Disruption of the right temporoparietal junction with transcranial magnetic stimulation reduces the role of beliefs in moral judgments

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 15, 2010, Pages 6753-6758

  Young, Liane ^a   Camprodon, Joan Albert ^b   Hauser, Marc ^c   Pascual Leone, Alvaro ^b   Saxe, Rebecca ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

Functional MRI; Morality; Theory of mind

Indexed keywords

ADULT; ARTICLE; BEHAVIOR; BRAIN; DECISION MAKING; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; MALE; MENTAL HEALTH; MORALITY; PRIORITY JOURNAL; RIGHT TEMPOROPARIETAL JUNCTION; TRANSCRANIAL MAGNETIC STIMULATION;

ADOLESCENT; ADULT; COGNITION; CULTURE; FEMALE; HUMANS; JUDGMENT; MAGNETIC RESONANCE IMAGING; MALE; MORALS; NEURONS; PARIETAL LOBE; TEMPORAL LOBE; TIME FACTORS; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 77951066646     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914826107     Document Type: Article

References (53)

1. Baird JA, Astington JW (2004) The role of mental state understanding in the development of moral cognition and moral action. New Dir Child Adolesc Dev 103:37-49.
2. Karniol R (1978) Children's use of intention cues in evaluating behavior. Psychol Bull 85:76-85.
3. Piaget J (1932) The Moral Judgment of the Child (Free Press, New York).
4. Gallagher HL, Frith CD (2003) Functional imaging of 'theory of mind'. Trends Cogn Sci 7:77-83.
5. Gobbini MI, Koralek AC, Bryan RE, Montgomery KJ, Haxby JV (2007) Two takes on the social brain: A comparison of theory of mind tasks. J Cognit Neurosci 19:1803-1814.
6. Perner J, Aichhorn M, Kronbichler M, Staffen W, Ladurner G (2006) Thinking of mental and other representations: The roles of left and right temporo-parietal junction. Social Neuroscience 1:245-258.
7. Saxe R, Kanwisher N (2003) People thinking about thinking people. The role of the temporo-parietal junction in "theory of mind." NeuroImage 19:1835-1842.
8. Saxe R, Powell L (2006) It's the thought that counts: Specific brain regions for one component of Theory of Mind. Psychol Sci 17:692-699. (Pubitemid 44179880)
9. Young L, Cushman F, Hauser M, Saxe R (2007) The neural basis of the interaction between theory of mind and moral judgment. Proc Natl Acad Sci USA 104:8235-8240. (Pubitemid 47175471)
10. Young L, Saxe R (2008) The neural basis of belief encoding and integration in moral judgment. NeuroImage 40:1912-1920.
11. Valero-Cabre A, Payne BR, Pascual-Leone A (2007) Opposite impact on 14C-2-deoxyglucose brain metabolism following patterns of high and low frequency repetitive transcranial magnetic stimulation in the posterior parietal cortex. Exp Brain Res 176:603-615. (Pubitemid 46175191)
12. Valero-Cabre A, Payne B, Rushmore J, Lomber S, Pascual-Leone A (2005) Impact of repetitive transcranial magnetic stimulation of the parietal cortex on metabolic brain activity: A 14C-2DG tracing study in the cat. Exp Brain Res 163:1-12. (Pubitemid 40868510)
13. Greicius MD, Krasnow B, Reiss AL, Menon V (2003) Functional connectivity in the resting brain: A network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 100:253-258. (Pubitemid 36078061)
14. Walsh V, Cowey A (2000) Transcranial magnetic stimulation and cognitive neuroscience. Nat Rev Neurosci 1:73-79.
15. Cushman F (2008) Crime and punishment: Distinguishing the roles of causal and intentional analysis in moral judgment. Cognition 108:353-380.
16. Greene JD, Sommerville RB, Nystrom LE, Darley JM, Cohen JD (2001) An fMRI investigation of emotional engagement in moral judgment. Science 293:2105-2108.
17. Cushman F, Young L, Hauser MD (2006) The role of conscious reasoning and intuitions in moral judgment: Testing three principles of harm. Psychol Sci 17:1082-1089. (Pubitemid 44952683)
18. Kliemann D, Young L, Scholz J, Saxe R (2008) The influence of prior record on moral judgment. Neuropsychologia 46:2949-2957.
19. Greene JD, Nystrom LE, Engell AD, Darley JM, Cohen JD (2004) The neural bases of cognitive conflict and control in moral judgment. Neuron 44:389-400.
20. Woolfolk RL, Doris JM, Darley JM (2006) Identification, situational constraint, and social cognition: Studies in the attribution of moral responsibility. Cognition 100:283-301.
21. Young L, Nichols S, Saxe R Investigating the neural and cognitive basis of moral luck: It's not what you do but what you know. Review of Philosophy and Psychology, in press.
22. Robertson EM, Theoret H, Pascual-Leone A (2003) Studies in cognition: The problems solved and created by transcranial magnetic stimulation. J Cognit Neurosci 15:948-960. (Pubitemid 37281759)
23. Wagner T, Valero-Cabre A, Pascual-Leone A (2007) Noninvasive human brain stimulation. Annu Rev Biomed Eng 9:527-565.
24. Young L, Saxe R (2009) Innocent intentions: A correlation between forgiveness for accidental harm and neural activity. Neuropsychologia 47:2065-2072.
25. Young L, Saxe R (2009) An FMRI investigation of spontaneous mental state inference for moral judgment. J Cognit Neurosci 21:1396-1405.
26. Valero-Cabre A, Rushmore RJ, Payne BR (2006) Low frequency transcranial magnetic stimulation on the posterior parietal cortex induces visuotopically specific neglect-like syndrome. Exp Brain Res 172:14-21. (Pubitemid 43780116)
27. Wagner T, et al. (2007) Transcranial direct current stimulation: A computer-based human model study. NeuroImage 35:1113-1124. (Pubitemid 46507817)
28. Apperly IA, Samson D, Chiavarino C, Humphreys GW (2004) Frontal and temporoparietal lobe contributions to theory of mind: Neuropsychological evidence from a false-belief task with reduced language and executive demands. J Cognit Neurosci 16:1773-1784. (Pubitemid 40052457)
29. Adolphs R (2009) The social brain: Neural basis of social knowledge. Annu Rev Psychol 60:693-716.
30. Bechara A (2002) The neurology of social cognition. Brain 125:1673-1675.
31. Ciaramelli E, Muccioli M, Ladavas E, di Pellegrino G (2007) Selective deficit in personal moral judgment following damage to ventromedial prefrontal cortex. Social Cognitive and Affective Neuroscience 2:84-92.
32. Koenigs M, et al. (2007) Damage to the prefrontal cortex increases utilitarian moral judgments. Nature 446:908-911. (Pubitemid 46633159)
33. Mendez MF, Anderson E, Shapira JS (2005) An investigation of moral judgment in frontotemporal dementia. Cognitive and Behavioral Neurology 18:193-197. (Pubitemid 41790256)
34. Young L, Cushman FA, Adolphs R, Tranel D, Hauser MD (2006) Does emotion mediate the relationship between an action's moral status and its intentional status? Neuropsychological evidence. Journal of Cognition and Culture 6:291-304.
35. Knoch D, Pascual-Leone A, Meyer K, Treyer V, Fehr E (2006) Diminishing reciprocal fairness by disrupting the right prefrontal cortex. Science 314:829-832. (Pubitemid 44706651)
36. Priori A, et al. (2008) Lie-specific involvement of dorsolateral prefrontal cortex in deception. Cereb Cortex 18:451-455. (Pubitemid 351197805)
37. Corbetta M, Kincade JM, Ollinger JM, McAvoy MP, Shulman GL (2000) Voluntary orienting is dissociated from target detection in human posterior parietal cortex. Nat Neurosci 3:292-297. (Pubitemid 30140793)
38. Mitchell JP (2007) Activity in right temporo-parietal junction is not selective for theory-of-mind. Cereb Cortex 18:262-271.
39. Scholz J, Triantafyllou C, Whitfield-Gabrieli S, Brown EN, Saxe R (2009) Distinct regions of right temporo-parietal junction are selective for theory of mind and exogenous attention. PLoS One 4:1-7.
40. Decety J, Lamm C (2007) The role of the right temporoparietal junction in social interaction: How low-level computational processes contribute to meta-cognition. Neuroscientist 13:580-593. (Pubitemid 350077309)
41. Kammer T (1999) Phosphenes and transient scotomas induced by magnetic stimulation of the occipital lobe: Their topographic relationship. Neuropsychologia 37:191-198.
42. Gogtay N, et al. (2008) Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry. Proc Natl Acad Sci USA 105:15979-15984.
43. Blakemore SJ (2008) The social brain in adolescence. Nat Rev Neurosci 9:267-277.
44. Saxe RR, Whitfield-Gabrieli S, Scholz J, Pelphrey KA (2009) Brain regions for perceiving and reasoning about other people in school-aged children. Child Dev 80:1197-1209.
45. Leslie AM, Mallon R, DiCorcia JA (2006) Transgressors, victims, and crybabies: Is basic moral judgment spared in autism? Social Neuroscience 1:270-283.
46. Blair RJ (1996) Brief report: Morality in the autistic child. J Autism Dev Disord 26:571-579.
47. Baron-Cohen S, Leslie AM, Frith U (1985) Does the autistic child have a "theory of mind"? Cognition 21:37-46.
48. Senju A, Southgate V, White S, Frith U (2009) Mindblind eyes: An absence of spontaneous theory of mind in Asperger syndrome. Science 325:883-885.
49. Kana RK, Keller TA, Cherkassky VL, Minshew NJ, Just MA (2009) Atypical frontal-posterior synchronization of Theory of Mind regions in autism during mental state attribution. Soc Neurosci 4:135-152.
50. Mikhail JM (2007) Universal moral grammar: Theory, evidence and the future. Trends Cogn Sci 11:143-152.
51. Chen R, et al. (1997) Safety of different inter-train intervals for repetitive transcranial magnetic stimulation and recommendations for safe ranges of stimulation parameters. Electroencephalogr Clin Neurophysiol 105:415-421. (Pubitemid 28020517)
52. Maeda F, Keenan JP, Tormos JM, Topka H, Pascual-Leone A (2000) Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability. Exp Brain Res 133:425-430. (Pubitemid 30609368)
53. Gugino LD, et al. (2001) Transcranial magnetic stimulation coregistered with MRI: A comparison of a guided versus blind stimulation technique and its effect on evoked compound muscle action potentials. Clin Neurophysiol 112:1781-1792.