How does morality work in the brain? A functional and structural perspective of moral behavior

Frontiers in Integrative Neuroscience

Volumn 7, Issue SEP, 2013, Pages

  Pascual, Leo ^a   Rodrigues, Paulo ^a,b   Gallardo Pujol, David ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Mint Labs SL   (Spain)

Author keywords

fMRI; Moral judgement; Morality; Neuroimaging; Neuroscience; Social brain

Indexed keywords

ANTERIOR CINGULATE; BEHAVIOR; BRAIN FUNCTION; BRAIN REGION; DECISION MAKING; EMOTION; EMPATHY; HUMAN; INSULA; MORALITY; ORBITAL PREFRONTAL CORTEX; PARIETAL LOBE; PREFRONTAL CORTEX; PSYCHOLOGY; REVIEW; TEMPORAL LOBE; VENTROMEDIAL PREFRONTAL CORTEX;

EID: 84885064107     PISSN: 16625145     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnint.2013.00065     Document Type: Review

References (79)

1. Allison, T., Puce, A., and McCarty, G. (2000). Social perception from visual cues: role of the STS region. Trends Cogn. Sci. 4, 267-278. doi: 10.1016/S1364-6613(00)01501-1
2. Amodio, D., and Frith, C. D. (2006). Meeting the minds: the medial frontal cortex and social cognition. Nat. Rev. Neurosci. 7, 177-268. doi: 10.1038/nrn1884
3. Bargh, J. A., and Chartrand, T. L. (1999). The unbearable automaticity of being. Am. Psychol. 54, 462-479. doi: 10.1037/0003-066X.54.7.462
4. Blair, R. J. R. (2010). Psychopathy, frustration, and reactive aggression: the role of ventromedial prefrontal cortex. Br. J. Psychol. 110, 383-399. doi: 10.1348/000712609X418480
5. Borg, J. S., Hynes, C., Van Horn, J., Grafton, S., and Sinnott-Armstrong, W. (2006). Consequences, action, and intention as factors in moral judgments: an FMRI investigation. J. Cogn. Neurosci. 18, 803-817. doi: 10.1162/jocn.2006.18.5.803
6. Brink, D. O. (1986). Utilitarian morality and the personal point of view. J. Philos. 83, 417-438. doi: 10.2307/2026328
7. Buckholtz, J. W., Asplund, C. L., Dux, P. E., Zald, D. H., Gore, J. C., Jones, O. D., et al. (2008). The neural correlates of third-party punishment. Neuron 60, 930-940. doi: 10.1016/j.neuron.2008.10.016
8. Bush, G., Luu, P., and Posner, M. I. (2000). Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn. Sci. 6, 215-222. doi: 10.1016/S1364-6613(00)01483-2
9. Cáceda, R., James, G. A., Ely, T. D., Snarey, J., and Kilts, C. D. (2011). Mode of effective connectivity within a putative neural network differentiates moral cognitions related to care and justice ethics. PLoS ONE 6:e14730. doi: 10.1371/journal.pone.0014730
10. Chapman, H. A., Kim, D. A., Susskind, J. M., and Anderson, A. K. (2009). In bad taste: evidence for the oral origins of moral disgust. Science 323, 1222-1226. doi: 10.1126/science.1165565
11. Ciaramidaro, A., Adenzato, M., Enrici, I., Erk, S., Pia, L., Bara, B. G., et al. (2007). The intentional network: how the brain reads varieties of intentions. Neuropsychologia 45, 3105-3113. doi: 10.1016/j.neuropsychologia.2007.05.011
12. Cooper, J. C., Kreps, T. A., Wiebe, T., Pirkl, T., and Knutson, B. (2010). When giving is good: ventromedial prefrontal cortex activation for others' intentions. Neuron 67, 511-521. doi: 10.1016/j.neuron.2010.06.030
13. De Neys, W., and Glumicic, T. (2008). Conflict monitoring in dual process theories of reasoning. Cognition 106, 1248-1299. doi: 10.1016/j.cognition.2007.06.002
14. de Quervain, D. J., Fischbacher, U., Treyer, V., Schellhammer, M., Schnyder, U., and Buck, A. (2004). The neural basis of altruistic punishment. Science 305, 1254-1258.
15. Decety, J., Michalska, K. J., and Kinzler, K. D. (2011). The contribution of emotion and cognition to moral sensitivity: a neurodevelopmental study. Cereb. Cortex 22, 209-220. doi: 10.1093/cercor/bhr111
16. Farrow, T. F., Zheng, Y., Wilkinson, I. D., Spence, S. A., Deakin, J. F., Tarrier, N., et al. (2001). Investigating the functional anatomy of empathy and forgiveness. Neuroreport 12, 2433-2438. doi: 10.1097/00001756-200108080-00029
17. Flack, J., and de Waal, F. B. M. (2000). "Any animal whatever": darwinian building blocks of morality in monkeys and apes. J. Conscious. Stud. 7, 1-29.
18. Frith, U. (2001). Mind blindness and the brain in autism. Neuron 32, 969-979. doi: 10.1016/S0896-6273(01)00552-9
19. Funk, C. M., and Gazzaniga, M. S. (2009). The functional brain architecture of human morality. Curr. Opin. Neurobiol. 19, 678-681. doi: 10.1016/j.conb.2009.09.011
20. Fusar-Poli, P., Placentino, A., Carletti, F., Landi, P., Allen, P., Surgu-ladze, S., et al. (2009). Functional atlas of emo-tional faces processing: a voxel-based meta-analysis of 105 functional magnetic resonance imaging studies. J. Psychiatr. Neurosci. 34, 418-432.
21. Gert, B. (2012). The definition of morality. Stanford Encyclopedia of Philosophy. Stanford, CA: Stanford University.
22. Gottfried, K. (1999). Moral calculus and the bom. Nature 401, 117. doi: 10.1038/43571
23. Greene, J., and Haidt, J. (2002). How (and where) does moral judgment work? Trends Cogn. Sci. 6, 517-523. doi: 10.1016/S1364-6613(02)02011-9
24. Greene, J. D. (2007). "The secret joke of Kant's soul, " in Moral Psychology: The Neuroscience of Morality: Emotion, Disease, and Development, Vol. 3, ed W. Sinnott-Armstrong (Cambridge, MA: MIT Press), 35-117.
25. Greene, J. D., Nystrom, L. E., Engell, A. D., Darley, J. M., and Cohen, J. D. (2004). The neural bases of cognitive conflict and control in moral judgment. Neuron 44, 389-400. doi: 10.1016/j.neuron.2004.09.027
26. Greene, J. D., and Paxton, J. M. (2009). Patterns of neural activity associated with honest and dishonest moral decisions. Proc. Natl. Acad. Sci. U.S.A. 106, 12506-12511. doi: 10.1073/pnas.0900152106
27. Greene, J. D., Sommerville, R. B., Nystrom, L. E., Darley, J. M., and Cohen, J. D. (2001). An fMRI investigation of emotional engagement in moral judgment. Science 293, 2105-2108. doi: 10.1126/science.1062872
28. Haidt, J. (2001). The emotional dog and its rational tail: a social intuitionist approach to moral judgment. Psychol. Rev. 108, 814-834. doi: 10.1037/0033-295X.108.4.814
29. Harada, T., Itakura, S., Xu, F., Lee, K., Nakashita, S., Saito, D. N., and Sadato, N. (2009). Neural correlates of the judgment of lying: a functional magnetic resonance imaging study. Neurosci. Res. 63, 24-34. doi: 10.1016/j.neures.2008.09.010
30. Harenski, C. L., Antonenko, O., Shane, M. S., and Kiehl, K. (2008). Gender differences in neural mechanisms underlying moral sensitivity. Soc. Cogn. Affect. Neurosci. 3, 313-321. doi: 10.1093/scan/nsn026
31. Harenski, C. L., and Hamaan, S. (2006). Neural correlates of regulating negative emotions related to moral violations. Neuroimage 30, 313-324. doi: 10.1016/j.neuroimage.2005.09.034
32. Hauser, M. D. (2006). Moral Minds: How Nature Designed Our Universal Sense of Right and Wrong. New York, NY: Ecco/HarperCollins Publishers.
33. Haushofer, J., and Fehr, E. (2008). You shouldn't have: your brain on others' crimes. Neuron 60, 738-740. doi: 10.1016/j.neuron.2008.11.019
34. Hsu, M. (2008). The right and the good: distributive justice and neural encoding of equity and efficiency. Science 320, 1092-1095. doi: 10.1126/science.1153651
35. Immordino-Yang, M. H., and Singh, V. (2011). Hippocampal contributions to the processing of social emotions. Hum. Brain Mapp. 34, 945-955. doi: 10.1002/hbm.21485
36. Jackson, P. L., Meltzoff, A. N., and Decety, J. (2005). How do we perceive the pain of others? A window into the neural processes involved in empathy. Image Process. 24, 771-779.
37. Kahneman, D., and Frederick, S. (2007). Frames and brains: elicitation and control of response tendencies. Trends Cogn. Sci. 11, 45-46. doi: 10.1016/j.tics.2006.11.007
38. Kent, A., and Kiehl. (2006). A cognitive neuroscience perspective on psychopathy: evidence for paralimbic system dysfunction. Psychiatry Res. 142, 107-128. doi: 10.1016/j.psychres.2005.09.013
39. Koenigs, M., Young, L., Adolphs, R., Tranel, D., Cushman, F., Hauser, M., and Damasio, A. (2007). Damage to the prefrontal cortex increases utilitarian moral judgements. Nature 446, 908-911. doi: 10.1038/nature05631
40. Kohlberg, L. (1963). Moral Development and Identification. Child Psychology: The Sixty-Second Yearbook of the National Society for the Study of Education. Part 1.
41. Kohlberg, L. (1984). Essays in Moral Development, Volume I: The Psychology of Moral Development. New York, NY: Harper and Row.
42. Krajbich, I., Adolphs, R., Tranel, D., Denburg, N. L., and Camerer, C. F. (2009). Economic games quantify diminished sense of guilt in patients with damage to the prefrontal cortex. J. Neurosci. 29, 2188-2192. doi: 10.1523/JNEUROSCI.5086-08.2009
43. Lindsay, J. (2004). Darkly Dreaming Dexter. New York, NY: Vintage Books.
44. Luo, Q., Nakic, M., Wheatley, T., Richell, R., Martin, A., and Blair, R. J. R. (2006). The neural basis of implicit moral attitude-an IAT study using event-related fMRI. Neuroimage 30, 1449-1457. doi: 10.1016/j.neuroimage.2005.11.005
45. McClure, S. M., Botvinick, M. M., Yeung, N., Greene, J., and Cohen, J. D. (2007). "Conflict monitoring in cognition-emotion competition, " in Handbook of Emotion Regulation, ed J. J. J. Gross (New York, NY: Guilford), 204-226.
46. Mendez, M. F. (2006). What frontotemporal dementia reveals about the neurobiological basis of morality. Med. Hypotheses 67, 411-418. doi: 10.1016/j.mehy.2006.01.048
47. Moll, J., de Oliviera-Souza, R., and Eslinger, P. (2003). Morals and the human brain. Neuroreport 14, 299-305. doi: 10.1097/00001756-200303030-00001
48. Moll, J., Eslinger, P. J., and de Oliveira-Souza, R. (2001). Frontopolar and anterior temporal cortex activation in a moral judgment task: preliminary functionalMRI results in normal subjects. Arq. Neuropsiquiatr. 59, 657-664. doi: 10.1590/S0004-282X2001000500001
49. Moll, J., Krueger, F., Zahn, R., Pardini, M., Oliveira-souza, R., and Graham, J. (2006). Human fronto-mesolimbic networks guide decisions about charitable donation. Proc. Natl. Acad. Sci. U.S.A. 103, 15623-15628. doi: 10.1073/pnas.0604475103
50. Moll, J., Oliveira-souza, R. De, Eslinger, P. J., Bramati, I. E., Andreiuolo, P. A., and Pessoa, L. (2002). The neural correlates of moral sensitivity: a functional magnetic resonance imaging investigation of basic and moral Emotions 22, 2730-2736.
51. Moll, J., and Schulkin, J. (2009). Social attachment and aversion in human moral cognition. Neurosci. Biobehav. Rev. 33, 456-465. doi: 10.1016/j.neubiorev.2008.12.001
52. Moll, J., Zahn, R., de Oliveira-Souza, R., Krueger, F., and Grafman, J. (2005). Opinion: the neural basis of human moral cognition. Nat. Rev. Neurosci. 6, 799-809. doi: 10.1038/nrn1768
53. Moor, B. G., Güroǧlu, B., Op de Macks, Z. A., Rombouts, S. A., Van der Molen, M. W., and Crone, E. (2011). Social exclusion and punishment of excluders: neural correlates and developmental trajectories. Neuroimage 59, 708-717. doi: 10.1016/j.neuroimage.2011.07.028
54. Muller, F., Simion, A., Reviriego, E., Galera, C., Mazaux, J.-M., Barat, M., et al. (2010). Exploring theory of mind after severe traumatic brain injury. Cortex 46, 1088-1099. doi: 10.1016/j.cortex.2009.08.014
55. Navarrete, C. D., McDonald, M. M., Mott, M. L., and Asher, B. (2012). Virtual morality: emotion and action in a simulated three-dimensional "Trolley Problem. " Emotion 12, 364-370.
56. O'Doherty, J. O., Kringelbach, M. L., Rolls, E. T., Hornak, J., and Andrews, C. (2001). Abstract reward and punishment representations in the human orbitofrontal cortex. Nat. Neurosci. 4, 95-102. doi: 10.1038/82959
57. Partiot, A., Grafman, J., Sadato, N., Wachs, J., and Hallett, M. (1995). Brain activation during the generation of non-emotional and emotional plans. Neuroreport 10, 1269-1272.
58. Pinker, S. (1997). How the Mind Works. New York, NY: Norton.
59. Prehn, K., Wartenburger, I., Meriau, K., Scheibe, C., Goodenough, O. R., and Villringer, A. (2008). Individual differences in moral judgment competence influence neural correlates of socio-normative judgments. Soc. Cogn. Affect. Neurosci. 3, 33-46. doi: 10.1093/scan/nsm037
60. Pujol, J., Batalla, I., Contreras-Rodríguez, O., Harrison, B. J., Pera, V., Hernández-Ribas, R., et al. (2011). Breakdown in the brain network subserving moral judgment in criminal psychopathy. Soc. Cogn. Affect. Neurosci. 7, 917-923. doi: 10.1093/scan/nsr075
61. Rand, A. (1964). The Virtue of Selfishness. New York, NY: Penguin Books.
62. Rush, J. A., First, M. B., and Blacker, D. (2008). Handbook of Psychiatric Measures. Washington, DC: American Psychiatric Publishing.
63. Sestieri, C., Corbetta, M., and Romani, G. L., and Shulman, G. L. (2011). Episodic memory retrieval, parietal cortex, and the default mode network: functional and topographic analyses. J. Neurosci. 31, 4407-4420. doi: 10.1523/JNEUROSCI.3335-10.2011
64. Shackman, A. J., Salomons, T. V., Slagter, H. A., Fox, A. S., Winter, J. J., and Davidson, R. J. (2011). The integration of negative affect, pain and cognitive control in the cingulate cortex. Nat. Rev. Neurosci. 12, 154-167. doi: 10.1038/nrn2994
65. Shenhav, A., and Greene, J. D. (2010). Moral judgments recruit domain-general valuationmechanisms to integrate representations of probability and magnitude. Neuron 67, 667-677. doi: 10.1016/j.neuron.2010.07.020
66. Slater, M., Antley, A., Davison, A., Swapp, D., Guger, C., Barker, C., et al. (2006). A virtual reprise of the Stanley Milgram obedience experiments. PLoS ONE 1:e39. doi: 10.1371/journal.pone.0000039
67. Sommer, M., Rothmayr, C., Döhhnel, K., Meinhardt, J., Schwerdtner, J., Sodian, B., et al. (2010). How should I decide? The neural correlates of everyday moral reasoning. Neuropsychologia 48, 2018-2026. doi: 10.1016/j.neuropsychologia.2010.03.023
68. Thomson, J. J. (1985). The trolley problem. Yale Law J. 94, 1395-1415. doi: 10.2307/796133
69. Trivers, R. L. (1971). The evolution of reciprocal altruism. Q. Rev. Biol. 46, 35-57. doi: 10.1086/406755
70. Tsetsenis, T., Ma, X. H., Lo Iacono, L., Beck, S. G., and Gross, C. (2007). Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus. Nat. Neurosci. 10, 896-902. doi: 10.1038/nn1919
71. van Dillen, L., van der Wal, R., and van den Bos, K. (2012). On the role of attention and emotion in morality: attentional control modulates unrelated disgust in moral. Pers. Soc. Psychol. Bull. 38, 1222-1231. doi: 10.1177/0146167212448485
72. Völlm, B. A., Taylor, A. N. W., Richardson, P., Corcoran, R., Stirling, J., McKie, S., et al. (2006). Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task. Neuroimage 29, 90-98. doi: 10.1016/j.neuroimage.2005.07.022
73. Wicker, B., Keysers, C., Plailly, J., Royet, J. P., Gallese, V., and Rizzolatti, G. (2003). Both of us disgusted in my insula: the common neural basis of seeing and feeling disgust. Neuron 40, 655-664. doi: 10.1016/S0896-6273(03)00679-2
74. Yarkoni, T., Poldrack, R., Nichols, T., Van Essen, D., and Wager, T. (2011). NeuroSynth: a new platform for large-scale automated synthesis of human functional neuroimaging data. Front. Neuroinform. Conference Abstract: 4th INCF Congress of Neuroinformatics. 8, 665-670. doi: 10.3389/conf.fninf.2011.08.00058
75. Young, L., Camprodon, J. A., Hauser, M., Pascual-Leone, A., and Saxe, R. (2010). Disruption of the right temporoparietal junction with transcranial magnetic stimulation reduces the role of beliefs in moral judgments. Proc. Natl. Acad. Sci. U.S.A. 107, 6753-6758. doi: 10.1073/pnas.0914826107
76. Young, L., and Dungan, J. (2011). Where in the brain is morality? Everywhere and maybe nowhere. Soc. Neurosci. 7, 1-10. doi: 10.1080/17470919.2011.569146
77. Young, L., and Dungan, J. (2012). Where in the brain is morality? Everywhere and maybe nowhere. Soc. Neurosci. 7, 1-10. doi: 10.1080/17470919.2011.569146
78. Young, L., and Koenigs, M. (2007). Investigating emotion in moral cognition: a review of evidence from functional neuroimaging and neuropsychology. Br. Med. Bull. 84, 69-79. doi: 10.1093/bmb/ldm031
79. Young, L., and Saxe, R. (2008). The neural basis of belief encoding and integration in moral judgment. NeuroImage 40, 1912-1920. doi: 10.1016/j.neuroimage.2008.01.057