3D imaging of tissue integration with porous biomaterials

Biomaterials

Volumn 29, Issue 28, 2008, Pages 3757-3761

  Guldberg, Robert E ^a   Duvall, Craig L ^a   Peister, Alexandra ^b   Oest, Megan E ^a   Lin, Angela S P ^a   Palmer, Ashley W ^a   Levenston, Marc E ^c  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b MOREHOUSE COLLEGE   (United States)

^c Stanford University   (United States)

Author keywords

Bone; Cartilage; Imaging; Micro CT; Scaffolds; Vascularization

Indexed keywords

BIODEGRADABLE POLYMERS; BIOLOGICAL MATERIALS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC RADIOGRAPHY; HEALTH; IMAGING SYSTEMS; MEDICAL IMAGING; STABILIZERS (AGENTS); TISSUE; TISSUE CULTURE; TOMOGRAPHY;

3D IMAGING; CELLULAR INFILTRATION; COMPARATIVE STUDIES; CONTRAST AGENT (CA); ELSEVIER (CO); EXTRACELLULAR MATRIX FORMATION; FUNCTIONAL TISSUE; HIGH RESOLUTIONS; IMPLANT FIXATION; MICRO COMPUTED TOMOGRAPHY (MICRO CT); POROUS BIOMATERIALS; QUALITATIVE EVALUATIONS; QUANTITATIVE METRICS; RELIANCE (CO); THREE DIMENSIONAL (3D) IMAGING TECHNIQUES; TISSUE FORMATION; TISSUE INTEGRATION; TISSUE REPAIRING; VASCULATURE;

TISSUE ENGINEERING;

BIOMATERIAL; CALCIUM PHOSPHATE; GLYCOSAMINOGLYCAN POLYSULFATE; INTERLEUKIN 1; LEAD CHROMATE; MEGLUMINE IOXAGLATE PLUS SODIUM IOXAGLATE; MICROFIL MV 122; POLYCAPROLACTONE; POLYMER; PROTEOGLYCAN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT GROWTH FACTOR; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA3; RECOMBINANT VASCULOTROPIN; SILASTIC; TRANSFORMING GROWTH FACTOR BETA3;

ANGIOGENESIS; ARTICLE; BIOREACTOR; CARTILAGE CELL; CARTILAGINOUS TISSUE; CELL INFILTRATION; CHONDROGENESIS; CONTRAST ENHANCEMENT; EXPERIMENTAL MODEL; EXTRACELLULAR MATRIX; MICRO-COMPUTED TOMOGRAPHY; MINERALIZATION; MOLECULAR INTERACTION; MORPHOGENESIS; MORPHOMETRICS; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN SECRETION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REVASCULARIZATION; TISSUE CHARACTERIZATION; TISSUE ENGINEERING; TISSUE GROWTH; TISSUE REGENERATION; VASCULARIZATION;

BIOCOMPATIBLE MATERIALS; EXTRACELLULAR MATRIX; GUIDED TISSUE REGENERATION; HUMANS; IMAGING, THREE-DIMENSIONAL; IMPLANTS, EXPERIMENTAL; MATERIALS TESTING; NEOVASCULARIZATION, PHYSIOLOGIC; POLYMERS; POROSITY; TISSUE ENGINEERING; TOMOGRAPHY, X-RAY COMPUTED;

EID: 48049091146     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2008.06.018     Document Type: Article

References (37)

1. Lin A.S., Barrows T.H., Cartmell S.H., and Guldberg R.E. Microarchitectural and mechanical characterization of oriented porous polymer scaffolds. Biomaterials 24 3 (2003) 481-489
2. Oest M.E., Dupont K.M., Kong H.J., Mooney D.J., and Guldberg R.E. Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects. J Orthop Res 25 7 (2007) 941-950
3. Boskey A., and Pleshko Camacho N. FT-IR imaging of native and tissue-engineered bone and cartilage. Biomaterials 28 15 (2007) 2465-2478
4. Campbell C.T., and Kim G. SPR microscopy and its applications to high-throughput analyses of biomolecular binding events and their kinetics. Biomaterials 28 15 (2007) 2380-2392
5. Huebsch N.D., and Mooney D.J. Fluorescent resonance energy transfer: a tool for probing molecular cell-biomaterial interactions in three dimensions. Biomaterials 28 15 (2007) 2424-2437
6. Silva E.A., and Mooney D.J. Spatiotemporal control of vascular endothelial growth factor delivery from injectable hydrogels enhances angiogenesis. J Thromb Haemost 5 3 (2007) 590-598
7. Oliveira A.L., Malafaya P.B., Costa S.A., Sousa R.A., and Reis R.L. Micro-computed tomography (micro-CT) as a potential tool to assess the effect of dynamic coating routes on the formation of biomimetic apatite layers on 3D-plotted biodegradable polymeric scaffolds. J Mater Sci Mater Med 18 2 (2007) 211-223
8. Porter B.D., Lin A.S., Peister A., Hutmacher D., and Guldberg R.E. Noninvasive image analysis of 3D construct mineralization in a perfusion bioreactor. Biomaterials 28 15 (2007) 2525-2533
9. Jones A.C., Milthorpe B., Averdunk H., Limaye A., Senden T.J., Sakellariou A., et al. Analysis of 3D bone ingrowth into polymer scaffolds via micro-computed tomography imaging. Biomaterials 25 20 (2004) 4947-4954
10. Otsuki B., Takemoto M., Fujibayashi S., Neo M., Kokubo T., and Nakamura T. Pore throat size and connectivity determine bone and tissue ingrowth into porous implants: three-dimensional micro-CT based structural analyses of porous bioactive titanium implants. Biomaterials 27 35 (2006) 5892-5900
11. Jones A.C., Arns C.H., Sheppard A.P., Hutmacher D.W., Milthorpe B.K., and Knackstedt M.A. Assessment of bone ingrowth into porous biomaterials using MICRO-CT. Biomaterials 28 15 (2007) 2491-2504
12. Jones J.R., Poologasundarampillai G., Atwood R.C., Bernard D., and Lee P.D. Non-destructive quantitative 3D analysis for the optimisation of tissue scaffolds. Biomaterials 28 7 (2007) 1404-1413
13. Hilldore A., Wojtowicz A., and Johnson A.W. Micro-CT based quantification of non-mineralized tissue on cultured hydroxyapatite scaffolds. J Biomed Mater Res A 82 4 (2007) 1012-1021
14. Guldberg R.E., Lin A.S., Coleman R., Robertson G., and Duvall C. Microcomputed tomography imaging of skeletal development and growth. Birth Defects Res C Embryo Today 72 3 (2004) 250-259
15. Cartmell S., Huynh K., Lin A., Nagaraja S., and Guldberg R. Quantitative microcomputed tomography analysis of mineralization within three-dimensional scaffolds in vitro. J Biomed Mater Res A 69 1 (2004) 97-104
16. Liu G., Zhao L., Zhang W., Cui L., Liu W., and Cao Y. Repair of goat tibial defects with bone marrow stromal cells and beta-tricalcium phosphate. J Mater Sci Mater Med 19 6 (2008) 2367-2376
17. Byers B.A., Guldberg R.E., Hutmacher D.W., and Garcia A.J. Effects of Runx2 genetic engineering and in vitro maturation of tissue-engineered constructs on the repair of critical size bone defects. J Biomed Mater Res A 76 3 (2006) 646-655
18. Gauthier O., Muller R., von Stechow D., Lamy B., Weiss P., Bouler J.M., et al. In vivo bone regeneration with injectable calcium phosphate biomaterial: a three-dimensional micro-computed tomographic, biomechanical and SEM study. Biomaterials 26 27 (2005) 5444-5453
19. Hu W.W., Wang Z., Hollister S.J., and Krebsbach P.H. Localized viral vector delivery to enhance in situ regenerative gene therapy. Gene Ther 14 11 (2007) 891-901
20. Lin X., Pena L.A., Zamora P.O., Campion S.L., and Takahashi K. Augmentation of demineralized bone matrix (DBM) mineralization by a synthetic growth factor mimetic. J Orthop Res 24 11 (2006) 2051-2058
21. Rai B., Oest M.E., Dupont K.M., Ho K.H., Teoh S.H., and Guldberg R.E. Combination of platelet-rich plasma with polycaprolactone-tricalcium phosphate scaffolds for segmental bone defect repair. J Biomed Mater Res A 81 4 (2007) 888-899
22. Ford N.L., Thornton M.M., and Holdsworth D.W. Fundamental image quality limits for microcomputed tomography in small animals. Med Phys 30 11 (2003) 2869-2877
23. Rocha F.G., Sundback C.A., Krebs N.J., Leach J.K., Mooney D.J., Ashley S.W., et al. The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine. Biomaterials (2008)
24. Chen R.R., Silva E.A., Yuen W.W., Brock A.A., Fischbach C., Lin A.S., et al. Integrated approach to designing growth factor delivery systems. FASEB J 21 14 (2007) 3896-3903
25. Kaigler D., Wang Z., Horger K., Mooney D.J., and Krebsbach P.H. VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects. J Bone Miner Res 21 5 (2006) 735-744
26. Huang Y.C., Kaigler D., Rice K.G., Krebsbach P.H., and Mooney D.J. Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration. J Bone Miner Res 20 5 (2005) 848-857
27. Kaigler D., Krebsbach P.H., Wang Z., West E.R., Horger K., and Mooney D.J. Transplanted endothelial cells enhance orthotopic bone regeneration. J Dent Res 85 7 (2006) 633-637
28. Ford N.L., Graham K.C., Groom A.C., Macdonald I.C., Chambers A.F., and Holdsworth D.W. Time-course characterization of the computed tomography contrast enhancement of an iodinated blood-pool contrast agent in mice using a volumetric flat-panel equipped computed tomography scanner. Invest Radiol 41 4 (2006) 384-390
29. Graham K.C., Ford N.L., MacKenzie L.T., Postenka C.O., Groom A.C., MacDonald I.C., et al. Noninvasive quantification of tumor volume in preclinical liver metastasis models using contrast-enhanced X-ray computed tomography. Invest Radiol 43 2 (2008) 92-99
30. Guldberg R.E., Ballock R.T., Boyan B.D., Duvall C.L., Lin A.S., Nagaraja S., et al. Analyzing bone, blood vessels, and biomaterials with microcomputed tomography. IEEE Eng Med Biol Mag 22 5 (2003) 77-83
31. Duvall C.L., Taylor W.R., Weiss D., and Guldberg R.E. Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury. Am J Physiol Heart Circ Physiol 287 1 (2004) H302-H310
32. Duvall C.L., Weiss D., Robinson S.T., Alameddine F.M., Guldberg R.E., and Taylor W.R. The role of osteopontin in recovery from hind limb ischemia. Arterioscler Thromb Vasc Biol 28 2 (2008) 290-295
33. Duvall C.L., Taylor W.R., Weiss D., Wojtowicz A.M., and Guldberg R.E. Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice. J Bone Miner Res 22 2 (2007) 286-297
34. Butcher J.T., Sedmera D., Guldberg R.E., and Markwald R.R. Quantitative volumetric analysis of cardiac morphogenesis assessed through micro-computed tomography. Dev Dyn 236 3 (2007) 802-809
35. Wang Y., Wan C., Deng L., Liu X., Cao X., Gilbert S.R., et al. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest 117 6 (2007) 1616-1626
36. Chen R.R., Snow J.K., Palmer J.P., Lin A.S., Duvall C.L., Guldberg R.E., et al. Host immune competence and local ischemia affects the functionality of engineered vasculature. Microcirculation 14 2 (2007) 77-88
37. Palmer A.W., Guldberg R.E., and Levenston M.E. Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography. Proc Natl Acad Sci U S A 103 51 (2006) 19255-19260