Performance of an exhaled nitric oxide and carbon dioxide sensor using quantum cascade laser-based integrated cavity output spectroscopy

Journal of Biomedical Optics

Volumn 12, Issue 3, 2007, Pages

  McCurdy, Matthew R ^a,b   Bakhirkin, Yury ^a   Wysocki, Gerard ^a   Tittel, Frank K ^a  

^a RICE UNIVERSITY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Breath analysis; Carbon dioxide; Chemiluminescence; Integrated cavity output spectroscopy; Nitric oxide; Quantum cascade laser

Indexed keywords

CARBON DIOXIDE; DIAGNOSTIC AGENT; NITRIC OXIDE;

ADULT; AGED; ARTICLE; BREATH ANALYSIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; EQUIPMENT; EQUIPMENT DESIGN; EVALUATION; FEMALE; HUMAN; INSTRUMENTATION; LASER; LUNG GAS EXCHANGE; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPECTROSCOPY; SYSTEM ANALYSIS;

ADULT; AGED; BREATH TESTS; CARBON DIOXIDE; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FEMALE; HUMANS; LASERS; MALE; MIDDLE AGED; NITRIC OXIDE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY GAS EXCHANGE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTRUM ANALYSIS; SYSTEMS INTEGRATION;

BIOMARKERS; CARBON DIOXIDE; CHEMILUMINESCENCE; INFRARED SPECTROSCOPY; NITRIC OXIDE; PULMONARY DISEASES; QUANTUM WELL LASERS;

BLAND-ALTMAN METHOD; BREATH ANALYSIS; INTEGRATED CAVITY OUTPUT SPECTROSCOPY; NONDISPERSIVE INFRARED (NDIR); QUANTUM CASCADE LASER;

CHEMICAL SENSORS;

EID: 34547895821     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.2747608     Document Type: Article

References (43)

1. L. E. Gustafsson, A. M. Leone, M. G. Persson, N. P. Wiklund, and S. Moncada, "Endogenous nitric oxide is present in the exhaledair of rabbits, guinea pigs and humans," Biochem. Biophys. Res. Commun. 181, 852-857 (1991).
2. D. Bukstein, M. Kraft, A. H. Liu, and S. P. Peters, "Asthma endpoints and outcomes: What have we learned?" J. Allergy Clin. Immunol. 118, S1-S15 (2006). (Pubitemid 44508697)
3. A. D. Smith, J. O. Cowan, K. P. Brassett, G. P. Herbison, and D. R. Taylor, "Use of exhaled nitric oxide measurements to guide treatment in chronic asthma," N. Engl. J. Med. 352, 2163-2173 (2005).
4. D. R. Taylor, M. W. Pijnenburg, A. D. Smith, and J. C. De Jongste, "Exhaled nitric oxide measurements: clinical application and interpretation," Thorax 61, 817-827 (2006). (Pubitemid 44369409)
5. P. E. Silkoff, P. A. McClean, A. S. Slutsky, H. G. Furlott, E. Hoff-stein, S. Wakita, K. R. Chapman, J. P. Szalai, and N. Zamel, "Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide," Am. J. Respir. Crit. Care Med. 155, 260267 (1997). (Pubitemid 27053174)
6. American Thoracic Society and European Respiratory Society, "ATS/ ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005," Am. J. Respir. Crit. Care Med. 171, 912930 (2005).
7. S. C. George, M. Hogman, S. Permutt, and P. E. Silkoff, "Modeling pulmonary nitric oxide exchange," J. Appl. Physiol. 96, 831-839 (2004). (Pubitemid 38248651)
8. A. Artlich, B. Jonsson, M. Bhiladvala, P. A. Lonnqvist, and L. E. Gustafsson, "Single breath analysis of endogenous nitric oxide in the newborn," Biol. Neonate 79, 21-26 (2001). (Pubitemid 32041370)
9. E. Baraldi, C. Dario, R. Ongaro, M. Scollo, N. M. Azzolin, N. Panza, N. Paganini, and F. Zacchello, "Exhaled nitric oxide concentrations during treatment of wheezing exacerbation ininfants and young children," Am. J. Respir. Crit. Care Med. 159, 1284-1288 (1999). (Pubitemid 29202568)
10. T. Birken, J. Schubert, W. Miekisch, and G. Noldge-Schomburg, "A novel visually CO2 controlled alveolar breath sampling technique," Technol. Health Care 14, 499-506 (2006). (Pubitemid 44885294)
11. G. L. Hall, B. Reinmann, J. H. Wildhaber, and U. Frey, "Tidal exhaled nitric oxide in healthy, unsedated newborn infants with prenatal tobacco exposure," J. Appl. Physiol. 92,59-66(2002). (Pubitemid 34669989)
12. C. B. Roller, K. Namjou, J. D. Jeffers, W. Potter, P. J. McCann, and J. Grego, "Simultaneous NO and CO2 measurement in human breath with a single IV-VI mid-infrared laser," Opt. Lett. 27, 107-109 (2002). (Pubitemid 34617916)
13. K. Namjou, C. B. Roller, T. E. Reich, J. D. Jeffers, G. L. McMillen, P. J. McCann, and M. A. Camp, "Determination of exhaled nitric oxide distributions in a diverse sample population using tunable diode laser absorption spectroscopy," Appl. Phys. B 85, 427-435 (2006). (Pubitemid 44451364)
14. T. Hemmingsson, D. Linnarsson, and R. Gambert, "Novel hand-held device for exhaled nitric oxide-analysis in research and clinical applications," J. Clin. Monit Comput. 18, 379-387 (2004). (Pubitemid 40867424)
15. K. Alving, C. Janson, and L. Nordvall, "Performance of a new handheld device for exhaled nitric oxide measurement in adults and children," Respir. Res. 20, 57-67 (2006).
16. C. McGill, G. Malik, and S. W. Turner, "Validation of a hand-held exhaled nitric oxide analyzer for use in children," Pediatr. Pulmonol 41, 1053-1057 (2006). (Pubitemid 44752807)
17. L. C. Short, R. Frey, and T. Benter, "Real-time analysis of exhaled breath via resonance-enhanced multiphoton ionization-mass spec-trometry with a medium pressure laser ionization source: observed nitric oxide profile," Appl. Spectrosc. 60, 217-222 (2006). (Pubitemid 43341863)
18. A. Fontijn, A. Sabadell, and R. Ronco, "Homogenous chemilumines-cent measurement of nitric oxide with ozone. Implications for continuous selective monitoring of gaseous air pollutants," Anal. Chem. 42, 575-579 (1970).
19. P. Silkoff, M. Carlson, T. Bourke, R. Katial, E. Ogren, and S. Szefler, "The aerocrine exhaled nitric oxide monitoring system NIOX is cleared by the Us Food and Drug Administration for monitoring therapy in asthma," J. Allergy Clin. Immunol. 11 4, 1241-1256 (2004). (Pubitemid 39469172)
20. A. Elia, P. M. Lugara, and C. Giancaspro, "Photoacoustic detection of nitric oxide by use of a quantum-cascade laser," Opt. Lett. 30,988-990 (2005). (Pubitemid 40749258)
21. C. B. Roller, K. Namjou, J. D. Jeffers, M. Camp, A. Mock, P. J. McCann, and J. Grego, "Nitric oxide breath testing by tunable-diode laser absorption spectroscopy: application in monitoring respiratory inflammation," Appl. Opt. 41, 6018-6029 (2002). (Pubitemid 35167169)
22. D. D. Nelson, J. B. McManus, S. C. Herndon, J. H. Shorter, M. S. Zahniser, S. Blaser, L. Hvozdara, A. Muller, M. Giovannini, and J. Faist, "Characterization of a near-room-temperature, continuous-wave quantum cascade laser for long-term, unattended monitoring of nitric oxide in the atmosphere," Opt. Lett. 31, 2012-2014 (2006). (Pubitemid 44542758)
23. B. W. M. Moeskops, S. M. Cstescu, and F. J. M. Harren, "Sub-part-per billion monitoring of nitric oxide using wavelength modulation spectroscopy in combination with a thermoelectrically cooled, continuous wave quantum cascade laser," Opt. Lett. 31, 823-825 (2006).
24. H. Ganser, W. Urban, and J. Brown, "The sensitive detection of NO by Faraday modulation spectroscopy with a quantum cascade laser," Mol. Phys. 101, 545-550 (2003).
25. B. A. Paldus and A. A. Kachanov, "An historical overview of cavity-enhanced methods," Can. J. Phys. 83, 975-999 (2005). (Pubitemid 43168275)
26. A. A. Kosterev, A. L. Malinovsky, F. K. Tittel, C. Gmachl, F. Ca-passo, D. L. Sivco, J. N. Baillargeon, A. L. Hutchinson, and A. Y. Cho, "Cavity ring down spectroscopic detection of nitricoxide with a continuous-wave quantum-cascade laser," Appl. Opt. 40, 5522-5529 (2001).
27. D. Halmer, G. von Basum, M. Horstjann, P. Herring, and M. Murtz, "Time resolved simultaneous detection of (NO)-N-14 and (NO)-N-15 via mid-infrared cavity leak-out spectroscopy," Isotopes Environ. Health Stud. 41, 303-311 (2005). (Pubitemid 43084548)
28. A. O'Keefe, J. J. Scherer, and J. B. Paul, "CW integrated cavity output spectroscopy," Chem. Phys. Lett. 307, 343-349 (1999). (Pubitemid 129592596)
29. J. B. Paul, L. Larson, and J. G. Anderson, "Ultrasensitive absorption spectroscopy with a high-finesse optical cavity and off-axis alignment," Appl. Opt. 40, 4904-4910 (2001).
30. D. S. Baer, J. B. Paul, M. Gupta, and A. O'Keefe, "Sensitive absorption measurements in the near-infrared region using off-axis integrated-cavity-output spectroscopy," Appl. Phys. B 75, 261-265 (2002). (Pubitemid 35354442)
31. M. L. Silva, D. M. Sonnenfroh, D. I. Rosen, M. G. Allen, and A. O'Keefe, "Integrated cavity output spectroscopy measurements of NO levels in breath with a pulsed room-temperature QCL," Appl. Phys. B 81, 705-710 (2004). (Pubitemid 41344120)
32. Y. A. Bakhirkin, A. A. Kosterev, C. Roller, R. F. Curl, and F. K. Tittel, "Mid-infrared quantum cascade laser based off-axis integrated cavity output spectroscopy for biogenic nitric oxide detection," Appl. Opt. 43, 2257-2266 (2004).
33. Y. A. Bakhirkin, A. A. Kosterev, R. F. Curl, F. K. Tittel, D. A. Yarekha, L. Hvozdara, M. Giovannini, and J. Faist, "Sub-ppbv nitric oxide concentration measurements using cw thermoelectrically cooled quantum cascade laser-based integrated cavity output spec-troscopy," Appl. Phys. B 82, 149-154 (2006). (Pubitemid 41788382)
34. S. Blaser, D. A. Yarekha, L. Hvozdara, Y. Bonetti, A. Muller, M. Giovannini, and J. Faist, "Room-temperature, continuous-wave, single-mode quantum cascade lasers at λ-5.4 μm," Appl. Phys. Lett. 86, 041109 (2005).
35. L. Diehl, D. Bour, S. Corzine, J. Zhu, G. Hofler, M. Loncar, M. Troccoli, and F. Capasso, "High-temperature continuous wave operation of strain-balanced quantum cascade lasers grown by metal organic vapor-phase epitaxy," Appl. Phys. Lett. 89, 081101 (2006).
36. M. R. McCurdy, Y. A. Bakhirkin, and F. K. Tittel, "Quantum cascade laser-based integrated cavity output spectroscopy of exhaled nitric oxide," Appl. Phys. B 85, 445-452 (2006). (Pubitemid 44451366)
37. Z. Borrill, D. Clough, N. Truman, J. Morris, S. Langley, and D. Singh, "A comparison of exhaled nitric oxide measurements performed using three different analysers," Respir. Med. 100, 1392-1396 (2006). (Pubitemid 43964493)
38. K. C. Muller, R. A. Jorres, H. Magnussen, and O. Holz, "Comparison of exhaled nitric oxide analysers," Respir. Med. 99, 631-637 (2005). (Pubitemid 40468512)
39. J. M. Bland and D. G. Altman, "Statistical methods for assessing agreement between two methods of linical measurement," Lancet 8, 307-310 (1986). (Pubitemid 16134762)
40. J. Ludbrook, "Statistical techniques for comparing measurers and methods of measurement: a critical review," Clin. Exp. Pharmacol. Physiol. 29, 527-536 (2002). (Pubitemid 34639322)
41. C. T. Anderson and P. H. Breen, "Carbon dioxide kinetics and cap-nography during critical care," Crit. Care 4, 207-215 (2000). (Pubitemid 30622085)
42. J. Reid and D. Labrie, "Second-harmonic detection with tunabled iode lasers-comparison of experiment and theory," Appl. Phys. B 26, 203-210 (1981). (Pubitemid 12501923)
43. A. Zybin, Y. A. Kuritsyn, V. R. Mironenko, and K. Niemax, "Cavity enhanced wavelength modulation spectrometry for application in chemical analysis," Appl. Phys. B 78, 103-109 (2004).