Inhibition of dipeptidyl peptidase activity by flavonol glycosides of guava (Psidium guajava L.): A key to the beneficial effects of guava in type II diabetes mellitus

Fitoterapia

Volumn 89, Issue 1, 2013, Pages 74-79

  Eidenberger, Thomas ^a   Selg, Manuel ^a   Krennhuber, Klaus ^a  

^a UNIVERSITY OF APPLIED SCIENCES UPPER AUSTRIA   (Austria)

Author keywords

Diabetes mellitus; Dipeptidyl peptidase inhibition; Flavonol glycosides; Gastrointestinal absorption; HPLC separation; Psidium guajava L. extract

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; FLAVONOID GLYCOSIDE; FLAVONOL; GUAIJAVERIN; GUAVA EXTRACT; HYPERIN; ISOQUERCITRIN; METHYL QUER; MORIN; MORIN PENTOSIDE; PELTATOSIDE; PLANT GLYCOSIDE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME INHIBITION; EPITHELIUM CELL; GUAVA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; NON INSULIN DEPENDENT DIABETES MELLITUS; PLANT LEAF; PRIORITY JOURNAL;

PSIDIUM; PSIDIUM GUAJAVA;

EID: 84885132657     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2013.05.015     Document Type: Article

References (38)

1. Arima H, Danno G. Isolation of antimicrobial compounds from guava (Psidium guajava L.) and their structural elucidation. Biosci Biotechnol Biochem 2002;66:1727-30. (Pubitemid 39246833)
2. Mouraa PM, Pradob GHC, Meirelesb MAA, Pereiraa CG. Supercritical fluid extraction from guava (Psidium guajava) leaves: global yield, composition and kinetic data. J Supercrit Fluids 2012;62:116-22.
3. Fu HZ, Yang JZ, Li CJ, Zhang DM. A new benzophenone glycoside from the leaves of Psidium guajava L. Chin Chem Lett 2011;22:178-80.
4. Shu J, Chou G, Wang Z. Two new benzophenone glycosides from the fruit of Psidium guajava L. Fitoterapia 2010;81:532-5.
5. Begum S, Hassan SI, Ali SN, Siddiqui BS. Chemical constituents from the leaves of Psidium guajava. Nat Prod Res 2004;18:135-40. (Pubitemid 38213210)
6. Gutierrez RMP, Mitchell S, Solis RV. Psidium guajava: a review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 2008;117:1-27.
7. Abdelrahim SI, Almagboul AZ, Omer MEA, Elegami A. Antimicrobial activity of Psidium guajava L. Fitoterapia 2002;73:713-5.
8. Lozoya X, Meckes M, Abou-Zaid M, Tortoriello J, Nozzolillo C. Arnason JT Quercetin glycosides in Psidium guajava L. leaves and determination of a spasmolytic principle. Arch Med Res 1994;25:11-5. (Pubitemid 24138167)
9. Shaheen HM, Ali BH, Alqarawi AA, Bashir AK. Effect of Psidium guajava leaves on some aspects of central nervous system in mice. Phytother Res 2000;14:107-11. (Pubitemid 30168560)
10. Tanaka T, Ishida N, Ishimatsu M, Nonaka G, Nishioka I. Tannins and related compounds. CXVI: six new complex tannins, guajavins, psidins and psiguavin from the bark of Psidium guajava L. Chem Pharm Bull 1992;40:2092-8.
11. Tangpu TV, Yadav AK. Anticestodal efficacy of Psidium guajava against experimental Hymenolepis diminuta infection in rats. Indian J Pharmacol 2006;38:29-32. (Pubitemid 43288650)
12. Ojewole JAO. Anti-inflammatory and analgesic effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extracts in rats and mice. Methods Find Exp Clin Pharmacol 2006;28:441-6. (Pubitemid 44568620)
13. Nair R, Chanda S. In-vitro antimicrobial activity of Psidium guajava L. leaf extracts against clinically important pathogenic microbial strains. Braz J Microbiol 2007;38:452-8. (Pubitemid 350132335)
14. Roy CK, Kamath JV, Asad M. Hepatoprotective activity of Psidium guajava Linn. leaf extract. Indian J Exp Biol 2006;44:305-11.
15. Ojewole JAO. Hypoglycaemic and hypotensive effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract. Meth Find Exp Clin Pharmacol 2005;27:689-95. (Pubitemid 43266853)
16. Sunagawa M, Shimada S, Zhang Z, Oonishi A, Nakamura M, Kosugi T. Plasma insulin concentration was increased by long-term ingestion of guava juice in spontaneous non-insulin-dependent diabetes mellitus (NIDDM) rats. J Health Sci 2004;50:674-8. (Pubitemid 41295283)
17. Deguchi Y, Osada K, Uchida K, Kimura H, Yoshikawa M, Kudo T, et al. Effects of extract of guava leaves on the development of diabetes in the db/db mouse and on the postprandial blood glucose of human subjects. Nippon Nogei Kagaku Kaishi 1998;72:923-31. (Pubitemid 128668286)
18. Oha WK, Leea CH, Leea MS, Baea EY, Sohnb CB, Oha H, et al. Antidiabetic effects of extracts from Psidium guajava. J Ethnopharmacol 2005;96: 411-5.
19. Kaushik G, Satya S, Khandelwal RK, Naik SN. Commonly consumed Indian plant food materials in the management of diabetes mellitus Diab Metab Syndrome. Clin Res Rev 2010;4:21-40.
20. Matsuda H, Morikawa T, Yoshikawa M. Antidiabetogenic constituents from several natural medicines. Pure Appl Chem 2002;74:1301-8.
21. Huang CS, Yin MC, Chiu LC. Antihyperglycemic and antioxidative potential of Psidium guajava fruit in streptozotocin-induced diabetic rats. Food Chem Toxicol 2011;49:2189-95.
22. Soman S, Rajamanickam C, Rauf AA, Indira M. Beneficial effects of Psidium guajava leaf extract on diabetic myocardium.Exp Toxicol Pathol July 13 2011 [available, online].
23. Maruyama Y, Matsuda H, Matsuda R, Kubo M, Hatano T, Okuda T. Study on Psidium guajava L. (I). Antidiabetic effect and effective components of the leaf of Psidium guajava L. (Part 1). Shoyakugaku Zasshi 1985;39: 261-9.
24. Patel DK, Prasad SK, Kumar R, Hemalatha S, Asian Pacific J, Biomed Trop, et al. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pacific J Trop Biomed 2012:320-30.
25. Matsuda H, Moikawa T, Toguchida I, Yoshikawa M. Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity. Chem Pharm Bull 2002;50:788-95. (Pubitemid 41694896)
26. Pospisilik JA, Stafford SG, Demuth HU, McIntosh CHS, Pederson RA. Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat. Diabetes 2002;51:2677-83. (Pubitemid 34970918)
27. Reimer MK, Holst JJ, Ahren B. Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice. Eur J Endocrinol 2002;146:717-27. (Pubitemid 34552507)
28. Ahren B, Simonsson E, Larsson H, Landin-Olsson M, Torgeirsson H, Lansson PA, et al. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes. Diabetes Care 2002;25:869-75. (Pubitemid 41094285)
29. Pospisilik JA, Stafford SG, Demuth HU, Brownsey R, Parkhouse W, Finegood DT, et al. Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and β-cell glucose responsiveness in VDF (fa/fa) Zucker Rats. Diabetes 2002;51:943-50. (Pubitemid 34438335)
30. Delie F, Rubas W. A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limitations of the Caco-2 model. Crit Rev Ther Drug Carrier Syst 1997;14: 221-86. (Pubitemid 27355917)
31. Hidalgo IJ, Raub TJ, Borchardt RT. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterol 1989;96:736-49. (Pubitemid 19057595)
32. Takahashi Y, Kondo H, Yasuda T, Watanabe T, Kobayashi S, Yokohama S. Common solubilizers to estimate the Caco-2 transport of poorly water-soluble drugs. Int J Pharm 2002;246:85-94. (Pubitemid 35247981)
33. DaViolante G, Zerrouk N, Richard I, Frendo JL, Zhiri A, Li-Khuan R, et al. Short term Caco-2/TC7 cell culture: comparison between of conventional 21-d and a commercially available 3-d system. Biol Pharm Bull 2004;27:1986-92. (Pubitemid 41701576)
34. Yamashita S, Konishi K, Yamazaki Y, Taki Y, Sakane T, Szaki H, et al. New and better protocols for a short-term Caco-2 cell culture system. J Pharm Sci 2002;91:669-79. (Pubitemid 34639630)
35. Nagatsu T, Hino M, Fuyamada H, Hayakawa T, Sakakibara S. New chromogenic substrates for X-prolyl dipeptidyl-aminopeptidase. Anal Biochem 1976;74:466-76.
36. Metwally AM, Omar AA, Ghazy NM, Harraz FM, El Sohafy SM. Monograph of Psidium guajava L. leaves. Phcog J 2011;3:89-104.
37. Boyer J, Brown D, Liu RH. In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. Nutr J 2005;4:1-15.
38. Lee J, Mitchell AE. Pharmacokinetics of quercetin absorption from apples and onions in healthy humans. J Agric Food Chem 2012;60:3874-81.