Cx32 formation and/or Cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytic cell line

Experimental Cell Research

Volumn 276, Issue 1, 2002, Pages 40-51

  Kojima, Takashi ^a   Spray, David C ^b   Kokai, Yasuo ^a   Chiba, Hideki ^a   Mochizuki, Yohichi ^a   Sawada, Norimasa ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Actin; Claudin 1; Gap junctions; Occludin; ZO 1

Indexed keywords

COMPLEMENTARY DNA; CONNEXIN 26; CONNEXIN 32; CONNEXIN 43; GLYCYRRHETINIC ACID; MESSENGER RNA;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL FUNCTION; CELL IMMORTALIZATION; CELL LINE; CONTROLLED STUDY; GAP JUNCTION; IMMUNOCYTOCHEMISTRY; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TIGHT JUNCTION; WILD TYPE;

EID: 0036343899     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5511     Document Type: Article

References (64)

1. c-AMP increases junctional conductance and stimulates phosphorylation of the 27 KDa principal gap junction polypeptide
2. Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-triphosphate and to calcium ions
3. The gap junction communication channel
4. Junctional intercellular communication and the control of growth
5. Gap junctions: New tools, new answers, new questions
6. Connexins and glucagon receptors during development of rat hepatic acinus
7. Role of connexin genes in growth control
8. Cell-cell communication in carcinogenesis
9. Vitamin A-induced mucous metaplasia. An in vitro system for modulating tight and gap junction differentiation
10. Intercellular junctional complexes of the rat seminiferous tubules: A freeze-fracture study
11. Establishment of hepatic cell polarity in the rat hepatoma-human fibroblast hybrid WIF-B9
12. Changes in cellular distribution of connexin 32 and 26 during formation of gap junctions in primary cultures of adult rat hepatocytes
13. Different changes in expression and function of connexin 26 and connexin 32 during DNA synthesis and redifferentiation in primary rat hepatocytes using a DMSO culture system
14. Identification of ZO-1: A high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia
15. Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cells
16. The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein
17. Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes
18. Breaking through the tight junction barrier
19. Structure, function, and regulation of cellular tight junctions
20. Further observations on the fine structure of freeze-cleaved tight junctions
21. Occludin: A novel integral membrane protein localizing at tight junctions
22. Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
23. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands
24. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration
25. Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein
26. ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin
27. Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2
28. Cingulin, a new peripheral component of tight junctions
29. Symplekin, a novel type of tight junction plaque protein
30. Expression and polarized targeting of a rab3 isoform in epithelial cells
31. The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells
32. An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3
33. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions
34. Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin
35. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
36. Two homologous protein components of hepatic gap junctions
37. Comparative characterization of the 21-kD and 26-kD gap junction proteins in murine liver and cultured hepatocytes
38. Gap and tight junctions in liver: Composition, regulation and function
39. Reappearance and long-term maintenance of connexin 32 in proliferated adult rat hepatocytes: Use of serum-free L-15 medium supplemented with EGF and DMSO
40. Induction and regulation of connexin26 by glucagon in primary cultures of adult rat hepatocytes
41. Cx32 but not Cx26 is associated with tight junctions in primary cultures of rat hepatocytes
42. Conditional transformation of mouse liver epithelial cells. An in vitro model for analysis of genetic events in hepatocarcinogenesis
43. Induction of tight junctions in human connexin 32 (hCx32)-transfected mouse hepatocytes: Connexin 32 interacts with occludin
44. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice
45. Strongly decreased gap junctional permeability to inositol 1,4,5-trisphosphate in connexin32 deficient hepatocytes
46. High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32
47. Gap junction expression and cell proliferation in differentiating primary cultures of Cx32 KO mouse hepatocytes
48. Preparation of isolated rat liver cells
49. Cloning and characterization of human and rat liver cDNAs coding for a gap junction protein
50. Altered trafficking of mutant connexin32
51. TPA induced expression and function of human connexin 26 by post-translational mechanisms in stably transfected neuroblastoma cells
52. Effects of cGMP-dependent phosphorylation on rat and human connexin43 gap junction channels
53. Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein
54. Growth-suppressive function of human connexin32 in a conditional immortalized mouse hepatocyte cell line
55. The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction
56. Tight junctions and the molecular basis for regulation of paracellular permeability
57. Role of tight junctions in establishing and maintaining cell cell polarity
58. Effects of plant cytokinins on microfilaments and tight junction permeability
59. Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: Further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivity
60. Functional coupling of tight junctions and microfilaments in T84 monolayers
61. Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells
62. Uncoupling of gate and fence functions of MDCK cells by the actin depolymerizing reagent mycalolide B
63. Cell-to-cell adherens junction formation and actin filament organization: Similarities and differences between non-polarized fibroblasts and polarized epithelial cells
64. ATP-mediated glia signaling