Non-celiac gluten sensitivity: Clinical relevance and recommendations for future research

Neurogastroenterology and Motility

Volumn 25, Issue 11, 2013, Pages 864-871

  Mooney, P D ^a   Aziz, I ^a   Sanders, D S ^a  

^a ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

Celiac disease; Gluten sensitivity; Irritable bowel syndrome; Non celiac gluten sensitivity

Indexed keywords

GLUTEN;

ABDOMINAL DISCOMFORT; BLOATING; CELIAC DISEASE; DEPRESSION; DIARRHEA; FATIGUE; GASTROINTESTINAL SYMPTOM; GLUTEN FREE DIET; HEADACHE; HUMAN; INTESTINE VILLUS ATROPHY; IRRITABLE COLON; MUSCULOSKELETAL PAIN; NON CELIAC GLUTEN SENSITIVITY; PAIN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; WHEAT ALLERGY;

CELIAC DISEASE; GLUTEN SENSITIVITY; IRRITABLE BOWEL SYNDROME; NON-CELIAC GLUTEN SENSITIVITY;

CELIAC DISEASE; DIET, GLUTEN-FREE; GASTROINTESTINAL DISEASES; GLUTENS; HUMANS; WHEAT HYPERSENSITIVITY;

EID: 84884989931     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.12216     Document Type: Review

References (54)

1. Ludvigsson JF, Leffler DA, Bai JC et al. The Oslo definitions for coeliac disease and related terms. Gut 2013; 62: 43-52.
2. West J, Logan RF, Hill PG et al. Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut 2003; 52: 960-5.
3. Mustalahti K, Catassi C, Reunanen A et al. The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med 2010; 42: 587-95.
4. Institute A. AGA institute medical position statement on the diagnosis and management of celiac disease. Gastroenterology 2006; 131: 1977-80.
5. Hopper AD, Cross SS, Hurlstone DP et al. Pre-endoscopy serological testing for coeliac disease: evaluation of a clinical decision tool. BMJ 2007; 334: 729.
6. Hall NJ, Rubin G, Charnock A. Systematic review: adherence to a gluten-free diet in adult patients with coeliac disease. Aliment Pharmacol Ther 2009; 30: 315-30.
7. Hauser W, Stallmach A, Caspary WF, Stein J. Predictors of reduced health-related quality of life in adults with coeliac disease. Aliment Pharmacol Ther 2007; 25: 569-78.
8. Layton L. 3 years after deadline, FDA still hasn't defined 'gluten free'. Washington Post; 29 April 2011: Available at: http://www.washingtonpost.com/politics/3-years-after-deadline-fda-still-hasnt-defined-gluten-free/2011/04/22/AFRq6i8E_story_1.html (online).
9. Di Sabatino A, Corazza GR. Nonceliac gluten sensitivity: sense or sensibility? Ann Intern Med 2012; 156: 309-11.
10. Ferch CC, Chey WD. Irritable bowel syndrome and gluten sensitivity without celiac disease: separating the wheat from the chaff. Gastroenterology 2012; 142: 664-6.
11. Aziz I, Sanders DS. Emerging concepts: from coeliac disease to non-coeliac gluten sensitivity. Proc Nutr Soc 2012; 71: 576-80.
12. Volta U, De Giorgio R. New understanding of gluten sensitivity. Nat Rev Gastroenterol Hepatol 2012; 9: 295-9.
13. Verdu EF, Armstrong D, Murray JA. Between celiac disease and irritable bowel syndrome: the "no man's land" of gluten sensitivity. Am J Gastroenterol 2009; 104: 1587-94.
14. Cooper BT, Holmes GK, Ferguson R, Thompson RA, Allan RN, Cooke WT. Gluten-sensitive diarrhea without evidence of celiac disease. Gastroenterology 1980; 79: 801-6.
15. Kaukinen K, Turjanmaa K, Mäki M et al. Intolerance to cereals is not specific for coeliac disease. Scand J Gastroenterol 2000; 35: 942-6.
16. Sapone A, Bai JC, Ciacci C et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med 2012; 10: 13.
17. Carroccio A, Mansueto P, Iacono G et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. Am J Gastroenterol 2012; 107: 1898-906; quiz 1907.
18. DiGiacomo DV, Tennyson CA, Green PH, Demmer RT. Prevalence of gluten-free diet adherence among individuals without celiac disease in the USA: results from the Continuous National Health and Nutrition Examination Survey 2009-2010. Scand J Gastroenterol 2013; 48: 921-5.
19. Volta U, Tovoli F, Cicola R et al. Serological tests in gluten sensitivity (nonceliac gluten intolerance). J Clin Gastroenterol 2012; 46: 680-5.
20. Wahnschaffe U, Ullrich R, Riecken EO, Schulzke JD. Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome. Gastroenterology 2001; 121: 1329-38.
21. Wahnschaffe U, Schulzke JD, Zeitz M, Ullrich R. Predictors of clinical response to gluten-free diet in patients diagnosed with diarrhea-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol 2007; 5: 844-50; quiz 769.
22. Vazquez-Roque MI, Camilleri M, Smyrk T et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology 2013; 144: 903-11, e903.
23. Sanders DS, Carter MJ, Hurlstone DP et al. Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care. Lancet 2001; 358: 1504-8.
24. Sanders DS, Patel D, Stephenson TJ et al. A primary care cross-sectional study of undiagnosed adult coeliac disease. Eur J Gastroenterol Hepatol 2003; 15: 407-13.
25. Biesiekierski JR, Newnham ED, Irving PM et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol 2011; 106: 508-14; quiz 515.
26. Pimentel M, Chang C. Inflammation and microflora. Gastroenterol Clin North Am 2011; 40: 69-85.
27. Shepherd SJ, Parker FC, Muir JG, Gibson PR. Dietary triggers of abdominal symptoms in patients with irritable bowel syndrome: randomized placebo-controlled evidence. Clin Gastroenterol Hepatol 2008; 6: 765-71.
28. Biesiekierski JR, Rosella O, Rose R et al. Quantification of fructans, galacto-oligosacharides and other short-chain carbohydrates in processed grains and cereals. J Hum Nutr Diet 2011; 24: 154-76.
29. Barrett JS, Gibson PR. Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) and nonallergic food intolerance: FODMAPs or food chemicals? Therap Adv Gastroenterol 2012; 5: 261-8.
30. Aziz I, Evans KE, Hopper AD, Smillie DM, Sanders DS. A prospective study into the aetiology of lymphocytic duodenosis. Aliment Pharmacol Ther 2010; 32: 1392-7.
31. Molina-Infante J, Martin-Noguerol E, Alvarado-Arenas M, Porcel-Carreno SL, Jimenez-Timon S, Hernandez-Arbeiza FJ. Reply. J Allergy Clin Immunol 2013; 131: 613-4.
32. Kurppa K, Collin P, Viljamaa M et al. Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study. Gastroenterology 2009; 136: 816-23.
33. Husby S, Koletzko S, Korponay-Szabo IR et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012; 54: 136-60.
34. Carroccio A, Iacono G, D'Amico D et al. Production of anti-endomysial antibodies in cultured duodenal mucosa: usefulness in coeliac disease diagnosis. Scand J Gastroenterol 2002; 37: 32-8.
35. Carroccio A, Iacono G, Di Prima L et al. Antiendomysium antibodies assay in the culture medium of intestinal mucosa: an accurate method for celiac disease diagnosis. Eur J Gastroenterol Hepatol 2011; 23: 1018-23.
36. Biesiekierski JR, Peters SL, Newnham ED, Rosella O, Muir JG, Gibson PR. No effects of gluten in patients with self-reported non-celiac gluten sensitivity following dietary reduction of low-fermentable, poorly-absorbed, short-chain carbohydrates. Gastroenterology 2013; 145: 320-8.
37. Vazquez-Roque MI, Camilleri M, Smyrk T et al. Association of HLA-DQ gene with bowel transit, barrier function, and inflammation in irritable bowel syndrome with diarrhea. Am J Physiol Gastrointest Liver Physiol 2012; 303: G1262-9.
38. Smecuol E, Bai JC, Vazquez H et al. Gastrointestinal permeability in celiac disease. Gastroenterology 1997; 112: 1129-36.
39. Schulzke JD, Bentzel CJ, Schulzke I, Riecken EO, Fromm M. Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue. Pediatr Res 1998; 43: 435-41.
40. Vogelsang H, Schwarzenhofer M, Steiner B, Wyatt J, Oberhuber G. In vivo and in vitro permeability in coeliac disease. Aliment Pharmacol Ther 2001; 15: 1417-25.
41. Sander GR, Cummins AG, Henshall T, Powell BC. Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins. FEBS Lett 2005; 579: 4851-5.
42. Ciccocioppo R, Finamore A, Ara C, Di Sabatino A, Mengheri E, Corazza GR. Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac disease. Am J Clin Pathol 2006; 125: 502-11.
43. Sapone A, Lammers KM, Casolaro V et al. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med 2011; 9: 23.
44. Dunlop SP, Hebden J, Campbell E et al. Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am J Gastroenterol 2006; 101: 1288-94.
45. Bernardo D, Garrote JA, Fernández-Salazar L, Riestra S, Arranz E. Is gliadin really safe for non-coeliac individuals? Production of interleukin 15 in biopsy culture from non-coeliac individuals challenged with gliadin peptides. Gut 2007; 56: 889-90.
46. Di Sabatino A, Ciccocioppo R, Cupelli F et al. Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease. Gut 2006; 55: 469-77.
47. Bernardo D, Garrote JA, Allegretti Y et al. Higher constitutive IL15R alpha expression and lower IL-15 response threshold in coeliac disease patients. Clin Exp Immunol 2008; 154: 64-73.
48. Bernardo D, Garrote JA, Arranz E. Are non-celiac disease gluten-intolerant patients innate immunity responders to gluten? Am J Gastroenterol 2011; 106: 2201; author reply 2201-2202.
49. Sapone A, Lammers KM, Mazzarella G et al. Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch Allergy Immunol 2010; 152: 75-80.
50. Brottveit M, Beitnes AC, Tollefsen S et al. Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity. Am J Gastroenterol 2013; 108: 842-50.
51. Brottveit M, Vandvik PO, Wojniusz S, Lovik A, Lundin KE, Boye B. Absence of somatization in non-coeliac gluten sensitivity. Scand J Gastroenterol 2012; 47: 770-7.
52. Spiller R, Aziz Q, Creed F et al. Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut 2007; 56: 1770-98.
53. Carroccio A, Brusca I, Mansueto P et al. A cytologic assay for diagnosis of food hypersensitivity in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2010; 8: 254-60.
54. Carroccio A, Brusca I, Mansueto P et al. A comparison between two different in vitro basophil activation tests for gluten- and cow's milk protein sensitivity in irritable bowel syndrome (IBS)-like patients. Clin Chem Lab Med 2013; 51: 1257-63.