testicular microlithiasis: what is its association with testicular cancer?Radiology. 2001;220:70-75.
48. Cast JE, Nelson WM, Early AS, et al. Testicular microlithiasis: prevalence and tumor risk in a population referred for scrotal sonography. AJR Am J Roentgenol. 2000;175: 1703-1706.
49. Derogee M, Bevers RF, Prins HJ, Jonges TG, Elbers FH, Boon TA. Testicular microlithiasis, a premalignant condition: prevalence, histopathologic findings, and relation to testicular tumor. Urology. 2001;57:1133-1137.
50. Schrey A, Reiter WJ, Kratzik C. [Value of ultrasound in microlithiasis of the testis in andrological patients]. Ultraschall Med. 2001;22:143-145.
51. Konstantinos S, Alevizos A, Anargiros M, et al. Association between testicular microlithiasis, testicular cancer, cryptorchidism and history of ascending testis. Int Braz J Urol. 2006;32:434-438; discussion 439.
52. Ringdahl E, Claybrook K, Teague JL, Northrup M. Testicular microlithiasis and its relation to testicular cancer on ultrasound findings of symptomatic men. J Urol. 2004;172(5 pt 1):1904-1906.
53. Bach AM, Hann LE, Shi W, et al. Is there an increased incidence of contralateral testicular cancer in patients with intratesticular microlithiasis? AJR Am J Roentgenol. 2003; 180:497-500.
54. Holm M, Hoei-Hansen CE, Rajpert-De Meyts E, Skakkebaek NE. Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle. J Urol. 2003;170(4 pt 1):1163-1167.
55. Shichijo T, Sakamoto H, Saito K, Ogawa Y, Yoshida H, Kushima M. [Relevance of testicular microlithiasis to the testicular carcinoma in situ in the contralateral testicle]. Nippon Hinyokika Gakkai Zasshi. 2007;98: 541-546.
56. Leinmuller R, Schmelz HU, Weissbach L. [Testicular microlithiasis and testicular carcinoma: bilateral calcifications go with increased CIS risk]. Aktuelle Urol. 2004;35:367-369.
57. DeCastro BJ, Peterson AC, Costabile RA. A 5-year followup study of asymptomatic men with testicular microlithiasis. J Urol. 2008;179:1420-1423; discussion 1423.
58. Sakamoto H, Saito K, Shichizyo T, Ishikawa K, Igarashi A, Yoshida H. Color Doppler ultrasonography as a routine clinical examination in male infertility. Int J Urol. 2006;13:1073-1078.
59. Janzen DL, Mathieson JR, Marsh JI, et al. Testicular microlithiasis: sonographic and clinical features. AJR Am J Roentgenol. 1992;158:1057-1060.
60. Pourbagher MA, Kilinc F, Guvel S, Pourbagher A, Egilmez T, Ozkardes H. Follow-up of testicular microlithiasis for subsequent testicular cancer development. Urol Int. 2005;74:108-112; discussion 113.
61. Hobarth K, Susani M, Szabo N, Kratzik C. Incidence of testicular microlithiasis. Urology. 1992;40:464-467.