The predictive value of testicular ultrasound abnormalities for carcinoma in situ of the testis in men at risk for testicular cancer

International Journal of Andrology

Volumn 33, Issue 4, 2010, Pages 597-603

  Elzinga Tinke, J E ^a   Sirre, M E ^a   Looijenga, L H J ^b   Van Casteren, N ^a   Wildhagen, M F ^a   Dohle, G R ^a  

^a Andrology Unit   (Netherlands)

^b JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

Author keywords

carcinoma in situ; inhomogeneous testicular parenchyma; predictive value; scrotal ultrasonography; testicular dysgenesis; testicular microlithiasis

Indexed keywords

INHIBIN B; SEX HORMONE; INHIBIN;

ARTICLE; CANCER RISK; CARCINOMA IN SITU; CONTROLLED STUDY; GERM CELL; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PARENCHYMA; PREDICTION AND FORECASTING; PRIORITY JOURNAL; RISK FACTOR; SENSITIVITY AND SPECIFICITY; STEM CELL; TESTICULAR MICROLITHIASIS; TESTIS BIOPSY; TESTIS CANCER; TESTIS DISEASE; ULTRASOUND; ADULT; BLOOD; ECHOGRAPHY; MIDDLE AGED; PREDICTIVE VALUE; RETROSPECTIVE STUDY; RISK; SCROTUM; STONE FORMATION; TESTICULAR NEOPLASMS; TESTIS;

ADULT; CARCINOMA IN SITU; HUMANS; INHIBINS; LITHIASIS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; RISK; SCROTUM; TESTICULAR DISEASES; TESTICULAR NEOPLASMS; TESTIS;

EID: 77954403201     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2009.00997.x     Document Type: Article

References (29)

1. Aizenstein, R. I., Hibbeln, J. F., Sagireddy, B., Wilbur, A. C. O'Neil, H. K. (1997) Klinefelter's syndrome associated with testicular microlithiasis and mediastinal germ-cell neoplasm. Journal of Clinical Ultrasound 25, 508 510.
2. Aizenstein, R. I., DiDomenico, D., Wilbur, A. C. O'Neil, H. K. (1998) Testicular microlithiasis: association with male infertility. Journal of Clinical Ultrasound 26, 195 198.
3. Bieger, R. C., Passarge, E. McAdams, A. J. (1965) Testicular intratubular bodies. Journal of Clinical Endocrinology and Metabolism 25, 1340 1346.
4. van Casteren, N. J., Stoop, H., Dohle, G. R., de Wit, R., Oosterhuis, J. W. Looijenga, L. H. (2008) Noninvasive detection of testicular carcinoma in situ in semen using OCT3/4. European Urology 54, 153 158.
5. van Casteren, N. J., Looijenga, L. H. Dohle, G. R. (2009) Testicular microlithiasis and carcinoma in situ overview and proposed clinical guideline. International Journal of Andrology 32, 279 287.
6. Dieckmann, K. P. Skakkebaek, N. E. (1999) Carcinoma in situ of the testis: review of biological and clinical features. International Journal of Cancer 83, 815 822.
7. Dieckmann, K. P., Kulejewski, M., Pichlmeier, U. Loy, V. (2007) Diagnosis of contralateral testicular intraepithelial neoplasia (TIN) in patients with testicular germ cell cancer: systematic two-site biopsies are more sensitive than a single random biopsy. European Urology 51, 175 183 discussion 183-175.
8. Dohle, G. R. Schroder, F. H. (2000) Ultrasonographic assessment of the scrotum. Lancet 356, 1625 1626.
9. Dohle, G. R., Colpi, G. M., Hargreave, T. B., Papp, G. K., Jungwirth, A. Weidner, W. (2005) EAU guidelines on male infertility. European Urology 48, 703 711.
10. von Eckardstein, S., Tsakmakidis, G., Kamischke, A., Rolf, C. Nieschlag, E. (2001) Sonographic testicular microlithiasis as an indicator of premalignant conditions in normal and infertile men. Journal of Andrology 22, 818 824.
11. Ganem, J. P., Workman, K. R. Shaban, S. F. (1999) Testicular microlithiasis is associated with testicular pathology. Urology 53, 209 213.
12. de Gouveia Brazao, C. A., Pierik, F. H., Oosterhuis, J. W., Dohle, G. R., Looijenga, L. H. Weber, R. F. (2004) Bilateral testicular microlithiasis predicts the presence of the precursor of testicular germ cell tumors in subfertile men. Journal of Urology 171, 158 160.
13. Guzman Martinez-Valls, P. L., Hita Villaplana, G., Fernandez Aparicio, T., Minana Lopez, B., Martinez Diaz, F. Sanchez Gascon, F. (2003) [Significance and management of testicular microlithiasis]. Archivos Espanoles de Urologia 56, 472 477.
14. Holm, M., Lenz, S., De Meyts, E. R. Skakkebaek, N. E. (2001) Microcalcifications and carcinoma in situ of the testis. BJU International 87, 144 149.
15. Holm, M., Hoei-Hansen, C. E., Rajpert-De Meyts, E. Skakkebaek, N. E. (2003) Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle. Journal of Urology 170, 1163 1167.
16. Husmann, D. A. (2005) Cryptorchidism and its relationship to testicular neoplasia and microlithiasis. Urology 66, 424 426.
17. Ikinger, U., Wurster, K., Terwey, B. Mohring, K. (1982) Microcalcifications in testicular malignancy: diagnostic tool in occult tumor? Urology 19, 525 528.
18. Jaramillo, D., Perez-Atayde, A. Teele, R. L. (1989) Sonography of testicular microlithiasis. Urologic Radiology 11, 55 7.
19. Kaveggia, F. F., Strassman, M. J., Apfelbach, G. L., Hatch, J. L. Wirtanen, G. W. (1996) Diffuse testicular microlithiasis associated with intratubular germ cell neoplasia and seminoma. Urology 48, 794 796.
20. Krege, S., Beyer, J., Souchon, R., Albers, P., Albrecht, W., Algaba, F. et al. (2008) European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I. European Urology 53, 478 496.
21. Lenz, S., Giwercman, A., Skakkebaek, N. E., Bruun, E. Frimodt-Moller, C. (1987) Ultrasound in detection of early neoplasia of the testis. International Journal of Andrology 10, 187 190.
22. Lenz, S., Skakkebaek, N. E. Hertel, N. T. (1996) Abnormal ultrasonic pattern in contralateral testes in patients with unilateral testicular cancer. World Journal of Urology 14 (Suppl 1 S55 S58.
23. Miller, F. N. Sidhu, P. S. (2002) Does testicular microlithiasis matter? A review. Clinical Radiology 57, 883 890.
24. Patel, R. P., Kolon, T. F., Huff, D. S., Carr, M. C., Zderic, S. A., Canning, D. A. et al. (2005) Testicular microlithiasis and antisperm antibodies following testicular biopsy in boys with cryptorchidism. Journal of Urology 174, 2008 2010.
25. Peterson, A. C., Bauman, J. M., Light, D. E., McMann, L. P. Costabile, R. A. (2001) The prevalence of testicular microlithiasis in an asymptomatic population of men 18 to 35 years old. Journal of Urology 166, 2061 2064.
26. Riebel, T., Herrmann, C., Wit, J. Sellin, S. (2000) Ultrasonographic late results after surgically treated cryptorchidism. Pediatric Radiology 30, 151 155.
27. Skakkebaek, N. E., Rajpert-De Meyts, E. Main, K. M. (2001) Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Human Reproduction 16, 972 978. (Pubitemid 32451837)
28. Thomas, K., Wood, S. J., Thompson, A. J., Pilling, D. Lewis-Jones, D. I. (2000) The incidence and significance of testicular microlithiasis in a subfertile population. British Journal of Radiology 73, 494 497.
29. Yagci, C., Ozcan, H., Aytac, S., Aydos, K. Atasoy, C. (1996) Testicular microlithiasis associated with seminoma: gray-scale and color Doppler ultrasound findings. Urologia Internationalis 57, 255 258.