Germinal center kinase-like kinase overexpression in T cells as a novel biomarker in rheumatoid arthritis

Arthritis and Rheumatism

Volumn 65, Issue 10, 2013, Pages 2573-2582

  Chen, Yi Ming ^a   Chuang, Huai Chia ^b   Lin, Wen Chun ^c   Tsai, Ching Yi ^c   Wu, Chia Wei ^c   Gong, Ning Rong ^c   Hung, Wei Ting ^c   Lan, Tsuo Hung ^a   Lan, Joung Liang ^a,d   Tan, Tse Hua ^a,d   Chen, Der Yuan ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; GERMINAL CENTER KINASE LIKE KINASE; MESSENGER RNA; PROTEIN KINASE; PROTEIN KINASE C THETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ACTIVITY SCORE; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PATHOGENESIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; SYNOVIUM; T LYMPHOCYTE; WESTERN BLOTTING;

ADULT; AGED; ANIMALS; ANTIGENS, CD3; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DIAGNOSIS, DIFFERENTIAL; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; OSTEOARTHRITIS; PROTEIN KINASES; SEVERITY OF ILLNESS INDEX; SYNOVIAL FLUID; SYNOVIAL MEMBRANE; T-LYMPHOCYTES;

EID: 84885121132     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.38067     Document Type: Article

References (24)

1. Van Vollenhoven RF,. Switching between anti-tumour necrosis factors: trying to get a handle on a complex issue. Ann Rheum Dis 2007; 66: 849-51.
2. Smolen JS, Aletaha D, Koeller M, Weisman MH, Emery P,. New therapies for treatment of rheumatoid arthritis. Lancet 2007; 370: 1861-74.
3. Van Gestel AM, Prevoo ML, van 't Hof MA, van Rijswijk MH, van de Putte LB, van Riel PL,. Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis: comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against Rheumatism criteria. Arthritis Rheum 1996; 39: 34-40.
4. Elliott MJ, Maini RN, Feldmann M, Long-Fox A, Charles P, Katsikis P, et al. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α. Arthritis Rheum 1993; 36: 1681-90.
5. Breedveld FC, Combe B,. Understanding emerging treatment paradigms in rheumatoid arthritis. Arthritis Res Ther 2011; 13 Suppl 1: S3.
6. Sweeney SE, Firestein GS,. Signal transduction in rheumatoid arthritis. Curr Opin Rheumatol 2004; 16: 231-7.
7. Kremer JM, Bloom BJ, Breedveld FC, Coombs JH, Fletcher MP, Gruben D, et al. The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo [published erratum appears in Arthritis Rheum 2012;64:1487]. Arthritis Rheum 2009; 60: 1895-905.
8. Weinblatt ME, Kavanaugh A, Genovese MC, Musser TK, Grossbard EB, Magilavy DB,. An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis. N Engl J Med 2010; 363: 1303-12.
9. Schett G, Zwerina J, Firestein G,. The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis. Ann Rheum Dis 2008; 67: 909-16.
10. Hammaker D, Firestein GS,. "Go upstream, young man": lessons learned from the p38 saga. Ann Rheum Dis 2010; 69 Suppl 1: i77-82.
11. Ghoreschi K, Laurence A, O'Shea JJ,. Selectivity and therapeutic inhibition of kinases: to be or not to be? Nat Immunol 2009; 10: 356-60.
12. Diener K, Wang XS, Chen C, Meyer CF, Keesler G, Zukowski M, et al. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc Natl Acad Sci U S A 1997; 94: 9687-92.
13. Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, et al. The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells. Nat Immunol 2011; 12: 1113-8.
14. Gustafsson K, Karlsson M, Andersson L, Holmdahl R,. Structures on the I-A molecule predisposing for susceptibility to type II collagen-induced autoimmune arthritis. Eur J Immunol 1990; 20: 2127-31.
15. Healy AM, Izmailova E, Fitzgerald M, Walker R, Hattersley M, Silva M,. et al. PKC-θ-deficient mice are protected from Th1-dependent antigen-induced arthritis. J Immunol 2006; 177: 1886-93.
16. Schopf L, Savinainen A, Anderson K, Kujawa J, DuPont M, Silva M,. et al. IKKβ inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis. Arthritis Rheum 2006; 54: 3163-73.
17. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
18. Prevoo ML, van 't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL,. Modified disease activity scores that include twenty-eight-joint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995; 38: 44-8.
19. Smolen JS, Aletaha D, Bijlsma JW, Breedveld FC, Boumpas D, Burmester G, et al. Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis 2011; 69: 631-7.
20. Brand DD, Latham KA, Rosloniec EF,. Collagen-induced arthritis. Nat Protoc 2007; 2: 1269-75.
21. Tan SL, Zhao J, Bi C, Chen XC, Hepburn DL, Wang J, et al. Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C θ-deficient mice. J Immunol 2006; 176: 2872-9.
22. Zanin-Zhorov A, Ding Y, Kumari S, Attur M, Hippen KL, Brown M, et al. Protein kinase C-θ mediates negative feedback on regulatory T cell function. Science 2010; 328: 372-6.
23. Tian L, Philp JA, Shipston MJ,. Glucocorticoid block of protein kinase C signalling in mouse pituitary corticotroph AtT20 D16:16 cells. J Physiol 1999; 516: 757-68.
24. Parker A, Izmailova ES, Narang J, Badola S, Le T, Roubenoff R, et al. Peripheral blood expression of nuclear factor-κb-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-α versus methotrexate. J Rheumatol 2007; 34: 1817-22.