Connexin 43 gap junction plaque endocytosis implies molecular remodelling of ZO-1 and c-Src partners

Communicative and Integrative Biology

Volumn 2, Issue 2, 2009, Pages 104-106

  Gilleron, Jérome ^a   Carette, Diane ^b   Fiorini, Céline ^b   Benkdane, Merieme ^a   Segretain, Dominique ^a   Pointis, Georges ^b  

^a INSERM   (France)

^b CENTRE MÉDITERRANÉEN DE MÉDECINE MOLÉCULAIRE C3M   (France)

Author keywords

c Src; Cx43; Gap junction plaque endocytosis; HCH; ZO 1

Indexed keywords

EID: 67650599486     PISSN: None     EISSN: 19420889     Source Type: Journal    
DOI: 10.4161/cib.7626     Document Type: Article

References (30)

1. Leithe E, Sirnes S, Omori Y, Rivedal E. Downregulation of gap junctions in cancer cells. Crit Rev Oncog 2006; 12:225-56.
2. Pointis G, Fiorini C, Gilleron J, Carette D, Segretain D. Connexins as precocious markers and molecular targets for chemical and pharmacological agents in carcinogenesis. Curr Med Chem 2007; 14:2288-303.
3. Sáez JC, Retamal MA, Basilio D, Bukauskas FF, Bennett MV. Connexin-based gap junction hemichannels: gating mechanisms. Biochim Biophys Acta 2005; 1711:215-24.
4. Hervé JC, Bourmeyster N, Sarrouilhe D, Duffy HS. Gap junctional complexes: from partners to functions. Prog Biophys Mol Biol 2007; 94:29-65.
5. Giepmans B, Moolenaar W. The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein. Curr Biol 1998; 8:931-4.
6. Toyofuku T, Yabuki M, Otsu K, Kuzuya T, Hori M, Tada M. Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes. J Biol Chem 1998; 273:12725-31.
7. Nielsen PA, Beahm DL, Giepmans BN, Baruch A, Hall JE, Kumar NM. Molecular cloning, functional expression and tissue distribution of a novel human gap junction-forming protein, connexin-31.9. Interaction with zona occludens protein-1. J Biol Chem 2002; 277:38272-83.
8. Li X, Olson C, Lu S, Kamasawa N, Yasumura T, Rash JE, Nagy JI. Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1. Eur J Neurosci 2004; 19:2132-46.
9. Laing JG, Manley-Markowski RN, Koval M, Civitelli R, Steinberg TH. Connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cells. J Biol Chem 2001; 276:23051-5.
10. Kausalya PJ, Reichert M, Hunziker W. Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells. FEBS Lett 2001; 505:92-6.
11. Nielsen PA, Baruch A, Shestopalov VI, Giepmans BN, Dunia I, Benedetti EL, et al. Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1). Mol Biol Cell 2003; 14:2470-81.
12. Fishman GI, Moreno AP, Spray DC, Leinwand LA. Functional analysis of human cardiac gap junction channel mutants. Proc Natl Acad Sci USA 1991; 88:3525-9.
13. Dunham B, Liu S, Taffet S, Trabka-Janik E, Delmar M, Petryshyn R, et al. Immunolocalization and expression of functional andnonfunctional cell-to-cell channels from wild-type and mutant rat heart connexin43 cDNA. Circ Res 1992; 70:1233-43.
14. Unger VM, Kumar NM, Gilula NB, Yeager M. Three-dimensional structure of a recombinant gap junction membrane channel. Science 1999; 283:1176-80.
15. Duffy H, Ashton A, O'Donnell P, Coombs W, Taffet S, Delmar M, Spray D. Regulation of connexin43 protein complexes by intercellular acidification. Circ Res 2004; 94:215-22.
16. Akoyev V, Takemoto DJ. ZO-1 is required for protein kinase C gamma-driven disassembly of connexin 43. Cell Signal 2007; 19:958-67.
17. Barker RJ, Price RL, Gourdie RG. Increased association of ZO-1 with connexin43 during remodeling of cardiac gap junctions. Circ Res 2002; 90:317-24.
18. Hunter AW, Barker RJ, Zhu C, Gourdie RG. Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion. Mol Biol Cell 2005; 16:5686-98.
19. Segretain D, Fiorini C, Decrouy X, Defamie N, Prat JR, Pointis G. A proposed role for ZO-1 in targeting connexin 43 gap junctions to the endocytic pathway. Biochimie 2004; 86:241-4.
20. Gilleron J, Fiorini C, Carette D, Avondet C, Falk MM, Segretain D, et al. Molecular reorganization of Cx43, ZO-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen. J Cell Sci 2008; 121:4069-78.
21. Hartsock A, Nelson WJ. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta 2008; 1778:660-9.
22. Toyofuku T, Akamatsu H, Zhang T, Kuzuya T, Tada M, Hori M. C-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes. J Biol Chem 2001; 276:1780-8.
23. Postma FR, Hengeveld T, Alblas J, Giepmans BNG, Zondag GCM, Jalink K, et al. Acute loss of cell-cell communication caused by G protein-coupled receptors: a critical role for c-Src. J Cell Biol 1998; 140:1199-209.
24. Sorgen P, Duffy H, Sahoo P. Coombs W, Delmar M, Spray D. Structural changes in carboxyl terminus of the gap junction protein connexin-43 indicates signaling between binding domains for c-Src and zonula occludens-1. J Biol Chem 2004; 279:54695-701.
25. Li W, Hertzberg EL, Spray DC. Regulation of connexin43-protein binding in astrocytes in response to chemical ischemia/hypoxia. J Biol Chem 2005; 280:7941-8.
26. Defamie N, Mograbi B, Roger C, Cronier L, Malassine A, Brucker-Davis F, et al. Disruption of gap junctional intercellular communication by lindane is associated with aberrant localization of connexin43 and zonula occludens-1 in 42GPA9 Sertoli cells. Carcinogenesis 2001; 22:1537-42.
27. Mograbi B, Corcelle E, Defamie N, Samson M, Nebout M, Segretain D, et al. Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK/mitogen-activated protein kinase pathway. Carcinogenesis 2003; 24:1415-23.
28. Fiorini C, Gilleron J, Carette D, Valette A, Tilloy A, Chevalier S, et al. Accelerated internalization of junctional membrane proteins (connexin 43, -cadherin and ZO-1) within endocytic vacuoles: an early event of DDT carcinogenicity. Biochim Biophys Acta 2008; 1778:56-67.
29. Frame MC. Src in cancer: deregulation and consequences for cell behaviour. Biochim Biophys Acta 2002; 1602:114-30.
30. Pahujaa M, Anikin M, Goldberg GS. Phosphorylation of connexin43 induced by Src: regulation of gap junctional communication between transformed cells. Exp Cell Res 2007; 313:4083-90.