Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage

European Journal of Neuroscience

Volumn 12, Issue 7, 2000, Pages 2265-2272

  Grilli, Mariagrazia ^a   Barbieri, Ilaria ^a   Basudev, Harsha ^a   Brusa, Rossella ^a   Casati, Carlo ^a   Lozza, Gianluca ^a   Ongini, Ennio ^a  

^a San Raffaele Science Park   (Italy)

Author keywords

Cerebral ischaemia; Cytokines; Interleukin 10; Knock out mice; Neurodegeneration; Neuroprotection

Indexed keywords

EXCITOTOXIN; GLUCOSE; INTERLEUKIN 10; OXYGEN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN TISSUE; CELL CULTURE; CELLULAR IMMUNITY; CONTROLLED STUDY; ENCEPHALITIS; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CELL DEATH; CELLS, CULTURED; EXCITATORY AMINO ACID AGONISTS; GLUCOSE; INFARCTION, MIDDLE CEREBRAL ARTERY; INTERLEUKIN-10; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; N-METHYLASPARTATE; NECROSIS; NEURONS; NEUROTOXINS; OXYGEN; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033930743     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00090.x     Document Type: Article

References (38)

1. Bederson, J.B., Pitts, L.H., Tsuji, M., Nishimura, M.C., Davis, R.L. & Bartkowski, H. (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurological examination. Stroke, 17, 472-476.
2. Bell, M.J., Kochanek, P.M., Doughty, L.A., Carcillo, J.A., Adelson, P.D., Clark, R.S., Whalen, M.J. & DeKosky, S.T. (1997) Comparison of the interleukin-6 and interleukin-10 response in children after severe traumatic brain injury or septic shock. Acta Neurochir., 70, 96-97.
3. Benveniste, E.N., Tang, L.P. & Law, R.M. (1995) Differential regulation of astrocyte TNF-alpha expression by the cytokines TGFβ, IL-6 and IL-10. Int. J. Dev. Neurosci., 13, 341-349.
4. Berg, D.J., Davidson, N., Kühn, R., Muller, W., Menon, S., Holland, G., Thompson-Snipes, L., Leach, M.W. & Rennick, D. (1996) Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4+ TH1-like responses. J. Clin. Invest., 98, 1010-1020.
5. Berkman, N., John, M., Roesems, G., Jose, P.J., Barnes, P.J. & Chung, K.F. (1995) Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages. J. Immunol., 155, 4412-4418.
6. Bethea, J.R., Nagashima, H., Acosta, M.C., Briceno, C., Gomez, F., Marcillo, A.E., Loor, K., Green, J. & Dietrich, W.D. (1999) Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats. J. Neurotrauma, 16, 851-863.
7. Brodie, C. (1996) Differential effects of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes. FEBS Lett., 394, 117-120.
8. Chao, C.C., Hu, S., Molitor, T.W., Shaskan, E.G. & Peterson, P.K. (1992) Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J. Immunol., 149, 2736-2741.
9. Clemens, J.A., Stephenson, D.T., Yin, T., Smalstig, E.B., Panetta, J.A. & Little, S.P. (1998) Drug-induced neuroprotection from global ischemia is associated with prevention of persistent but not transient activation of nuclear factor-κB in rats. Stroke, 29, 677-682.
10. Diab, A., Zhu, J., Xiao, B.G., Mustafa, M. & Link, H. (1997) High IL-6 and low IL-10 in the central nervous system are associated with protracted relapsing EAE in DA rats. J. Neuropath. Exp. Neural., 56, 641-650.
11. Di Santo, E., Adami, M., Bertorelli, R. & Ghezzi, P. (1997) Systemic interleukin-10 administration inhibits brain tumor necrosis factor production in mice. Eur. J. Pharmacol., 336, 197-202.
12. Ehrlich, L.C., Hu, S., Peterson, P.K. & Chao, C.C. (1998) IL-10 downregulates human microglial IL-8 by inhibition of NF-kappaB activation. Neuroreport, 9, 1723-1726.
13. Engles, R.E., Huber, T.S., Zander, D.S., Hess, P.J., Welborn, M.B., Moldawer, L.L. & Seeger, J.M. (1997) Exogenous human recombinant interleukin-10 attenuates hindlimb ischemia-reperfusion injury. J. Surg. Res., 69, 425-428.
14. Feuerstein, G.Z., Wang, X.K. & Barone, F.C. (1996) Inflammation-related gene expression and stroke: Implications for new therapeutic targets. In Krieglstein, J. (ed.), Pharmacology of Cerebral Ischemia. Medpharm Scientific Publishers, Stuttgart, pp. 405-415.
15. Feuerstein, G.Z., Wang, X.K. & Barone, F.C. (1998) Inflammatory mediators and brain injury. The Role of Cytokine and Chemokines in Stroke and CNS Disease. In Ginsberg, M., Bogouslavsky, J. (eds), Blackwell Science Ltd, Oxford, pp. 507-531.
16. Fuchs, A.C., Granowitz, E.V., Shapiro, L., Vannier, E., Lonnemann, G., Angel, J.B., Kennedy, J.S., Rabson, A.R., Radwanski, E., Affrime, M.B., Cutler, D.L., Grint, P.C. & Dinarello, C.A., (1996) Clinical, hematologic and immunologic effects of interleukin-10 in humans. J. Clin. Immunol., 16, 291-303.
17. Goldberg, M.P. & Choi, D.W. (1990) Intracellular free calcium increases in cultured cortical neurons deprived of oxygen and glucose. Stroke, 21, III75-III77.
18. Grilli, M., Pizzi, M., Memo, M. & Spano, P.F. (1996) Neuroprotection by salicylates through blockade of NF-κB activation. Science, 274, 1383-1385.
19. Hayward, R., Nossuli, T.O., Scalia, R. & Lefer, A.M. (1997) Cardioprotective effect of interleukin-10 in murine myocardial ischemia-reperfusion. Eur. J. Pharmacol., 334, 157-163.
20. Kühn, R., Lohler, J., Rennick, D., Rajewsky, K. & Muller, W. (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell, 75, 263-274.
21. Kline, J.N., Fisher, P.A., Monick, M.M. & Hunninghake, G.W. (1995) Regulation of interleukin-1 receptor antagonist by Th1 and Th2 cytokines. Am. J. Physiol., 269, L92-L98.
22. Knoblach, S.M. & Faden, A.I. (1998) Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury. Exp. Neural., 153, 143-151.
23. Levi, G., Patrizio, M. & Gallo, V. (1991) Release of endogenous and newly synthetized glutamate and of other aminoacids induced by non-N-methyl-D-aspartate receptor activation in cerebellar granule cell cultures. J. Neurochem., 56, 199-206.
24. Merrill, J.E. & Benveniste, E.N. (1996) Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci., 19, 331-338.
25. Mosmann, T.R. (1994) Properties and function of interleukin-10. Adv. Immunol., 56, 1-26.
26. Piani, D., Spranger, M., Frei, K., Schaffner, A. & Fontana, A. (1992) Macrophage-induced cytotoxicity of N-methyl-D-aspartate receptor positive neurons involves excitatory aminoacids rather than reactive oxygen intermediates and cytokines. Eur. J. Immunol., 22, 2429-2436.
27. Rennick, D.M., Davidson, N. & Berg, D. (1995) Interleukin-10 gene knock-out mice: a model of chronic inflammation. Clin. Immunol. Immunopathol., 76, S174-S178.
28. -/-mice: an overview. J. Leukoc. Biol., 61, 389-396.
29. Rothwell, N.J. & Hopkins, S.J. (1995) Cytokines and the nervous system II: actions and mechanisms of action. Trends Neurosci., 18, 130-136.
30. Sanna, A., Pflug, B., Colangelo, A.M. & Mocchetti, I. (1998) Interleukin-10 prevents glutamate-induced apoptosis in cerebellar granule cells. Soc. Neurosci. Abstr., 24, 1787.
31. Savman, K., Blennow, M., Gustafson, K., Tarkowski, E. & Hagberg, H. (1998) Cytokine response in cerebrospinal fluid after birth asphyxia. Pediatr. Res., 43, 746-751.
32. Sheng, W.S., Hu, S., Kravitz, F.H., Peterson. P.K. & Chao, C.C. (1995) Tumor necrosis factor alpha upregulates human microglial cell production of interleukin-10 in vitro. Clin. Diagn. Lab. Immunol., 2, 604-608.
33. Shrikant, P., Weber, E., Jilling, T. & Benveniste, E.N. (1995) Intercellular adhesion molecule-1 gene expression by glial cells. Differential mechanisms of inhibition by IL-10 and IL.-6. J. Immunol., 155, 1489-1501.
34. Spera, P.A., Ellison, J.A., Feuerstein, G.Z. & Barone, F.C. (1998) IL-10 reduces rat brain injury following focal stroke. Neurosci. Lett., 251, 189-192.
35. Tarkowski, E., Rosengren, L., Blomstrand, C., Wikkelso, C., Jensen, C., Ekholm, S. & Tarkowski, A. (1997) Intrathecal release of pro-and anti-inflammatory cytokines during stroke. Clin. Exp. Immunol., 110, 492-499.
36. Wang, P., Wu, P., Siegel, M.I., Egan, R.W. & Billah, M.M. (1995) Interleukin (IL) -10 inhibits Nuclear factor κB (NFκB) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms, J. Biol. Chem., 270, 9558-9563.
37. Williams, K., Dooley, N., Ulvestad, E., Becher, B. & Antel, J.P. (1996) IL-10 production by adult human derived microglial cells. Neurochem. Int., 29, 55-64.
38. Zhai, Q.H., Futrell, N. & Chen, F.J. (1997) Gene expression of IL-10 in relationship to TNF-alpha, IL-1 beta and IL-2 in the rat brain following middle cerebral artery occlusion. J. Neurol. Sci., 152, 119-124.