-
1
-
-
18344380647
-
Molecular genetics of multiple endocrine neoplasia types 1 and 2
-
Marx SJ. Molecular genetics of multiple endocrine neoplasia types 1 and 2. Nat. Rev. Cancer 5(5), 367-375 (2005).
-
(2005)
Nat. Rev. Cancer
, vol.5
, Issue.5
, pp. 367-375
-
-
Marx, S.J.1
-
2
-
-
0030963446
-
Positional cloning of the gene for multiple endocrine neoplasia-type 1
-
Chandrasekharappa SC, Guru SC, Manickam P et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276(5311), 404-407 (1997).
-
(1997)
Science
, vol.276
, Issue.5311
, pp. 404-407
-
-
Chandrasekharappa, S.C.1
Guru, S.C.2
Manickam, P.3
-
3
-
-
38149112594
-
Multiple endocrine neoplasia type 1 (MEN1): Analysis of 1336 mutations reported in the first decade following identification of the gene
-
Lemos MC, Thakker RV. Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene. Hum. Mutat. 29(1), 22-32 (2008).
-
(2008)
Hum. Mutat.
, vol.29
, Issue.1
, pp. 22-32
-
-
Lemos, M.C.1
Thakker, R.V.2
-
4
-
-
84862777931
-
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
-
Huang J, Gurung B, Wan B et al. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature 482(7386), 542-546 (2012).
-
(2012)
Nature
, vol.482
, Issue.7386
, pp. 542-546
-
-
Huang, J.1
Gurung, B.2
Wan, B.3
-
5
-
-
0033534510
-
Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription
-
Agarwal SK, Guru SC, Heppner C et al. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell 96(1), 143-152 (1999).
-
(1999)
Cell
, vol.96
, Issue.1
, pp. 143-152
-
-
Agarwal, S.K.1
Guru, S.C.2
Heppner, C.3
-
6
-
-
20044380143
-
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors
-
Milne TA, Hughes CM, Lloyd R et al. Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc. Natl Acad. Sci. USA 102(3), 749-754 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, Issue.3
, pp. 749-754
-
-
Milne, T.A.1
Hughes, C.M.2
Lloyd, R.3
-
7
-
-
26844548626
-
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c
-
Karnik SK, Hughes CM, Gu X et al. Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc. Natl Acad. Sci. USA 102(41), 14659-14664 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, Issue.41
, pp. 14659-14664
-
-
Karnik, S.K.1
Hughes, C.M.2
Gu, X.3
-
8
-
-
76549105779
-
MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele
-
Thiel AT, Blessington P, Zou T et al. MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. Cancer Cell 17(2), 148-159 (2010).
-
(2010)
Cancer Cell
, vol.17
, Issue.2
, pp. 148-159
-
-
Thiel, A.T.1
Blessington, P.2
Zou, T.3
-
9
-
-
6344222803
-
Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes
-
Pal S, Vishwanath SN, Erdjument-Bromage H, Tempst P, Sif S. Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. Mol. Cell Biol. 24(21), 9630-9645 (2004).
-
(2004)
Mol. Cell Biol.
, vol.24
, Issue.21
, pp. 9630-9645
-
-
Pal, S.1
Vishwanath, S.N.2
Erdjument-Bromage, H.3
Tempst, P.4
Sif, S.5
-
10
-
-
84876902432
-
Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome
-
Gurung B, Feng Z, Iwamoto DV et al. Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome. Cancer Res. 73(8), 2650-2658 (2013).
-
(2013)
Cancer Res
, vol.73
, Issue.8
, pp. 2650-2658
-
-
Gurung, B.1
Feng, Z.2
Iwamoto, D.V.3
-
11
-
-
79958207835
-
Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function
-
Allen BL, Song JY, Izzi L et al. Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. Dev. Cell 20(6), 775-787 (2011).
-
(2011)
Dev. Cell
, vol.20
, Issue.6
, pp. 775-787
-
-
Allen, B.L.1
Song, J.Y.2
Izzi, L.3
-
12
-
-
34249011892
-
Gas1 extends the range of Hedgehog action by facilitating its signaling
-
Martinelli DC, Fan CM. Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev. 21(10), 1231-1243 (2007).
-
(2007)
Genes Dev
, vol.21
, Issue.10
, pp. 1231-1243
-
-
Martinelli, D.C.1
Fan, C.M.2
-
13
-
-
57049089995
-
Hedgehog signaling in development and cancer
-
Jiang J, Hui CC. Hedgehog signaling in development and cancer. Dev. Cell 15(6), 801-812 (2008).
-
(2008)
Dev. Cell
, vol.15
, Issue.6
, pp. 801-812
-
-
Jiang, J.1
Hui, C.C.2
-
14
-
-
0031913524
-
Activating smoothened mutations in sporadic basal-cell carcinoma
-
Xie J, Murone M, Luoh SM et al. Activating smoothened mutations in sporadic basal-cell carcinoma. Nature 391(6662), 90-92 (1998).
-
(1998)
Nature
, vol.391
, Issue.6662
, pp. 90-92
-
-
Xie, J.1
Murone, M.2
Luoh, S.M.3
-
15
-
-
33646362581
-
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
-
Thompson MC, Fuller C, Hogg TL et al. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J. Clin. Oncol. 24(12), 1924-1931 (2006).
-
(2006)
J. Clin. Oncol.
, vol.24
, Issue.12
, pp. 1924-1931
-
-
Thompson, M.C.1
Fuller, C.2
Hogg, T.L.3
-
16
-
-
33846998990
-
Sonic hedgehog-Gli1 signaling pathway might become an effective therapeutic target in gastrointestinal neuroendocrine carcinomas
-
Shida T, Furuya M, Nikaido T et al. Sonic hedgehog-Gli1 signaling pathway might become an effective therapeutic target in gastrointestinal neuroendocrine carcinomas. Cancer Biol. Ther. 5(11), 1530-1538 (2006).
-
(2006)
Cancer Biol. Ther.
, vol.5
, Issue.11
, pp. 1530-1538
-
-
Shida, T.1
Furuya, M.2
Nikaido, T.3
-
17
-
-
81255171373
-
A crucial requirement for hedgehog signaling in small cell lung cancer
-
Park KS, Martelotto LG, Peifer M et al. A crucial requirement for hedgehog signaling in small cell lung cancer. Nat. Med. 17(11), 1504-1508 (2011).
-
(2011)
Nat. Med.
, vol.17
, Issue.11
, pp. 1504-1508
-
-
Park, K.S.1
Martelotto, L.G.2
Peifer, M.3
-
18
-
-
77951835156
-
Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult b-cell function
-
Lau J, Hebrok M. Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult b-cell function. Diabetes 59(5), 1211-1221 (2010).
-
(2010)
Diabetes
, vol.59
, Issue.5
, pp. 1211-1221
-
-
Lau, J.1
Hebrok, M.2
-
19
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive KP, Jacobetz MA, Davidson CJ et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324(5933), 1457-1461 (2009).
-
(2009)
Science
, vol.324
, Issue.5933
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
-
20
-
-
0041970059
-
Of mice and MEN1: Insulinomas in a conditional mouse knockout
-
Crabtree JS, Scacheri PC, Ward JM et al. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol. Cell Biol. 23(17), 6075-6085 (2003).
-
(2003)
Mol. Cell Biol.
, vol.23
, Issue.17
, pp. 6075-6085
-
-
Crabtree, J.S.1
Scacheri, P.C.2
Ward, J.M.3
-
21
-
-
70349244812
-
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
-
Rudin CM, Hann CL, Laterra J et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N. Engl. J. Med. 361(12), 1173-1178 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, Issue.12
, pp. 1173-1178
-
-
Rudin, C.M.1
Hann, C.L.2
Laterra, J.3
-
23
-
-
10644296443
-
The surgical management of MEN-1 pancreatoduodenal neuroendocrine disease
-
Hausman MS Jr, Thompson NW, Gauger PG, Doherty GM. The surgical management of MEN-1 pancreatoduodenal neuroendocrine disease. Surgery 136(6), 1205-1211 (2004).
-
(2004)
Surgery
, vol.136
, Issue.6
, pp. 1205-1211
-
-
Hausman Jr., M.S.1
Thompson, N.W.2
Gauger, P.G.3
Doherty, G.M.4
-
24
-
-
84861856844
-
Efficacy and safety of vismodegib in advanced basal-cell carcinoma
-
Sekulic A, Migden MR, Oro AE et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N. Engl. J. Med. 366(23), 2171-2179 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, Issue.23
, pp. 2171-2179
-
-
Sekulic, A.1
Migden, M.R.2
Oro, A.E.3
|